Publications by authors named "Robert A Casero"

99Publications

Epigenetic Reexpression of Hemoglobin F Using Reversible LSD1 Inhibitors: Potential Therapies for Sickle Cell Disease.

ACS Omega 2020 Jun 9;5(24):14750-14758. Epub 2020 Jun 9.

Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, 70 President St., Charleston, South Carolina 29414, United States.

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http://dx.doi.org/10.1021/acsomega.0c01585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315572PMC
June 2020

A phase I dose-escalation study of the polyamine analog PG-11047 in patients with advanced solid tumors.

Cancer Chemother Pharmacol 2020 Jun 23;85(6):1089-1096. Epub 2020 May 23.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, 1650 Orleans Street, CRB 1, Room 551, Baltimore, MD, 21287, USA.

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http://dx.doi.org/10.1007/s00280-020-04082-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337042PMC
June 2020

Autophagy induction by exogenous polyamines is an artifact of bovine serum amine oxidase activity in culture serum.

J Biol Chem 2020 Jul 19;295(27):9061-9068. Epub 2020 May 19.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland, USA

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http://dx.doi.org/10.1074/jbc.RA120.013867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335804PMC
July 2020

Elevation of cellular Mg levels by the Mg transporter, Alr1, supports growth of polyamine-deficient cells.

J Biol Chem 2019 11 22;294(45):17131-17142. Epub 2019 Sep 22.

Molecular and Cellular Biochemistry Section, NIDCR, National Institutes of Health, Bethesda, Maryland 20892

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http://dx.doi.org/10.1074/jbc.RA119.009705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851305PMC
November 2019

Dual inhibitors of LSD1 and spermine oxidase.

Medchemcomm 2019 May 8;10(5):778-790. Epub 2019 Feb 8.

Department of Drug Discovery and Biomedical Sciences , Medical University of South Carolina , 70 President St. , Charleston , SC 29425 , USA . Email:

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http://dx.doi.org/10.1039/c8md00610eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533887PMC
May 2019

Polyamine Homeostasis in Snyder-Robinson Syndrome.

Med Sci (Basel) 2018 Dec 7;6(4). Epub 2018 Dec 7.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.3390/medsci6040112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318755PMC
December 2018

Polyamine catabolism and oxidative damage.

J Biol Chem 2018 11 17;293(48):18736-18745. Epub 2018 Oct 17.

From the Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 and

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http://www.jbc.org/lookup/doi/10.1074/jbc.TM118.003337
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http://dx.doi.org/10.1074/jbc.TM118.003337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290137PMC
November 2018

Polyamine metabolism and cancer: treatments, challenges and opportunities.

Nat Rev Cancer 2018 11;18(11):681-695

Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA, USA.

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http://dx.doi.org/10.1038/s41568-018-0050-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487480PMC
November 2018

Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies.

PLoS One 2018 23;13(8):e0202677. Epub 2018 Aug 23.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202677PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107220PMC
February 2019

Polymeric Prodrugs Targeting Polyamine Metabolism Inhibit Zika Virus Replication.

Mol Pharm 2018 09 6;15(9):4284-4295. Epub 2018 Aug 6.

Department of Pharmacology and Experimental Neuroscience , University of Nebraska Medical Center , Omaha , Nebraska 68198 , United States.

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http://dx.doi.org/10.1021/acs.molpharmaceut.8b00068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538062PMC
September 2018

Corrigendum to "Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures" [Bioorg. Med. Chem. 23 (2015) 1601-1612].

Bioorg Med Chem 2018 07 30;26(12):3728-3729. Epub 2018 May 30.

Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, 70 President St., Charleston, SC 29425, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2018.05.032DOI Listing
July 2018

Efficacy and Safety of Curcumin in Treatment of Intestinal Adenomas in Patients With Familial Adenomatous Polyposis.

Gastroenterology 2018 09 23;155(3):668-673. Epub 2018 May 23.

Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085183456
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http://dx.doi.org/10.1053/j.gastro.2018.05.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120769PMC
September 2018

Coupling of the polyamine and iron metabolism pathways in the regulation of proliferation: Mechanistic links to alterations in key polyamine biosynthetic and catabolic enzymes.

