Robert E Sinden

Robert E Sinden

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Robert E Sinden

Publications by authors named "Robert E Sinden"

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Vital role for Plasmodium berghei Kinesin8B in axoneme assembly during male gamete formation and mosquito transmission.

Cell Microbiol 2020 Mar 12;22(3):e13121. Epub 2019 Dec 12.

Unité Molécules de Communication et Adaptation des Microorganismes (MCAM), UMR 7245, CNRS Muséum National d'Histoire Naturelle, Paris Cedex 05, France.

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http://dx.doi.org/10.1111/cmi.13121DOI Listing
March 2020

Developing transmission-blocking strategies for malaria control.

Authors:
Robert E Sinden

PLoS Pathog 2017 07 6;13(7):e1006336. Epub 2017 Jul 6.

Department of Life Sciences, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.ppat.1006336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500365PMC
July 2017

Adaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery.

Nanomedicine 2017 02 5;13(2):515-525. Epub 2016 Oct 5.

Nanomalaria Group, Institute for Bioengineering of Catalonia (IBEC), Barcelona, Spain; Barcelona Institute for Global Health (ISGlobal), Barcelona Center for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona), Barcelona, Spain; Nanoscience and Nanotechnology Institute (IN2UB), University of Barcelona, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.nano.2016.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332526PMC
February 2017

Development of malaria transmission-blocking vaccines: from concept to product.

Adv Parasitol 2015 Jun 8;89:109-52. Epub 2015 May 8.

Fraunhofer USA Center for Molecular Biotechnology, Newark, DE, USA.

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http://dx.doi.org/10.1016/bs.apar.2015.04.001DOI Listing
June 2015

Experimental study of the relationship between Plasmodium gametocyte density and infection success in mosquitoes; implications for the evaluation of malaria transmission-reducing interventions.

Exp Parasitol 2015 Feb 23;149:74-83. Epub 2014 Dec 23.

Institut de Recherche en Sciences de la Santé, Direction Régionale, 399 avenue de la liberté, Bobo Dioulasso 01 01 BP 545, Burkina Faso; Institut de Recherche pour le Développement, unité MIVEGEC (UM1-UM2-CNRS 5290-IRD 224), 911 avenue Agropolis, Montpellier Cedex 5 34394, France. Electronic address:

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http://dx.doi.org/10.1016/j.exppara.2014.12.010DOI Listing
February 2015

Reality check for malaria proteomics.

Authors:
Robert E Sinden

Genome Biol 2009 26;10(2):211. Epub 2009 Feb 26.

The Malaria Centre, Department of Life Sciences, Imperial College London, SW7 2AZ, UK.

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http://dx.doi.org/10.1186/gb-2009-10-2-211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688283PMC
September 2013

The rhoptry proteome of Eimeria tenella sporozoites.

Int J Parasitol 2013 Feb 20;43(2):181-8. Epub 2012 Dec 20.

Institute for Animal Health, Compton, Newbury, Berkshire, UK.

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http://dx.doi.org/10.1016/j.ijpara.2012.10.024DOI Listing
February 2013

Laboratory maintenance of rodent malaria parasites.

Methods Mol Biol 2013 ;923:51-72

The Malaria Centre, Department of Life Sciences, Imperial College, London, UK.

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http://dx.doi.org/10.1007/978-1-62703-026-7_5DOI Listing
January 2013

Assessing transmission blockade in Plasmodium spp.

Methods Mol Biol 2013 ;923:577-600

The Malaria Centre, Department of Life Sciences, Imperial College, London, UK.

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http://link.springer.com/10.1007/978-1-62703-026-7_40
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http://dx.doi.org/10.1007/978-1-62703-026-7_40DOI Listing
January 2013

The design and interpretation of laboratory assays measuring mosquito transmission of Plasmodium.

Trends Parasitol 2012 Nov 11;28(11):457-65. Epub 2012 Sep 11.

The Malaria Centre, Imperial College London, South Kensington, London SW7 2AZ, UK.

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http://dx.doi.org/10.1016/j.pt.2012.07.005DOI Listing
November 2012

A GFP-actin reporter line to explore microfilament dynamics across the malaria parasite lifecycle.

Mol Biochem Parasitol 2012 Mar-Apr;182(1-2):93-6. Epub 2011 Nov 25.

Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.

