Publications by authors named "Robert C Liddington"

82Publications

Fibulin-1 purification from human plasma using affinity chromatography on Factor H-Sepharose.

Protein Expr Purif 2016 May 28;121:118-24. Epub 2016 Jan 28.

Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, United States.

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http://dx.doi.org/10.1016/j.pep.2016.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803571PMC
May 2016

Structural basis of protein-protein interactions.

Methods Mol Biol 2015 ;1278:3-22

Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA,

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http://dx.doi.org/10.1007/978-1-4939-2425-7_1DOI Listing
December 2015

Effects of human anti-spike protein receptor binding domain antibodies on severe acute respiratory syndrome coronavirus neutralization escape and fitness.

J Virol 2014 Dec 17;88(23):13769-80. Epub 2014 Sep 17.

Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute; Department of Medicine, Harvard Medical School, Boston Massachusetts, USA

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http://dx.doi.org/10.1128/JVI.02232-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248992PMC
December 2014

Structural aspects of integrins.

Adv Exp Med Biol 2014 ;819:111-26

Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA,

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http://dx.doi.org/10.1007/978-94-017-9153-3_8DOI Listing
November 2014

Sulindac-derived RXRα modulators inhibit cancer cell growth by binding to a novel site.

Chem Biol 2014 May 3;21(5):596-607. Epub 2014 Apr 3.

School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, China; Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2014.02.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035439PMC
May 2014

Structure-based design of covalent Siah inhibitors.

Chem Biol 2013 Aug 25;20(8):973-82. Epub 2013 Jul 25.

Signal Transduction Program and Cell Death Program, Cancer Center, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.chembiol.2013.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763817PMC
August 2013

Activity, specificity, and probe design for the smallpox virus protease K7L.

J Biol Chem 2012 Nov 25;287(47):39470-9. Epub 2012 Sep 25.

Program in Apoptosis and Cell Death Research, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M112.388678
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http://dx.doi.org/10.1074/jbc.M112.388678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501048PMC
November 2012

αE-catenin is an autoinhibited molecule that coactivates vinculin.

Proc Natl Acad Sci U S A 2012 May 14;109(22):8576-81. Epub 2012 May 14.

Department of Structural Biology, Stanford University School of Medicine, 299 Campus Drive, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1073/pnas.1203906109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365184PMC
May 2012

Crystal structure of C5b-6 suggests structural basis for priming assembly of the membrane attack complex.

J Biol Chem 2012 Jun 12;287(23):19642-52. Epub 2012 Apr 12.

Program on Infectious Diseases, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1074/jbc.M112.361121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365999PMC
June 2012

Structure of complement C6 suggests a mechanism for initiation and unidirectional, sequential assembly of membrane attack complex (MAC).

J Biol Chem 2012 Mar 20;287(13):10210-22. Epub 2012 Jan 20.

Infectious and Inflammatory Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1074/jbc.M111.327809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323040PMC
March 2012

Fine epitope mapping of monoclonal antibodies against hemagglutinin of a highly pathogenic H5N1 influenza virus using yeast surface display.

Biochem Biophys Res Commun 2011 Jun 5;409(2):253-9. Epub 2011 May 5.

Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Ave., Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.bbrc.2011.04.139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119598PMC
June 2011

Wide prevalence of heterosubtypic broadly neutralizing human anti-influenza A antibodies.

Clin Infect Dis 2011 Apr;52(8):1003-9

Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1093/cid/cir121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070035PMC
April 2011

Structural basis of membrane targeting by the Dock180 family of Rho family guanine exchange factors (Rho-GEFs).

J Biol Chem 2010 Apr 18;285(17):13211-22. Epub 2010 Feb 18.

Infectious and Inflammatory Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1074/jbc.M110.102517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857062PMC
April 2010

Structure-based mutagenesis identifies important novel determinants of the NS2B cofactor of the West Nile virus two-component NS2B-NS3 proteinase.