Biochim Biophys Acta Mol Basis Dis 2018 09 16;1864(9 Pt B):2793-2813. Epub 2018 May 16.

Molecular Pharmacology and Pathology Program, Department of Pathology and Bosch Institute, University of Sydney, Sydney, New South Wales 2006, Australia; Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2018.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487307PMC
September 2018

N-Nonyl-1,4-diaminobutane ameliorates brain infarction size in photochemically induced thrombosis model mice.

Neurosci Lett 2018 04 22;672:118-122. Epub 2018 Feb 22.

Laboratory of Bioorganic Chemistry, Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyaki-dai, Sakado, Saitama 350-0295, Japan.

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http://dx.doi.org/10.1016/j.neulet.2018.01.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884741PMC
April 2018

Regulation of Polyamine Metabolism by Curcumin for Cancer Prevention and Therapy.

Med Sci (Basel) 2017 Dec 18;5(4). Epub 2017 Dec 18.

Johns Hopkins University, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA.

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http://www.mdpi.com/2076-3271/5/4/38
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http://dx.doi.org/10.3390/medsci5040038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753667PMC
December 2017

Elucidating the Structure of -Acetylisoputreanine: A Novel Polyamine Catabolite in Human Urine.

ACS Omega 2017 Jul 25;2(7):3921-3930. Epub 2017 Jul 25.

Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, 1682 Campus Delivery, Fort Collins, Colorado 80523, United States.

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http://dx.doi.org/10.1021/acsomega.7b00872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537715PMC
July 2017

Targeting hexokinase 2 inhibition promotes radiosensitization in HPV16 E7-induced cervical cancer and suppresses tumor growth.

Int J Oncol 2017 Jun 2;50(6):2011-2023. Epub 2017 May 2.

Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, P.R. China.

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http://dx.doi.org/10.3892/ijo.2017.3979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435328PMC
June 2017

Biochemical evaluation of the anticancer potential of the polyamine-based nanocarrier Nano11047.

PLoS One 2017 19;12(4):e0175917. Epub 2017 Apr 19.

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0175917PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396973PMC
April 2017

Self-immolative nanoparticles for simultaneous delivery of microRNA and targeting of polyamine metabolism in combination cancer therapy.

J Control Release 2017 01 23;246:110-119. Epub 2016 Dec 23.

Center for Drug Delivery and Nanomedicine, Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2016.12.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5258827PMC
January 2017

Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue.

J Med Chem 2016 12 21;59(23):10642-10660. Epub 2016 Nov 21.

Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo , 2801, W. Bancroft Street, Toledo, Ohio 43606, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574184PMC
December 2016

Targeting polyamine metabolism for cancer therapy and prevention.

Biochem J 2016 10;473(19):2937-53

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 1650 Orleans Street, Bunting, Blaustein Building, Room 551, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1042/BCJ20160383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711482PMC
October 2016

Decrease in acrolein toxicity based on the decline of polyamine oxidases.

Int J Biochem Cell Biol 2016 10 30;79:151-157. Epub 2016 Aug 30.

Amine Pharma Research Institute, Innovation Plaza at Chiba University, 1-8-15 Inohana, Chuo-ku, Chiba, 260-0856, Japan; Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2016.08.039DOI Listing
October 2016

MOF Acetylates the Histone Demethylase LSD1 to Suppress Epithelial-to-Mesenchymal Transition.

Cell Rep 2016 06 9;15(12):2665-78. Epub 2016 Jun 9.

Department of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL 32610, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.05.050DOI Listing
June 2016

Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection.

Amino Acids 2016 10 13;48(10):2375-88. Epub 2016 Apr 13.

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Vanderbilt University School of Medicine, 2215 Garland Avenue, 1030C Medical Research Building IV, Nashville, TN, 37232, USA.

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http://dx.doi.org/10.1007/s00726-016-2231-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042810PMC
October 2016

Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures.

Bioorg Med Chem 2015 Apr 7;23(7):1601-12. Epub 2015 Feb 7.

Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, 70 President St., Charleston, SC 29425, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09680896150007
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http://dx.doi.org/10.1016/j.bmc.2015.01.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396983PMC
April 2015

Proximal tubule epithelial cell specific ablation of the spermidine/spermine N1-acetyltransferase gene reduces the severity of renal ischemia/reperfusion injury.

