Robert C Hider

Robert C Hider

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CN128: A New Orally Active Hydroxypyridinone Iron Chelator.

J Med Chem 2020 Apr 2. Epub 2020 Apr 2.

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, Zhejiang Province, China.

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http://dx.doi.org/10.1021/acs.jmedchem.0c00137DOI Listing
April 2020

Synthetic Approaches for Piperidone-Based Templates as Scaffolds to Access Chirally Enriched Donepezil Analogues.

ACS Omega 2020 Feb 3;5(5):2378-2396. Epub 2020 Feb 3.

Institute of Pharmaceutical Science, King's College London, Stamford Street, London SE1 9NH, U.K.

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http://dx.doi.org/10.1021/acsomega.9b03808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017409PMC
February 2020

Synthesis and iron coordination properties of schizokinen and its imide derivative.

Dalton Trans 2019 Nov;48(46):17395-17401

Institute of Pharmaceutical Science, King's College London, London, SE1 9NH, UK.

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http://dx.doi.org/10.1039/c9dt02731aDOI Listing
November 2019

The Efficacy of Iron Chelators for Removing Iron from Specific Brain Regions and the Pituitary-Ironing out the Brain.

Pharmaceuticals (Basel) 2019 Sep 17;12(3). Epub 2019 Sep 17.

Institute of Pharmaceutical Science, King's College London, London SE1 9NH, UK.

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http://dx.doi.org/10.3390/ph12030138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789569PMC
September 2019

A chemically characterized ethanolic extract of Thai Perilla frutescens (L.) Britton fruits (nutlets) reduces oxidative stress and lipid peroxidation in human hepatoma (HuH7) cells.

Phytother Res 2019 Aug 29;33(8):2064-2074. Epub 2019 May 29.

Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.

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http://dx.doi.org/10.1002/ptr.6396DOI Listing
August 2019

Enzymatic characteristics of polyphenoloxidase from shrimp () and its inhibition by a novel hydroxypyridinone derivative.

Food Sci Biotechnol 2019 Aug 23;28(4):1047-1055. Epub 2019 Jan 23.

1School of Food Science and Biotechnology, Zhejiang Gongshang University, 18 Xuezheng Street, Xiasha, Hangzhou, 310018 Zhejiang People's Republic of China.

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http://dx.doi.org/10.1007/s10068-018-00544-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595021PMC
August 2019

A Simple Metal-Free Cyclization for the Synthesis of 4-Methylene-3-Substituted Quinazolinone and Quinazolinthione Derivatives: Experiment and Theory.

Front Chem 2019 16;7:584. Epub 2019 Aug 16.

School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou, China.

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http://dx.doi.org/10.3389/fchem.2019.00584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706782PMC
August 2019

The role of mitochondrial labile iron in Friedreich's ataxia skin fibroblasts sensitivity to ultraviolet A.

Metallomics 2019 03;11(3):656-665

Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK.

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http://dx.doi.org/10.1039/c8mt00257fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438355PMC
March 2019

Synthesis and iron chelating properties of hydroxypyridinone and hydroxypyranone hexadentate ligands.

Dalton Trans 2019 Mar;48(10):3459-3466

School of Food Science and Biotechnology, Zhejiang Gongshang University, 18 Xuezheng Street, Xiasha, Hangzhou, Zhejiang 310018, P. R. China.

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http://dx.doi.org/10.1039/c8dt05014gDOI Listing
March 2019

Tuning the properties of tris(hydroxypyridinone) ligands: efficient Ga chelators for PET imaging.

Dalton Trans 2019 Mar;48(13):4299-4313

King's College London, School of Biomedical Engineering and Imaging Sciences, St Thomas' Hospital, London SE1 7EH, UK.

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http://dx.doi.org/10.1039/c8dt04454fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469224PMC
March 2019

The Role of Deferiprone in Iron Chelation. Reply.

N Engl J Med 2019 02;380(9):892-893

Royal Free Hospital, London, United Kingdom.

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http://dx.doi.org/10.1056/NEJMc1817335DOI Listing
February 2019

The Role of Deferiprone in Iron Chelation.

N Engl J Med 2018 11;379(22):2140-2150

From the Institute of Pharmaceutical Science, King's College London (R.C.H.), and the Department of Haematology, Royal Free Hospital (A.V.H.) - both in London.

