Robert A Sweet

Robert A Sweet

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Increased Protein Insolubility in Brains From a Subset of Patients With Schizophrenia.

Am J Psychiatry 2019 Sep 6;176(9):730-743. Epub 2019 May 6.

The Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore (L.G. Nucifora, Lee, Peters, Yang, Margolis, Pevsner, Ross, Sawa, F.C. Nucifora); the Departments of Psychiatry and Neurology, University of Pittsburgh, and the VISN 4 Mental Illness Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh (MacDonald, Sweet); the Department of Neurology, Kennedy Krieger Institute, Baltimore (Norris, Pevsner); the Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore (Norris, Pevsner, Ross, Sawa); Protein Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Frederick, Md. (Orsburn); the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas (Gleason, Tamminga); the Department of Neurology, Johns Hopkins University School of Medicine, Baltimore (Margolis, Ross, Sawa, F.C. Nucifora); Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore (Lee, Sawa); the Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore (Ross).

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http://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2019.18
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http://dx.doi.org/10.1176/appi.ajp.2019.18070864DOI Listing
September 2019

Effects of Vitamin D Use on Outcomes of Psychotic Symptoms in Alzheimer Disease Patients.

Am J Geriatr Psychiatry 2019 Sep 27;27(9):908-917. Epub 2019 Mar 27.

Department of Neurology (EAW, OLL, RAS), University of Pittsburgh School of Medicine, Pittsburgh; Department of Psychiatry (MAADS, OLL, RAS), University of Pittsburgh School of Medicine, Pittsburgh; VISN 4 Mental Illness Research, Education and Clinical Center (RAS), VA Pittsburgh Healthcare System, Pittsburgh. Electronic address:

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http://dx.doi.org/10.1016/j.jagp.2019.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693492PMC
September 2019

Animal Models of Psychosis in Alzheimer Disease.

Am J Geriatr Psychiatry 2019 May 17. Epub 2019 May 17.

Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA; Mental Illness Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA. Electronic address:

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http://dx.doi.org/10.1016/j.jagp.2019.05.009DOI Listing
May 2019

Synaptic Proteome Compensation and Resilience to Psychosis in Alzheimer's Disease.

Am J Psychiatry 2018 10 19;175(10):999-1009. Epub 2018 Jul 19.

From the Departments of Psychiatry, Cell Biology, Neurology, and Pathology, University of Pittsburgh School of Medicine, Pittsburgh; the Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh; the Departments of Physiology and Psychiatry and Behavioral Sciences, Northwestern University, Feinberg School of Medicine, Chicago; the Geriatric Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh; and the Mental Illness Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh.

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http://dx.doi.org/10.1176/appi.ajp.2018.17080858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167138PMC
October 2018

Synergism of antihypertensives and cholinesterase inhibitors in Alzheimer's disease.

Alzheimers Dement (N Y) 2018 14;4:542-555. Epub 2018 Oct 14.

Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy; NIDA National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1016/j.trci.2018.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205113PMC
October 2018

DNA methylation age is not accelerated in brain or blood of subjects with schizophrenia.

Schizophr Res 2018 06 5;196:39-44. Epub 2017 Oct 5.

University of Pittsburgh, Department of Psychiatry, Pittsburgh, PA, United States; University of Pittsburgh, Department of Neurology, Pittsburgh, PA, United States; VISN4 Mental Illness Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA, United States.

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http://dx.doi.org/10.1016/j.schres.2017.09.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886835PMC
June 2018

A putative electrophysiological biomarker of auditory sensory memory encoding is sensitive to pharmacological alterations of excitatory/inhibitory balance in male macaque monkeys.

J Psychiatry Neurosci 2018 05;43(3):182-193

From the Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA (Holliday, Gurnsey, Sweet, Teichert); the Department of Neurology, University of Pittsburgh, Pittsburgh, PA (Sweet); the Mental Illness Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA (Sweet); and the Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA (Teichert).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915239PMC
May 2018

A Schizophrenia-Linked KALRN Coding Variant Alters Neuron Morphology, Protein Function, and Transcript Stability.

Biol Psychiatry 2018 03 7;83(6):499-508. Epub 2017 Nov 7.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2017.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809265PMC
March 2018

Stereological Assessments of Neuronal Pathology in Auditory Cortex in Schizophrenia.

Front Neuroanat 2017 9;11:131. Epub 2018 Jan 9.

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States.