PLoS One 2014 12;9(11):e110161. Epub 2014 Nov 12.

Division of Nephrology and Hypertension, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America; Veterans Affair Medical Center, Cincinnati, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0110161PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229091PMC
July 2015

Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups.

Eur J Med Chem 2014 Oct 6;86:528-41. Epub 2014 Sep 6.

Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, 2801, W. Bancroft Street, Toledo, OH 43606, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188730PMC
October 2014

A selective phenelzine analogue inhibitor of histone demethylase LSD1.

ACS Chem Biol 2014 Jun 7;9(6):1284-93. Epub 2014 Apr 7.

Department of Pharmacology, ∥Center for Epigenetics and Department of Medicine, ⊥Department of Ophthalmology, and ¶The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine , Baltimore, Maryland 21205, United States.

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http://pubs.acs.org/doi/10.1021/cb500018s
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http://dx.doi.org/10.1021/cb500018sDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076021PMC
June 2014

Activation of EGFR and ERBB2 by Helicobacter pylori results in survival of gastric epithelial cells with DNA damage.

Gastroenterology 2014 Jun 13;146(7):1739-51.e14. Epub 2014 Feb 13.

Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2014.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035375PMC
June 2014

Say what? The activity of the polyamine biosynthesis inhibitor difluoromethylornithine in chemoprevention is a result of reduced thymidine pools?

Authors:
Robert A Casero

Cancer Discov 2013 Sep;3(9):975-7

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786367PMC
September 2013

Histone deacetylase inhibition overcomes drug resistance through a miRNA-dependent mechanism.

Mol Cancer Ther 2013 Oct 13;12(10):2088-99. Epub 2013 Aug 13.

Corresponding Author: Robert A. Casero, Jr., CRB 1 Room 551, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 1650 Orleans Street, Bunting Blaustein Building, Baltimore, MD 21287.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-13
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http://dx.doi.org/10.1158/1535-7163.MCT-13-0418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808125PMC
October 2013

Spermine oxidase is a regulator of macrophage host response to Helicobacter pylori: enhancement of antimicrobial nitric oxide generation by depletion of spermine.

Amino Acids 2014 Mar 3;46(3):531-42. Epub 2013 Jul 3.

Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, 1030C MRBIV, 2215 Garland Avenue, Nashville, TN, 37232, USA.

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http://dx.doi.org/10.1007/s00726-013-1531-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812355PMC
March 2014

Polyamine catabolism in carcinogenesis: potential targets for chemotherapy and chemoprevention.

Amino Acids 2014 Mar 15;46(3):511-9. Epub 2013 Jun 15.

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Bunting Blaustein Bldg., Room 551, 1650 Orleans Street, Baltimore, MD, 21287, USA.

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http://dx.doi.org/10.1007/s00726-013-1529-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795954PMC
March 2014

The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines.

Amino Acids 2014 Mar 19;46(3):585-94. Epub 2013 Mar 19.

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Bunting Blaustein Bldg, Room 551, 1650 Orleans Street, Baltimore, MD, 21287, USA.

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http://dx.doi.org/10.1007/s00726-013-1485-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692581PMC
March 2014

Polyamines and cancer: implications for chemotherapy and chemoprevention.

Expert Rev Mol Med 2013 Feb 22;15:e3. Epub 2013 Feb 22.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1017/erm.2013.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027058PMC
February 2013

Loss of LSD1 (lysine-specific demethylase 1) suppresses growth and alters gene expression of human colon cancer cells in a p53- and DNMT1(DNA methyltransferase 1)-independent manner.

Biochem J 2013 Jan;449(2):459-68

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1042/BJ20121360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525012PMC
January 2013

Role of ornithine decarboxylase in regulation of estrogen receptor alpha expression and growth in human breast cancer cells.

Breast Cancer Res Treat 2012 Nov 14;136(1):57-66. Epub 2012 Sep 14.

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.1007/s10549-012-2235-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715085PMC
November 2012

Low molecular weight amidoximes that act as potent inhibitors of lysine-specific demethylase 1.

