Robert A Waterland

Robert A Waterland

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Robert A Waterland

Robert A Waterland

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Early postnatal overnutrition accelerates aging-associated epigenetic drift in pancreatic islets.

Environ Epigenet 2019 Jul 25;5(3):dvz015. Epub 2019 Aug 25.

Department of Pediatrics, Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center, Houston, TX, USA.

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http://dx.doi.org/10.1093/eep/dvz015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735752PMC
July 2019

Establishment of environmentally sensitive DNA methylation states in the very early human embryo.

Sci Adv 2018 07 11;4(7):eaat2624. Epub 2018 Jul 11.

Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.

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http://advances.sciencemag.org/lookup/doi/10.1126/sciadv.aat
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http://dx.doi.org/10.1126/sciadv.aat2624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040841PMC
July 2018

Meeting summary: the inaugural meeting of the US DOHaD society.

Environ Epigenet 2017 Jan 17;3(1):dvw026. Epub 2017 Feb 17.

Department of Pediatrics, Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center, Houston, TX, USA.

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http://academic.oup.com/eep/article/doi/10.1093/eep/dvw026/3
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http://dx.doi.org/10.1093/eep/dvw026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804540PMC
January 2017

Assisted reproductive technology alters deoxyribonucleic acid methylation profiles in bloodspots of newborn infants.

Fertil Steril 2016 09 8;106(3):629-639.e10. Epub 2016 Jun 8.

Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan; Center for Molecular Medicine and Genetics, C. S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, Michigan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00150282166126
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http://dx.doi.org/10.1016/j.fertnstert.2016.05.006DOI Listing
September 2016

Maternal exercise during pregnancy promotes physical activity in adult offspring.

FASEB J 2016 07 31;30(7):2541-8. Epub 2016 Mar 31.

U.S. Department of Agriculture/Agricultural Research Service (USDA/ARS) Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas, USA; Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA

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http://www.fasebj.org/doi/10.1096/fj.201500018R
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http://dx.doi.org/10.1096/fj.201500018RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904289PMC
July 2016

Developmental programming of energy balance regulation: is physical activity more 'programmable' than food intake?

Proc Nutr Soc 2016 Feb 29;75(1):73-77. Epub 2015 Oct 29.

Department of Pediatrics,Baylor College of Medicine,USDA/ARS Children's Nutrition Research Center,Houston, TX,USA.

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http://dx.doi.org/10.1017/S0029665115004127DOI Listing
February 2016

CpG methylation differences between neurons and glia are highly conserved from mouse to human.

Hum Mol Genet 2016 Jan 12;25(2):223-32. Epub 2015 Nov 12.

Department of Pediatrics, Department of Molecular & Human Genetics, Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center,Houston, TX, USA

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http://dx.doi.org/10.1093/hmg/ddv459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706111PMC
January 2016

Epigenetic mechanisms affecting regulation of energy balance: many questions, few answers.

Annu Rev Nutr 2014 16;34:337-55. Epub 2014 May 16.

Departments of Pediatrics and Molecular & Human Genetics, Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center, Houston, Texas 77030; email:

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http://dx.doi.org/10.1146/annurev-nutr-071813-105315DOI Listing
March 2015

Integrative analysis of 111 reference human epigenomes.

Nature 2015 Feb;518(7539):317-30

1] Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, 32 Vassar St, Cambridge, Massachusetts 02139, USA. [2] The Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/nature14248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530010PMC
February 2015

On the meaning of the word 'epimutation': a comment.

Trends Genet 2015 Jan 2;31(1). Epub 2014 Dec 2.

Department of Pediatrics, Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tig.2014.11.001DOI Listing
January 2015

Comparison and quantitative verification of mapping algorithms for whole-genome bisulfite sequencing.

Nucleic Acids Res 2014 Apr 3;42(6):e43. Epub 2014 Jan 3.

Department of Pediatrics, Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center, Houston, TX 77030, USA, Department of Molecular & Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA and Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1093/nar/gkt1325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973287PMC
April 2014

Maternal nutrition at conception modulates DNA methylation of human metastable epialleles.

Nat Commun 2014 Apr 29;5:3746. Epub 2014 Apr 29.

MRC International Nutrition Group at MRC Keneba, The Gambia and London School of Hygiene & Tropical Medicine, EPH, LSHTM, Keppel Street, London WC1E 7HT, UK.

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http://dx.doi.org/10.1038/ncomms4746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015319PMC
April 2014

Early postnatal nutrition determines adult physical activity and energy expenditure in female mice.

Diabetes 2013 Aug 1;62(8):2773-83. Epub 2013 Apr 1.

Department of Pediatrics, Baylor College of Medicine, United States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Houston, Texas, USA.

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http://dx.doi.org/10.2337/db12-1306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717861PMC
August 2013

Developmentally programmed 3' CpG island methylation confers tissue- and cell-type-specific transcriptional activation.

Mol Cell Biol 2013 May 4;33(9):1845-58. Epub 2013 Mar 4.

Department of Pediatrics, Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center, Houston, Texas, USA.