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http://www.nejm.org/doi/10.1056/NEJMra1800219
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http://dx.doi.org/10.1056/NEJMra1800219DOI Listing
November 2018

Design of Bifunctional Dendritic 5-Aminolevulinic Acid and Hydroxypyridinone Conjugates for Photodynamic Therapy.

Bioconjug Chem 2018 10 5;29(10):3411-3428. Epub 2018 Oct 5.

Division of Surgery and Interventional Science , University College London , Charles Bell House, 43-45 Foley Street , London W1W 7TS , U.K.

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http://dx.doi.org/10.1021/acs.bioconjchem.8b00574DOI Listing
October 2018

Synthesis, iron binding and antimicrobial properties of hexadentate 3-hydroxypyridinones-terminated dendrimers.

Bioorg Med Chem Lett 2018 08 30;28(14):2504-2512. Epub 2018 May 30.

Division of Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.05.058DOI Listing
August 2018

Hydroxypyridinone Journey into Metal Chelation.

Chem Rev 2018 08 23;118(16):7657-7701. Epub 2018 Jul 23.

Institute of Pharmaceutical Science , King's College London , Stamford Street , London SE1 9NH , United Kingdom.

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http://dx.doi.org/10.1021/acs.chemrev.8b00254DOI Listing
August 2018

Protein-Corona-by-Design in 2D: A Reliable Platform to Decode Bio-Nano Interactions for the Next-Generation Quality-by-Design Nanomedicines.

Adv Mater 2018 Aug 24:e1802732. Epub 2018 Aug 24.

Institute of Pharmaceutical Science, Faculty of Life Science & Medicine, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.

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http://dx.doi.org/10.1002/adma.201802732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952277PMC
August 2018

Novel hydroxypyridinone derivatives containing an oxime ether moiety: Synthesis, inhibition on mushroom tyrosinase and application in anti-browning of fresh-cut apples.

Food Chem 2018 Mar 12;242:174-181. Epub 2017 Sep 12.

School of Food Science and Biotechnology, Zhejiang Gongshang University, 18 Xuezheng Street, Xiasha, Hangzhou, Zhejiang 310018, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.foodchem.2017.09.054DOI Listing
March 2018

Ion-Pairing with Spermine Targets Theophylline To the Lungs via the Polyamine Transport System.

Mol Pharm 2018 03 9;15(3):861-870. Epub 2018 Feb 9.

Institute of Pharmaceutical Science , King's College London , Franklin-Wilkins Building, 150 Stamford Street , London SE1 9NH , United Kingdom.

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http://dx.doi.org/10.1021/acs.molpharmaceut.7b00715DOI Listing
March 2018

The interaction of pyridoxal isonicotinoyl hydrazone (PIH) and salicylaldehyde isonicotinoyl hydrazone (SIH) with iron.

J Inorg Biochem 2018 03 21;180:194-203. Epub 2017 Dec 21.

Institute of Pharmaceutical Sciences, King's College London, 150 Stamford Street London SE1 9NH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jinorgbio.2017.12.007DOI Listing
March 2018

Preparation, antioxidant and antimicrobial evaluation of hydroxamated degraded polysaccharides from Enteromorpha prolifera.

Food Chem 2017 Dec 24;237:481-487. Epub 2017 May 24.

School of Food Science and Biotechnology, Zhejiang Gongshang University, 18 Xuezheng Street, Xiasha, Hangzhou, Zhejiang 310018, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.foodchem.2017.05.119DOI Listing
December 2017

Ga-THP-PSMA: A PET Imaging Agent for Prostate Cancer Offering Rapid, Room-Temperature, 1-Step Kit-Based Radiolabeling.

J Nucl Med 2017 08 13;58(8):1270-1277. Epub 2017 Apr 13.

Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom; and

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http://dx.doi.org/10.2967/jnumed.117.191882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175039PMC
August 2017

Hydroxypyridinone and 5-Aminolaevulinic Acid Conjugates for Photodynamic Therapy.

J Med Chem 2017 04 6;60(8):3498-3510. Epub 2017 Apr 6.

School of Food Science and Biotechnology, Zhejiang Gongshang University , Hangzhou, Zhejiang 310018, P. R. China.