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http://journal.frontiersin.org/article/10.3389/fnana.2017.00
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http://dx.doi.org/10.3389/fnana.2017.00131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767177PMC
January 2018

A putative electrophysiological biomarker of auditory sensory memory encoding is sensitive to pharmacological alterations of excitatory/inhibitory balance in male macaque monkeys.

J Psychiatry Neurosci 2017 Dec 13;43(1):170093. Epub 2017 Dec 13.

From the Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA (Holliday, Gurnsey, Sweet, Teichert); the Department of Neurology, University of Pittsburgh, Pittsburgh, PA (Sweet); the Mental Illness Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA (Sweet); and the Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA (Teichert).

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http://dx.doi.org/10.1503/jpn.170093DOI Listing
December 2017

Loss of precuneus dendritic spines immunopositive for spinophilin is related to cognitive impairment in early Alzheimer's disease.

Neurobiol Aging 2017 07 4;55:159-166. Epub 2017 Feb 4.

Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA; Geriatric Research Education and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.01.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440205PMC
July 2017

Kalirin reduction rescues psychosis-associated behavioral deficits in APPswe/PSEN1dE9 transgenic mice.

Neurobiol Aging 2017 06 16;54:59-70. Epub 2017 Feb 16.

Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Mental Illness Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502748PMC
June 2017

Selective Loss of Smaller Spines in Schizophrenia.

Am J Psychiatry 2017 06 31;174(6):586-594. Epub 2017 Mar 31.

From the Departments of Psychiatry, Neurology, Statistics, and Neurobiology, Translational Neuroscience Program, University of Pittsburgh School of Medicine, Pittsburgh; the Mental Illness Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh; and the Departments of Physiology and of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago.

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http://dx.doi.org/10.1176/appi.ajp.2017.16070814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800878PMC
June 2017

Polygenic risk scores in familial Alzheimer disease.

Neurology 2017 Mar 17;88(12):1180-1186. Epub 2017 Feb 17.

From the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (G.T., J.M., R.O., N.S., Y.S., R.M.), Gertrude H. Sergievsky Center (G.T., J.M., N.S., Y.S., R.M.), and Department of Neurology (G.T., J.M., R.O., N.S., Y.S.), Columbia University College of Physicians and Surgeons, New York; New York Presbyterian Hospital (G.T., J.M., R.O., N.S., Y.S.), NY; Departments of Neurology and Medicine (T.D.B., D.T.), University of Washington, Seattle; Rush Alzheimer's Disease Center (D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN; Hope Center for Neurological Disorders (C.C.), Washington University, St Louis, MO; Department of Medical and Molecular Genetics (K.F., T.M.F.), Indiana University; Department of Neurology (M.F.), Indiana University Center for Alzheimer's Disease and Related Disorders, Indianapolis; Department of Neuroscience (A.M.G., S.B.), Mount Sinai School of Medicine, New York, NY; Department of Neurology (N.R.G.-R.), Mayo Clinic, Jacksonville, FL; School of Medicine (M.M., R.M.), Mother and Teacher Pontifical Catholic University, Santiago, Dominican Republic; Department of Medicine (R.L.) and Department of Epidemiology, Mailman School of Public Health (R.O., N.S.), Columbia University, New York; Division of Epidemiology (R.O.), New York State Psychiatric Institute, New York; Department of Neurology and Neurotherapeutics (R.R.), The University of Texas Southwestern Medical Center, Dallas; Department of Health Sciences Research (D.J.S.), Mayo Clinic, Rochester, MN; and Department of Psychiatry, Neurology and Epidemiology (R.A.S.), University of Pittsburgh, PA.

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http://dx.doi.org/10.1212/WNL.0000000000003734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373783PMC
March 2017

DNA methylation evidence against the accelerated aging hypothesis of schizophrenia.

NPJ Schizophr 2017 23;3:13. Epub 2017 Mar 23.

Departments of Psychiatry, University of Pittsburgh, Pittsburgh, PA USA.

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http://dx.doi.org/10.1038/s41537-017-0017-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441537PMC
March 2017

Genetics of psychosis of Alzheimer disease.

Am J Med Genet B Neuropsychiatr Genet 2017 01 12;174(1):27-35. Epub 2016 Jan 12.

Department of Psychiatry and Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1002/ajmg.b.32413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154859PMC
January 2017

Incident Psychosis in Subjects With Mild Cognitive Impairment or Alzheimer's Disease.

J Clin Psychiatry 2016 Dec;77(12):e1564-e1569

Biomedical Science Tower, Rm W-1645, 3811 O'Hara St, Pittsburgh, PA 15213-2593.

