Publications by authors named "Robert B Clarke"

97Publications

Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts.

Breast Cancer Res 2019 11 29;21(1):130. Epub 2019 Nov 29.

Department of Oncology and Metabolism, Mellanby Centre for Bone Research, University of Sheffield, Beech Hill Road, Sheffield, S10 2RX, UK.

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http://dx.doi.org/10.1186/s13058-019-1220-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884811PMC
November 2019

Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling.

Nat Commun 2019 11 1;10(1):5016. Epub 2019 Nov 1.

Breast Biology Group, Manchester Breast Centre, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Wilmslow Road, Manchester, M20 4GJ, UK.

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http://dx.doi.org/10.1038/s41467-019-12807-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825219PMC
November 2019

The Notch Pathway Promotes Osteosarcoma Progression through Activation of Ephrin Reverse Signaling.

Mol Cancer Res 2019 12 30;17(12):2383-2394. Epub 2019 Sep 30.

Breast Cancer Now Research Unit, Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1158/1541-7786.MCR-19-0493DOI Listing
December 2019

The Milk Protein Alpha-Casein Suppresses Triple Negative Breast Cancer Stem Cell Activity Via STAT and HIF-1alpha Signalling Pathways in Breast Cancer Cells and Fibroblasts.

J Mammary Gland Biol Neoplasia 2019 09 12;24(3):245-256. Epub 2019 Sep 12.

Breast Biology Group, Breast Cancer Now Research Unit, Division of Cancer Sciences, Manchester Cancer Research Centre, University of Manchester, Manchester, M20 4GJ, UK.

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http://dx.doi.org/10.1007/s10911-019-09435-1DOI Listing
September 2019

PAK4 regulates stemness and progression in endocrine resistant ER-positive metastatic breast cancer.

Cancer Lett 2019 08 20;458:66-75. Epub 2019 May 20.

Breast Biology Group, Manchester Breast Centre, Division of Cancer Sciences, Oglesby Cancer Research Building, University of Manchester, Manchester, M20 4GJ, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2019.05.014DOI Listing
August 2019

Targeting Endometrial Cancer Stem Cell Activity with Metformin Is Inhibited by Patient-Derived Adipocyte-Secreted Factors.

Cancers (Basel) 2019 May 11;11(5). Epub 2019 May 11.

Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, St Mary's Hospital, Manchester M13 9WL, UK.

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http://dx.doi.org/10.3390/cancers11050653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562824PMC
May 2019

Estrogenicity of essential oils is not required to relieve symptoms of urogenital atrophy in breast cancer survivors.

Ther Adv Med Oncol 2018 2;10:1758835918766189. Epub 2018 Apr 2.

Breast Cancer Now Research Unit, Division of Cancer Sciences, University of Manchester, Manchester Cancer Research Centre, 555 Wilmslow Road, Manchester M20 4GJ, UK.

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http://dx.doi.org/10.1177/1758835918766189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888815PMC
April 2018

The Role of Steroid Hormones in Breast and Effects on Cancer Stem Cells.

Curr Stem Cell Rep 2018 13;4(1):81-94. Epub 2018 Mar 13.

Breast Biology Group, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine, and Health, Manchester Cancer Research Centre, Wilmslow Road, Manchester, M20 4GJ UK.

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http://dx.doi.org/10.1007/s40778-018-0114-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866269PMC
March 2018

Ethnicity influences breast cancer stem cells' drug resistance.

Breast J 2018 07 2;24(4):701-703. Epub 2018 Mar 2.

Breast Biology Group, Division of Molecular and Clinical Cancer Sciences, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1111/tbj.13021DOI Listing
July 2018

G Protein-Coupled Receptors at the Crossroad between Physiologic and Pathologic Angiogenesis: Old Paradigms and Emerging Concepts.

Int J Mol Sci 2017 Dec 14;18(12). Epub 2017 Dec 14.

Department of Pharmacy, Health and Nutrition Sciences, University of Calabria via Savinio, 87036 Rende, Italy.

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http://dx.doi.org/10.3390/ijms18122713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751314PMC
December 2017

GPER mediates the angiocrine actions induced by IGF1 through the HIF-1α/VEGF pathway in the breast tumor microenvironment.

Breast Cancer Res 2017 Dec 6;19(1):129. Epub 2017 Dec 6.

Breast Cancer Now Research Unit, Division of Cancer Sciences, Manchester Cancer Research Centre, University of Manchester, Wilmslow Road, Manchester, M204GJ, UK.