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http://dx.doi.org/10.1016/j.molbiopara.2011.11.008DOI Listing
May 2012

The biology of sexual development of Plasmodium: the design and implementation of transmission-blocking strategies.

Malar J 2012 Mar 16;11:70. Epub 2012 Mar 16.

The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK.

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http://malariajournal.biomedcentral.com/articles/10.1186/147
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http://dx.doi.org/10.1186/1475-2875-11-70DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315749PMC
March 2012

Stage-specific depletion of myosin A supports an essential role in motility of malarial ookinetes.

Cell Microbiol 2011 Dec 28;13(12):1996-2006. Epub 2011 Sep 28.

Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 71110 Heraklion, Crete, Greece.

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http://dx.doi.org/10.1111/j.1462-5822.2011.01686.xDOI Listing
December 2011

PbGEST mediates malaria transmission to both mosquito and vertebrate host.

Mol Microbiol 2011 Oct 30;82(2):462-74. Epub 2011 Sep 30.

Department of Life Sciences, Imperial College London, SW72AZ London, UK.

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http://dx.doi.org/10.1111/j.1365-2958.2011.07823.xDOI Listing
October 2011

Vital functions of the malarial ookinete protein, CTRP, reside in the A domains.

Int J Parasitol 2011 Aug 22;41(10):1029-39. Epub 2011 Jun 22.

Division of Cell and Molecular Biology, Sir Alexander Fleming Building, Imperial College London, South Kensington Campus, London SW72AZ, UK.

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http://dx.doi.org/10.1016/j.ijpara.2011.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068204PMC
August 2011

Population biology of malaria within the mosquito: density-dependent processes and potential implications for transmission-blocking interventions.

Malar J 2010 Nov 4;9:311. Epub 2010 Nov 4.

Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, Imperial College London, UK.

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http://dx.doi.org/10.1186/1475-2875-9-311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988043PMC
November 2010

Wolbachia stimulates immune gene expression and inhibits plasmodium development in Anopheles gambiae.

PLoS Pathog 2010 Oct 7;6(10):e1001143. Epub 2010 Oct 7.

Department of Zoology, University of Oxford, Peter Medawar Building for Pathogen Research, Oxford, United Kingdom.

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http://dx.doi.org/10.1371/journal.ppat.1001143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951381PMC
October 2010

Intranasal and intramuscular immunization with Baculovirus Dual Expression System-based Pvs25 vaccine substantially blocks Plasmodium vivax transmission.

Vaccine 2010 Aug 14;28(37):6014-20. Epub 2010 Jul 14.

Division of Cell and Molecular Biology, Department of Life Sciences, Sir Alexander Fleming Building, Imperial College London, Imperial College Road, London SW7 2AZ, UK.

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http://dx.doi.org/10.1016/j.vaccine.2010.06.100DOI Listing
August 2010

A Plasmodium falciparum strain expressing GFP throughout the parasite's life-cycle.

PLoS One 2010 Feb 10;5(2):e9156. Epub 2010 Feb 10.

Division of Cell and Molecular Biology, Imperial College London, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009156PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819258PMC
February 2010

A biologist's perspective on malaria vaccine development.

Authors:
Robert E Sinden

Hum Vaccin 2010 Jan 24;6(1):3-11. Epub 2010 Jan 24.

Department of Life Sciences, Imperial College London, UK.

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http://dx.doi.org/10.4161/hv.6.1.9604DOI Listing
January 2010

The temporal dynamics of Plasmodium density through the sporogonic cycle within Anopheles mosquitoes.

Trans R Soc Trop Med Hyg 2009 Dec 5;103(12):1197-8. Epub 2009 Apr 5.

Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place, London W2 1PG, UK.

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http://dx.doi.org/10.1016/j.trstmh.2009.03.009DOI Listing
December 2009

Anopheles mortality is both age- and Plasmodium-density dependent: implications for malaria transmission.

Malar J 2009 Oct 12;8:228. Epub 2009 Oct 12.

Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.1186/1475-2875-8-228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770541PMC
October 2009

Plasmodium berghei HAP2 induces strong malaria transmission-blocking immunity in vivo and in vitro.

Vaccine 2009 Aug 9;27(38):5187-94. Epub 2009 Jul 9.

Division of Cell and Molecular Biology, Sir Alexander Fleming Building, Imperial College London, South Kensington, London SW7 2AZ, UK.

