Robert E W Hancock

Robert E W Hancock

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Robert E W Hancock

Publications by authors named "Robert E W Hancock"

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Insights into the mechanism of action of two analogues of aurein 2.2.

Biochim Biophys Acta Biomembr 2020 Jun 5;1862(6):183262. Epub 2020 Mar 5.

Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbamem.2020.183262DOI Listing
June 2020

MetaBridge: An Integrative Multi-Omics Tool for Metabolite-Enzyme Mapping.

Curr Protoc Bioinformatics 2020 Jun;70(1):e98

Center for Microbial Disease and Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1002/cpbi.98DOI Listing
June 2020

and antibiotic capacity of two host defence peptides.

Antimicrob Agents Chemother 2020 May 4. Epub 2020 May 4.

Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, A.P. 510-3, Cuernavaca Mor., 62250, México.

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http://dx.doi.org/10.1128/AAC.00145-20DOI Listing
May 2020

EcDBS1R6: A novel cationic antimicrobial peptide derived from a signal peptide sequence.

Biochim Biophys Acta Gen Subj 2020 May 13;1864(9):129633. Epub 2020 May 13.

S-Inova Biotech, Pós-graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande, MS, Brazil; Centro de Análises Proteômicas e Bioquímicas, Pós-Graduação em Ciências Genômicas e Biotecnologia Universidade Católica de Brasília, Brasília, DF, Brazil; Molecular Pathology Post-graduate Program, University of Brasília, Brasília, Distrito Federal, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2020.129633DOI Listing
May 2020

Overexpression of the Small RNA PA0805.1 in Pseudomonas aeruginosa Modulates the Expression of a Large Set of Genes and Proteins, Resulting in Altered Motility, Cytotoxicity, and Tobramycin Resistance.

mSystems 2020 May 19;5(3). Epub 2020 May 19.

Center for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada

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http://dx.doi.org/10.1128/mSystems.00204-20DOI Listing
May 2020

NtrBC Regulates Invasiveness and Virulence of During High-Density Infection.

Front Microbiol 2020 5;11:773. Epub 2020 May 5.

Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.3389/fmicb.2020.00773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214821PMC
May 2020

Surfing motility is a complex adaptation dependent on the stringent stress response in Pseudomonas aeruginosa LESB58.

PLoS Pathog 2020 Mar 24;16(3):e1008444. Epub 2020 Mar 24.

Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1371/journal.ppat.1008444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122816PMC
March 2020

Multidrug Adaptive Resistance of Pseudomonas aeruginosa Swarming Cells.

Antimicrob Agents Chemother 2020 02 21;64(3). Epub 2020 Feb 21.

Center for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada

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http://dx.doi.org/10.1128/AAC.01999-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038238PMC
February 2020

Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin.

Biochim Biophys Acta Biomembr 2020 Feb 29:183228. Epub 2020 Feb 29.

Biochemistry Research Group, Department of Biological Sciences, University of Calgary, 2500 University Dr. NW, Calgary, AB T2N 1N4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbamem.2020.183228DOI Listing
February 2020

Effect of Long-term Exposure to Peptides on Mono- and Multispecies Biofilms in Dentinal Tubules.

J Endod 2019 Dec 9;45(12):1522-1528. Epub 2019 Oct 9.

Division of Endodontics, Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.joen.2019.09.003DOI Listing
December 2019

Metabolomics Study of the Synergistic Killing of Polymyxin B in Combination with Amikacin against Polymyxin-Susceptible and -Resistant Pseudomonas aeruginosa.

Antimicrob Agents Chemother 2019 12 20;64(1). Epub 2019 Dec 20.

Department of Pharmacology and Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia

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http://dx.doi.org/10.1128/AAC.01587-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187587PMC
December 2019

Influence of Non-natural Cationic Amino Acids on the Biological Activity Profile of Innate Defense Regulator Peptides.

J Med Chem 2019 11 12;62(22):10294-10304. Epub 2019 Nov 12.

Centre for Microbial Diseases and Immunity Research , University of British Columbia , Vancouver , BC V6T 1Z4 , Canada.

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http://dx.doi.org/10.1021/acs.jmedchem.9b01344DOI Listing
November 2019

Outer Membrane Interaction Kinetics of New Polymyxin B Analogs in Gram-Negative Bacilli.

Antimicrob Agents Chemother 2019 10 23;63(10). Epub 2019 Sep 23.

Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada

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http://dx.doi.org/10.1128/AAC.00935-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761527PMC
October 2019

Hyaluronic acid-based nanogels improve in vivo compatibility of the anti-biofilm peptide DJK-5.

Nanomedicine 2019 08 4;20:102022. Epub 2019 Jun 4.

Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.. Electronic address:

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http://dx.doi.org/10.1016/j.nano.2019.102022DOI Listing
August 2019

Short Cationic Peptide Derived from Archaea with Dual Antibacterial Properties and Anti-Infective Potential.

ACS Infect Dis 2019 07 1;5(7):1081-1086. Epub 2019 May 1.

Centro de Análises Proteômicas e Bioquímicas, Pós-Graduação em Ciências Genômicas e Biotecnologia , Universidade Católica de Brasília , SGAN 916 Módulo B , Asa Norte, Brasília , Distrito Federal 70790160 , Brazil.

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http://dx.doi.org/10.1021/acsinfecdis.9b00073DOI Listing
July 2019

Dismantling the bacterial virulence program.

Microb Biotechnol 2019 05 12;12(3):409-413. Epub 2019 Mar 12.

Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1111/1751-7915.13388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465231PMC
May 2019

Aurein-Derived Antimicrobial Peptides Formulated with Pegylated Phospholipid Micelles to Target Methicillin-Resistant Staphylococcus aureus Skin Infections.

ACS Infect Dis 2019 03 2;5(3):443-453. Epub 2019 Jan 2.

Department of Chemistry , University of British Columbia , 2036 Main Mall , Vancouver , British Columbia , Canada , V6T 1Z1.

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http://dx.doi.org/10.1021/acsinfecdis.8b00319DOI Listing
March 2019

Reassessing the Host Defense Peptide Landscape.

Front Chem 2019 4;7:43. Epub 2019 Feb 4.

Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.3389/fchem.2019.00043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369191PMC
February 2019

Characterization of Host Responses during Pseudomonas aeruginosa Acute Infection in the Lungs and Blood and after Treatment with the Synthetic Immunomodulatory Peptide IDR-1002.

Infect Immun 2019 01 19;87(1). Epub 2018 Dec 19.

Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada

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http://dx.doi.org/10.1128/IAI.00661-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300642PMC
January 2019

Surfing Motility: a Conserved yet Diverse Adaptation among Motile Bacteria.

J Bacteriol 2018 12 6;200(23). Epub 2018 Nov 6.

Center for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada

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http://dx.doi.org/10.1128/JB.00394-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222206PMC
December 2018

Antimicrobial Effect of Peptide DJK-5 Used Alone or Mixed with EDTA on Mono- and Multispecies Biofilms in Dentin Canals.

J Endod 2018 Nov 19;44(11):1709-1713. Epub 2018 Sep 19.

Faculty of Dentistry, Division of Endodontics, Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00992399183051
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http://dx.doi.org/10.1016/j.joen.2018.07.018DOI Listing
November 2018

Bone Environment Influences Irreversible Adhesion of a Methicillin-Susceptible Strain.

Front Microbiol 2018 27;9:2865. Epub 2018 Nov 27.

EA 4691 Biomaterials and Inflammation in Bone Site (BIOS), SFR Cap Santé (FED 4231), University of Reims-Champagne-Ardenne, Reims, France.

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http://dx.doi.org/10.3389/fmicb.2018.02865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277558PMC
November 2018

MetaBridge: enabling network-based integrative analysis via direct protein interactors of metabolites.

Bioinformatics 2018 09;34(18):3225-3227

Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1093/bioinformatics/bty331DOI Listing
September 2018

Broad-Spectrum Adaptive Antibiotic Resistance Associated with Pseudomonas aeruginosa Mucin-Dependent Surfing Motility.

Antimicrob Agents Chemother 2018 09 27;62(9). Epub 2018 Aug 27.

Center for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada

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http://dx.doi.org/10.1128/AAC.00848-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125533PMC
September 2018

Design and Assessment of Anti-Biofilm Peptides: Steps Toward Clinical Application.

J Innate Immun 2019 22;11(3):193-204. Epub 2018 Aug 22.

Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada,

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http://dx.doi.org/10.1159/000491497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738209PMC
August 2018

Helicobacter pylori Biofilm Formation Is Differentially Affected by Common Culture Conditions, and Proteins Play a Central Role in the Biofilm Matrix.