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http://dx.doi.org/10.1128/MCB.01124-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624169PMC
May 2013

Highlights of the 2012 Research Workshop: Using nutrigenomics and metabolomics in clinical nutrition research.

JPEN J Parenter Enteral Nutr 2013 Mar 5;37(2):190-200. Epub 2012 Oct 5.

University of North Carolina at Chapel Hill, Kannapolis, North Carolina, USA.

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http://dx.doi.org/10.1177/0148607112462401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593226PMC
March 2013

Nutritional regulation of epigenetic changes.

Adv Nutr 2012 Sep 1;3(5):749-50. Epub 2012 Sep 1.

Department of Nutritional Sciences and Arizona Cancer Center, The University of Arizona, Tucson, AZ, USA.

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http://dx.doi.org/10.3945/an.112.002675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648767PMC
September 2012

Epigenetic regulation in murine offspring as a novel mechanism for transmaternal asthma protection induced by microbes.

J Allergy Clin Immunol 2011 Sep 15;128(3):618-25.e1-7. Epub 2011 Jun 15.

Department of Clinical Chemistry and Molecular Diagnostics, Philipps University of Marburg, Marburg, Germany.

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http://dx.doi.org/10.1016/j.jaci.2011.04.035DOI Listing
September 2011

Season of conception in rural gambia affects DNA methylation at putative human metastable epialleles.

PLoS Genet 2010 Dec 23;6(12):e1001252. Epub 2010 Dec 23.

Department of Pediatrics, Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center, Houston, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1001252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009670PMC
December 2010

Epigenetic maturation in colonic mucosa continues beyond infancy in mice.

Hum Mol Genet 2010 Jun 2;19(11):2168-76. Epub 2010 Mar 2.

Department of Pediatrics, Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1093/hmg/ddq095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865374PMC
June 2010

Early environmental effects on epigenetic regulation in humans.

Epigenetics 2009 Nov 22;4(8):523-5. Epub 2009 Nov 22.

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http://dx.doi.org/10.4161/epi.4.8.10155DOI Listing
November 2009

Epigenomic profiling indicates a role for DNA methylation in early postnatal liver development.

Hum Mol Genet 2009 Aug 20;18(16):3026-38. Epub 2009 May 20.

Department of Pediatrics, Baylor College of Medicine, USDA Children's Nutrition Research Center, 1100 Bates St., Ste. 5080, Houston, TX 77030, USA.

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https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/
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http://dx.doi.org/10.1093/hmg/ddp241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714727PMC
August 2009

Is epigenetics an important link between early life events and adult disease?

Horm Res 2009 Jan 21;71 Suppl 1:13-6. Epub 2009 Jan 21.

Departments of Pediatrics and Molecular and Human Genetics, Baylor College of Medicine, USDA Children's Nutrition Research Center, Houston, Tex., USA.

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http://dx.doi.org/10.1159/000178030DOI Listing
January 2009

Individual epigenetic variation: when, why, and so what?

Nestle Nutr Workshop Ser Pediatr Program 2008 ;62:141-50; discussion 151-5

Departments of Pediatrics and Molecular and Human Genetics, Baylor College of Medicine, USDA Children's Nutrition Research Center, Houston, TX, USA.

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http://dx.doi.org/10.1159/000146257DOI Listing
November 2008

Epigenetic epidemiology of obesity: application of epigenomic technology.

Nutr Rev 2008 Aug;66 Suppl 1:S21-3

The Department of Pediatrics, Baylor College of Medicine, USDA Children's Nutrition Research Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1111/j.1753-4887.2008.00060.xDOI Listing
August 2008

Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline.

Hum Mol Genet 2008 May 5;17(9):1306-17. Epub 2008 Feb 5.

Verna and Marrs McLean Department of Biochemistry and Molecular Biology, USDA Children's Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

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http://dx.doi.org/10.1093/hmg/ddn019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686304PMC
May 2008

Epigenetic epidemiology of the developmental origins hypothesis.

Annu Rev Nutr 2007 ;27:363-88

Department of Pediatrics, USDA Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX, USA.

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http://dx.doi.org/10.1146/annurev.nutr.27.061406.093705DOI Listing
November 2007

Diet-induced hypermethylation at agouti viable yellow is not inherited transgenerationally through the female.

FASEB J 2007 Oct 5;21(12):3380-5. Epub 2007 Jun 5.

Department of Pediatrics, Baylor College of Medicine, USDA Children's Nutrition Research Center, Houston, TX 77030, USA.

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http://www.fasebj.org/doi/10.1096/fj.07-8229com
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http://dx.doi.org/10.1096/fj.07-8229comDOI Listing
October 2007

Tumor suppressor gene inactivation during cadmium-induced malignant transformation of human prostate cells correlates with overexpression of de novo DNA methyltransferase.

Environ Health Perspect 2007 Oct;115(10):1454-9

Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1289/ehp.10207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2022656PMC
October 2007

Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters.

PLoS Genet 2007 Oct 10;3(10):2023-36. Epub 2007 Sep 10.