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http://dx.doi.org/10.1186/s13058-017-0923-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719673PMC
December 2017

Complexity galore: 3D cultures, biomechanics and systems medicine at the eighth ENBDC workshop "Methods in Mammary Gland Development and Cancer".

Breast Cancer Res 2016 11 25;18(1):115. Epub 2016 Nov 25.

Section of Molecular Cytology and Van Leeuwenhoek Centre for Advance Microscopy, Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098, XH, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/s13058-016-0777-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124316PMC
November 2016

Erratum to: Patient-Derived Mammosphere and Xenograft Tumour Initiation Correlates with Progression to Metastasis.

J Mammary Gland Biol Neoplasia 2016 12;21(3-4):111

Breast Biology Group, Breast Cancer Now Research Unit, Division of Molecular and Clinical Cancer Sciences, Manchester Cancer, Research Centre, University of Manchester, Wilmslow Road, Manchester, M20 4QL, UK.

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http://dx.doi.org/10.1007/s10911-016-9364-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828361PMC
December 2016

Patient-derived Mammosphere and Xenograft Tumour Initiation Correlates with Progression to Metastasis.

J Mammary Gland Biol Neoplasia 2016 12 28;21(3-4):99-109. Epub 2016 Sep 28.

Breast Biology Group, Breast Cancer Now Research Unit, Division of Molecular and Clinical Cancer Sciences, Manchester Cancer Research Centre, University of Manchester, Wilmslow Road, Manchester, M20 4QL, UK.

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http://dx.doi.org/10.1007/s10911-016-9361-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159442PMC
December 2016

SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling.

Proc Natl Acad Sci U S A 2016 09 12;113(39):E5731-40. Epub 2016 Sep 12.

School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China;

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047180PMC
http://dx.doi.org/10.1073/pnas.1611532113DOI Listing
September 2016

Cisplatin selects for stem-like cells in osteosarcoma by activating Notch signaling.

Oncotarget 2016 May;7(22):33055-68

Breast Cancer Now Research Unit, Institute of Cancer Sciences, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.18632/oncotarget.8849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078075PMC
May 2016

A Role for Notch Signalling in Breast Cancer and Endocrine Resistance.

Stem Cells Int 2016 10;2016:2498764. Epub 2016 Jan 10.

Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1155/2016/2498764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736972PMC
February 2016

Multifunctionalized iron oxide nanoparticles for selective drug delivery to CD44-positive cancer cells.

Nanotechnology 2016 Feb 12;27(6):065103. Epub 2016 Jan 12.

Instituto Madrileño de Estudios Avanzados en Nanociencia (IMDEA Nanociencia), Campus de Cantoblanco, 28049 Madrid, Spain. CNB-CSIC-IMDEA Nanociencia Associated Unit, Cantoblanco, Madrid, Spain.

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http://dx.doi.org/10.1088/0957-4484/27/6/065103DOI Listing
February 2016

An integrated genomic approach identifies that the PI3K/AKT/FOXO pathway is involved in breast cancer tumor initiation.

Oncotarget 2016 Jan;7(3):2596-610

Breast Biology Group, Breast Cancer Now Research Unit, Institute of Cancer Sciences, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.18632/oncotarget.6354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823058PMC
January 2016

The role of steroid hormones in breast cancer stem cells.

Endocr Relat Cancer 2015 Dec 17;22(6):T177-86. Epub 2015 Sep 17.

Breast Biology GroupBreast Cancer Now Research Unit, Institute of Cancer Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UKDepartment of Medical OncologyThe Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK.

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http://dx.doi.org/10.1530/ERC-15-0350DOI Listing
December 2015

The seventh ENBDC workshop on methods in mammary gland development and cancer.

Breast Cancer Res 2015 Sep 2;17:119. Epub 2015 Sep 2.

Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstr. 66, CH-4058, Basel, Switzerland.

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http://dx.doi.org/10.1186/s13058-015-0629-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557821PMC
September 2015

Co-ordination of cell cycle, migration and stem cell-like activity in breast cancer.

Oncotarget 2014 Sep;5(17):7833-42

Breakthrough Breast Cancer Unit , Institute of Cancer Sciences, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester, UK. Center for Molecular Pathology, Department of Laboratory Medicine, Lund university, Skåne University Hospital, Malmö, Sweden. Sahlgrenska Cancer Center, University of Gothenburg, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202164PMC
http://dx.doi.org/10.18632/oncotarget.2312DOI Listing
September 2014

Focal adhesion kinase and Wnt signaling regulate human ductal carcinoma in situ stem cell activity and response to radiotherapy.

