Robert B Hinton

Robert B Hinton

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Robert B Hinton

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Loss of flow responsive Tie1 results in Impaired
Aortic valve remodeling.

Dev Biol 2019 Nov 15;455(1):73-84. Epub 2019 Jul 15.

Division of Pediatrics Cardiology, Vanderbilt University, Nashville, TN, USA; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2019.07.011DOI Listing
November 2019

Familial co-occurrence of congenital heart defects follows distinct patterns.

Eur Heart J 2018 03;39(12):1015-1022

Wilhelm Johannsen Centre for Functional Genome Research, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1093/eurheartj/ehx314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018923PMC
March 2018

Genetic Testing in Pediatric Left Ventricular Noncompaction.

Circ Cardiovasc Genet 2017 Dec;10(6)

From the Division of Cardiology (E.M.M., R.B.H., R.C., A.L., A.P., A.R.S.) and Division of Biostatistics and Epidemiology (R.F.I.), Cincinnati Children's Hospital Medical Center, OH; and Department of Pediatrics and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis (S.M.W.).

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http://dx.doi.org/10.1161/CIRCGENETICS.117.001735DOI Listing
December 2017

Proteomic Alterations Associated with Biomechanical Dysfunction are Early Processes in the Emilin1 Deficient Mouse Model of Aortic Valve Disease.

Ann Biomed Eng 2017 Nov 15;45(11):2548-2562. Epub 2017 Aug 15.

Division of Cardiology, Cincinnati Children's Hospital Medical Center, 240 Albert Sabin Way, MLC 7020, Cincinnati, OH, 45229, USA.

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http://dx.doi.org/10.1007/s10439-017-1899-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665708PMC
November 2017

Exome Sequencing Identifies Candidate Genetic Modifiers of Syndromic and Familial Thoracic Aortic Aneurysm Severity.

J Cardiovasc Transl Res 2017 Aug 26;10(4):423-432. Epub 2017 May 26.

Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati Children's Research Foundation, 3333 Burnet Ave, MLC 2003, Cincinnati, OH, 45229, USA.

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http://dx.doi.org/10.1007/s12265-017-9753-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702585PMC
August 2017

Fetal origins of adult cardiac disease: a novel approach to prevent fetal growth restriction induced cardiac dysfunction using insulin like growth factor.

Pediatr Res 2017 Jun 18;81(6):919-925. Epub 2017 Jan 18.

Center for Molecular Fetal Therapy, Cincinnati Children's Hospital, Cincinnati, Ohio.

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http://dx.doi.org/10.1038/pr.2017.18DOI Listing
June 2017

Heart Failure in Pediatric Patients With Congenital Heart Disease.

Circ Res 2017 Mar;120(6):978-994

From the Department of Pediatrics and Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis.

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http://dx.doi.org/10.1161/CIRCRESAHA.116.308996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391045PMC
March 2017

Molecular Characterization of Pediatric Restrictive Cardiomyopathy from Integrative Genomics.

Sci Rep 2017 01 18;7:39276. Epub 2017 Jan 18.

Department of Pediatrics and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, U.S.A.

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http://dx.doi.org/10.1038/srep39276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241776PMC
January 2017

Analysis of TGFBR1*6A variant in individuals evaluated for Marfan syndrome.

Am J Med Genet A 2016 07 26;170(7):1786-90. Epub 2016 Apr 26.

Indiana University School of Medicine, Indianapolis, Indiana.

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http://dx.doi.org/10.1002/ajmg.a.37668DOI Listing
July 2016

Altered amniotic fluid leptin levels in twin-twin transfusion syndrome with concurrent placental insufficiency.

J Matern Fetal Neonatal Med 2015 10;28(14):1647-52. Epub 2014 Oct 10.

a Cincinnati Fetal Center, Center for Fetal Cellular and Molecular Therapy, Cincinnati Children's Hospital Medical Center , Cincinnati , OH , USA and.

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http://www.tandfonline.com/doi/full/10.3109/14767058.2014.96
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http://dx.doi.org/10.3109/14767058.2014.968122DOI Listing
June 2016

Clinically relevant variants identified in thoracic aortic aneurysm patients by research exome sequencing.

Am J Med Genet A 2016 May 7;170A(5):1288-94. Epub 2016 Feb 7.

Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio.

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http://dx.doi.org/10.1002/ajmg.a.37568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125072PMC
May 2016

Integrin β3 inhibition is a therapeutic strategy for supravalvular aortic stenosis.

J Exp Med 2016 Mar 8;213(3):451-63. Epub 2016 Feb 8.