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http://dx.doi.org/10.1021/acs.jmedchem.7b00346DOI Listing
April 2017

Hydroxypyridinone Chelators: From Iron Scavenging to Radiopharmaceuticals for PET Imaging with Gallium-68.

Int J Mol Sci 2017 Jan 8;18(1). Epub 2017 Jan 8.

Division of Imaging Sciences and Biomedical Engineering, King's College London, Fourth Floor Lambeth Wing, St. Thomas' Hospital, London SE1 7EH, UK.

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http://dx.doi.org/10.3390/ijms18010116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297750PMC
January 2017

Novel Hyaluronic Acid Conjugates for Dual Nuclear Imaging and Therapy in CD44-Expressing Tumors in Mice .

Nanotheranostics 2017 1;1(1):59-79. Epub 2017 Jan 1.

Institute of Pharmaceutical Science, Faculty of Life Sciences & Medicine, King's College London, Franklin-Wilkins Building, London SE19NH, United Kingdom.

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http://dx.doi.org/10.7150/ntno.17896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646725PMC
January 2017

Cardioprotective effects of CuATSM in human vascular smooth muscle cells and cardiomyocytes mediated by Nrf2 and DJ-1.

Sci Rep 2016 Dec 21;6(1). Epub 2016 Dec 21.

Cardiovascular Division, British Heart Foundation Centre of Research Excellence, Faculty of Life Sciences & Medicine, King's College London, 150 Stamford Street, London, SE1 9NH, UK.

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http://dx.doi.org/10.1038/s41598-016-0012-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431352PMC
December 2016

Improved antioxidant and anti-tyrosinase activity of polysaccharide from Sargassum fusiforme by degradation.

Int J Biol Macromol 2016 Nov 25;92:715-722. Epub 2016 Jul 25.

School of Food Science and Biotechnology, Zhejiang Gongshang University, Xiasha, Hangzhou, Zhejiang 310018, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ijbiomac.2016.07.082DOI Listing
November 2016

Design and synthesis of novel pegylated iron chelators with decreased metabolic rate.

Future Med Chem 2015 16;7(18):2439-49. Epub 2015 Dec 16.

Institute of Pharmaceutical Science, King's College London, SE1 9NH London, UK.

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http://dx.doi.org/10.4155/fmc.15.154DOI Listing
September 2016

A Powerful Mitochondria-Targeted Iron Chelator Affords High Photoprotection against Solar Ultraviolet A Radiation.

J Invest Dermatol 2016 08 22;136(8):1692-1700. Epub 2016 Apr 22.

Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2016.03.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946793PMC
August 2016

Design and synthesis of novel hydroxypyridinone derivatives as potential tyrosinase inhibitors.

Bioorg Med Chem Lett 2016 07 4;26(13):3103-3108. Epub 2016 May 4.

School of Food Science and Biotechnology, Zhejiang Gongshang University, Xiasha, Hangzhou, Zhejiang 310018, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.05.006DOI Listing
July 2016

Copper(II) binding properties of hepcidin.

J Biol Inorg Chem 2016 06 16;21(3):329-38. Epub 2016 Feb 16.

Institute of Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.

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http://dx.doi.org/10.1007/s00775-016-1342-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850187PMC
June 2016

Iron Deficiency Impairs Intra-Hepatic Lymphocyte Mediated Immune Response.

PLoS One 2015 19;10(8):e0136106. Epub 2015 Aug 19.

Department of Liver Studies, Division of Transplantation Immunology & Mucosal Biology, Medical Research Council (MRC) Centre for Transplantation, Faculty of Life Sciences & Medicine, King's College London University, King's College Hospital, Denmark Hill, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136106PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542211PMC
May 2016

Dual selective iron chelating probes with a potential to monitor mitochondrial labile iron pools.

Chem Commun (Camb) 2016 Jan;52(4):784-7

Institute of Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK.

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http://dx.doi.org/10.1039/c5cc06170aDOI Listing
January 2016

Synthesis of polymers containing 3-hydroxypyridin-4-one bidentate ligands for treatment of iron overload.

Res Pharm Sci 2015 Jul-Aug;10(4):364-77

Department of Pharmacy, King's College London, London, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623625PMC
November 2015

Synthesis of double-clickable functionalised graphene oxide for biological applications.