Stem Cells 2015 Feb;33(2):327-41

Surgical Oncology, University Hospital of South Manchester NHS Foundation Trust, Wythenshawe Hospital, Education and Research Centre, Manchester, United Kingdom; Cancer Stem Cell Research, University of Manchester, Institute of Cancer Sciences, Manchester Academic Health Science Centre, The Christie NHS Foundation Trust, Manchester, United Kingdom.

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http://dx.doi.org/10.1002/stem.1843DOI Listing
February 2015

A differential role for CXCR4 in the regulation of normal versus malignant breast stem cell activity.

Oncotarget 2014 Feb;5(3):599-612

Breast Biology Group, Institute of Cancer Sciences, Paterson Building, University of Manchester, Wilmslow Road, Manchester,M20 4BX,UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996659PMC
http://dx.doi.org/10.18632/oncotarget.1169DOI Listing
February 2014

Enrichment of human osteosarcoma stem cells based on hTERT transcriptional activity.

Oncotarget 2013 Dec;4(12):2326-38

Department of Orthopedics, Renmin Hospital of Wuhan University, Jiefang Road, Wuhan, Hubei, P.R. China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926830PMC
http://dx.doi.org/10.18632/oncotarget.1554DOI Listing
December 2013

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.

Breast Cancer Res 2013 Oct 1;15(5):R92. Epub 2013 Oct 1.

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http://dx.doi.org/10.1186/bcr3493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907091PMC
October 2013

Lapatinib inhibits stem/progenitor proliferation in preclinical in vitro models of ductal carcinoma in situ (DCIS).

Cell Cycle 2014 18;13(3):418-25. Epub 2013 Nov 18.

Surgical Oncology; University Hospital of South Manchester NHS Foundation Trust; Wythenshawe Hospital; Manchester, UK.

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http://dx.doi.org/10.4161/cc.27201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956537PMC
January 2015

Targeting IL-8 signalling to inhibit breast cancer stem cell activity.

Expert Opin Ther Targets 2013 Nov 14;17(11):1235-41. Epub 2013 Sep 14.

University of Manchester, Institute of Cancer Sciences, Paterson Institute for Cancer Research, Breast Biology Group , Wilmslow Road, Manchester, M20 4BX , UK +44 161 446 3210 ;

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http://dx.doi.org/10.1517/14728222.2013.835398DOI Listing
November 2013

Wnt pathway activity in breast cancer sub-types and stem-like cells.

PLoS One 2013 4;8(7):e67811. Epub 2013 Jul 4.

Breakthrough Breast Cancer Research Unit, University of Manchester, Manchester, England.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0067811PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701602PMC
February 2014

Cell cycle regulators cyclin D1 and CDK4/6 have estrogen receptor-dependent divergent functions in breast cancer migration and stem cell-like activity.

Cell Cycle 2013 Aug 26;12(15):2384-94. Epub 2013 Jun 26.

Breakthrough Breast Cancer Unit; Institute of Cancer Sciences; Paterson Institute for Cancer Research; University of Manchester; Manchester, UK.

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http://dx.doi.org/10.4161/cc.25403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841318PMC
August 2013

Combined inhibition of ErbB1/2 and Notch receptors effectively targets breast ductal carcinoma in situ (DCIS) stem/progenitor cell activity regardless of ErbB2 status.

PLoS One 2013 14;8(2):e56840. Epub 2013 Feb 14.

Cancer Stem Cell Research, University of Manchester, Manchester Academic Health Science Centre, Paterson Institute for Cancer Research, The Christie NHS Foundation Trust, Manchester, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0056840PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572946PMC
August 2013

Combining Notch inhibition with current therapies for breast cancer treatment.

Ther Adv Med Oncol 2013 Jan;5(1):17-24

Wellcome Trust Centre for Cell-Matrix Research and Manchester Breast Centre, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1177/1758834012457437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539271PMC
January 2013

Contrasting hypoxic effects on breast cancer stem cell hierarchy is dependent on ER-α status.

Cancer Res 2013 Feb 17;73(4):1420-33. Epub 2012 Dec 17.