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http://dx.doi.org/10.4088/JCP.15m10617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372698PMC
December 2016

Contextual processing in unpredictable auditory environments: the limited resource model of auditory refractoriness in the rhesus.

J Neurophysiol 2016 11 10;116(5):2125-2139. Epub 2016 Aug 10.

Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania.

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http://www.physiology.org/doi/10.1152/jn.00419.2016
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http://dx.doi.org/10.1152/jn.00419.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102310PMC
November 2016

Age-dependent increase in Kalirin-9 and Kalirin-12 transcripts in human orbitofrontal cortex.

Eur J Neurosci 2016 10 18;44(7):2483-2492. Epub 2016 Aug 18.

Departments of Psychiatry and Neurology, University of Pittsburgh School of Medicine, Biomedical Science Tower, Rm W-1645, 3811 O'Hara Street, Pittsburgh, PA, 15213-2593, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048532PMC
http://dx.doi.org/10.1111/ejn.13351DOI Listing
October 2016

The Role of Cardiovascular Risk Factors and Stroke in Familial Alzheimer Disease.

JAMA Neurol 2016 Oct;73(10):1231-1237

Taub Institute for Research on Alzheimer's Disease, The Aging Brain and the Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, New York2Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York3New York Presbyterian Hospital in New York City14Department of Epidemiology, Columbia University, New York, New York.

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http://dx.doi.org/10.1001/jamaneurol.2016.2539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155512PMC
October 2016

Developmental Trajectories of Auditory Cortex Synaptic Structures and Gap-Prepulse Inhibition of Acoustic Startle Between Early Adolescence and Young Adulthood in Mice.

Cereb Cortex 2016 May 10;26(5):2115-26. Epub 2015 Mar 10.

Center for Neuroscience Translational Neuroscience Program, Department of Psychiatry Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Mental Illness Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1093/cercor/bhv040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830289PMC
May 2016

A Bayesian model of psychosis symptom trajectory in Alzheimer's disease.

Int J Geriatr Psychiatry 2016 Feb 27;31(2):204-10. Epub 2015 Jul 27.

Department of Psychiatry, University of Pittsburgh, PA, USA.

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http://dx.doi.org/10.1002/gps.4326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707989PMC
February 2016

FastGGM: An Efficient Algorithm for the Inference of Gaussian Graphical Model in Biological Networks.

PLoS Comput Biol 2016 Feb 12;12(2):e1004755. Epub 2016 Feb 12.

Division of Pulmonary Medicine, Allergy and Immunology; Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1004755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752261PMC
February 2016

Genetic variants associated with susceptibility to psychosis in late-onset Alzheimer's disease families.

Neurobiol Aging 2015 Nov 15;36(11):3116.e9-3116.e16. Epub 2015 Aug 15.

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center and New York Presbyterian Hospital, New York, NY, USA; Gertrude H. Sergievsky Center, Columbia University Medical Center and New York Presbyterian Hospital, New York, NY, USA; Department of Neurology, Columbia University Medical Center and New York Presbyterian Hospital, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609604PMC
November 2015

Loss of Microtubule-Associated Protein 2 Immunoreactivity Linked to Dendritic Spine Loss in Schizophrenia.

Biol Psychiatry 2015 Sep 30;78(6):374-85. Epub 2015 Jan 30.

Translational Neuroscience Program, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Mental Illness Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2014.12.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520801PMC
September 2015

Auditory dysfunction in schizophrenia: integrating clinical and basic features.

Nat Rev Neurosci 2015 Sep;16(9):535-50

Departments of Psychiatry and Neurology, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1038/nrn4002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692466PMC
September 2015

Dendritic spine alterations in schizophrenia.

Neurosci Lett 2015 Aug 3;601:46-53. Epub 2014 Dec 3.

Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA; VISN 4 Mental Illness Research, Education and Clinical Center (MIRECC), VA Pittsburgh Healthcare System, Pittsburgh, PA 15206, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2014.11.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454616PMC
August 2015

More evidence for association of a rare TREM2 mutation (R47H) with Alzheimer's disease risk.

Neurobiol Aging 2015 Aug 25;36(8):2443.e21-6. Epub 2015 Apr 25.

Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465085PMC
August 2015

Genetic determinants of disease progression in Alzheimer's disease.