Chem Commun (Camb) 2015 Oct;51(81):14981-4

Institute of Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK.

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http://dx.doi.org/10.1039/c5cc05412eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594119PMC
October 2015

Solvent-Free Click-Mechanochemistry for the Preparation of Cancer Cell Targeting Graphene Oxide.

ACS Appl Mater Interfaces 2015 Sep 20;7(34):18920-3. Epub 2015 Aug 20.

Institute of Pharmaceutical Science, King's College London , Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, United Kingdom.

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http://pubs.acs.org/doi/10.1021/acsami.5b06250
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http://dx.doi.org/10.1021/acsami.5b06250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559840PMC
September 2015

Structural analysis of cytochrome P450 105N1 involved in the biosynthesis of the zincophore, coelibactin.

Int J Mol Sci 2012 1;13(7):8500-13. Epub 2012 Jun 1.

Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA; E-Mails: (L.L.); (M.R.W.).

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http://www.mdpi.com/1422-0067/13/7/8500
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http://dx.doi.org/10.3390/ijms13078500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430247PMC
August 2015

Design of novel fluorescent mitochondria-targeted peptides with iron-selective sensing activity.

Biochem J 2015 Aug 26;469(3):357-66. Epub 2015 May 26.

Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, U.K.

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http://biochemj.org/lookup/doi/10.1042/BJ20150149
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http://dx.doi.org/10.1042/BJ20150149DOI Listing
August 2015

Organic Solvent-Free, One-Step Engineering of Graphene-Based Magnetic-Responsive Hybrids Using Design of Experiment-Driven Mechanochemistry.

ACS Appl Mater Interfaces 2015 Jul 25;7(26):14176-81. Epub 2015 Jun 25.

†Institute of Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, United Kingdom.

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http://pubs.acs.org/doi/10.1021/acsami.5b03577
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http://dx.doi.org/10.1021/acsami.5b03577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500448PMC
July 2015

Characterisation of a novel oral iron chelator: 1-(N-Acetyl-6-Aminohexyl)-3-Hydroxy-2-Methylpyridin-4-one.

J Pharm Pharmacol 2015 May 28;67(5):703-13. Epub 2015 Jan 28.

Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; College of Medicine and Public Health, Ubon Ratchathani University, Chiang Mai, Thailand.

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http://doi.wiley.com/10.1111/jphp.12373
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http://dx.doi.org/10.1111/jphp.12373DOI Listing
May 2015

pFe(3+) determination of multidentate ligands by a fluorescence assay.

Analyst 2015 May 10;140(10):3603-6. Epub 2015 Apr 10.

College of Pharmaceutical Science, Zhejiang Chinese Medical University, 548 Binwen Road, Hangzhou, 310053, P R China.

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http://dx.doi.org/10.1039/c5an00123dDOI Listing
May 2015

Mode of iron(III) chelation by hexadentate hydroxypyridinones.

Chem Commun (Camb) 2015 Apr;51(26):5614-7

Department of Applied Chemistry, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, Zhejiang 310018, China.

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http://dx.doi.org/10.1039/c4cc10339dDOI Listing
April 2015

Hexadentate 3-hydroxypyridin-4-ones with high iron(III) affinity: design, synthesis and inhibition on methicillin resistant Staphylococcus aureus and Pseudomonas strains.

Eur J Med Chem 2015 Apr 26;94:8-21. Epub 2015 Feb 26.

School of Food Science and Biotechnology, Zhejiang Gongshang University, 18 Xuezheng Street, Xiasha, Hangzhou, Zhejiang, 310018, PR China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S02235234150014
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http://dx.doi.org/10.1016/j.ejmech.2015.02.050DOI Listing
April 2015

Tripodal tris(hydroxypyridinone) ligands for immunoconjugate PET imaging with (89)Zr(4+): comparison with desferrioxamine-B.

Dalton Trans 2015 Mar;44(11):4884-900

King's College London, Division of Imaging Sciences and Biomedical Engineering, 4th Floor Lambeth Wing, St Thomas' Hospital, London SE1 7EH, UK.

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http://xlink.rsc.org/?DOI=C4DT02978J
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http://dx.doi.org/10.1039/c4dt02978jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357251PMC
March 2015

Deferitazole, a new orally active iron chelator.