J Gen Virol 2008 Mar;89(Pt 3):636-641

Inflammatory and Infectious Disease Center, Burnham Institute for Medical Research, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1099/vir.0.83359-0DOI Listing
March 2008

Modifying murine von Willebrand factor A1 domain for in vivo assessment of human platelet therapies.

Nat Biotechnol 2008 Jan 16;26(1):114-9. Epub 2007 Dec 16.

Department of Pediatrics, Columbia University Medical Center, Irving Cancer Research Institute, 1130 St. Nicholas Ave., New York, NY 10032, USA.

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http://www.nature.com/articles/nbt1373
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http://dx.doi.org/10.1038/nbt1373DOI Listing
January 2008

The PTB domain of tensin: NMR solution structure and phosphoinositides binding studies.

Biopolymers 2008 Jan;89(1):86-92

Cancer Center and Infectious and Inflammatory Disease Center, Burnham Institute for Medical Research, La Jolla, CA, USA.

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http://dx.doi.org/10.1002/bip.20862DOI Listing
January 2008

Structure of the PTB domain of tensin1 and a model for its recruitment to fibrillar adhesions.

Protein Sci 2007 Jun 1;16(6):1223-9. Epub 2007 May 1.

Cancer Center, Burnham Institute for Medical Research, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1110/ps.072798707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206669PMC
June 2007

Structural evidence for regulation and specificity of flaviviral proteases and evolution of the Flaviviridae fold.

Protein Sci 2007 May 30;16(5):795-806. Epub 2007 Mar 30.

Infectious and Inflammatory Disease Center, Burnham Institute for Medical Research, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1110/ps.072753207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206648PMC
May 2007

The crystal structure of Bacillus subtilis YycI reveals a common fold for two members of an unusual class of sensor histidine kinase regulatory proteins.

J Bacteriol 2007 Apr 16;189(8):3290-5. Epub 2007 Feb 16.

Division of Cellular Biology, Mail code MEM-116, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1128/JB.01937-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855859PMC
April 2007

Minor capsid proteins of simian virus 40 are dispensable for nucleocapsid assembly and cell entry but are required for nuclear entry of the viral genome.

J Virol 2007 Apr 31;81(8):3778-85. Epub 2007 Jan 31.

Molecular Biology Institute and Department of Molecular, Cell, and Developmental Biology, 456 Boyer Hall, University of California, Los Angeles, 611 East Charles E. Young Dr., Box 951570, Los Angeles, CA 90095-1570, USA.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.02664-06
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http://dx.doi.org/10.1128/JVI.02664-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866110PMC
April 2007

Selection of anthrax toxin protective antigen variants that discriminate between the cellular receptors TEM8 and CMG2 and achieve targeting of tumor cells.

J Biol Chem 2007 Mar 24;282(13):9834-45. Epub 2007 Jan 24.

Laboratory of Bacterial Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892-3202, USA.

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http://dx.doi.org/10.1074/jbc.M611142200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2530824PMC
March 2007

Expression and purification of a two-component flaviviral proteinase resistant to autocleavage at the NS2B-NS3 junction region.

Protein Expr Purif 2007 Apr 1;52(2):334-9. Epub 2006 Dec 1.

Inflammatory and Infectious Disease Center, Burnham Institute for Medical Research, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.pep.2006.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1857357PMC
April 2007

Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein.

Protein Sci 2007 Jan 22;16(1):118-24. Epub 2006 Nov 22.

Burnham Institute for Medical Research, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1110/ps.062454707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2222835PMC
January 2007

Structural basis of neutralization by a human anti-severe acute respiratory syndrome spike protein antibody, 80R.

J Biol Chem 2006 Nov 5;281(45):34610-6. Epub 2006 Sep 5.

Infectious and Inflammatory Disease Center, Burnham Institute for Medical Research, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1074/jbc.M603275200DOI Listing
November 2006

The structure and regulation of vinculin.