Department of Leukemia, The University of Texas at M. D. Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1371/journal.pgen.0030181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2041996PMC
October 2007

Methods of DNA methylation analysis.

Curr Opin Clin Nutr Metab Care 2007 Sep;10(5):576-81

Department of Leukemia, University of Texas MD Anderson Cancer Center, USA.

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http://dx.doi.org/10.1097/MCO.0b013e3282bf6f43DOI Listing
September 2007

Does nutrition during infancy and early childhood contribute to later obesity via metabolic imprinting of epigenetic gene regulatory mechanisms?

Nestle Nutr Workshop Ser Pediatr Program 2005 ;56:157-71; discussion 171-4

Department of Pediatrics, Baylor College of Medicine, USDA Children's Nutrition Research Center, Houston, TX, USA.

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http://dx.doi.org/10.1159/000086298DOI Listing
January 2007

Epigenetic mechanisms and gastrointestinal development.

J Pediatr 2006 Nov;149(5 Suppl):S137-42

Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S002234760600624
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http://dx.doi.org/10.1016/j.jpeds.2006.06.064DOI Listing
November 2006

Maternal methyl supplements increase offspring DNA methylation at Axin Fused.

Genesis 2006 Sep;44(9):401-6

Department of Pediatrics, Baylor College of Medicine, USDA Children's Nutrition Research Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1002/dvg.20230DOI Listing
September 2006

Assessing the effects of high methionine intake on DNA methylation.

J Nutr 2006 06;136(6 Suppl):1706S-1710S

Department of Pediatrics, Baylor College of Medicine, U.S. Department of Agriculture Children's Nutrition Research Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1093/jn/136.6.1706SDOI Listing
June 2006

Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome.

Environ Health Perspect 2006 Apr;114(4):567-72

Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA.

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https://ehp.niehs.nih.gov/doi/10.1289/ehp.8700
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1440782PMC
http://dx.doi.org/10.1289/ehp.8700DOI Listing
April 2006

Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus.

Hum Mol Genet 2006 Mar 18;15(5):705-16. Epub 2006 Jan 18.

Departments of Pediatrics and Molecular and Human Genetics, Baylor College of Medicine, USDA Children's Nutrition Research Center, Houston, TX 77030-2600, USA.

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http://academic.oup.com/hmg/article/15/5/705/596694/Postwean
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http://dx.doi.org/10.1093/hmg/ddi484DOI Listing
March 2006

Molecular events associated with arsenic-induced malignant transformation of human prostatic epithelial cells: aberrant genomic DNA methylation and K-ras oncogene activation.

Toxicol Appl Pharmacol 2005 Aug 18;206(3):288-98. Epub 2005 Jan 18.

Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, MD F0-09, 111 Alexander Drive, Research Triangle Park, NC 27709, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0041008X0400540
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http://dx.doi.org/10.1016/j.taap.2004.11.017DOI Listing
August 2005

Analysis of CpG methylation in the killifish CYP1A promoter.

Comp Biochem Physiol C Toxicol Pharmacol 2005 Aug 28;141(4):406-11. Epub 2005 Oct 28.

Nicholas School of the Environment and Earth Sciences/Integrated Toxicology Program, Box 90328, Duke University, Durham, NC, USA.

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http://dx.doi.org/10.1016/j.cbpc.2005.09.009DOI Listing
August 2005

Commentary: The global relevance of "biological Freudianism".

Int J Epidemiol 2005 Feb 13;34(1):15-7. Epub 2005 Jan 13.

Department of Pediatrics, Baylor College of Medicine, 1100 Bates Street, Ste. 9070, Houston, TX 77030, USA.

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https://academic.oup.com/ije/article-lookup/doi/10.1093/ije/
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http://dx.doi.org/10.1093/ije/dyh360DOI Listing
February 2005

Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases.

Nutrition 2004 Jan;20(1):63-8

Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1016/j.nut.2003.09.011DOI Listing
January 2004

Transposable elements: targets for early nutritional effects on epigenetic gene regulation.

Mol Cell Biol 2003 Aug;23(15):5293-300

Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC165709PMC
http://dx.doi.org/10.1128/mcb.23.15.5293-5300.2003DOI Listing
August 2003

Tissue-specific inactivation of murine M6P/IGF2R.

Am J Pathol 2003 Jan;162(1):321-8

Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1851115PMC
http://dx.doi.org/10.1016/S0002-9440(10)63823-0DOI Listing
January 2003

Do maternal methyl supplements in mice affect DNA methylation of offspring?

J Nutr 2003 01;133(1):238; author reply 239

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http://dx.doi.org/10.1093/jn/133.1.238DOI Listing
January 2003

Early postnatal nutrition determines adult pancreatic glucose-responsive insulin secretion and islet gene expression in rats.

J Nutr 2002 Mar;132(3):357-64

Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA.

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https://academic.oup.com/jn/article/132/3/357/4687350
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http://dx.doi.org/10.1093/jn/132.3.357DOI Listing
March 2002