Dalton Trans 2015 Mar;44(11):5197-204

Institute of Pharmaceutical Science, King's College, London, UK.

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http://dx.doi.org/10.1039/c5dt00063gDOI Listing
March 2015

Iron and zinc sensing in cells and the body.

Metallomics 2015 Feb;7(2):200-1

Institute of Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK.

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http://dx.doi.org/10.1039/c4mt90051kDOI Listing
February 2015

Design, synthesis and biological evaluation of 5-aminolaevulinic acid/3-hydroxypyridinone conjugates as potential photodynamic therapeutical agents.

Bioorg Med Chem Lett 2015 Feb 15;25(3):558-61. Epub 2014 Dec 15.

School of Food Science and Biotechnology, Zhejiang Gongshang University, 18 Xuezheng Street, Xiasha, Hangzhou, Zhejiang 310018, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2014.12.018DOI Listing
February 2015

Design, synthesis, and antimicrobial evaluation of hexadentate hydroxypyridinones with high iron(III) affinity.

Chem Biol Drug Des 2014 Dec 26;84(6):659-68. Epub 2014 Jun 26.

School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, Zhejiang, 310018, P. R. China.

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http://dx.doi.org/10.1111/cbdd.12358DOI Listing
December 2014

Synthesis and characterizations of pyridazine-based iron chelators.

Dalton Trans 2014 Dec;43(45):17120-8

College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, P R China.

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http://dx.doi.org/10.1039/c4dt02687jDOI Listing
December 2014

A novel method for non-transferrin-bound iron quantification by chelatable fluorescent beads based on flow cytometry.

Biochem J 2014 Nov;463(3):351-62

†King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, U.K.

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http://dx.doi.org/10.1042/BJ20140795DOI Listing
November 2014

Iron: effect of overload and deficiency.

Met Ions Life Sci 2013 ;13:229-94

Institute of Pharmaceutical Science, King's College London, Franklin-Wilkins Building, Stamford Street, London, SE1 9NH, UK,

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http://dx.doi.org/10.1007/978-94-007-7500-8_8DOI Listing
June 2014

In vitro antimicrobial activity of hydroxypyridinone hexadentate-based dendrimeric chelators alone and in combination with norfloxacin.

FEMS Microbiol Lett 2014 Jun 3;355(2):124-30. Epub 2014 Jun 3.

School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, Zhejiang, China.

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http://dx.doi.org/10.1111/1574-6968.12465DOI Listing
June 2014

Feruloyl-CoA 6'-Hydroxylase1-dependent coumarins mediate iron acquisition from alkaline substrates in Arabidopsis.

Plant Physiol 2014 Jan 18;164(1):160-72. Epub 2013 Nov 18.

Department of Physiology and Cell Biology, Leibniz Institute for Plant Genetics and Crop Plant Research, Corrensstrasse 3, 06466 Gatersleben, Germany.

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http://dx.doi.org/10.1104/pp.113.228544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875798PMC
January 2014

Design, synthesis and biological evaluation of peptide derivatives of L-dopa as anti-parkinsonian agents.

Bioorg Med Chem Lett 2013 Oct 11;23(19):5279-82. Epub 2013 Aug 11.

School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, Zhejiang 310035, PR China.

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http://dx.doi.org/10.1016/j.bmcl.2013.08.007DOI Listing
October 2013

Functional characterization of fluorescent hepcidin.

Bioconjug Chem 2013 Sep 14;24(9):1527-32. Epub 2013 Aug 14.

Chemical Biology Group, Institute of Pharmaceutical Sciences, and ‡Nutrition and Diabetes Research Group, King's College London , Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, U.K.

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http://dx.doi.org/10.1021/bc400121xDOI Listing
September 2013

Design and synthesis of hydroxypyridinone-L-phenylalanine conjugates as potential tyrosinase inhibitors.

J Agric Food Chem 2013 Jul 26;61(27):6597-603. Epub 2013 Jun 26.

School of Food Science and Biotechnology, Zhejiang Gongshang University , Hangzhou, Zhejiang 310035, People's Republic of China.

