Robert E Fleming

Robert E Fleming

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Robert E Fleming

Robert E Fleming

Publications by authors named "Robert E Fleming"

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The selfishly selfless placenta.

J Clin Invest 2020 Feb;130(2):590-592

Department of Pediatrics and the.

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http://dx.doi.org/10.1172/JCI134272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994136PMC
February 2020

suppression benefits β-thalassemic erythropoiesis.

Blood 2018 11;132(21):2215-2216

Saint Louis University School of Medicine.

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http://dx.doi.org/10.1182/blood-2018-10-876110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251007PMC
November 2018

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry.

J Vis Exp 2018 01 12(131). Epub 2018 Jan 12.

Molecular and Clinical Nutrition Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases.

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http://dx.doi.org/10.3791/56910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908551PMC
January 2018

Releasing the FKBP12 brake on hepcidin.

Blood 2017 11;130(19):2049-2050

SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE.

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http://dx.doi.org/10.1182/blood-2017-09-805390DOI Listing
November 2017

Measurements of red cell deformability and hydration reflect HbF and HbA in blood from patients with sickle cell anemia.

Blood Cells Mol Dis 2017 06 18;65:41-50. Epub 2017 Apr 18.

Molecular and Clinical Nutrition Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcmd.2017.04.005DOI Listing
June 2017

Decreasing TfR1 expression reverses anemia and hepcidin suppression in β-thalassemic mice.

Blood 2017 03 1;129(11):1514-1526. Epub 2017 Feb 1.

Hunan Key Laboratory of Carcinogenesis and Cancer Invasion, Cancer Research Institute, Central South University, Ministry of Education, Changsha, China.

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http://dx.doi.org/10.1182/blood-2016-09-742387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356456PMC
March 2017

Improved Management of Harlequin Ichthyosis With Advances in Neonatal Intensive Care.

Pediatrics 2017 01 20;139(1). Epub 2016 Dec 20.

Department of Dermatology, State University of New York Downstate Medical Center, Brooklyn, New York;

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http://dx.doi.org/10.1542/peds.2016-1003DOI Listing
January 2017

Liver sinusoidal endothelial cells as iron sensors.

Blood 2017 01;129(4):397-398

SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2016-12
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http://dx.doi.org/10.1182/blood-2016-12-754499DOI Listing
January 2017

Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera.

Blood 2016 07 6;128(2):265-76. Epub 2016 May 6.

Division of Hematology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA; Division of Hematology-Oncology, Department of Pediatrics, Weill Cornell Medical College, New York, NY; Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, NY; and Cell and Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1182/blood-2015-10-676742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946204PMC
July 2016

Bone morphogenetic proteins as regulators of iron metabolism.

Annu Rev Nutr 2014 6;34:77-94. Epub 2014 Jun 6.

Division of Molecular and Clinical Nutrition, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892.

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http://dx.doi.org/10.1146/annurev-nutr-071813-105646DOI Listing
March 2015

Effects of strain and age on hepatic gene expression profiles in murine models of HFE-associated hereditary hemochromatosis.

Genes Nutr 2015 Jan 27;10(1):443. Epub 2014 Nov 27.

Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, South Korea,

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http://link.springer.com/10.1007/s12263-014-0443-1
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http://dx.doi.org/10.1007/s12263-014-0443-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245401PMC
January 2015

Sequestration and scavenging of iron in infection.

Infect Immun 2013 Oct 8;81(10):3503-14. Epub 2013 Jul 8.

Division of Molecular and Clinical Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1128/IAI.00602-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811770PMC
October 2013

Smad6 and Smad7 are co-regulated with hepcidin in mouse models of iron overload.

Biochim Biophys Acta 2013 Jan 31;1832(1):76-84. Epub 2012 Aug 31.

Department of Pediatric Oncology, Hematology and Immunology, University Hospital of Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.bbadis.2012.08.013DOI Listing
January 2013

Ferritin upregulates hepatic expression of bone morphogenetic protein 6 and hepcidin in mice.