Appl Environ Microbiol 2018 07 2;84(14). Epub 2018 Jul 2.

Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

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http://dx.doi.org/10.1128/AEM.00391-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029101PMC
July 2018

Liposomal Therapy Attenuates Dermonecrosis Induced by Community-Associated Methicillin-Resistant Staphylococcus aureus by Targeting α-Type Phenol-Soluble Modulins and α-Hemolysin.

EBioMedicine 2018 Jul 20;33:211-217. Epub 2018 Jun 20.

Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, 2259 Lower Mall Research Station, V6T1Z4 Vancouver, British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.06.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085503PMC
July 2018

Development of Molecularly Imprinted Polymers To Block Quorum Sensing and Inhibit Bacterial Biofilm Formation.

ACS Appl Mater Interfaces 2018 Jun 25;10(22):18450-18457. Epub 2018 May 25.

Food, Nutrition and Health Program, Faculty of Land and Food Systems , The University of British Columbia , Vancouver , British Columbia V6T 1Z4 , Canada.

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http://dx.doi.org/10.1021/acsami.8b01584DOI Listing
June 2018

Retinoic acid elicits a coordinated expression of gut homing markers on T lymphocytes of Zambian men receiving oral Vivotif, but not Rotarix, Dukoral or OPVERO vaccines.

Vaccine 2018 06 22;36(28):4134-4141. Epub 2018 May 22.

Tropical Gastroenterology & Nutrition Group, Department of Medicine, School of Medicine, University of Zambia, Lusaka, Zambia; Blizard Institute, Barts & The London School of Medicine, Queen Mary University of London, London, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X183059
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http://dx.doi.org/10.1016/j.vaccine.2018.04.083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020133PMC
June 2018

Synergy between conventional antibiotics and anti-biofilm peptides in a murine, sub-cutaneous abscess model caused by recalcitrant ESKAPE pathogens.

PLoS Pathog 2018 06 21;14(6):e1007084. Epub 2018 Jun 21.

Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1371/journal.ppat.1007084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013096PMC
June 2018

Critical Assessment of Methods to Quantify Biofilm Growth and Evaluate Antibiofilm Activity of Host Defence Peptides.

Biomolecules 2018 05 21;8(2). Epub 2018 May 21.

Department of Microbiology and Immunology, Center for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.

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http://dx.doi.org/10.3390/biom8020029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022921PMC
May 2018

Induction by innate defence regulator peptide 1018 of pro-angiogenic molecules and endothelial cell migration in a high glucose environment.

Peptides 2018 03 17;101:135-144. Epub 2018 Jan 17.

Medical Research Unit-Zacatecas, Mexican Institute for Social Security-IMSS, Zacatecas, Mexico. Electronic address:

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http://dx.doi.org/10.1016/j.peptides.2018.01.010DOI Listing
March 2018

Novel roles for two-component regulatory systems in cytotoxicity and virulence-related properties in .

AIMS Microbiol 2018 8;4(1):173-191. Epub 2018 Mar 8.

Centre for Microbial Diseases and Immunity Research, Department of Microbiology & Immunology, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.3934/microbiol.2018.1.173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605022PMC
March 2018

High-throughput detection of RNA processing in bacteria.

BMC Genomics 2018 03 27;19(1):223. Epub 2018 Mar 27.

Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada.

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http://dx.doi.org/10.1186/s12864-018-4538-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870498PMC
March 2018

Antimicrobial Peptides: An Introduction.

Methods Mol Biol 2017 ;1548:3-22

Department of Microbiology and Immunology, Center for Microbial Diseases and Immunity Research, University of British Columbia, 2259 Lower Mall, Vancouver, BC, Canada, V6T 1Z4.

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http://link.springer.com/10.1007/978-1-4939-6737-7_1
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http://dx.doi.org/10.1007/978-1-4939-6737-7_1DOI Listing
February 2018

High-Performance Liquid Chromatography and Mass Spectrometry-Based Design of Proteolytically Stable Antimicrobial Peptides.

Methods Mol Biol 2017 ;1548:61-71

Department of Microbiology and Immunology, Center forMicrobial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1007/978-1-4939-6737-7_5DOI Listing
February 2018

New Perspectives in Biofilm Eradication.