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http://dx.doi.org/10.1016/j.vaccine.2009.06.069DOI Listing
August 2009

Localisation and timing of expression of putative Plasmodium berghei rhoptry proteins in merozoites and sporozoites.

Mol Biochem Parasitol 2009 Jul 27;166(1):22-31. Epub 2009 Feb 27.

The Malaria Centre, and the Division of Cell and Molecular Biology, Imperial College London, London, UK.

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http://dx.doi.org/10.1016/j.molbiopara.2009.02.009DOI Listing
July 2009

Plasmodium male development gene-1 (mdv-1) is important for female sexual development and identifies a polarised plasma membrane during zygote development.

Int J Parasitol 2009 Jun 24;39(7):755-61. Epub 2008 Dec 24.

The Division of Cell and Molecular Biology, Imperial College London, London, UK.

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http://dx.doi.org/10.1016/j.ijpara.2008.11.008DOI Listing
June 2009

Reverse genetics screen identifies six proteins important for malaria development in the mosquito.

Mol Microbiol 2008 Oct 27;70(1):209-20. Epub 2008 Aug 27.

Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, UK.

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http://dx.doi.org/10.1111/j.1365-2958.2008.06407.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658712PMC
October 2008

PCR-based detection of Plasmodium in Anopheles mosquitoes: a comparison of a new high-throughput assay with existing methods.

Malar J 2008 Sep 15;7:177. Epub 2008 Sep 15.

Department of Biological Chemistry, Center for Sustainable Pest and Disease Management, Rothamsted Research, Harpenden, UK.

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http://dx.doi.org/10.1186/1475-2875-7-177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553798PMC
September 2008

Determining the protein repertoire of Cryptosporidium parvum sporozoites.

Proteomics 2008 Apr;8(7):1398-414

Departments of Pre-clinical Veterinary Science and Veterinary Pathology, Faculty of Veterinary Science, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1002/pmic.200700804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770187PMC
April 2008

Malaria, mosquitoes and the legacy of Ronald Ross.

Authors:
Robert E Sinden

Bull World Health Organ 2007 Nov;85(11):894-6

Division of Cell and Molecular Biology, Faculty of Natural Sciences, Imperial College, London, England.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636258PMC
http://dx.doi.org/10.2471/blt.04.020735DOI Listing
November 2007

Minimum requirements for ookinete to oocyst transformation in Plasmodium.

Int J Parasitol 2007 Sep 30;37(11):1221-32. Epub 2007 Mar 30.

Centre for Applied Entomology and Parasitology, Institute for Science and Technology in Medicine, Huxley Building, Keele University, Staffordshire ST5 5BG, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S002075190700098
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http://dx.doi.org/10.1016/j.ijpara.2007.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2474741PMC
September 2007

Plasmodium berghei: plasmodium perforin-like protein 5 is required for mosquito midgut invasion in Anopheles stephensi.

Exp Parasitol 2007 Aug 1;116(4):504-8. Epub 2007 Feb 1.

Division of Cell and Molecular Biology, Faculty of Natural Sciences, Imperial College London, Sir Alexander Fleming Building, Imperial College Road, London, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S00144894070003
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http://dx.doi.org/10.1016/j.exppara.2007.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1916484PMC
August 2007

The role of metacaspase 1 in Plasmodium berghei development and apoptosis.

Mol Biochem Parasitol 2007 May 2;153(1):41-7. Epub 2007 Feb 2.

Department of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom.

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http://dx.doi.org/10.1016/j.molbiopara.2007.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2075530PMC
May 2007

Female inheritance of malarial lap genes is essential for mosquito transmission.

PLoS Pathog 2007 Mar;3(3):e30

Division of Cell and Molecular Biology, Faculty of Natural Sciences, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.ppat.0030030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808070PMC
March 2007

The use of transgenic Plasmodium berghei expressing the Plasmodium vivax antigen P25 to determine the transmission-blocking activity of sera from malaria vaccine trials.

Vaccine 2007 Jan 20;25(5):886-94. Epub 2006 Sep 20.

Division of Cell and Molecular Biology, Sir Alexander Fleming Building, Imperial College London, Imperial College Road, London SW7 2AZ, UK.

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http://dx.doi.org/10.1016/j.vaccine.2006.09.035DOI Listing
January 2007

Generation of gene targeting constructs for Plasmodium berghei by a PCR-based method amenable to high throughput applications.