J Med Chem 2012 Sep 4;55(17):7378-91. Epub 2012 Sep 4.

Department of Pharmaceutical Sciences, Wayne State University, 259 Mack Avenue, Detroit, Michigan 48202, USA.

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http://dx.doi.org/10.1021/jm3002845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482425PMC
September 2012

Hepatocyte-specific ablation of spermine/spermidine-N1-acetyltransferase gene reduces the severity of CCl4-induced acute liver injury.

Am J Physiol Gastrointest Liver Physiol 2012 Sep 21;303(5):G546-60. Epub 2012 Jun 21.

Division of Nephrology and Hypertension, Department of Medicine, University of Cincinnati College of Medicine, Ohio, USA.

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http://dx.doi.org/10.1152/ajpgi.00431.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468550PMC
September 2012

Polyamine-regulated translation of spermidine/spermine-N1-acetyltransferase.

Mol Cell Biol 2012 Apr 21;32(8):1453-67. Epub 2012 Feb 21.

Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1128/MCB.06444-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318587PMC
April 2012

Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes.

Biochem J 2012 Mar;442(3):693-701

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1042/BJ20111271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286856PMC
March 2012

Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands.

Cancer Cell 2011 Nov;20(5):606-19

Department of Oncology and The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1016/j.ccr.2011.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220885PMC
November 2011

Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: synthesis and biological evaluation.

J Med Chem 2011 Nov 10;54(21):7453-63. Epub 2011 Oct 10.

Department of Medicinal and Biological Chemistry, The University of Toledo, OH 43606, USA.

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http://dx.doi.org/10.1021/jm200432aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208063PMC
November 2011

Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis.

Proc Natl Acad Sci U S A 2011 Sep 29;108(37):15354-9. Epub 2011 Aug 29.

Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1073/pnas.1010203108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174648PMC
September 2011

Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA.

Gastroenterology 2011 Nov 10;141(5):1696-708.e1-2. Epub 2011 Aug 10.

Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232-0252, USA.

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http://dx.doi.org/10.1053/j.gastro.2011.07.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202654PMC
November 2011

Knockdown of ornithine decarboxylase antizyme 1 causes loss of uptake regulation leading to increased N1, N11-bis(ethyl)norspermine (BENSpm) accumulation and toxicity in NCI H157 lung cancer cells.

Amino Acids 2012 Feb 4;42(2-3):529-38. Epub 2011 Aug 4.

Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Bunting-Blaustein Cancer Research Building 1, 1650 Orleans Street, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1007/s00726-011-1030-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240712PMC
February 2012

Polyamine analogs modulate gene expression by inhibiting lysine-specific demethylase 1 (LSD1) and altering chromatin structure in human breast cancer cells.

Amino Acids 2012 Feb 30;42(2-3):887-98. Epub 2011 Jul 30.

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

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http://link.springer.com/10.1007/s00726-011-1004-1
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http://dx.doi.org/10.1007/s00726-011-1004-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240695PMC
February 2012

Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction.

PLoS One 2011 Feb 28;6(2):e17510. Epub 2011 Feb 28.

Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0017510PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046249PMC
February 2011

A simple assay for mammalian spermine oxidase: a polyamine catabolic enzyme implicated in drug response and disease.

Methods Mol Biol 2011 ;720:173-81

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1007/978-1-61779-034-8_10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652264PMC
May 2011

Current status of the polyamine research field.

Methods Mol Biol 2011 ;720:3-35

College of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, PA, USA.

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http://dx.doi.org/10.1007/978-1-61779-034-8_1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652263PMC
May 2011

(Bis)urea and (bis)thiourea inhibitors of lysine-specific demethylase 1 as epigenetic modulators.

J Med Chem 2010 Jul;53(14):5197-212

Department of Pharmaceutical Sciences, Wayne State University, 259 Mack Avenue, Detroit, Michigan 48202, USA.

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http://dx.doi.org/10.1021/jm100217aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920492PMC
July 2010

Id1 overexpression is independent of repression and epigenetic silencing of tumor suppressor genes in melanoma.

Epigenetics 2010 Jul 1;5(5):410-21. Epub 2010 Jul 1.