ACS Infect Dis 2018 02 27;4(2):93-106. Epub 2017 Dec 27.

Department of Microbiology and Immunology, Center for Microbial Diseases and Immunity Research, University of British Columbia , Room 232, 2259 Lower Mall Research Station, Vancouver, British Columbia V6T 1Z4, Canada.

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http://dx.doi.org/10.1021/acsinfecdis.7b00170DOI Listing
February 2018

Computer-aided Discovery of Peptides that Specifically Attack Bacterial Biofilms.

Sci Rep 2018 01 30;8(1):1871. Epub 2018 Jan 30.

Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, British Columbia, V6T1Z4, Canada.

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http://dx.doi.org/10.1038/s41598-018-19669-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789975PMC
January 2018

Antibiofilm Effect of D-enantiomeric Peptide Alone and Combined with EDTA In Vitro.

J Endod 2017 Nov 23;43(11):1862-1867. Epub 2017 Sep 23.

Faculty of Dentistry, Division of Endodontics, Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.joen.2017.06.037DOI Listing
November 2017

Mechanisms of the Innate Defense Regulator Peptide-1002 Anti-Inflammatory Activity in a Sterile Inflammation Mouse Model.

J Immunol 2017 11 9;199(10):3592-3603. Epub 2017 Oct 9.

Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1700985
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http://dx.doi.org/10.4049/jimmunol.1700985DOI Listing
November 2017

Synthetic host defense peptide IDR-1002 reduces inflammation in Pseudomonas aeruginosa lung infection.

PLoS One 2017 6;12(11):e0187565. Epub 2017 Nov 6.

Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187565PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673212PMC
November 2017

Sensing Mg contributes to the resistance of Pseudomonas aeruginosa to complement-mediated opsonophagocytosis.

Environ Microbiol 2017 10 15;19(10):4278-4286. Epub 2017 Sep 15.

Instituto Universitario de Investigación en Ciencias de la Salud, Universidad de las Islas Baleares, Palma de Mallorca, Spain.

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http://dx.doi.org/10.1111/1462-2920.13889DOI Listing
October 2017

Ciprofloxacin-nitroxide hybrids with potential for biofilm control.

Eur J Med Chem 2017 Sep 28;138:590-601. Epub 2017 Jun 28.

ARC Centre of Excellence for Free Radical Chemistry and Biotechnology, Faculty of Science and Engineering, Queensland University of Technology, Queensland 4001, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2017.06.058DOI Listing
September 2017

Synthetic Peptides to Target Stringent Response-Controlled Virulence in a Murine Cutaneous Infection Model.

Front Microbiol 2017 27;8:1867. Epub 2017 Sep 27.

Department of Microbiology and Immunology, Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.3389/fmicb.2017.01867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623667PMC
September 2017

A novel small RNA is important for biofilm formation and pathogenicity in Pseudomonas aeruginosa.

PLoS One 2017 3;12(8):e0182582. Epub 2017 Aug 3.

Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0182582PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542712PMC
August 2017

Aggregation and Its Influence on the Immunomodulatory Activity of Synthetic Innate Defense Regulator Peptides.

Cell Chem Biol 2017 Aug 10;24(8):969-980.e4. Epub 2017 Aug 10.

Center for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, #232, 2259 Lower Mall Research Station, Vancouver, BC V6T 1Z4, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24519456173024
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http://dx.doi.org/10.1016/j.chembiol.2017.07.010DOI Listing
August 2017

Treatment of Oral Biofilms by a D-Enantiomeric Peptide.

PLoS One 2016 23;11(11):e0166997. Epub 2016 Nov 23.

Division of Endodontics, Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, British Columbia, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0166997PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120842PMC
June 2017

Anti-adhesive antimicrobial peptide coating prevents catheter associated infection in a mouse urinary infection model.

Biomaterials 2017 02 24;116:69-81. Epub 2016 Nov 24.

Centre for Blood Research, Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada; Department of Chemistry, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2016.11.047DOI Listing
February 2017

Anticancer activities of bovine and human lactoferricin-derived peptides.

Biochem Cell Biol 2017 02 3;95(1):91-98. Epub 2016 Nov 3.

a Biochemistry Research Group, Department of Biological Sciences, University of Calgary, Calgary, AB T2N 1N4, Canada.

