Robert C Elston

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Robert C Elston

Publications by authors named "Robert C Elston"

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100Publications

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Statistical Genetic Terminology.

Methods Mol Biol 2017 ;1666:1-9

Texas State University, San Marcos, TX, USA.

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May 2018

Correcting for Ascertainment.

Methods Mol Biol 2017 ;1666:211-232

Case Western Reserve University, Cleveland, OH, USA.

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May 2018

ONETOOL for the analysis of family-based big data.

Bioinformatics 2018 Mar 27. Epub 2018 Mar 27.

Interdisciplinary Program of Bioinformatics, Seoul National University, Seoul, Korea.

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March 2018

Applying family analyses to electronic health records to facilitate genetic research.

Bioinformatics 2018 Feb;34(4):635-642

Center for Human Genetics, Marshfield Clinic Research Institute, Marshfield, WI 54449, USA.

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February 2018

Statistical interactions and Bayes estimation of log odds in case-control studies.

Stat Methods Med Res 2017 04 12;26(2):1021-1038. Epub 2015 Jan 12.

2 Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.

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April 2017

On the association analysis of CNV data: a fast and robust family-based association method.

BMC Bioinformatics 2017 Apr 18;18(1):217. Epub 2017 Apr 18.

Interdisciplinary Program of Bioinformatics, Seoul National University, Seoul, 151-742, South Korea.

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April 2017

Immunoglobulin G genotypes and the risk of schizophrenia.

Hum Genet 2016 10 8;135(10):1175-9. Epub 2016 Jul 8.

Case Western Reserve University, Cleveland, OH, USA.

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October 2016

Family-Based Rare Variant Association Analysis: A Fast and Efficient Method of Multivariate Phenotype Association Analysis.

Genet Epidemiol 2016 09 17;40(6):502-11. Epub 2016 Jun 17.

Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Korea.

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September 2016

Joint modeling of longitudinal data and discrete-time survival outcome.

Stat Methods Med Res 2016 08 23;25(4):1512-26. Epub 2013 May 23.

Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.

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August 2016

A weighted U statistic for association analyses considering genetic heterogeneity.

Stat Med 2016 07 1;35(16):2802-14. Epub 2016 Feb 1.

Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, U.S.A.

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July 2016

Predicting Barrett's Esophagus in Families: An Esophagus Translational Research Network (BETRNet) Model Fitting Clinical Data to a Familial Paradigm.

Cancer Epidemiol Biomarkers Prev 2016 05 29;25(5):727-35. Epub 2016 Feb 29.

Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio. Division of Gastroenterology and Hepatology, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.

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May 2016

Defining "mutation" and "polymorphism" in the era of personal genomics.

BMC Med Genomics 2015 Jul 15;8:37. Epub 2015 Jul 15.

Danbury Hospital Research Institute, Western Connecticut Health Network, 131 West Street, Danbury, CT, 06810, USA.

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July 2015

Reply to Ashktorab et al.: Mutational landscape of colon cancers in African Americans.

Proc Natl Acad Sci U S A 2015 Jun 4;112(22):E2853. Epub 2015 May 4.

Case Comprehensive Cancer Center, and Department of Medicine, Case Medical Center, Case Western Reserve University, Cleveland, OH 44106; Department of Pathology.

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June 2015

Will formal genetics become dispensable?

Hum Hered 2013 2;76(2):47-52. Epub 2013 Oct 2.

INSERM U-781, Département de Génétique, Hôpital Necker-Enfants Malades, Paris, France.

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March 2015

Putative linkage signals identified for breast cancer in African American families.

Cancer Epidemiol Biomarkers Prev 2015 Feb 4;24(2):442-7. Epub 2014 Dec 4.

Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio. Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.

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February 2015

Novel approaches to the analysis of family data in genetic epidemiology.

Front Genet 2015 6;6:27. Epub 2015 Feb 6.