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT 06511

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http://jem.rupress.org/content/213/3/451.full.pdf
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http://www.jem.org/lookup/doi/10.1084/jem.20150688
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http://dx.doi.org/10.1084/jem.20150688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813675PMC
March 2016

First principles.

Authors:
Robert B Hinton

Pharos Alpha Omega Alpha Honor Med Soc 2016 ;79(1):24-6

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March 2016

MALDI Imaging Mass Spectrometry as a Lipidomic Approach to Heart Valve Research.

J Heart Valve Dis 2016 03;25(2):240-252

Mass Spectrometry Research Center and Department of Biochemistry, Medicine, Pharmacology and Chemistry, Vanderbilt University Medical Center, Nashville, TN, USA.

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March 2016

Valve Endothelial Cell-Derived Tgfβ1 Signaling Promotes Nuclear Localization of Sox9 in Interstitial Cells Associated With Attenuated Calcification.

Arterioscler Thromb Vasc Biol 2016 Feb 3;36(2):328-38. Epub 2015 Dec 3.

From the Molecular and Cellular Pharmacology Graduate Program, Leonard M. Miller School of Medicine, Miami, FL (D.J.H.); Center for Cardiovascular Research and The Heart Center at Nationwide Children's Hospital Research Institute, Columbus, OH (D.J.H., B.F.A., T.E.H., J.L.); Division of Cardiology, The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (R.B.H.); Battelle Center for Mathematical Medicine, Nationwide Children's Hospital Research Institute, Columbus, OH (W.C.R.); The Ohio State University Interdisciplinary Graduate Program in Biophysics, Columbus, OH (W.C.R.); Department of Pediatrics, The Ohio State University, Columbus, OH (W.C.R., J.L.); and Division of Cardiovascular Medicine and Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA (D.D.H.).

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.115.306091
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http://dx.doi.org/10.1161/ATVBAHA.115.306091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732913PMC
February 2016

CHD associated with syndromic diagnoses: peri-operative risk factors and early outcomes.

Cardiol Young 2016 Jan 8;26(1):30-52. Epub 2015 Sep 8.

Heart Institute,Cincinnati Children's Hospital Medical Center,Cincinnati,Ohio,United States of America.

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http://dx.doi.org/10.1017/S1047951115001389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125077PMC
January 2016

Exon 3 deletion of ryanodine receptor causes left ventricular noncompaction, worsening catecholaminergic polymorphic ventricular tachycardia, and sudden cardiac arrest.

Am J Med Genet A 2015 Sep 27;167A(9):2197-200. Epub 2015 May 27.

Department of Pediatrics, Cincinnati Children's Hospital Medical Center, The Heart Institute, Cincinnati, Ohio.

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http://dx.doi.org/10.1002/ajmg.a.37140DOI Listing
September 2015

Physiological Growth, Remodeling Potential, and Preserved Function of a Novel Bioprosthetic Tricuspid Valve: Tubular Bioprosthesis Made of Small Intestinal Submucosa-Derived Extracellular Matrix.

J Am Coll Cardiol 2015 Aug;66(8):877-88

Division of Pediatric Cardiothoracic Surgery, The Heart Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio.

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http://dx.doi.org/10.1016/j.jacc.2015.06.1091DOI Listing
August 2015

Clinical Stratification of Pediatric Patients with Idiopathic Thoracic Aortic Aneurysm.

J Pediatr 2015 Jul 24;167(1):131-7.e1-5. Epub 2015 Mar 24.

Division of Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. Electronic address:

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http://dx.doi.org/10.1016/j.jpeds.2015.02.042DOI Listing
July 2015

Preliminary Evidence for Aortopathy and an X-Linked Parent-of-Origin Effect on Aortic Valve Malformation in a Mouse Model of Turner Syndrome.

J Cardiovasc Dev Dis 2015 Jul 10;2(3):190-199. Epub 2015 Jul 10.

MRC Centre for Neuropsychiatric Genetics and Genomics and Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff CF24 4HQ, UK.

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http://www.mdpi.com/2308-3425/2/3/190
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http://dx.doi.org/10.3390/jcdd2030190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753145PMC
July 2015

COX2 inhibition reduces aortic valve calcification in vivo.

Arterioscler Thromb Vasc Biol 2015 Apr 26;35(4):938-47. Epub 2015 Feb 26.

From The Heart Institute, Cincinnati Children's Hospital Medical Center, OH.