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http://dx.doi.org/10.1021/jf401585fDOI Listing
July 2013

Synthesis and in-vitro antimicrobial evaluation of a high-affinity iron chelator in combination with chloramphenicol.

J Pharm Pharmacol 2013 Apr 14;65(4):512-20. Epub 2012 Dec 14.

College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China.

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http://dx.doi.org/10.1111/jphp.12013DOI Listing
April 2013

Iron speciation in the cytosol: an overview.

Dalton Trans 2013 Mar 11;42(9):3220-9. Epub 2012 Dec 11.

Institute of Pharmaceutical Science, King's College London, Franklin-Wilkins Building, Stamford Street, London SE1 9NH, UK.

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http://dx.doi.org/10.1039/c2dt32149aDOI Listing
March 2013

Conjugation to 4-aminoquinoline improves the anti-trypanosomal activity of Deferiprone-type iron chelators.

Bioorg Med Chem 2013 Feb 27;21(3):805-13. Epub 2012 Nov 27.

Institute of Pharmaceutical Science, School of Biomedical Sciences, King's College London, SE19NH, UK.

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http://dx.doi.org/10.1016/j.bmc.2012.11.009DOI Listing
February 2013

A novel fluorescence method for determination of pFe3+.

Analyst 2013 Jan 22;138(1):96-9. Epub 2012 Oct 22.

Institute of Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.

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http://dx.doi.org/10.1039/c2an36186hDOI Listing
January 2013

Prediction of Absolute Hydroxyl pKa Values for 3-Hydroxypyridin-4-ones.

J Phys Chem Lett 2012 Oct 2;3(20):2980-5. Epub 2012 Oct 2.

†Institute of Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, U.K.

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http://dx.doi.org/10.1021/jz301061mDOI Listing
October 2012

Prediction of 3-hydroxypyridin-4-one (HPO) log K1 values for Fe(III).

Dalton Trans 2012 Sep 1;41(35):10784-91. Epub 2012 Aug 1.

Institute of Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.

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http://dx.doi.org/10.1039/c2dt31254aDOI Listing
September 2012

Design of iron chelators with therapeutic application.

Dalton Trans 2012 Jun 6;41(21):6371-89. Epub 2012 Mar 6.

School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, Zhejiang 310012, P R China.

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http://dx.doi.org/10.1039/c2dt12159jDOI Listing
June 2012

Prediction of 3-hydroxypyridin-4-one (HPO) hydroxyl pKa values.

Dalton Trans 2012 Jun 6;41(21):6549-57. Epub 2012 Mar 6.

Institute of Pharmaceutical Sciences, King's College London, London, UK.

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http://dx.doi.org/10.1039/c2dt12396gDOI Listing
June 2012

Iron mobilization from transferrin by therapeutic iron chelating agents.

Biochim Biophys Acta 2012 Mar 22;1820(3):282-90. Epub 2011 Nov 22.

Metalloprotein Research Group, Division of Biosciences, School of Health Sciences and Social Care, Brunel University, Uxbridge, Middlesex, UB8 3PH, UK.

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http://dx.doi.org/10.1016/j.bbagen.2011.11.007DOI Listing
March 2012

Design and synthesis of fluorinated iron chelators for metabolic study and brain uptake.

J Med Chem 2012 Mar 27;55(5):2185-95. Epub 2012 Feb 27.

Institute of Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK.

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http://dx.doi.org/10.1021/jm201475uDOI Listing
March 2012

Glutathione: a key component of the cytoplasmic labile iron pool.

Biometals 2011 Dec 17;24(6):1179-87. Epub 2011 Jul 17.

Institute of Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, UK.

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http://dx.doi.org/10.1007/s10534-011-9476-8DOI Listing
December 2011

Synthesis, iron(III)-binding affinity and in vitro evaluation of 3-hydroxypyridin-4-one hexadentate ligands as potential antimicrobial agents.

Bioorg Med Chem Lett 2011 Nov 28;21(21):6376-80. Epub 2011 Aug 28.

School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, Zhejiang 310012, PR China.

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http://dx.doi.org/10.1016/j.bmcl.2011.08.097DOI Listing
November 2011

Genetic epidemiology of induced CYP3A4 activity.

Pharmacogenet Genomics 2011 Oct;21(10):642-51

Department of Twin Research and Genetic Epidemiology, St Thomas' Hospital, London, UK.