Molecular Pathology, Breakthrough Breast Cancer, School of Cancer, Paterson Institute for Cancer Research, University of Manchester, UK.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-12-2505DOI Listing
February 2013

Targeting CXCR1/2 significantly reduces breast cancer stem cell activity and increases the efficacy of inhibiting HER2 via HER2-dependent and -independent mechanisms.

Clin Cancer Res 2013 Feb 13;19(3):643-56. Epub 2012 Nov 13.

Breast Biology Group, Institute of Cancer Sciences, Paterson Institute for Cancer Research, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-1063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868141PMC
February 2013

A detailed mammosphere assay protocol for the quantification of breast stem cell activity.

J Mammary Gland Biol Neoplasia 2012 Jun 5;17(2):111-7. Epub 2012 Jun 5.

Breast Biology Group, School of Cancer and Enabling Sciences, Paterson Institute for Cancer Research, The University of Manchester, Wilmslow Road, Manchester, UK.

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http://link.springer.com/content/pdf/10.1007/s10911-012-9255
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http://link.springer.com/10.1007/s10911-012-9255-3
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http://dx.doi.org/10.1007/s10911-012-9255-3DOI Listing
June 2012

Stem cells in breast tumours: are they ready for the clinic?

Eur J Cancer 2012 Sep 26;48(14):2104-16. Epub 2012 Apr 26.

Breast Biology Group, School of Cancer and Enabling Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.

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http://dx.doi.org/10.1016/j.ejca.2012.03.019DOI Listing
September 2012

The devil is in the methods: lineage tracing, functional screens and sequencing, hormones, tumour-stroma interactions, and expansion of human breast tumours as xenografts.

Breast Cancer Res 2011 Oct 14;13(5):316. Epub 2011 Oct 14.

CIC bioGUNECell Biology & Stem Cells UnitParque Tecnológico de Bizkaia, Ed 801A48160 Derio (Bizkaia), Spain.

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http://dx.doi.org/10.1186/bcr3021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262208PMC
October 2011

Breast cancer stem cells and their role in resistance to endocrine therapy.

Horm Cancer 2011 Apr;2(2):91-103

School of Cancer and Imaging Sciences, Paterson Institute for Cancer Research, University of Manchester, Manchester, M20 4BX, UK.

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http://dx.doi.org/10.1007/s12672-011-0066-6DOI Listing
April 2011

Hormones and cancer: update from Tokyo 2010.

Expert Rev Endocrinol Metab 2011 Jan;6(1):31-33

b Breast Biology Group, School of Cancer and Enabling Sciences, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester, M20 4BX, UK.

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http://dx.doi.org/10.1586/eem.10.71DOI Listing
January 2011

Breast cancer stem cells: something out of notching?

Cancer Res 2010 Nov 2;70(22):8973-6. Epub 2010 Nov 2.

Breast Biology Group, School of Cancer and Enabling Sciences, Paterson Institute for Cancer Research, University of Manchester;, Manchester, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-1559DOI Listing
November 2010

The embryonic transcription cofactor LBH is a direct target of the Wnt signaling pathway in epithelial development and in aggressive basal subtype breast cancers.

Mol Cell Biol 2010 Sep 6;30(17):4267-79. Epub 2010 Jul 6.

Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

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http://dx.doi.org/10.1128/MCB.01418-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937547PMC
September 2010

Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor.

Cancer Res 2010 Jan 12;70(2):709-18. Epub 2010 Jan 12.

Breast Biology Group, School of Cancer, Enabling Sciences and Technology, Paterson Institute for Cancer Research, University of Manchester, Manchester Academic Health Sciences Centre, The Christie NHS Foundation Trust; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester M20 4BX, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-1681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442245PMC
January 2010

It's all in the details: methods in breast development and cancer.

Breast Cancer Res 2009 14;11(4):305. Epub 2009 Aug 14.

Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstr, 66; CH-4058 Basel, Switzerland.

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http://dx.doi.org/10.1186/bcr2346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750118PMC
February 2010

Biomarkers of dietary energy restriction in women at increased risk of breast cancer.

Cancer Prev Res (Phila) 2009 Aug;2(8):720-31

Breast Biology Group, School of Cancer and Imaging Sciences, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, United Kingdom.

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http://dx.doi.org/10.1158/1940-6207.CAPR-09-0008DOI Listing
August 2009

Normal breast tissue implanted into athymic nude mice identifies biomarkers of the effects of human pregnancy levels of estrogen.

