Robert A Kirken

Robert A Kirken

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Robert A Kirken

Robert A Kirken

Publications by authors named "Robert A Kirken"

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Green barley mitigates cytotoxicity in human lymphocytes undergoing aggressive oxidative stress, via activation of both the Lyn/PI3K/Akt and MAPK/ERK pathways.

Sci Rep 2019 Apr 12;9(1):6005. Epub 2019 Apr 12.

The Cytometry, Screening and Imaging Core Facility & Border Biomedical Research Center & Department of Biological Sciences, The University of Texas at El Paso, El Paso, Texas, USA.

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http://www.nature.com/articles/s41598-019-42228-4
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http://dx.doi.org/10.1038/s41598-019-42228-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461650PMC
April 2019

Isoproterenol-induced beta-2 adrenergic receptor activation negatively regulates interleukin-2 signaling.

Biochem J 2018 09 18;475(18):2907-2923. Epub 2018 Sep 18.

Department of Biological Sciences and Border Biomedical Research Center, The University of Texas at El Paso, El Paso, TX 79968, U.S.A.

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http://dx.doi.org/10.1042/BCJ20180503DOI Listing
September 2018

Exploration of Nanoparticle-Mediated Photothermal Effect of TMB-HO Colorimetric System and Its Application in a Visual Quantitative Photothermal Immunoassay.

Anal Chem 2018 05 17;90(9):5930-5937. Epub 2018 Apr 17.

Department of Chemistry and Biochemistry , University of Texas at El Paso , 500 West University Avenue , El Paso , Texas 79968 , United States.

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http://dx.doi.org/10.1021/acs.analchem.8b00842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177380PMC
May 2018

The prohibitin protein complex promotes mitochondrial stabilization and cell survival in hematologic malignancies.

Oncotarget 2017 Sep 1;8(39):65445-65456. Epub 2017 Jul 1.

Department of Biological Sciences and Border Biomedical Research Center, The University of Texas at El Paso, El Paso, TX 79968, USA.

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http://dx.doi.org/10.18632/oncotarget.18920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630344PMC
September 2017

Sensitivity of imatinib-resistant T315I BCR-ABL CML to a synergistic combination of ponatinib and forskolin treatment.

Tumour Biol 2016 Sep 21;37(9):12643-12654. Epub 2016 Jul 21.

Department of Biological Sciences, The University of Texas at El Paso, 500 W. University Ave, El Paso, TX, 79968, USA.

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http://dx.doi.org/10.1007/s13277-016-5179-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080333PMC
September 2016

Transforming Mutations of Jak3 (A573V and M511I) Show Differential Sensitivity to Selective Jak3 Inhibitors.

Clin Cancer Drugs 2016 ;3(2):131-137

Department of Biological Sciences at The University of Texas at El Paso and the Border Biomedical Research Center, USA.

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http://www.eurekaselect.com/openurl/content.php?genre=articl
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http://dx.doi.org/10.2174/2212697X03666160610085943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642970PMC
January 2016

Interleukin-2 Receptor β Thr-450 Phosphorylation Is a Positive Regulator for Receptor Complex Stability and Activation of Signaling Molecules.

J Biol Chem 2015 Aug 7;290(34):20972-83. Epub 2015 Jul 7.

From the Department of Biological Sciences and Border Biomedical Research Center, The University of Texas at El Paso, El Paso, Texas 79968

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http://dx.doi.org/10.1074/jbc.M115.660654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543656PMC
August 2015

Arsenic-exposed Keratinocytes Exhibit Differential microRNAs Expression Profile; Potential Implication of miR-21, miR-200a and miR-141 in Melanoma Pathway.

Clin Cancer Drugs 2015;2(2):138-147

Department of Biological Sciences, Border Biomedical Research Center, the University of Texas at El Paso, 500 West University Ave. El Paso, Texas, 79968, USA; Cytometry, Screening and Imaging Core Facility, Border Biomedical Research Center, Department of Biological Sciences, the University of Texas at El Paso, El Paso, Texas, 79968, USA.

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http://dx.doi.org/10.2174/2212697X02666150629174704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819983PMC
January 2015

Analysis of Janus tyrosine kinase phosphorylation and activation.

Methods Mol Biol 2013 ;967:3-20

Department of Biological Sciences, The University of Texas at El Paso, El Paso, TX, USA.

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http://dx.doi.org/10.1007/978-1-62703-242-1_1DOI Listing
June 2013

Forskolin-inducible cAMP pathway negatively regulates T-cell proliferation by uncoupling the interleukin-2 receptor complex.

J Biol Chem 2013 Mar 22;288(10):7137-46. Epub 2013 Jan 22.

Department of Biological Sciences, The University of Texas at El Paso, El Paso, Texas 79902, USA.

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http://dx.doi.org/10.1074/jbc.M112.408765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591623PMC
March 2013

Protein phosphatase 2A regulates interleukin-2 receptor complex formation and JAK3/STAT5 activation.

J Biol Chem 2010 Feb 18;285(6):3582-91. Epub 2009 Nov 18.

Department of Biological Sciences, University of Texas, El Paso, Texas 79968, USA.

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http://dx.doi.org/10.1074/jbc.M109.053843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823499PMC
February 2010

STAT3: an important regulator of multiple cytokine functions.

