Publications by authors named "Robert D Gerard"

52 Publications

PDZK1 prevents neointima formation via suppression of breakpoint cluster region kinase in vascular smooth muscle.

Authors:
Wan Ru Lee Anastasia Sacharidou Erica Behling-Kelly Sarah C Oltmann Weifei Zhu Mohamed Ahmed Robert D Gerard David Y Hui Jun-ichi Abe Philip W Shaul Chieko Mineo

PLoS One 2015 17;10(4):e0124494. Epub 2015 Apr 17.

Center for Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.

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April 2016

Constitutive phosphorylation of cardiac myosin regulatory light chain in vivo.

Authors:
Audrey N Chang Pavan K Battiprolu Patrick M Cowley Guohua Chen Robert D Gerard Jose R Pinto Joseph A Hill Anthony J Baker Kristine E Kamm James T Stull

J Biol Chem 2015 Apr 2;290(17):10703-16. Epub 2015 Mar 2.

From the Departments of Physiology,

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April 2015

The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment.

Authors:
Rui Chen Min Xu Jason S Nagati Richard T Hogg Alok Das Robert D Gerard Joseph A Garcia

PLoS One 2015 17;10(2):e0116515. Epub 2015 Feb 17.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America; Department of Medicine, Veterans Affairs North Texas Health Care System, Dallas, Texas, United States of America.

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December 2015

Genetic variants of ApoE and ApoER2 differentially modulate endothelial function.

Authors:
Victoria Ulrich Eddy S Konaniah Joachim Herz Robert D Gerard Eunjeong Jung Ivan S Yuhanna Mohamed Ahmed David Y Hui Chieko Mineo Philip W Shaul

Proc Natl Acad Sci U S A 2014 Sep 2;111(37):13493-8. Epub 2014 Sep 2.

Center for Pulmonary and Vascular Biology, Department of Pediatrics, and

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September 2014

An acetate switch regulates stress erythropoiesis.

Authors:
Min Xu Jason S Nagati Jian Xie Jiwen Li Holly Walters Young-Ah Moon Robert D Gerard Chou-Long Huang Sarah A Comerford Robert E Hammer Jay D Horton Rui Chen Joseph A Garcia

Nat Med 2014 Sep 10;20(9):1018-26. Epub 2014 Aug 10.

1] Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA. [2] Department of Medicine, VA North Texas Health Care System, Dallas, Texas, USA. [3].

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September 2014

TALEN-mediated somatic mutagenesis in murine models of cancer.

Authors:
Shuyuan Zhang Lin Li Sara L Kendrick Robert D Gerard Hao Zhu

Cancer Res 2014 Sep 28;74(18):5311-21. Epub 2014 Jul 28.

Department of Pediatrics, Children's Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas. Department of Internal Medicine, Children's Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas.

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September 2014

Cytoglobin modulates myogenic progenitor cell viability and muscle regeneration.

Authors:
Sarvjeet Singh Diana C Canseco Shilpa M Manda John M Shelton Rajendra R Chirumamilla Sean C Goetsch Qiu Ye Robert D Gerard Jay W Schneider James A Richardson Beverly A Rothermel Pradeep P A Mammen

Proc Natl Acad Sci U S A 2014 Jan 23;111(1):E129-38. Epub 2013 Dec 23.

Departments of Internal Medicine, Molecular Biology, and Pathology, the Donald W. Reynolds Cardiovascular Clinical Research Center, and the Heart Failure, Ventricular Assist Device and Heart Transplant Program, University of Texas Southwestern Medical Center, Dallas, TX 75390.

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January 2014

Metabolic hormone FGF21 is induced in ground squirrels during hibernation but its overexpression is not sufficient to cause torpor.

Authors:
Bethany T Nelson Xunshan Ding Jamie Boney-Montoya Robert D Gerard Steven A Kliewer Matthew T Andrews

PLoS One 2013 2;8(1):e53574. Epub 2013 Jan 2.

Department of Biology, University of Minnesota Duluth, Duluth, Minnesota, United States of America.

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August 2013

C/EBP transcription factors mediate epicardial activation during heart development and injury.

Authors:
Guo N Huang Jeffrey E Thatcher John McAnally Yongli Kong Xiaoxia Qi Wei Tan J Michael DiMaio James F Amatruda Robert D Gerard Joseph A Hill Rhonda Bassel-Duby Eric N Olson

Science 2012 Dec 15;338(6114):1599-603. Epub 2012 Nov 15.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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December 2012

Nuclear receptors HNF4α and LRH-1 cooperate in regulating Cyp7a1 in vivo.