Trends Cell Biol 2006 Sep 8;16(9):453-60. Epub 2006 Aug 8.

IZKF Leipzig, Faculty of Medicine, University of Leipzig, 04103 Leipzig, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S096289240600193
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http://dx.doi.org/10.1016/j.tcb.2006.07.004DOI Listing
September 2006

A structural rationale for SV40 Vp1 temperature-sensitive mutants and their complementation.

Protein Sci 2006 Sep 1;15(9):2207-13. Epub 2006 Aug 1.

Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1110/ps.062195606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2242610PMC
September 2006

Role of vinculin in regulating focal adhesion turnover.

Eur J Cell Biol 2006 Jun 3;85(6):487-500. Epub 2006 Apr 3.

Department of Biochemistry, University of Leicester, University Road, Leicester LE1 7RH, UK.

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http://dx.doi.org/10.1016/j.ejcb.2006.01.014DOI Listing
June 2006

Structure of the alpha-actinin-vinculin head domain complex determined by cryo-electron microscopy.

J Mol Biol 2006 Mar 18;357(2):562-73. Epub 2006 Jan 18.

Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306-4380, USA.

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http://dx.doi.org/10.1016/j.jmb.2005.12.076DOI Listing
March 2006

Structure and lytic activity of a Bacillus anthracis prophage endolysin.

J Biol Chem 2005 Oct 15;280(42):35433-9. Epub 2005 Aug 15.

Infectious and Inflammatory Disease Center, The Burnham Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1074/jbc.M502723200DOI Listing
October 2005

Efficient synthetic inhibitors of anthrax lethal factor.

Proc Natl Acad Sci U S A 2005 Jul 27;102(27):9499-504. Epub 2005 Jun 27.

Burnham Institute, Cancer Research Center and Infectious and Inflammatory Disease Center, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0502733102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160517PMC
July 2005

Two-wavelength MAD phasing and radiation damage: a case study.

J Synchrotron Radiat 2005 May 14;12(Pt 3):285-91. Epub 2005 Apr 14.

Stanford Linear Accelerator Center, Menlo Park, CA 94025, USA.

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http://dx.doi.org/10.1107/S0909049505003249DOI Listing
May 2005

The snake venom protein botrocetin acts as a biological brace to promote dysfunctional platelet aggregation.

Nat Struct Mol Biol 2005 Feb 16;12(2):152-9. Epub 2005 Jan 16.

Infectious and Inflammatory Disease Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/nsmb892DOI Listing
February 2005

Structural basis for phosphatidylinositol phosphate kinase type Igamma binding to talin at focal adhesions.

J Biol Chem 2005 Mar 28;280(9):8381-6. Epub 2004 Dec 28.

Program on Cell Adhesion, The Burnham Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1074/jbc.M413180200DOI Listing
March 2005

Characterization of an actin-binding site within the talin FERM domain.

J Mol Biol 2004 Oct;343(3):771-84

Muscle Biology Group, Departments of Biochemistry, Biophysics, and Molecular Biology and of Animal Science, Iowa State University, Ames, IA 50011-3260, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S002228360401031
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http://dx.doi.org/10.1016/j.jmb.2004.08.069DOI Listing
October 2004

Determinants of retinoid X receptor transcriptional antagonism.

J Med Chem 2004 Aug;47(18):4360-72

Cancer Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1021/jm030651gDOI Listing
August 2004

Crystal structure of a complex between anthrax toxin and its host cell receptor.

Nature 2004 Aug 4;430(7002):905-8. Epub 2004 Jul 4.

Program on Cell Adhesion, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/nature02763DOI Listing
August 2004

Crystal structure of PqqC from Klebsiella pneumoniae at 2.1 A resolution.

Proteins 2004 Aug;56(2):401-3

The Burnham Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1002/prot.20085DOI Listing
August 2004

Structural basis for vinculin activation at sites of cell adhesion.

Nature 2004 Jul 13;430(6999):583-6. Epub 2004 Jun 13.