Am J Physiol Gastrointest Liver Physiol 2012 Jun 19;302(12):G1397-404. Epub 2012 Apr 19.

Department of Pediatrics, Saint Louis University School of Medicine, St. Louis, Missouri 63104, USA.

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http://dx.doi.org/10.1152/ajpgi.00020.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378091PMC
June 2012

Iron overload in human disease.

N Engl J Med 2012 Jan;366(4):348-59

Department of Pediatrics, Saint Louis University School of Medicine, St. Louis, USA.

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http://dx.doi.org/10.1056/NEJMra1004967DOI Listing
January 2012

Hepcidin in human iron disorders: diagnostic implications.

Clin Chem 2011 Dec 11;57(12):1650-69. Epub 2011 Oct 11.

Department of Laboratory Medicine, Laboratory of Genetic, Endocrine and Metabolic Disorders, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1373/clinchem.2009.140053DOI Listing
December 2011

Iron regulation of hepcidin despite attenuated Smad1,5,8 signaling in mice without transferrin receptor 2 or Hfe.

Gastroenterology 2011 Nov 13;141(5):1907-14. Epub 2011 Jul 13.

Program in Membrane Biology, Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1053/j.gastro.2011.06.077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634343PMC
November 2011

Knockout mouse models of iron homeostasis.

Annu Rev Nutr 2011 Aug;31:117-37

Departments of Pediatrics and Biochemistry & Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA.

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http://dx.doi.org/10.1146/annurev-nutr-072610-145117DOI Listing
August 2011

Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice.

Blood 2010 Apr 22;115(16):3374-81. Epub 2010 Feb 22.

Department of Cell and Developmental Biology, Oregon Health & Science University, Portland, OR, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2009-09-24
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http://dx.doi.org/10.1182/blood-2009-09-245209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858491PMC
April 2010

Global transcriptional response to Hfe deficiency and dietary iron overload in mouse liver and duodenum.

PLoS One 2009 Sep 29;4(9):e7212. Epub 2009 Sep 29.

Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007212PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747280PMC
September 2009

Expression of iron-related genes in human brain and brain tumors.

BMC Neurosci 2009 Apr 22;10:36. Epub 2009 Apr 22.

Institute of Medical Technology and School of Medicine, University of Tampere, Tampere University Hospital, Tampere, Finland.

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http://dx.doi.org/10.1186/1471-2202-10-36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679039PMC
April 2009

Iron sensing as a partnership: HFE and transferrin receptor 2.

Authors:
Robert E Fleming

Cell Metab 2009 Mar;9(3):211-2

Saint Louis University School of Medicine, St. Louis, MO 63104, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S155041310900042
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http://dx.doi.org/10.1016/j.cmet.2009.02.004DOI Listing
March 2009

HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron.

Arch Biochem Biophys 2008 Jun 7;474(1):193-7. Epub 2008 Mar 7.

Edward A. Doisy Department of Biochemistry & Molecular Biology, Saint Louis University Liver Center, Saint Louis University School of Medicine, St. Louis, MO 63104, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000398610800119
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http://dx.doi.org/10.1016/j.abb.2008.02.041DOI Listing
June 2008

Iron and inflammation: cross-talk between pathways regulating hepcidin.

Authors:
Robert E Fleming

J Mol Med (Berl) 2008 May;86(5):491-4

Department of Pediatrics, Saint Louis University School of Medicine, 1465 South Grand Ave, St. Louis, MO 63104, USA.

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http://link.springer.com/10.1007/s00109-008-0349-8
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http://dx.doi.org/10.1007/s00109-008-0349-8DOI Listing
May 2008

Effects of iron loading on muscle: genome-wide mRNA expression profiling in the mouse.

BMC Genomics 2007 Oct 19;8:379. Epub 2007 Oct 19.

Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland.

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http://dx.doi.org/10.1186/1471-2164-8-379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151772PMC
October 2007

Iron Imports. VI. HFE and regulation of intestinal iron absorption.