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http://dx.doi.org/10.1097/FPC.0b013e3283498ecfDOI Listing
October 2011

The binding of aluminum to mugineic acid and related compounds as studied by potentiometric titration.

Biometals 2011 Aug 25;24(4):723-7. Epub 2011 Feb 25.

Department of Applied Biological Chemistry, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.

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http://link.springer.com/10.1007/s10534-011-9424-7
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August 2011

Induction of hypoxia inducible factor (HIF-1α) in rat kidneys by iron chelation with the hydroxypyridinone, CP94.

Biochim Biophys Acta 2011 Apr-Jun;1809(4-6):262-8. Epub 2011 May 1.

Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S18749399110006
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http://dx.doi.org/10.1016/j.bbagrm.2011.04.010DOI Listing
August 2011

Efficient bifunctional gallium-68 chelators for positron emission tomography: tris(hydroxypyridinone) ligands.

Chem Commun (Camb) 2011 Jul 27;47(25):7068-70. Epub 2011 May 27.

King's College London, Division of Imaging Sciences and Biomedical Engineering, The Rayne Institute, St Thomas' Hospital, London, SE1 7EH, UK.

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http://dx.doi.org/10.1039/c1cc12123eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929899PMC
July 2011

Design of clinically useful macromolecular iron chelators.

J Pharm Pharmacol 2011 Jul 19;63(7):893-903. Epub 2011 May 19.

School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, Zhejiang, China.

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http://dx.doi.org/10.1111/j.2042-7158.2011.01291.xDOI Listing
July 2011

Ga(III) complexes--the effect of metal coordination on potential systemic absorption after topical exposure.

Toxicol Lett 2011 May 17;202(3):155-60. Epub 2011 Feb 17.

Pharmaceutical Science Research Division, King's College London, 150A Stamford Street, Waterloo, London SE19NN, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S03784274110001
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http://dx.doi.org/10.1016/j.toxlet.2011.01.017DOI Listing
May 2011

The potential application of iron chelators for the treatment of neurodegenerative diseases.

Metallomics 2011 Mar 22;3(3):239-49. Epub 2011 Feb 22.

King's College London, Institute of Pharmaceutical Science, Franklin-Wilkins Building, 150 Stamford Street, London, UKSE1 9NH.

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http://dx.doi.org/10.1039/c0mt00087fDOI Listing
March 2011

Synthesis, physical-chemical characterisation and biological evaluation of novel 2-amido-3-hydroxypyridin-4(1H)-ones: Iron chelators with the potential for treating Alzheimer's disease.

Bioorg Med Chem 2011 Feb 13;19(3):1285-97. Epub 2010 Dec 13.

Division of Pharmaceutical Science, King's College, Franklin-Wilkins Building, Waterloo Campus, Stamford Street, London SE1 9NH, UK.

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http://dx.doi.org/10.1016/j.bmc.2010.12.007DOI Listing
February 2011

In vitro inhibition of bacterial growth by iron chelators.

FEMS Microbiol Lett 2011 Jan 29;314(2):107-11. Epub 2010 Nov 29.

Faculty of Life Science and Biotechnology, Ningbo University, Ningbo, Zhejiang, China.

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http://dx.doi.org/10.1111/j.1574-6968.2010.02153.xDOI Listing
January 2011

Design, synthesis and biological evaluation of L-dopa amide derivatives as potential prodrugs for the treatment of Parkinson's disease.

Eur J Med Chem 2010 Sep 2;45(9):4035-42. Epub 2010 Jun 2.

School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, Zhejiang, 310035, PR China.

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http://dx.doi.org/10.1016/j.ejmech.2010.05.062DOI Listing
September 2010

Current status of the measurement of blood hepcidin levels in chronic kidney disease.

Clin J Am Soc Nephrol 2010 Sep 19;5(9):1681-9. Epub 2010 Aug 19.

Department of Renal Medicine, King's College Hospital, London, UK.

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http://dx.doi.org/10.2215/CJN.05990809DOI Listing
September 2010

Fluorescent 3-hydroxy-4-pyridinone hexadentate iron chelators: intracellular distribution and the relevance to antimycobacterial properties.