Program on Cell Adhesion, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/nature02610DOI Listing
July 2004

Quinone biogenesis: Structure and mechanism of PqqC, the final catalyst in the production of pyrroloquinoline quinone.

Proc Natl Acad Sci U S A 2004 May 17;101(21):7913-8. Epub 2004 May 17.

Departments of Chemistry and of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.

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http://dx.doi.org/10.1073/pnas.0402640101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC419531PMC
May 2004

Structure of the Chlamydia protein CADD reveals a redox enzyme that modulates host cell apoptosis.

J Biol Chem 2004 Jul 15;279(28):29320-4. Epub 2004 Apr 15.

The Burnham Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1074/jbc.M401268200DOI Listing
July 2004

Structural basis of protein-protein interactions.

Methods Mol Biol 2004 ;261:3-14

The Burnham Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1385/1-59259-762-9:003DOI Listing
July 2004

Crystal structure of the A domain from complement factor B reveals an integrin-like open conformation.

Structure 2004 Mar;12(3):371-8

The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037 USA.

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http://dx.doi.org/10.1016/j.str.2004.02.012DOI Listing
March 2004

The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.

Nat Struct Mol Biol 2004 Jan 29;11(1):60-6. Epub 2003 Dec 29.

Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/nsmb708DOI Listing
January 2004

Talin binding to integrin beta tails: a final common step in integrin activation.

Science 2003 Oct;302(5642):103-6

Department of Cell Biology, The Scripps Research Institute, The Burnham Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1126/science.1086652DOI Listing
October 2003

Importance of Vp1 calcium-binding residues in assembly, cell entry, and nuclear entry of simian virus 40.

J Virol 2003 Jul;77(13):7527-38

Department of Molecular, Cell and Developmental Biology and Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California 90095, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC164782PMC
http://dx.doi.org/10.1128/jvi.77.13.7527-7538.2003DOI Listing
July 2003

Engineered allosteric mutants of the integrin alphaMbeta2 I domain: structural and functional studies.

Biochem J 2003 May;372(Pt 1):121-7

The Burnham Institute, 10901 North Torrey Pines Rd, La Jolla, CA 92037, U.S.A.

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http://dx.doi.org/10.1042/BJ20021273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223386PMC
May 2003

Cell adhesion: a FERM grasp of membrane dynamics.

Curr Biol 2003 Feb;13(3):R94-5

Program on Cell Adhesion, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/s0960-9822(03)00035-6DOI Listing
February 2003

Structural determinants of integrin recognition by talin.

Mol Cell 2003 Jan;11(1):49-58

Program on Cell Adhesion, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/s1097-2765(02)00823-7DOI Listing
January 2003

S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death.

Science 2002 Aug;297(5584):1186-90

Center for Neuroscience and Aging, Program in Cell Adhesion and Extracellular Matrix Biology, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1126/science.1073634DOI Listing
August 2002

Structural basis of von Willebrand factor activation by the snake toxin botrocetin.

Structure 2002 Jul;10(7):943-50

The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1016/s0969-2126(02)00787-6DOI Listing
July 2002

Will the real integrin please stand up?

Structure 2002 May;10(5):605-7

Program on Cell Adhesion, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/s0969-2126(02)00766-9DOI Listing
May 2002

The phosphotyrosine binding-like domain of talin activates integrins.

J Biol Chem 2002 Jun 3;277(24):21749-58. Epub 2002 Apr 3.

Division of Vascular Biology, Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M111996200
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http://dx.doi.org/10.1074/jbc.M111996200DOI Listing
June 2002

Anthrax: a molecular full nelson.

Nature 2002 Jan;415(6870):373-4

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http://dx.doi.org/10.1038/415373aDOI Listing
January 2002

The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin.

Nat Struct Biol 2002 Feb;9(2):101-6

Program on Cell Adhesion, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037,USA.

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http://dx.doi.org/10.1038/nsb755DOI Listing
February 2002