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https://tspace.library.utoronto.ca/bitstream/1807/75643/1/bc
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http://www.nrcresearchpress.com/doi/10.1139/bcb-2016-0175
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http://dx.doi.org/10.1139/bcb-2016-0175DOI Listing
February 2017

New Mouse Model for Chronic Infections by Gram-Negative Bacteria Enabling the Study of Anti-Infective Efficacy and Host-Microbe Interactions.

mBio 2017 02 28;8(1). Epub 2017 Feb 28.

Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada

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http://dx.doi.org/10.1128/mBio.00140-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347345PMC
February 2017

Exosomes, your body's answer to immune health.

Ann Transl Med 2017 Feb;5(4):81

Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.21037/atm.2017.01.50DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337206PMC
February 2017

Peptide IDR-1002 Inhibits NF-κB Nuclear Translocation by Inhibition of IκBα Degradation and Activates p38/ERK1/2-MSK1-Dependent CREB Phosphorylation in Macrophages Stimulated with Lipopolysaccharide.

Front Immunol 2016 25;7:533. Epub 2016 Nov 25.

Laboratory of Molecular Immunology and Signal Transduction, Facultad de Medicina Veterinaria y Zootecnia, Centro Multidisciplinario de Estudios en Biotecnología, Universidad Michoacana de San Nicolás de Hidalgo , Morelia, Michoacán , México.

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http://dx.doi.org/10.3389/fimmu.2016.00533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122595PMC
November 2016

Bioinformatics: Novel Insights from Genomic Information.

Nestle Nutr Inst Workshop Ser 2016 14;84:35-46. Epub 2016 Jan 14.

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http://dx.doi.org/10.1159/000436950DOI Listing
October 2016

Antibiofilm Peptides: Potential as Broad-Spectrum Agents.

J Bacteriol 2016 10 9;198(19):2572-8. Epub 2016 Sep 9.

Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada

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http://jb.asm.org/lookup/doi/10.1128/JB.00017-16
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http://dx.doi.org/10.1128/JB.00017-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019066PMC
October 2016

Polymyxin: Alternative Mechanisms of Action and Resistance.

Cold Spring Harb Perspect Med 2016 Oct 3;6(10). Epub 2016 Oct 3.

Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.

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http://dx.doi.org/10.1101/cshperspect.a025288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046685PMC
October 2016

Bacterial Abscess Formation Is Controlled by the Stringent Stress Response and Can Be Targeted Therapeutically.

EBioMedicine 2016 Oct 17;12:219-226. Epub 2016 Sep 17.

Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2016.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078632PMC
October 2016

In Vivo, In Vitro, and In Silico Characterization of Peptoids as Antimicrobial Agents.

PLoS One 2016 5;11(2):e0135961. Epub 2016 Feb 5.

Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, E136, Evanston, IL, 60208, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0135961PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744035PMC
July 2016

Synthesis and Evaluation of Ciprofloxacin-Nitroxide Conjugates as Anti-Biofilm Agents.

Molecules 2016 Jun 27;21(7). Epub 2016 Jun 27.

ARC Centre of Excellence for Free Radical Chemistry and Biotechnology, Faculty of Science and Engineering, Queensland University of Technology, Queensland 4001, Australia.

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http://dx.doi.org/10.3390/molecules21070841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273952PMC
June 2016

Treatment of Oral Multispecies Biofilms by an Anti-Biofilm Peptide.

PLoS One 2015 13;10(7):e0132512. Epub 2015 Jul 13.

Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132512PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500547PMC
May 2016

Synthetic antibiofilm peptides.

Biochim Biophys Acta 2016 May 23;1858(5):1061-9. Epub 2015 Dec 23.

Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbamem.2015.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809770PMC
May 2016

The immunology of host defence peptides: beyond antimicrobial activity.

Nat Rev Immunol 2016 05 18;16(5):321-34. Epub 2016 Apr 18.

Center for Microbial Diseases Research, University of British Columbia, Vancouver, British Columbia, V6H 3Z6, Canada.

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http://dx.doi.org/10.1038/nri.2016.29DOI Listing
May 2016

Tryptic Stability of Synthetic Bactenecin Derivatives Is Determined by the Side Chain Length of Cationic Residues and the Peptide Conformation.

J Med Chem 2016 Apr 18;59(7):3079-86. Epub 2016 Mar 18.

Centre for Microbial Diseases and Immunity Research, University of British Columbia , 2259 Lower Mall Research Station, Vancouver, BC V6T 1Z4, Canada.