J Alzheimers Dis 2015 ;43(2):649-55

Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.3233/JAD-140729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245313PMC
July 2015

A rare duplication on chromosome 16p11.2 is identified in patients with psychosis in Alzheimer's disease.

PLoS One 2014 7;9(11):e111462. Epub 2014 Nov 7.

Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111462PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224411PMC
July 2015

Altered glutamate protein co-expression network topology linked to spine loss in the auditory cortex of schizophrenia.

Biol Psychiatry 2015 Jun 26;77(11):959-68. Epub 2014 Nov 26.

Departments of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania; Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania; Veterans Integrated Service Network 4 Mental Illness Research, Education and Clinical Center, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania.. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00063223140070
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http://dx.doi.org/10.1016/j.biopsych.2014.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428927PMC
June 2015

The glutamate hypothesis of schizophrenia: evidence from human brain tissue studies.

Ann N Y Acad Sci 2015 Mar 14;1338:38-57. Epub 2014 Oct 14.

Department of Behavioral Medicine and Psychiatry, West Virginia University Health Sciences Center, Morgantown, West Virginia.

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http://dx.doi.org/10.1111/nyas.12547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363164PMC
March 2015

VSNL1 Co-Expression Networks in Aging Include Calcium Signaling, Synaptic Plasticity, and Alzheimer's Disease Pathways.

Front Psychiatry 2015 9;6:30. Epub 2015 Mar 9.

Department of Psychiatry, University of Pittsburgh , Pittsburgh, PA , USA ; Department of Neurology, University of Pittsburgh , Pittsburgh, PA , USA ; VISN 4 Mental Illness Research, Education and Clinical Center (MIRECC), VA Pittsburgh Healthcare System , Pittsburgh, PA , USA.

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http://dx.doi.org/10.3389/fpsyt.2015.00030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353182PMC
March 2015

Hyperphosphorylated tau is elevated in Alzheimer's disease with psychosis.

J Alzheimers Dis 2014 ;39(4):759-73

Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA VISN 4 Mental Illness Research, Education and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://dx.doi.org/10.3233/JAD-131166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034758PMC
October 2014

Psychotic Alzheimer's disease is associated with gender-specific tau phosphorylation abnormalities.

Neurobiol Aging 2014 Sep 6;35(9):2021-8. Epub 2014 Mar 6.

The Litwin-Zucker Research Center for the Study of Alzheimer's Disease, The Feinstein Institute for Medical Research, Manhasset, NY, USA; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA; VISN Q2 4 Mental Illness Research, Education and Clinical Center (MIRECC), VA Pittsburgh Healthcare System, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155748PMC
September 2014

A sequence variant in human KALRN impairs protein function and coincides with reduced cortical thickness.

Nat Commun 2014 Sep 16;5:4858. Epub 2014 Sep 16.

1] Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA [2] Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1038/ncomms5858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166532PMC
September 2014

TAR DNA-binding protein 43 pathology in Alzheimer's disease with psychosis.

Int Psychogeriatr 2014 Jun 4;26(6):987-94. Epub 2014 Mar 4.

Translational Neuroscience Program, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1017/S1041610214000246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157359PMC
June 2014

Psychosis in Alzheimer's disease.

Biol Psychiatry 2014 Apr 6;75(7):542-52. Epub 2013 Oct 6.

Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania; Veterans Integrated Service Network 4 Mental Illness Research, Education and Clinical Center, US Department of Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2013.08.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036443PMC
April 2014

Abnormal kalirin signaling in neuropsychiatric disorders.

Brain Res Bull 2014 Apr 12;103:29-38. Epub 2013 Dec 12.

Department of Physiology, 303 E. Chicago Avenue, Chicago, IL 60611, USA; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, 303 E. Chicago Avenue, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.brainresbull.2013.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989394PMC
April 2014

Genetics of Psychosis in Alzheimer Disease.

Curr Genet Med Rep 2014 Mar;2(1):30-38

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA ; Department of Neurology, University of Pittsburgh, Pittsburgh, PA ; VISN 4 Mental Illness Research, Education and Clinical Center (MIRECC), VA Pittsburgh Healthcare System, Pittsburgh, PA.

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http://dx.doi.org/10.1007/s40142-014-0030-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034371PMC
March 2014

PAK1 protein expression in the auditory cortex of schizophrenia subjects.

PLoS One 2013 22;8(4):e59458. Epub 2013 Apr 22.

Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0059458PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632562PMC
November 2013

Adjusting for matching and covariates in linear discriminant analysis.