Cancer Prev Res (Phila) 2009 Mar 3;2(3):257-64. Epub 2009 Mar 3.

Breast Biology Group, School of Cancer and Imaging Sciences, Paterson Institute for Cancer Research, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1158/1940-6207.CAPR-08-0161DOI Listing
March 2009

Resistance to endocrine therapy: are breast cancer stem cells the culprits?

J Mammary Gland Biol Neoplasia 2009 Mar 28;14(1):45-54. Epub 2009 Feb 28.

Breast Biology Group, School of Cancer and Imaging Sciences, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1007/s10911-009-9115-yDOI Listing
March 2009

Are stem-like cells responsible for resistance to therapy in breast cancer?

Breast Dis 2008 ;29:83-9

Breast Biology Group, School of Cancer and Imaging Sciences, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester, M20 4BX, UK.

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http://dx.doi.org/10.3233/bd-2008-29109DOI Listing
February 2009

The removal of multiplicative, systematic bias allows integration of breast cancer gene expression datasets - improving meta-analysis and prediction of prognosis.

BMC Med Genomics 2008 Sep 21;1:42. Epub 2008 Sep 21.

Applied Bioinformatics of Cancer Research Group, Breakthrough Research Unit, Edinburgh Cancer Research Centre, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XR, UK.

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http://dx.doi.org/10.1186/1755-8794-1-42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2563019PMC
September 2008

Prolactin receptor antagonism reduces the clonogenic capacity of breast cancer cells and potentiates doxorubicin and paclitaxel cytotoxicity.

Breast Cancer Res 2008 5;10(4):R68. Epub 2008 Aug 5.

Breast Biology Group, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.

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http://dx.doi.org/10.1186/bcr2129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575541PMC
April 2009

The origin of estrogen receptor alpha-positive and alpha-negative breast cancer.

Adv Exp Med Biol 2008 ;617:79-86

Breast Biology Group, Division of Cancer Studies, University of Manchester Christie Hospital (NHS) Trust, Manchester, UK.

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http://dx.doi.org/10.1007/978-0-387-69080-3_7DOI Listing
July 2008

Mammary stem cells and breast cancer--role of Notch signalling.

Stem Cell Rev 2007 Jun;3(2):169-75

Breast Biology Group, Division of Cancer Studies, Faculty of Medicine and Human Sciences, University of Manchester, Paterson Institute for Cancer Research, Wilmslow Road, Manchester, M20 4BX, UK.

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http://dx.doi.org/10.1007/s12015-007-0023-5DOI Listing
June 2007

Origins of breast cancer subtypes and therapeutic implications.

Nat Clin Pract Oncol 2007 Sep;4(9):516-25

Breast Biology Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1038/ncponc0908DOI Listing
September 2007

Novel cell culture technique for primary ductal carcinoma in situ: role of Notch and epidermal growth factor receptor signaling pathways.

J Natl Cancer Inst 2007 Apr;99(8):616-27

Department of Surgery and Breast Biology Group, Division of Cancer Studies, Faculty of Medicine and Human Sciences, University of Manchester, Christie Hospital NHS Trust, Wilmslow Road, M20 9BX, Manchester, UK.

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https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnc
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http://dx.doi.org/10.1093/jnci/djk133DOI Listing
April 2007

Estrogen deprivation for breast cancer prevention.

Recent Results Cancer Res 2007 ;174:151-67

CRUK Department of Medical Oncology, Christie Hospital, University of Manchester, UK.

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http://dx.doi.org/10.1007/978-3-540-37696-5_13DOI Listing
March 2007

High-throughput genomic technology in research and clinical management of breast cancer. Exploiting the potential of gene expression profiling: is it ready for the clinic?

Breast Cancer Res 2006 ;8(5):214

Breast Biology Group, University of Manchester, Paterson Institute for Cancer Research, Wilmslow Road, Manchester, M20 4BX, UK.

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http://dx.doi.org/10.1186/bcr1605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779487PMC
January 2007

Ovarian steroids and the human breast: regulation of stem cells and cell proliferation.

Authors:
Robert B Clarke

Maturitas 2006 Jul 30;54(4):327-34. Epub 2006 Jun 30.

Breast Biology Group, CR-UK Department of Medical Oncology, University of Manchester, Christie Hospital, Manchester, M20 4BX, UK.

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http://dx.doi.org/10.1016/j.maturitas.2006.06.002DOI Listing
July 2006

Mechanisms of Disease: prediction and prevention of breast cancer--cellular and molecular interactions.