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http://dx.doi.org/10.1161/ATVBAHA.114.305159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979542PMC
April 2015

RNA extraction from healthy and failing human myocardium: a comparative evaluation.

Biopreserv Biobank 2015 Apr 31;13(2):123-30. Epub 2015 Mar 31.

1 Division of Cardiology, The Heart Institute, Cincinnati Children's Hospital Medical Center , Cincinnati, Ohio.

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http://dx.doi.org/10.1089/bio.2014.0062DOI Listing
April 2015

Rationale for the Cytogenomics of Cardiovascular Malformations Consortium: A Phenotype Intensive Registry Based Approach.

J Cardiovasc Dev Dis 2015 Apr 29;2(2):76-92. Epub 2015 Apr 29.

Departments of Pediatrics and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.3390/jcdd2020076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753096PMC
April 2015

Aortopathy in the 7q11.23 microduplication syndrome.

Am J Med Genet A 2015 Feb 26;167A(2):363-70. Epub 2014 Nov 26.

Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Heart Institute, Cincinnati, Ohio.

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http://dx.doi.org/10.1002/ajmg.a.36859DOI Listing
February 2015

Genetic testing practices in infants with congenital heart disease.

Congenit Heart Dis 2014 Mar-Apr;9(2):158-67. Epub 2013 Jun 20.

Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1111/chd.12112DOI Listing
December 2014

Review of molecular and mechanical interactions in the aortic valve and aorta: implications for the shared pathogenesis of aortic valve disease and aortopathy.

J Cardiovasc Transl Res 2014 Dec 20;7(9):823-46. Epub 2014 Nov 20.

Division of Cardiology, the Heart Institute, Cincinnati Children's Hospital Medical Center, 240 Albert Sabin Way, MLC 7020, Cincinnati, OH, 45229, USA.

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http://dx.doi.org/10.1007/s12265-014-9602-4DOI Listing
December 2014

Cross Talk between NOTCH Signaling and Biomechanics in Human Aortic Valve Disease Pathogenesis.

J Cardiovasc Dev Dis 2014 Dec 1;1(3):237-256. Epub 2014 Dec 1.

Division of Cardiology, the Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.3390/jcdd1030237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856658PMC
December 2014

Advances in the treatment of aortic valve disease: is it time for companion diagnostics?

Authors:
Robert B Hinton

Curr Opin Pediatr 2014 Oct;26(5):546-52

Division of Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1097/MOP.0000000000000137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176693PMC
October 2014

Asymmetric cell-matrix and biomechanical abnormalities in elastin insufficiency induced aortopathy.

Ann Biomed Eng 2014 Oct 7;42(10):2014-28. Epub 2014 Aug 7.

Division of Cardiology, the Heart Institute, Cincinnati Children's Hospital Medical Center, 240 Albert Sabin Way, MLC 7020, Cincinnati, OH, 45229, USA.

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http://dx.doi.org/10.1007/s10439-014-1072-yDOI Listing
October 2014

Twins with progressive thoracic aortic aneurysm, recurrent dissection and ACTA2 mutation.

Pediatrics 2014 Oct 15;134(4):e1218-23. Epub 2014 Sep 15.

Division of Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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http://pediatrics.aappublications.org/cgi/doi/10.1542/peds.2
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http://dx.doi.org/10.1542/peds.2013-2503DOI Listing
October 2014

TGF-β mediates early angiogenesis and latent fibrosis in an Emilin1-deficient mouse model of aortic valve disease.

Dis Model Mech 2014 Aug;7(8):987-96

Division of Cardiology, The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA

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http://dmm.biologists.org/cgi/doi/10.1242/dmm.015255
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http://dx.doi.org/10.1242/dmm.015255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107327PMC
August 2014

Angiogenic microenvironment augments impaired endothelial responses under diabetic conditions.

Am J Physiol Cell Physiol 2014 Apr 26;306(8):C768-78. Epub 2014 Feb 26.

Department of Biomedical, Chemical, and Environmental Engineering, University of Cincinnati, Cincinnati, Ohio;

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http://dx.doi.org/10.1152/ajpcell.00201.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989714PMC
April 2014

A pediatric approach to family history of cardiovascular disease: diagnosis, risk assessment, and management.

Pediatr Clin North Am 2014 Feb 30;61(1):187-205. Epub 2013 Oct 30.

Division of Cardiology, The Heart Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pcl.2013.09.018DOI Listing
February 2014

Somatic growth trajectory in the fetus with hypoplastic left heart syndrome.

Pediatr Res 2013 Sep 14;74(3):284-9. Epub 2013 Jun 14.