Department of Epidemiology and Biostatistics, Case Western Reserve University OH, USA.

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February 2015

Novel recurrently mutated genes in African American colon cancers.

Proc Natl Acad Sci U S A 2015 Jan 12;112(4):1149-54. Epub 2015 Jan 12.

Case Comprehensive Cancer Center, and Department of Medicine, Case Medical Center, Case Western Reserve University, Cleveland, OH 44106; Department of Pathology.

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January 2015

On the analysis of a repeated measure design in genome-wide association analysis.

Int J Environ Res Public Health 2014 Nov 28;11(12):12283-303. Epub 2014 Nov 28.

Department of Public Health Science, Seoul National University, Seoul 151-742, Korea.

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November 2014

Commingling analysis of age-of-onset in bipolar I disorder and the morbid risk for major psychoses in first degree relatives of bipolar I probands.

J Affect Disord 2014 Oct 9;168:197-204. Epub 2014 Jul 9.

Case Western Reserve University School of Medicine, Department of Epidemiology and Biostatistics, Cleveland, OH, USA.

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October 2014

The association of the vanin-1 N131S variant with blood pressure is mediated by endoplasmic reticulum-associated degradation and loss of function.

PLoS Genet 2014 Sep 18;10(9):e1004641. Epub 2014 Sep 18.

Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.

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September 2014

Genetic variation in 15-hydroxyprostaglandin dehydrogenase and colon cancer susceptibility.

PLoS One 2013 22;8(5):e64122. Epub 2013 May 22.

Department of Family Medicine and Community Health, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, USA.

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April 2014

A generalized genetic random field method for the genetic association analysis of sequencing data.

Genet Epidemiol 2014 Apr 30;38(3):242-53. Epub 2014 Jan 30.

Division of Biostatistics, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America.

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April 2014

Enhancing the power to detect low-frequency variants in genome-wide screens.

Genetics 2014 Apr 4;196(4):1293-302. Epub 2014 Feb 4.

McDermott Center of Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas 75390.

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April 2014

The null distribution of likelihood-ratio statistics in the conditional-logistic linkage model.

Front Genet 2013 19;4:244. Epub 2013 Nov 19.

Department of Epidemiology and Biostatistics, Case Western Reserve University Cleveland, OH, USA.

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December 2013

PedWiz: a web-based tool for pedigree informatics.

Front Genet 2013 25;4:189. Epub 2013 Sep 25.

Department of Epidemiology and Biostatistics, Case Western Reserve University Cleveland, OH, USA.

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October 2013

Gene, pathway and network frameworks to identify epistatic interactions of single nucleotide polymorphisms derived from GWAS data.

BMC Syst Biol 2012 17;6 Suppl 3:S15. Epub 2012 Dec 17.

Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, OH, USA.

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June 2013

Evaluation of removable statistical interaction for binary traits.

Stat Med 2013 Mar 27;32(7):1164-90. Epub 2012 Sep 27.

Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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March 2013

A variance component based multi-marker association test using family and unrelated data.

BMC Genet 2013 Mar 4;14:17. Epub 2013 Mar 4.

Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA.

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March 2013

Model-free tests for genetic linkage.

Curr Protoc Hum Genet 2012 Oct;Chapter 1:Unit1.8

University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA.

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October 2012

A likelihood ratio-based Mann-Whitney approach finds novel replicable joint gene action for type 2 diabetes.

Genet Epidemiol 2012 Sep 3;36(6):583-93. Epub 2012 Jul 3.

Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, Michigan, USA.

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September 2012

Paternal age effect on age of onset in bipolar I disorder is mediated by sex and family history.

Am J Med Genet B Neuropsychiatr Genet 2012 Jul 16;159B(5):567-79. Epub 2012 May 16.

Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania.

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July 2012

Power of single- vs. multi-marker tests of association.

Genet Epidemiol 2012 Jul 30;36(5):480-7. Epub 2012 May 30.

Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106-7281, USA.

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July 2012

Autosomal linkage scan for loci predisposing to comorbid dependence on multiple substances.

Am J Med Genet B Neuropsychiatr Genet 2012 Jun 21;159B(4):361-9. Epub 2012 Feb 21.

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.

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June 2012

Genetic terminology.

Methods Mol Biol 2012 ;850:1-9

Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.

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May 2012

Correcting for ascertainment.

Methods Mol Biol 2012 ;850:187-209

Department of Biology, University of Pennsylvania, Philadelphia, PA, USA.

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May 2012

The meaning of interaction.

Hum Hered 2010 8;70(4):269-77. Epub 2010 Dec 8.

Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106-7281, USA.

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February 2012

A framework for structural equation models in general pedigrees.

Hum Hered 2010 6;70(4):278-86. Epub 2011 Jan 6.

Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA.

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February 2012

Familial aggregation of allergen-specific sensitization and asthma.

Pediatr Allergy Immunol 2012 Feb 21;23(1):21-7. Epub 2011 Oct 21.

Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85724, USA.

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February 2012

Two-marker association tests yield new disease associations for coronary artery disease and hypertension.

Hum Genet 2011 Dec 28;130(6):725-33. Epub 2011 May 28.

Department of Genetics, Center for Human Genetics, University Hospitals of Cleveland and Case Western Reserve University, 10524 Euclid Avenue, Cleveland, OH, USA.

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December 2011

A non-parametric method for building predictive genetic tests on high-dimensional data.

Hum Hered 2011 20;71(3):161-70. Epub 2011 Jul 20.

College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, PR China.

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December 2011

In silico gene prioritization by integrating multiple data sources.

PLoS One 2011 24;6(6):e21137. Epub 2011 Jun 24.

Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, Ohio, United States of America.

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November 2011

Estimating heritability using family and unrelated individuals data.

BMC Proc 2011 Nov 29;5 Suppl 9:S34. Epub 2011 Nov 29.

Case Western Reserve University School of Medicine, 2103 Cornell Road, Cleveland, OH 44106, USA.

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November 2011

Interrogating population structure and its impact on association tests.

BMC Proc 2011 Nov 29;5 Suppl 9:S25. Epub 2011 Nov 29.

Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

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November 2011

Testing gene-environment interactions in gene-based association studies.

BMC Proc 2011 Nov 29;5 Suppl 9:S26. Epub 2011 Nov 29.

Department of Epidemiology and Biostatistics, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH 44106-7281, USA.

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November 2011

A novel method to detect rare variants using both family and unrelated case-control data.

BMC Proc 2011 Nov 29;5 Suppl 9:S80. Epub 2011 Nov 29.

Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Wolstein Research Building, 2103 Cornell Road, Cleveland, OH 44106, USA.

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November 2011

Evaluation of a LASSO regression approach on the unrelated samples of Genetic Analysis Workshop 17.

BMC Proc 2011 Nov 29;5 Suppl 9:S12. Epub 2011 Nov 29.

Department of Epidemiology and Biostatistics, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA.

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November 2011

A method to detect single-nucleotide polymorphisms accounting for a linkage signal using covariate-based affected relative pair linkage analysis.

BMC Proc 2011 Nov 29;5 Suppl 9:S84. Epub 2011 Nov 29.

Department of Epidemiology and Biostatistics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.

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November 2011

Capability of common SNPs to tag rare variants.

BMC Proc 2011 Nov 29;5 Suppl 9:S88. Epub 2011 Nov 29.

Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA.

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November 2011

Detecting genetic interactions for quantitative traits with U-statistics.

Genet Epidemiol 2011 Sep 26;35(6):457-68. Epub 2011 May 26.

Department of Epidemiology, Michigan State University, East Lansing, MI 48824, USA.

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September 2011

Detecting rare and common variants for complex traits: sibpair and odds ratio weighted sum statistics (SPWSS, ORWSS).