Nat Clin Pract Oncol 2005 Dec;2(12):635-46

Dept of Medical Oncology, University of Manchester, Christie Hospital, Withington, UK.

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http://dx.doi.org/10.1038/ncponc0361DOI Listing
December 2005

Human breast epithelial stem cells and their regulation.

J Pathol 2006 Jan;208(1):7-16

Breast Biology Group, Division of Cancer Studies, University of Manchester, Christie Hospital, Wilmslow Road, Manchester, M20 4BX, UK.

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http://dx.doi.org/10.1002/path.1881DOI Listing
January 2006

The mammary gland "side population": a putative stem/progenitor cell marker?

J Mammary Gland Biol Neoplasia 2005 Jan;10(1):37-47

The Breakthrough Breast Cancer Centre, The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1007/s10911-005-2539-0DOI Listing
January 2005

Stem cells and tissue homeostasis in mammary glands.

J Mammary Gland Biol Neoplasia 2005 Jan;10(1):1-3

Breast Biology Group, University of Manchester, Christie Hospital, Manchester, M20 4BX UK.

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http://dx.doi.org/10.1007/s10911-005-2535-4DOI Listing
January 2005

Do early premalignant changes in normal breast epithelial cells predict cancer development?

Breast Cancer Res 2005 19;7(1):18-20. Epub 2004 Nov 19.

CR-UK Department of Medical Oncology, University of Manchester, Christie Hospital NHS Trust, Manchester, UK.

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http://dx.doi.org/10.1186/bcr967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1064113PMC
January 2006

A putative human breast stem cell population is enriched for steroid receptor-positive cells.

Dev Biol 2005 Jan;277(2):443-56

Breast Biology Group, Cancer Research UK Department of Medical Oncology, University of Manchester, Christie Hospital (NHS) Trust, Wilmslow Road, Withington, Manchester M20 4BX, UK.

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http://dx.doi.org/10.1016/j.ydbio.2004.07.044DOI Listing
January 2005

The centrosomal kinase Nek2 displays elevated levels of protein expression in human breast cancer.

Cancer Res 2004 Oct;64(20):7370-6

Department of Biochemistry, University of Leicester, Leicester, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-0960DOI Listing
October 2004

Steroid receptors in human breast cancer.

Trends Endocrinol Metab 2004 Sep;15(7):316-23

CR-UK Department of Medical Oncology, Christie Hospital, Manchester, UK.

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http://dx.doi.org/10.1016/j.tem.2004.07.004DOI Listing
September 2004

Complementary yet distinct roles for oestrogen receptor-alpha and oestrogen receptor-beta in mouse mammary epithelial proliferation.

Authors:
Robert B Clarke

Breast Cancer Res 2004 1;6(3):135-6. Epub 2004 Apr 1.

Breast Biology Group, Clinical Research Department, Christie Hospital NHS Trust, Wilmslow Road, Manchester.

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http://dx.doi.org/10.1186/bcr795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400684PMC
July 2004

Steroid receptors and cell cycle in normal mammary epithelium.

J Mammary Gland Biol Neoplasia 2004 Jan;9(1):3-13

Christie Hospital NHS Trust, Manchester, UK.

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http://dx.doi.org/10.1023/B:JOMG.0000023584.01750.16DOI Listing
January 2004

Steroid receptors and proliferation in the human breast.

Authors:
Robert B Clarke

Steroids 2003 Nov;68(10-13):789-94

Breast Biology Group, Clinical Research Department, Christie Hospital, Manchester M20 4BX, UK.

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http://dx.doi.org/10.1016/s0039-128x(03)00122-3DOI Listing
November 2003

Regulation of human breast epithelial stem cells.

Cell Prolif 2003 Oct;36 Suppl 1:45-58

Breast Biology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Withington, Manchester, UK.

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http://dx.doi.org/10.1046/j.1365-2184.36.s.1.5.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6495733PMC
October 2003

p27KIP1 phosphorylation by PKB/Akt leads to poor breast cancer prognosis.

Authors:
Robert B Clarke

Breast Cancer Res 2003 31;5(3):162-3. Epub 2003 Mar 31.

Breast Biology Group, Clinical Research Department, Christie Hospital NHS Trust, Wilmslow Road, Withington, Manchester, UK.

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http://dx.doi.org/10.1186/bcr596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC165008PMC
June 2003