Mol Biochem Parasitol 2006 Feb 24;145(2):265-8. Epub 2005 Oct 24.

Division of Cell and Molecular Biology, Imperial College London, Exhibition Road, London SW7 2AZ, UK.

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http://dx.doi.org/10.1016/j.molbiopara.2005.10.006DOI Listing
February 2006

Close association of invading Plasmodium berghei and beta integrin in the Anopheles gambiae midgut.

Arch Insect Biochem Physiol 2005 Sep;60(1):13-9

Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Crete, Greece.

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http://dx.doi.org/10.1002/arch.20077DOI Listing
September 2005

Transcriptome analysis of Anopheles stephensi-Plasmodium berghei interactions.

Mol Biochem Parasitol 2005 Jul 12;142(1):76-87. Epub 2005 Apr 12.

Department of Biological Sciences, Imperial College, London SW7 2AZ, UK.

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http://dx.doi.org/10.1016/j.molbiopara.2005.02.013DOI Listing
July 2005

Plasmodium berghei ookinetes bind to Anopheles gambiae and Drosophila melanogaster annexins.

Mol Microbiol 2005 Jul;57(1):171-9

Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology - Hellas, Vassilika Vouton, PO Box 1527, 71110 Heraklion, Crete, Greece.

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http://dx.doi.org/10.1111/j.1365-2958.2005.04664.xDOI Listing
July 2005

A malaria membrane skeletal protein is essential for normal morphogenesis, motility, and infectivity of sporozoites.

J Cell Biol 2004 Nov;167(3):425-32

Department of Biological Sciences, Imperail College London, London SW7 2AZ, England, UK.

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http://www.jcb.org/lookup/doi/10.1083/jcb.200406068
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http://dx.doi.org/10.1083/jcb.200406068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172497PMC
November 2004

Functional characterization of an LCCL-lectin domain containing protein family in Plasmodium berghei.

J Parasitol 2004 Oct;90(5):1062-71

Immunology and Infection Section, Department of Biological Sciences, Imperial College London, South Kensington, London SW7 2AZ, UK.

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http://dx.doi.org/10.1645/GE-3368DOI Listing
October 2004

Isonicotinic acid hydrazide: an anti-tuberculosis drug inhibits malarial transmission in the mosquito gut.

Exp Parasitol 2004 Jan-Feb;106(1-2):30-6

Department of Biological Sciences, Imperial College of Science, Technology, and Medicine, London SW7 2AZ, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S001448940400005
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http://dx.doi.org/10.1016/j.exppara.2004.01.002DOI Listing
April 2004

LCCL proteins of apicomplexan parasites.

Trends Parasitol 2004 Mar;20(3):102-8

Department of Biological Sciences, Imperial College London, Sir Alexander Fleming Building, South Kensington Campus, Imperial College Road, London, SW7 2AZ, UK.

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http://dx.doi.org/10.1016/j.pt.2004.01.002DOI Listing
March 2004

SOAP, a novel malaria ookinete protein involved in mosquito midgut invasion and oocyst development.

Mol Microbiol 2003 Jul;49(2):319-29

Department of Biological Sciences, Sir Alexander Fleming Building, Imperial College London, South Kensington Campus, SW7 2AZ, UK.

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http://dx.doi.org/10.1046/j.1365-2958.2003.03566.xDOI Listing
July 2003

Azadirachtin disrupts formation of organised microtubule arrays during microgametogenesis of Plasmodium berghei.

J Eukaryot Microbiol 2002 Nov-Dec;49(6):489-97

Department of Biological Sciences, Imperial College of Science, Technology and Medicine, London SW7 2AZ UK.

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http://dx.doi.org/10.1111/j.1550-7408.2002.tb00234.xDOI Listing
February 2003

Persistence of atovaquone in human sera following treatment: inhibition of Plasmodium falciparum development in vivo and in vitro.

Am J Trop Med Hyg 2003 Jan;68(1):111-4

Department of Biologic Sciences, Imperial College of Science Technology and Medicine, London, UK.

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January 2003

A malaria scavenger receptor-like protein essential for parasite development.

Mol Microbiol 2002 Sep;45(6):1473-84

Department of Biological Sciences, Imperial College of Science Technology and Medicine, London, UK.

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http://dx.doi.org/10.1046/j.1365-2958.2002.03118.xDOI Listing
September 2002