J Biol Inorg Chem 2010 Aug 3;15(6):861-77. Epub 2010 Apr 3.

REQUIMTE, Departamento de Química, Faculdade de Ciências, Universidade do Porto, 4069-007, Porto, Portugal.

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http://dx.doi.org/10.1007/s00775-010-0650-1DOI Listing
August 2010

Mechanisms for the shuttling of plasma non-transferrin-bound iron (NTBI) onto deferoxamine by deferiprone.

Transl Res 2010 Aug 27;156(2):55-67. Epub 2010 May 27.

Department of Hematology, University College London Medical School, London, United Kingdom.

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http://dx.doi.org/10.1016/j.trsl.2010.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927975PMC
August 2010

Glucosylated deferiprone and its brain uptake: implications for developing glucosylated hydroxypyridinone analogues intended to cross the blood-brain barrier.

J Med Chem 2010 Aug;53(15):5886-9

Pharmaceutical Science Division, King's College London, London, UK.

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http://dx.doi.org/10.1021/jm100380kDOI Listing
August 2010

Amido-3-hydroxypyridin-4-ones as iron(III) ligands.

Chemistry 2010 Jun;16(21):6374-81

Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, 50200 Thailand.

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http://dx.doi.org/10.1002/chem.200902455DOI Listing
June 2010

Release of redox-active iron by muscle crush trauma: no liberation into the circulation.

Shock 2010 May;33(5):513-8

Institut für Physiologische Chemie, Universitätsklinikum, Hufelandstrasse 55, Essen, Germany.

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http://dx.doi.org/10.1097/SHK.0b013e3181c4f56eDOI Listing
May 2010

Chemistry and biology of siderophores.

Nat Prod Rep 2010 May;27(5):637-57

Division of Pharmaceutical Science, King's College, London, SE1 9NH, UK.

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http://dx.doi.org/10.1039/b906679aDOI Listing
May 2010

Quantitation of hepcidin in serum using ultra-high-pressure liquid chromatography and a linear ion trap mass spectrometer.

Rapid Commun Mass Spectrom 2010 May;24(9):1251-9

Pharmaceutical Sciences Division, King's College London, 150 Stamford Street, Waterloo, London SE1 9NH, UK.

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http://doi.wiley.com/10.1002/rcm.4512
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May 2010

Charge states of deferasirox-ferric iron complexes.

Authors:
Robert C Hider

Am J Kidney Dis 2010 Mar;55(3):614-5

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http://dx.doi.org/10.1053/j.ajkd.2009.10.065DOI Listing
March 2010

The selective quantification of iron by hexadentate fluorescent probes.

Bioorg Med Chem 2009 Dec 8;17(23):8093-101. Epub 2009 Oct 8.

Department of Pharmacy, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK.

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http://dx.doi.org/10.1016/j.bmc.2009.09.052DOI Listing
December 2009

Influence of non-enzymatic post-translation modifications on the ability of human serum albumin to bind iron. Implications for non-transferrin-bound iron speciation.

Biochim Biophys Acta 2009 Oct 6;1794(10):1449-58. Epub 2009 Jun 6.

Pharmaceutical Sciences Research Division, King's College London, London SE1 9 NH, UK.

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http://dx.doi.org/10.1016/j.bbapap.2009.06.003DOI Listing
October 2009

Iron(III) citrate speciation in aqueous solution.

Dalton Trans 2009 Oct 19(40):8616-25. Epub 2009 Aug 19.

Pharmaceutical Sciences Research Division, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, UK SE1 9NH.

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http://dx.doi.org/10.1039/b910970fDOI Listing
October 2009

Quantification of hepcidin using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

Rapid Commun Mass Spectrom 2009 Jun;23(11):1531-42

King's College London, Pharmaceutical Sciences Division 150 Stamford Street, Waterloo, London SE1 9NH, UK.

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http://doi.wiley.com/10.1002/rcm.4033
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http://dx.doi.org/10.1002/rcm.4033DOI Listing
June 2009

Iron chelation as a potential therapy for neurodegenerative disease.

Biochem Soc Trans 2008 Dec;36(Pt 6):1304-8

Division of Pharmaceutical Sciences, King's College London, London, UK.

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http://dx.doi.org/10.1042/BST0361304DOI Listing
December 2008