Transplantation 2008 May;85(10):1372-7

Department of Medical Microbiology and Immunology, University of Toledo, College of Medicine, Toledo, OH 43614, USA.

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http://pdfs.journals.lww.com/transplantjournal/2008/05270/ST
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/TP.0b013e3181739d25DOI Listing
May 2008

Phosphorylation of human Jak3 at tyrosines 904 and 939 positively regulates its activity.

Mol Cell Biol 2008 Apr 4;28(7):2271-82. Epub 2008 Feb 4.

Department of Biological Sciences, Biosciences Building, University of Texas at El Paso, 500 W. University Ave., El Paso, TX 79902, USA.

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http://dx.doi.org/10.1128/MCB.01789-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268424PMC
April 2008

The PHB1/2 phosphocomplex is required for mitochondrial homeostasis and survival of human T cells.

J Biol Chem 2008 Feb 17;283(8):4699-713. Epub 2007 Dec 17.

Department of Biological Sciences, University of Texas, El Paso, Texas 79902, USA.

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http://dx.doi.org/10.1074/jbc.M708232200DOI Listing
February 2008

Regulation of T cell homeostasis by JAKs and STATs.

Arch Immunol Ther Exp (Warsz) 2007 Jul-Aug;55(4):231-45. Epub 2007 Jul 23.

Department of Biological Sciences, University of Texas at El Paso, 500 W. University Ave., El Paso, TX, 79902, USA.

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http://dx.doi.org/10.1007/s00005-007-0030-xDOI Listing
October 2007

Autocrine release of interleukin-9 promotes Jak3-dependent survival of ALK+ anaplastic large-cell lymphoma cells.

Blood 2006 Oct 8;108(7):2407-15. Epub 2006 Jun 8.

Department of Hematopathology, Box 72, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.

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http://dx.doi.org/10.1182/blood-2006-04-020305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895569PMC
October 2006

A preferential role for STAT5, not constitutively active STAT3, in promoting survival of a human lymphoid tumor.

J Immunol 2006 Oct;177(8):5032-40

Department of Biological Sciences, University of Texas, El Paso, TX 79968, USA.

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http://dx.doi.org/10.4049/jimmunol.177.8.5032DOI Listing
October 2006

Janus tyrosine kinases and signal transducers and activators of transcription regulate critical functions of T cells in allograft rejection and transplantation tolerance.

Transplantation 2006 Aug;82(3):295-303

Department of Surgery, Division of Organ Transplantation, University of Texas Health Science Center at Houston, 77030, USA.

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https://insights.ovid.com/crossref?an=00007890-200608150-000
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http://dx.doi.org/10.1097/01.tp.0000228903.03118.beDOI Listing
August 2006

Allograft rejection requires STAT5a/b-regulated antiapoptotic activity in T cells but not B cells.

J Immunol 2006 Jan;176(1):128-37

Division of Immunology and Organ Transplantation, Department of Surgery, University of Texas Medical School, Houston, TX 77030, USA.

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http://dx.doi.org/10.4049/jimmunol.176.1.128DOI Listing
January 2006

The Mannich base NC1153 promotes long-term allograft survival and spares the recipient from multiple toxicities.

J Immunol 2005 Oct;175(7):4236-46

Division of Immunology and Organ Transplantation, Department of Surgery, University of Texas Medical School at Houston, Houston, TX 77030, USA.

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http://dx.doi.org/10.4049/jimmunol.175.7.4236DOI Listing
October 2005

Regulation of lymphoid cell apoptosis by Jaks and Stats.

Crit Rev Immunol 2004 ;24(2):87-110

University of Texas Health Science Center at Houston, Department of Integrative Biology and Pharmacology, 77030, USA.

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March 2005

Selectin inhibitor bimosiamose prolongs survival of kidney allografts by reduction in intragraft production of cytokines and chemokines.

J Am Soc Nephrol 2004 Nov;15(11):2893-901

Division of Immunology and Organ Transplantation, Department of Surgery, The University of Texas Medical School-Houston, 6431 Fannin, Suite 6.240, Houston, TX 77030, USA.

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http://dx.doi.org/10.1097/01.ASN.0000142425.23036.ACDOI Listing
November 2004

Interleukin 4 regulates phosphorylation of serine 756 in the transactivation domain of Stat6. Roles for multiple phosphorylation sites and Stat6 function.

J Biol Chem 2004 Jun 6;279(24):25196-203. Epub 2004 Apr 6.

Department of Integrative Biology and Pharmacology, The University of Texas Medical School, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1074/jbc.M313668200DOI Listing
June 2004

Specific inhibition of Stat5a/b promotes apoptosis of IL-2-responsive primary and tumor-derived lymphoid cells.

J Immunol 2003 Oct;171(8):3919-27

Department of Integrative Biology and Pharmacology, University of Texas Medical School, Houston, TX 77030, USA.

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http://dx.doi.org/10.4049/jimmunol.171.8.3919DOI Listing
October 2003

Allochimeric class I MHC protein-induced tolerance by partial TCR engagement requires activation of both CTL4- and common gamma-chain-dependent cytokine signals.

Transplantation 2002 Apr;73(8):1227-35

Division of Immunology and Organ Transplantation, Department of Surgery, The University of Texas Medical School at Houston, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1097/00007890-200204270-00007DOI Listing
April 2002