Authors:
Serkan Kir Yuan Zhang Robert D Gerard Steven A Kliewer David J Mangelsdorf

J Biol Chem 2012 Nov 4;287(49):41334-41. Epub 2012 Oct 4.

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.

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November 2012

Scavenger receptor class B type I is a plasma membrane cholesterol sensor.

Authors:
Sonika Saddar Véronique Carriere Wan-Ru Lee Keiji Tanigaki Ivan S Yuhanna Sajesh Parathath Etienne Morel Manya Warrier Janet K Sawyer Robert D Gerard Ryan E Temel J Mark Brown Margery Connelly Chieko Mineo Philip W Shaul

Circ Res 2013 Jan 28;112(1):140-51. Epub 2012 Sep 28.

Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA.

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January 2013

The microRNA (miR)-199a/214 cluster mediates opposing effects of progesterone and estrogen on uterine contractility during pregnancy and labor.

Authors:
Koriand'r C Williams Nora E Renthal Robert D Gerard Carole R Mendelson

Mol Endocrinol 2012 Nov 12;26(11):1857-67. Epub 2012 Sep 12.

Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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November 2012

Foxk1 promotes cell proliferation and represses myogenic differentiation by regulating Foxo4 and Mef2.

Authors:
Xiaozhong Shi Alicia M Wallis Robert D Gerard Kevin A Voelker Robert W Grange Ronald A DePinho Mary G Garry Daniel J Garry

J Cell Sci 2012 Nov 6;125(Pt 22):5329-37. Epub 2012 Sep 6.

Lillehei Heart Institute, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA.

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November 2012

The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling.

Authors:
Rui Chen Min Xu Richard T Hogg Jiwen Li Bertis Little Robert D Gerard Joseph A Garcia

J Biol Chem 2012 Aug 17;287(36):30800-11. Epub 2012 Jul 17.

Department of Medicine, Veterans Affairs North Texas Health Care System, Dallas, TX 75216, USA.

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August 2012

MicroRNA-200a serves a key role in the decline of progesterone receptor function leading to term and preterm labor.

Authors:
Koriand'r C Williams Nora E Renthal Jennifer C Condon Robert D Gerard Carole R Mendelson

Proc Natl Acad Sci U S A 2012 May 23;109(19):7529-34. Epub 2012 Apr 23.

Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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May 2012

Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice.

Authors:
Pavan K Battiprolu Berdymammet Hojayev Nan Jiang Zhao V Wang Xiang Luo Myriam Iglewski John M Shelton Robert D Gerard Beverly A Rothermel Thomas G Gillette Sergio Lavandero Joseph A Hill

J Clin Invest 2012 Mar 13;122(3):1109-18. Epub 2012 Feb 13.

Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center, Dallas, Texas 75390-8573, USA.

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March 2012

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ.

Authors:
Wei Wei Paul A Dutchak Xunde Wang Xunshan Ding Xueqian Wang Angie L Bookout Regina Goetz Moosa Mohammadi Robert D Gerard Paul C Dechow David J Mangelsdorf Steven A Kliewer Yihong Wan

Proc Natl Acad Sci U S A 2012 Feb 6;109(8):3143-8. Epub 2012 Feb 6.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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February 2012

Human 1-acylglycerol-3-phosphate O-acyltransferase isoforms 1 and 2: biochemical characterization and inability to rescue hepatic steatosis in Agpat2(-/-) gene lipodystrophic mice.

Authors:
Anil K Agarwal Suja Sukumaran Víctor A Cortés Katie Tunison Dario Mizrachi Shireesha Sankella Robert D Gerard Jay D Horton Abhimanyu Garg

J Biol Chem 2011 Oct 27;286(43):37676-91. Epub 2011 Aug 27.

Division of Nutrition and Metabolic Diseases, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.

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October 2011

FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1α pathway.

Authors:
Matthew J Potthoff Jamie Boney-Montoya Mihwa Choi Tianteng He Nishanth E Sunny Santhosh Satapati Kelly Suino-Powell H Eric Xu Robert D Gerard Brian N Finck Shawn C Burgess David J Mangelsdorf Steven A Kliewer

Cell Metab 2011 Jun;13(6):729-38

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

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June 2011

Regulator of G protein signaling (RGS16) inhibits hepatic fatty acid oxidation in a carbohydrate response element-binding protein (ChREBP)-dependent manner.