Division of Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

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http://dx.doi.org/10.1038/pr.2013.100DOI Listing
September 2013

Insufficient versican cleavage and Smad2 phosphorylation results in bicuspid aortic and pulmonary valves.

J Mol Cell Cardiol 2013 Jul 24;60:50-9. Epub 2013 Mar 24.

Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29464, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2013.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437693PMC
July 2013

Microcephaly is associated with early adverse neurologic outcomes in hypoplastic left heart syndrome.

Pediatr Res 2013 Jul 10;74(1):61-7. Epub 2013 Apr 10.

Division of Cardiology, The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

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http://dx.doi.org/10.1038/pr.2013.61DOI Listing
July 2013

Aorta Measurements are Heritable and Influenced by Bicuspid Aortic Valve.

Front Genet 2011 5;2:61. Epub 2011 Sep 5.

Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center Cincinnati, OH, USA.

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http://journal.frontiersin.org/article/10.3389/fgene.2011.00
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http://dx.doi.org/10.3389/fgene.2011.00061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268614PMC
October 2012

Bicuspid aortic valve and thoracic aortic aneurysm: three patient populations, two disease phenotypes, and one shared genotype.

Authors:
Robert B Hinton

Cardiol Res Pract 2012 27;2012:926975. Epub 2012 Aug 27.

Division of Cardiology, The Heart Institute, Cincinnati Children's Hospital Medical Center, 240 Albert Sabin Way, Cincinnati, OH 45219, USA.

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http://dx.doi.org/10.1155/2012/926975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434382PMC
September 2012

Left ventricular noncompaction cardiomyopathy and aortopathy in a patient with recessive dystrophic epidermolysis bullosa.

Circ Heart Fail 2012 Sep;5(5):e81-2

The Heart Institute, Divisions of Cardiology and Molecular Cardiovascular Biology, and Division of Dermatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

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https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.112
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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.112.969675DOI Listing
September 2012

Tetrasomy 15q25.2→qter identified with SNP microarray in a patient with multiple anomalies including complex cardiovascular malformation.

Am J Med Genet A 2012 Aug 18;158A(8):1971-6. Epub 2012 Jun 18.

Division of Human Genetics, Department of Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1002/ajmg.a.35428DOI Listing
August 2012

Pediatric cardiomyopathy: importance of genetic and metabolic evaluation.

J Card Fail 2012 May 10;18(5):396-403. Epub 2012 Mar 10.

Department of Pediatrics, Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S107191641200040
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http://dx.doi.org/10.1016/j.cardfail.2012.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345128PMC
May 2012

Maladaptive matrix remodeling and regional biomechanical dysfunction in a mouse model of aortic valve disease.

Matrix Biol 2012 Apr 12;31(3):197-205. Epub 2012 Jan 12.

Division of Cardiology, the Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1016/j.matbio.2012.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295865PMC
April 2012

Inhibitory role of Notch1 in calcific aortic valve disease.

PLoS One 2011 16;6(11):e27743. Epub 2011 Nov 16.

Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0027743PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218038PMC
March 2012

Heart valve structure and function in development and disease.

Annu Rev Physiol 2011 ;73:29-46

Division of Cardiology, The Heart Institute, Cincinnati Children's Hospital Medical Center, Ohio 45229, USA.

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http://dx.doi.org/10.1146/annurev-physiol-012110-142145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209403PMC
July 2011

Risk factors for aortic valve disease in bicuspid aortic valve: a family-based study.

Am J Med Genet A 2011 May 7;155A(5):1015-20. Epub 2011 Apr 7.

Division of Cardiology, Cincinnati Children's Hospital Medical Center, Ohio 45229-3039, USA.

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http://dx.doi.org/10.1002/ajmg.a.33974DOI Listing
May 2011

Differential expression of cartilage and bone-related proteins in pediatric and adult diseased aortic valves.

J Mol Cell Cardiol 2011 Mar 14;50(3):561-9. Epub 2010 Dec 14.

Division of Molecular Cardiovascular Biology, The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2010.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035730PMC
March 2011

Regional structure-function relationships in mouse aortic valve tissue.

J Biomech 2011 Jan 21;44(1):77-83. Epub 2010 Sep 21.

Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, USA.

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http://dx.doi.org/10.1016/j.jbiomech.2010.08.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003771PMC
January 2011

A fetus with hypertrophic cardiomyopathy, restrictive, and single-ventricle physiology, and a beta-myosin heavy chain mutation.

J Pediatr 2010 Jul 14;157(1):164-6. Epub 2010 Apr 14.