Genet Epidemiol 2011 Jul 18;35(5):398-409. Epub 2011 May 18.

Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA.

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July 2011

Heritability estimation for speech-sound traits with developmental trajectories.

Behav Genet 2011 Mar 10;41(2):184-91. Epub 2010 Jul 10.

Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA.

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March 2011

2010 William Allan Award introduction: Jürg Ott.

Authors:
Robert C Elston

Am J Hum Genet 2011 Mar;88(3):262-3

Epidemiology & Biostatistics, Case Western Reserve University, 2103 Cornell Rd., Cleveland OH 44106, USA.

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March 2011

Gene-gene interaction in maternal and perinatal research.

J Biomed Biotechnol 2010 27;2010. Epub 2010 Jul 27.

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December 2010

Using the optimal robust receiver operating characteristic (ROC) curve for predictive genetic tests.

Biometrics 2010 Jun 8;66(2):586-93. Epub 2009 Jun 8.

Department of Epidemiology, Michigan State University, East Lansing, Michigan 48823, USA.

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June 2010

A genome-wide linkage scan identifies multiple quantitative trait loci for HDL-cholesterol levels in families with premature CAD and MI.

J Lipid Res 2010 Jun 14;51(6):1442-51. Epub 2010 Jan 14.

Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Center for Cardiovascular Genetics, Cleveland, OH 44195, USA.

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June 2010

Examination of association with candidate genes for diabetic nephropathy in a Mexican American population.

Clin J Am Soc Nephrol 2010 Jun 18;5(6):1072-8. Epub 2010 Mar 18.

Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA.

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June 2010

Bagging optimal ROC curve method for predictive genetic tests, with an application for rheumatoid arthritis.

J Biopharm Stat 2010 Mar;20(2):401-14

Department of Epidemiology, Michigan State University, East Lansing, Michigan, USA.

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March 2010

Detecting rare variants for complex traits using family and unrelated data.

Genet Epidemiol 2010 Feb;34(2):171-87

Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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February 2010

Single-marker and two-marker association tests for unphased case-control genotype data, with a power comparison.

Genet Epidemiol 2010 Jan;34(1):67-77

Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106-7281, USA.

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January 2010

Program update and novel use of the DESPAIR program to design a genome-wide linkage study using relative pairs.

Hum Hered 2010 2;69(1):45-51. Epub 2009 Oct 2.

Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA.

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January 2010

Two-stage analysis strategy for identifying the IgM quantitative trait locus.

BMC Proc 2007 18;1 Suppl 1:S139. Epub 2007 Dec 18.

Department of Epidemiology and Biostatistics, Case Western Reserve University, 2103 Cornell Road, Cleveland, Ohio 44106, USA.

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December 2009

Genome-wide association studies using an adaptive two-stage analysis for a case-control design.

BMC Proc 2007 18;1 Suppl 1:S147. Epub 2007 Dec 18.

GlaxoSmithKline, 709 Swedeland Road, UW 2111, King of Prussia, Pennsylvania 19406, USA.

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December 2009

A logistic mixture model for a family-based association study.

BMC Proc 2007 18;1 Suppl 1:S44. Epub 2007 Dec 18.

Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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December 2009

Linkage studies of catechol-O-methyltransferase (COMT) and dopamine-beta-hydroxylase (DBH) cDNA expression levels.

BMC Proc 2007 18;1 Suppl 1:S95. Epub 2007 Dec 18.

Department of Epidemiology and Biostatistics, Case Western Reserve University, Wolstein Research Building 2103, Cornell Drive, Cleveland, Ohio 44106, USA.

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December 2009

A method to correct for population structure using a segregation model.

BMC Proc 2009 Dec 15;3 Suppl 7:S104. Epub 2009 Dec 15.

Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106 USA.

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December 2009

Comparison of a unified analysis approach for family and unrelated samples with the transmission-disequilibrium test to study associations of hypertension in the Framingham Heart Study.