Am J Physiol Gastrointest Liver Physiol 2006 Apr;290(4):G590-4

Department of Pediatrics, Saint Louis University Liver Center, Saint Louis University School of Medicine, MO 63104, USA.

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http://dx.doi.org/10.1152/ajpgi.00486.2005DOI Listing
April 2006

Pathophysiology of hereditary hemochromatosis.

Semin Liver Dis 2005 Nov;25(4):411-9

Department of Pediatrics, Saint Louis University Liver Center, Saint Louis University School of Medicine, St. Louis, Missouri 63104, USA.

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http://dx.doi.org/10.1055/s-2005-923313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587012PMC
November 2005

Orchestration of iron homeostasis.

N Engl J Med 2005 Apr;352(17):1741-4

Saint Louis University School of Medicine, St. Louis, USA.

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http://dx.doi.org/10.1056/NEJMp048363DOI Listing
April 2005

Advances in understanding the molecular basis for the regulation of dietary iron absorption.

Authors:
Robert E Fleming

Curr Opin Gastroenterol 2005 Mar;21(2):201-6

Saint Louis University School of Medicine, 1465 South Grand Avenue, Saint Louis, Missouri 63104, USA.

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http://dx.doi.org/10.1097/01.mog.0000153362.98276.dbDOI Listing
March 2005

Pathogenesis of hereditary hemochromatosis.

Clin Liver Dis 2004 Nov;8(4):755-73, vii

Department of Pediatrics, Saint Louis University School of Medicine, Cardinal Glennon Childrens Hospital, 1465 S. Grand Blvd, St. Louis, MO 63104, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S108932610400076
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http://dx.doi.org/10.1016/j.cld.2004.06.004DOI Listing
November 2004

Contribution of the H63D mutation in HFE to murine hereditary hemochromatosis.

Proc Natl Acad Sci U S A 2003 Dec 12;100(26):15788-93. Epub 2003 Dec 12.

Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, MO 63104, USA.

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http://dx.doi.org/10.1073/pnas.2237037100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC307646PMC
December 2003

Decreased liver hepcidin expression in the Hfe knockout mouse.

Blood Cells Mol Dis 2002 Nov-Dec;29(3):361-6

Department of Pediatrics, Saint Louis University School of Medicine, 1402 South Grand Avenue, St. Louis, MO 63130, USA.

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http://dx.doi.org/10.1006/bcmd.2002.0575DOI Listing
November 2003

Successful use of somatostatin in a case of neonatal chylothorax.

J Pediatr Surg 2003 Jul;38(7):1106-7

Division of Pediatric Surgery, Saint Louis University School of Medicine, St Louis, MO 63104, USA.

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http://dx.doi.org/10.1016/s0022-3468(03)00205-7DOI Listing
July 2003

Human platelets express hemochromatosis protein (HFE) and transferrin receptor 2.

Eur J Haematol 2003 Apr;70(4):201-6

Department of Clinical Chemistry, University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.1034/j.1600-0609.2003.00029.xDOI Listing
April 2003

Mechanisms of iron accumulation in hereditary hemochromatosis.

Annu Rev Physiol 2002 ;64:663-80

Department of Pediatrics, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St. Louis, Missouri 63104, USA.

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http://www.annualreviews.org/doi/10.1146/annurev.physiol.64.
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http://dx.doi.org/10.1146/annurev.physiol.64.081501.155838DOI Listing
May 2002

Pathogenesis of hereditary hemochromatosis: genetics and beyond.

Semin Gastrointest Dis 2002 Apr;13(2):68-79

Department of Internal Medicine, Saint Louis University School of Medicine, MO 63110-0250, USA.

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April 2002

Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosis.

Proc Natl Acad Sci U S A 2002 Mar 26;99(5):3117-22. Epub 2002 Feb 26.

Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA.

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http://dx.doi.org/10.1073/pnas.042701499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC122482PMC
March 2002