Biostatistics 2013 Sep 2;14(4):779-91. Epub 2013 May 2.

Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/biostatistics/kxt017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770000PMC
September 2013

Neuregulin1 signaling promotes dendritic spine growth through kalirin.

J Neurochem 2013 Sep 27;126(5):625-35. Epub 2013 Jun 27.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

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http://dx.doi.org/10.1111/jnc.12330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752328PMC
September 2013

Dendritic spine density, morphology, and fibrillar actin content surrounding amyloid-β plaques in a mouse model of amyloid-β deposition.

J Neuropathol Exp Neurol 2013 Aug;72(8):791-800

Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1097/NEN.0b013e31829ecc89DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763821PMC
August 2013

Developmental vulnerability of synapses and circuits associated with neuropsychiatric disorders.

J Neurochem 2013 Jul 22;126(2):165-82. Epub 2013 May 22.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1111/jnc.12261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700683PMC
July 2013

Incidence of mild cognitive impairment in the Pittsburgh Cardiovascular Health Study-Cognition Study.

Neurology 2012 Oct 26;79(15):1599-606. Epub 2012 Sep 26.

Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1212/WNL.0b013e31826e25f0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475628PMC
October 2012

The association between mental health and cognitive screening scores in older veterans.

Am J Geriatr Psychiatry 2012 Mar;20(3):215-27

Center for Integrated Healthcare, Department of Veterans Affairs, Buffalo, NY 14215, USA.

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http://dx.doi.org/10.1097/JGP.0b013e3182410cdbDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288824PMC
March 2012

TOMM40 poly-T repeat lengths, age of onset and psychosis risk in Alzheimer disease.

Neurobiol Aging 2011 Dec 5;32(12):2328.e1-9. Epub 2011 Aug 5.

Department of Statistics, Carnegie Mellon University, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2011.06.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192304PMC
December 2011

Differential distribution of proteins regulating GABA synthesis and reuptake in axon boutons of subpopulations of cortical interneurons.

Cereb Cortex 2011 Nov 21;21(11):2450-60. Epub 2011 Mar 21.

Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1093/cercor/bhr007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183419PMC
November 2011

Mapping Synaptic Pathology within Cerebral Cortical Circuits in Subjects with Schizophrenia.

Front Hum Neurosci 2010 23;4:44. Epub 2010 Jun 23.

Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh Pittsburgh, PA, USA.

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http://dx.doi.org/10.3389/fnhum.2010.00044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903233PMC
July 2011

Psychosis in Alzheimer's disease in the national Alzheimer's disease coordinating center uniform data set: clinical correlates and association with apolipoprotein e.

Int J Alzheimers Dis 2011 Mar 23;2011:926597. Epub 2011 Mar 23.

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213-2593, USA.

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http://dx.doi.org/10.4061/2011/926597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065057PMC
March 2011

Genetics of psychosis in Alzheimer's disease: a review.

J Alzheimers Dis 2010 ;19(3):761-80

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.3233/JAD-2010-1274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2942073PMC
May 2010

Assessment and familial aggregation of psychosis in Alzheimer's disease from the National Institute on Aging Late Onset Alzheimer's Disease Family Study.

Brain 2010 Apr 10;133(Pt 4):1155-62. Epub 2010 Feb 10.

Department of Psychiatry, University of Pittsburgh, Biomedical Science Tower, Rm W-1645, 3811 O'Hara Street, Pittsburgh, PA 15213-2593, USA.

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http://dx.doi.org/10.1093/brain/awq001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912688PMC
April 2010

Trajectories of cognitive decline in Alzheimer's disease.

Int Psychogeriatr 2010 Mar 28;22(2):281-90. Epub 2009 Sep 28.

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1017/S1041610209991001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834298PMC
March 2010

Depressed mood is not a risk factor for incident dementia in a community-based cohort.

Am J Geriatr Psychiatry 2009 Aug;17(8):653-63

Department of Psychiatry, School of Medicine, Graduate School of Public Health, University of Pittsburgh, 3501 Forbes Avenue, Pittsburgh, PA 15213, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714703PMC
August 2009

Schizophrenia from a neural circuitry perspective: advancing toward rational pharmacological therapies.

J Clin Invest 2009 Apr 1;119(4):706-16. Epub 2009 Apr 1.

University of Pittsburgh,Department of Psychiatry, W1651 Biomedical Science Tower, 3811 O'Hara Street, Pittsburgh, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1172/JCI37335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662560PMC
April 2009

Reduced dendritic spine density in auditory cortex of subjects with schizophrenia.