BMC Proc 2009 Dec 15;3 Suppl 7:S22. Epub 2009 Dec 15.

Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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December 2009

The effect of multiple genetic variants in predicting the risk of type 2 diabetes.

BMC Proc 2009 Dec 15;3 Suppl 7:S49. Epub 2009 Dec 15.

Department of Epidemiology, Michigan State University, B601 West Fee Hall, East Lansing, Michigan 48824 USA.

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December 2009

Bayesian intervals for linkage locations.

Genet Epidemiol 2009 Nov;33(7):604-16

Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106-7281, USA.

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November 2009

Identification of gene-gene interactions in the presence of missing data using the multifactor dimensionality reduction method.

Genet Epidemiol 2009 Nov;33(7):646-56

Bioinformatics Program, Seoul National University, Seoul, Korea.

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November 2009

Genetic association tests: a method for the joint analysis of family and case-control data.

Hum Genomics 2009 Oct;4(1):2-20

Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.

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October 2009

Phase uncertainty in case-control association studies.

Genet Epidemiol 2009 Sep;33(6):463-78

Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA.

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September 2009

Hybridization modeling of oligonucleotide SNP arrays for accurate DNA copy number estimation.

Nucleic Acids Res 2009 Sep 7;37(17):e117. Epub 2009 Jul 7.

School of Mathematical Sciences, Peking University, Beijing 100871 China.

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September 2009

Choosing an optimal method to combine P-values.

Stat Med 2009 May;28(11):1537-53

Department of Biostatistics, Harvard School of Public Health, MA, U.S.A.

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May 2009

A partial least-square approach for modeling gene-gene and gene-environment interactions when multiple markers are genotyped.

Genet Epidemiol 2009 Jan;33(1):6-15

Division of Biostatistics, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, USA.

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January 2009

The power of independent types of genetic information to detect association in a case-control study design.

Genet Epidemiol 2008 Dec;32(8):731-56

Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106-7281, USA.

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December 2008

Gene-gene interactions among CHRNA4, CHRNB2, BDNF, and NTRK2 in nicotine dependence.

Biol Psychiatry 2008 Dec 4;64(11):951-7. Epub 2008 Jun 4.

Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia 22911, USA.

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December 2008

Genetic markers of IgG influence the outcome of infection with hepatitis C virus.

J Infect Dis 2008 Nov;198(9):1334-6

Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA.

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November 2008

A combinatorial approach to detecting gene-gene and gene-environment interactions in family studies.

Am J Hum Genet 2008 Oct 2;83(4):457-67. Epub 2008 Oct 2.

Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22911, USA.

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October 2008

Association of vitamin D receptor gene variants, adiposity and colon cancer.

Carcinogenesis 2008 Sep 14;29(9):1788-93. Epub 2008 Jul 14.

Department of Social and Preventive Medicine, State University of New York at Buffalo, Buffalo, NY, USA.

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September 2008

Heritability and intrafamilial aggregation of arterial characteristics.

J Hypertens 2008 Apr;26(4):721-8

The Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium.

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April 2008

Identification of susceptibility genes for cancer in a genome-wide scan: results from the colon neoplasia sibling study.

Am J Hum Genet 2008 Mar 28;82(3):723-36. Epub 2008 Feb 28.

Department of Epidemiology and Biostatistics, University Hospitals of Cleveland/Case Western Reserve University, Cleveland, OH 44106, USA.

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March 2008

Using the optimal receiver operating characteristic curve to design a predictive genetic test, exemplified with type 2 diabetes.

Am J Hum Genet 2008 Mar;82(3):641-51

Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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March 2008

Immunoglobulin allotypes influence IgG antibody responses to hepatitis C virus envelope proteins E1 and E2.

Hum Immunol 2008 Mar 10;69(3):158-64. Epub 2008 Mar 10.

Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA.

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March 2008