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http://dx.doi.org/10.1021/acs.jmedchem.5b01740DOI Listing
April 2016

A polyalanine peptide derived from polar fish with anti-infectious activities.

Sci Rep 2016 Feb 26;6:21385. Epub 2016 Feb 26.

Centro de Análises Proteômicas e Bioquímicas, Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasília-DF, Brazil.

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http://dx.doi.org/10.1038/srep21385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768251PMC
February 2016

Enhanced killing of breast cancer cells by a d-amino acid analog of the winter flounder-derived pleurocidin NRC-03.

Exp Mol Pathol 2015 Dec 3;99(3):426-34. Epub 2015 Sep 3.

Department of Microbiology and Immunology, Dalhousie University, Halifax B3H 4R2, Canada; Department of Pathology, Dalhousie University, Halifax B3H 4R2, Canada; Department of Surgery, Dalhousie University, Halifax B3H 4R2, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00144800150018
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http://dx.doi.org/10.1016/j.yexmp.2015.08.021DOI Listing
December 2015

Toward Infection-Resistant Surfaces: Achieving High Antimicrobial Peptide Potency by Modulating the Functionality of Polymer Brush and Peptide.

ACS Appl Mater Interfaces 2015 Dec 21;7(51):28591-605. Epub 2015 Dec 21.

Department of Urologic Sciences, University of British Columbia , Vancouver, British Columbia V5Z 1M9, Canada.

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http://dx.doi.org/10.1021/acsami.5b10074DOI Listing
December 2015

High throughput screening methods for assessing antibiofilm and immunomodulatory activities of synthetic peptides.

Peptides 2015 Sep 31;71:276-85. Epub 2015 Mar 31.

Center for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.peptides.2015.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581888PMC
September 2015

Anti-infective peptide IDR-1002 augments monocyte chemotaxis towards CCR5 chemokines.

Biochem Biophys Res Commun 2015 Aug 10;464(3):800-6. Epub 2015 Jul 10.

Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, 2259 Lower Mall Research Station, University of British Columbia, Vancouver, V6T 1Z4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.07.038DOI Listing
August 2015

Potentiation of ciprofloxacin action against Gram-negative bacterial biofilms by a nitroxide.

Pathog Dis 2015 Jul 2;73(5). Epub 2015 Mar 2.

Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada

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http://dx.doi.org/10.1093/femspd/ftv016DOI Listing
July 2015

Antibiofilm peptides increase the susceptibility of carbapenemase-producing Klebsiella pneumoniae clinical isolates to β-lactam antibiotics.

Antimicrob Agents Chemother 2015 Jul 20;59(7):3906-12. Epub 2015 Apr 20.

Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada

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http://dx.doi.org/10.1128/AAC.00092-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468710PMC
July 2015

Rethinking the Antibiotic Discovery Paradigm.

EBioMedicine 2015 Jul 8;2(7):629-30. Epub 2015 Jul 8.

Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.

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http://dx.doi.org/10.1016/j.ebiom.2015.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534705PMC
July 2015

Cationic amphipathic peptides KT2 and RT2 are taken up into bacterial cells and kill planktonic and biofilm bacteria.

Biochim Biophys Acta 2015 Jun 10;1848(6):1352-8. Epub 2015 Mar 10.

Department of Biochemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand; Protein and Proteomics Research Center for Commercial and Industrial Purposes (ProCCI), Khon Kaen University, Khon Kaen, 40002, Thailand. Electronic address:

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http://dx.doi.org/10.1016/j.bbamem.2015.02.021DOI Listing
June 2015

NetworkAnalyst for statistical, visual and network-based meta-analysis of gene expression data.

Nat Protoc 2015 Jun 7;10(6):823-44. Epub 2015 May 7.

1] Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada. [2] Wellcome Trust Sanger Institute, Hinxton, United Kingdom.

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http://dx.doi.org/10.1038/nprot.2015.052DOI Listing
June 2015

An in situ Raman spectroscopy-based microfluidic "lab-on-a-chip" platform for non-destructive and continuous characterization of Pseudomonas aeruginosa biofilms.

Chem Commun (Camb) 2015 May;51(43):8966-9

Food, Nutrition, and Health Program, Faculty of Land and Food Systems, The University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.

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http://dx.doi.org/10.1039/c5cc02744fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433399PMC
May 2015