Neuropsychopharmacology 2009 Jan 7;34(2):374-89. Epub 2008 May 7.

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213-2593, USA.

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http://dx.doi.org/10.1038/npp.2008.67DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775717PMC
January 2009

An automated segmentation methodology for quantifying immunoreactive puncta number and fluorescence intensity in tissue sections.

Brain Res 2008 Nov 3;1240:62-72. Epub 2008 Sep 3.

Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1016/j.brainres.2008.08.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593455PMC
November 2008

Effect of chronic antipsychotic exposure on astrocyte and oligodendrocyte numbers in macaque monkeys.

Biol Psychiatry 2008 Apr 22;63(8):759-65. Epub 2007 Oct 22.

Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1016/j.biopsych.2007.08.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386415PMC
April 2008

Anatomical evidence of impaired feedforward auditory processing in schizophrenia.

Biol Psychiatry 2007 Apr 21;61(7):854-64. Epub 2006 Nov 21.

Department of Psychiatry, University of Pittsburgh, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1016/j.biopsych.2006.07.033DOI Listing
April 2007

Incidence of dementia in mild cognitive impairment in the cardiovascular health study cognition study.

Arch Neurol 2007 Mar;64(3):416-20

Departments of Neurology and Psychiatry, University of Pittsburgh School of Medicine, 3501 Forbes Ave, Suite 830, Oxford Bldg, Pittsburgh, PA 15213-3323, USA.

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http://dx.doi.org/10.1001/archneur.64.3.416DOI Listing
March 2007

Prediction of psychosis onset in Alzheimer disease: The role of cognitive impairment, depressive symptoms, and further evidence for psychosis subtypes.

Am J Geriatr Psychiatry 2006 Apr;14(4):352-60

Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1097/01.JGP.0000192500.25940.1bDOI Listing
April 2006

Neuregulin-1 polymorphism in late onset Alzheimer's disease families with psychoses.

Am J Med Genet B Neuropsychiatr Genet 2005 Nov;139B(1):28-32

University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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http://dx.doi.org/10.1002/ajmg.b.30219DOI Listing
November 2005

Mapping auditory core, lateral belt, and parabelt cortices in the human superior temporal gyrus.

J Comp Neurol 2005 Oct;491(3):270-89

Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1002/cne.20702DOI Listing
October 2005

Alzheimer disease subjects with psychosis have increased schizotypal symptoms before dementia onset.

Biol Psychiatry 2005 Aug;58(4):325-30

Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1016/j.biopsych.2005.04.017DOI Listing
August 2005

Heritability of psychosis in Alzheimer disease.

Am J Geriatr Psychiatry 2005 Jul;13(7):624-7

Dept. of Psychiatry, Univ. of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1176/appi.ajgp.13.7.624DOI Listing
July 2005

Non-cognitive symptoms in mild cognitive impairment subjects.

Neurocase 2005 Feb;11(1):65-71

Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1080/13554790490896893DOI Listing
February 2005

Alteration of a clinically meaningful outcome in the natural history of Alzheimer's disease by cholinesterase inhibition.

J Am Geriatr Soc 2005 Jan;53(1):83-7

Alzheimer's Disease Research Center and Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1111/j.1532-5415.2005.53015.xDOI Listing
January 2005

Neuropathologic correlates of late-onset major depression.

Neuropsychopharmacology 2004 Dec;29(12):2242-50

Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1038/sj.npp.1300554DOI Listing
December 2004

Pyramidal cell size reduction in schizophrenia: evidence for involvement of auditory feedforward circuits.

Biol Psychiatry 2004 Jun;55(12):1128-37

Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1016/j.biopsych.2004.03.002DOI Listing
June 2004

APOE is associated with age-of-onset, but not cognitive functioning, in late-life depression.

Int J Geriatr Psychiatry 2003 Dec;18(12):1075-81

Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1002/gps.1006DOI Listing
December 2003

Altered cortical glutamate neurotransmission in schizophrenia: evidence from morphological studies of pyramidal neurons.

Ann N Y Acad Sci 2003 Nov;1003:102-12

Department of Psychiatry, University of Pittsburgh, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1196/annals.1300.007DOI Listing
November 2003

Psychiatric symptoms vary with the severity of dementia in probable Alzheimer's disease.

J Neuropsychiatry Clin Neurosci 2003 ;15(3):346-53

Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1176/jnp.15.3.346DOI Listing
September 2003