Authors:
Victor Pashkov Jie Huang Vinay K Parameswara Wojciech Kedzierski Deborah M Kurrasch Gregory G Tall Victoria Esser Robert D Gerard Kosaku Uyeda Howard C Towle Thomas M Wilkie

J Biol Chem 2011 Apr 27;286(17):15116-25. Epub 2011 Feb 27.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9041, USA.

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April 2011

Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner.

Authors:
Rui Chen Elhadji M Dioum Richard T Hogg Robert D Gerard Joseph A Garcia

J Biol Chem 2011 Apr 23;286(16):13869-78. Epub 2011 Feb 23.

Department of Medicine, Veterans Affairs North Texas Health Care System, Dallas, Texas 75216, USA.

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April 2011

miR-200 family and targets, ZEB1 and ZEB2, modulate uterine quiescence and contractility during pregnancy and labor.

Authors:
Nora E Renthal Chien-Cheng Chen Koriand'r C Williams Robert D Gerard Janine Prange-Kiel Carole R Mendelson

Proc Natl Acad Sci U S A 2010 Nov 15;107(48):20828-33. Epub 2010 Nov 15.

Department of Biochemistry, North Texas March of Dimes Birth Defects Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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November 2010

Conditional HIF-1alpha expression produces a reversible cardiomyopathy.

Authors:
Raffi Bekeredjian Chad B Walton Keith A MacCannell Jennifer Ecker Fred Kruse Joel T Outten David Sutcliffe Robert D Gerard Richard K Bruick Ralph V Shohet

PLoS One 2010 Jul 21;5(7):e11693. Epub 2010 Jul 21.

Department of Cardiology, University of Heidelberg, Heidelberg, Germany.

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July 2010

Myocardin-related transcription factor-a controls myofibroblast activation and fibrosis in response to myocardial infarction.

Authors:
Eric M Small Jeffrey E Thatcher Lillian B Sutherland Hideyuki Kinoshita Robert D Gerard James A Richardson J Michael Dimaio Hesham Sadek Koichiro Kuwahara Eric N Olson

Circ Res 2010 Jul 17;107(2):294-304. Epub 2010 Jun 17.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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July 2010

Surfactant protein A2 mutations associated with pulmonary fibrosis lead to protein instability and endoplasmic reticulum stress.

Authors:
Meenakshi Maitra Yongyu Wang Robert D Gerard Carole R Mendelson Christine Kim Garcia

J Biol Chem 2010 Jul 13;285(29):22103-13. Epub 2010 May 13.

Eugene McDermott Center for Human Growth and Development, Dallas, Texas 75390, USA.

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July 2010

The CCAAT/enhancer binding protein beta (C/EBPbeta) cooperates with NFAT to control expression of the calcineurin regulatory protein RCAN1-4.

Authors:
Misook Oh Asim Dey Robert D Gerard Joseph A Hill Beverly A Rothermel

J Biol Chem 2010 May 6;285(22):16623-31. Epub 2010 Apr 6.

Department of Internal Medicine Cardiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.

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May 2010

Regulation of PI3-kinase/Akt signaling by muscle-enriched microRNA-486.

Authors:
Eric M Small Jason R O'Rourke Viviana Moresi Lillian B Sutherland John McAnally Robert D Gerard James A Richardson Eric N Olson

Proc Natl Acad Sci U S A 2010 Mar 8;107(9):4218-23. Epub 2010 Feb 8.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

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March 2010

Cardiac myosin is a substrate for zipper-interacting protein kinase (ZIPK).

Authors:
Audrey N Chang Guohua Chen Robert D Gerard Kristine E Kamm James T Stull

J Biol Chem 2010 Feb 28;285(8):5122-6. Epub 2009 Dec 28.

Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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February 2010

Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1.

Authors:
Elhadji M Dioum Rui Chen Matthew S Alexander Quiyang Zhang Richard T Hogg Robert D Gerard Joseph A Garcia

Science 2009 Jun;324(5932):1289-93

Veterans Affairs North Texas Health Care System, Department of Medicine, 4500 South Lancaster Road, Dallas, TX 75216, USA.

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June 2009

The basic helix-loop-helix transcription factor scleraxis regulates fibroblast collagen synthesis.

Authors:
Leon Espira Lise Lamoureux Stephen C Jones Robert D Gerard Ian M C Dixon Michael P Czubryt

J Mol Cell Cardiol 2009 Aug 10;47(2):188-95. Epub 2009 Apr 10.

Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, University of Manitoba, 351 Tache Avenue, Winnipeg, Manitoba, Canada.

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August 2009