Division of Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1016/j.jpeds.2010.02.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886151PMC
July 2010

Hormonal regulation of prostaglandin E2 receptors: localization and expression in rat cervical tissue.

Reprod Sci 2010 Feb 2;17(2):136-46. Epub 2009 Oct 2.

Division of Maternal Fetal Medicine, Good Samaritan Hospital, Cincinnati, Ohio 45220, USA.

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http://dx.doi.org/10.1177/1933719109348068DOI Listing
February 2010

Replacement of the aortic valve in a patient with mucolipidosis III.

Cardiol Young 2009 Dec 24;19(6):641-3. Epub 2009 Sep 24.

The Heart Institute, Cincinnati Children's Hospital Medical Center and The University of Cincinnati College of Medicine, Cincinnati, Ohio.

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http://dx.doi.org/10.1017/S1047951109991120DOI Listing
December 2009

Hypoplastic left heart syndrome links to chromosomes 10q and 6q and is genetically related to bicuspid aortic valve.

J Am Coll Cardiol 2009 Mar;53(12):1065-71

Division of Cardiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA.

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http://dx.doi.org/10.1016/j.jacc.2008.12.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703749PMC
March 2009

The presence of bicuspid aortic valve does not predict ventricular septal defect type.

Am J Med Genet A 2008 Dec;146A(24):3202-5

Division of Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1002/ajmg.a.32609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644069PMC
December 2008

Scleraxis is required for cell lineage differentiation and extracellular matrix remodeling during murine heart valve formation in vivo.

Circ Res 2008 Oct 18;103(9):948-56. Epub 2008 Sep 18.

Department of Molecular and Cellular Pharmacology, Leonard M Miller School of Medicine, University of Miami, Miami, FL 33101, USA.

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http://dx.doi.org/10.1161/CIRCRESAHA.108.177238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743952PMC
October 2008

Mouse heart valve structure and function: echocardiographic and morphometric analyses from the fetus through the aged adult.

Am J Physiol Heart Circ Physiol 2008 Jun 4;294(6):H2480-8. Epub 2008 Apr 4.

Division of Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA.

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http://dx.doi.org/10.1152/ajpheart.91431.2007DOI Listing
June 2008

The family history: reemergence of an established tool.

Authors:
Robert B Hinton

Crit Care Nurs Clin North Am 2008 Jun;20(2):149-58, v

Division of Cardiology, MLC 2003, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA.

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http://dx.doi.org/10.1016/j.ccell.2008.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2387215PMC
June 2008

Hypoplastic left heart syndrome is heritable.

J Am Coll Cardiol 2007 Oct 1;50(16):1590-5. Epub 2007 Oct 1.

Division of Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA.

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http://content.onlinejacc.org/data/Journals/JAC/23102/07021.
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http://linkinghub.elsevier.com/retrieve/pii/S073510970702390
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http://dx.doi.org/10.1016/j.jacc.2007.07.021DOI Listing
October 2007

Evidence in favor of linkage to human chromosomal regions 18q, 5q and 13q for bicuspid aortic valve and associated cardiovascular malformations.

Hum Genet 2007 Apr 4;121(2):275-84. Epub 2007 Jan 4.

Center for Epidemiology and Biostatistics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

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http://link.springer.com/10.1007/s00439-006-0316-9
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http://dx.doi.org/10.1007/s00439-006-0316-9DOI Listing
April 2007

BMP and FGF regulatory pathways in semilunar valve precursor cells.

Dev Dyn 2007 Apr;236(4):971-80

Division of Cardiology, MLC 7042, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.

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http://doi.wiley.com/10.1002/dvdy.21097
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http://dx.doi.org/10.1002/dvdy.21097DOI Listing
April 2007

Extracellular matrix remodeling and organization in developing and diseased aortic valves.

Circ Res 2006 Jun 27;98(11):1431-8. Epub 2006 Apr 27.

Division of Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA.

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http://dx.doi.org/10.1161/01.RES.0000224114.65109.4eDOI Listing
June 2006

Bilateral semilunar valve disease in a child with partial deletion of the Williams-Beuren syndrome region is associated with elastin haploinsufficiency.

J Heart Valve Dis 2006 May;15(3):352-5

Division of Cardiology, Cincinnati Children's Hospital, Cincinnati, Ohio 45229-3039, USA.

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May 2006

Dilated ascending aorta in a child with ring chromosome 21 syndrome.

Am J Med Genet A 2004 Oct;130A(2):191-5

Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1002/ajmg.a.30143DOI Listing
October 2004