Cancer Biology Program, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.4161/epi.5.5.11929DOI Listing
July 2010

Suppression of exogenous gene expression by spermidine/spermine N1-acetyltransferase 1 (SSAT1) cotransfection.

J Biol Chem 2010 May 8;285(20):15548-56. Epub 2010 Mar 8.

Oral and Pharyngeal Cancer Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1074/jbc.M109.092007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865325PMC
May 2010

Increased expression and cellular localization of spermine oxidase in ulcerative colitis and relationship to disease activity.

Inflamm Bowel Dis 2010 Sep;16(9):1557-66

Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232-0252, USA.

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http://dx.doi.org/10.1002/ibd.21224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894261PMC
September 2010

Polyamine analogues targeting epigenetic gene regulation.

Essays Biochem 2009 Nov 4;46:95-110. Epub 2009 Nov 4.

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1042/bse0460007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564236PMC
November 2009

Design of polyamine-based therapeutic agents: new targets and new directions.

Essays Biochem 2009 Nov 4;46:77-94. Epub 2009 Nov 4.

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48202, USA.

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http://dx.doi.org/10.1042/bse0460006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564240PMC
November 2009

Metabolism of N-alkylated spermine analogues by polyamine and spermine oxidases.

Amino Acids 2010 Feb 10;38(2):369-81. Epub 2009 Dec 10.

Laboratory of Chemistry, Department of Biosciences, Biocenter Kuopio, University of Kuopio, P.O.Box 1627, 70211, Kuopio, Finland.

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http://dx.doi.org/10.1007/s00726-009-0429-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992990PMC
February 2010

Polyamine catabolism is enhanced after traumatic brain injury.

J Neurotrauma 2010 Mar;27(3):515-25

Department of Internal Medicine, Division of Nephrology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1089/neu.2009.1097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867553PMC
March 2010

Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes.

Clin Cancer Res 2009 Dec 24;15(23):7217-28. Epub 2009 Nov 24.

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-1293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927136PMC
December 2009

Polyamine catabolism and disease.

Biochem J 2009 Jul 15;421(3):323-38. Epub 2009 Jul 15.

Department of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1042/BJ20090598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756025PMC
July 2009

Recent advances in the development of polyamine analogues as antitumor agents.

J Med Chem 2009 Aug;52(15):4551-73

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1021/jm900187vDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762202PMC
August 2009

Nuclear localization of human spermine oxidase isoforms - possible implications in drug response and disease etiology.

FEBS J 2008 Jun 17;275(11):2795-806. Epub 2008 Apr 17.

Department of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1111/j.1742-4658.2008.06419.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631774PMC
June 2008

Polyaminohydroxamic acids and polyaminobenzamides as isoform selective histone deacetylase inhibitors.

J Med Chem 2008 Apr 19;51(8):2447-56. Epub 2008 Mar 19.

Department of Pharmaceutical Sciences, Wayne State University, 259 Mack Avenue, Detroit, Michigan 48202, USA.

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http://dx.doi.org/10.1021/jm701384xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556737PMC
April 2008

Increased spermine oxidase expression in human prostate cancer and prostatic intraepithelial neoplasia tissues.

Prostate 2008 May;68(7):766-72

Department of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1002/pros.20735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065872PMC
May 2008

In vitro and in vivo effects of the conformationally restricted polyamine analogue CGC-11047 on small cell and non-small cell lung cancer cells.

Cancer Chemother Pharmacol 2008 Dec 27;63(1):45-53. Epub 2008 Feb 27.

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

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http://link.springer.com/10.1007/s00280-008-0706-x
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http://dx.doi.org/10.1007/s00280-008-0706-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634589PMC
December 2008

Activation of polyamine catabolism by N1,N11-diethylnorspermine leads to cell death in glioblastoma.

Int J Oncol 2007 Aug;31(2):431-40

Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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August 2007

Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases.

Nat Rev Drug Discov 2007 May;6(5):373-90

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1038/nrd2243DOI Listing
May 2007

Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes.

Proc Natl Acad Sci U S A 2007 May 26;104(19):8023-8. Epub 2007 Apr 26.

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Bunting-Blaustein Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1073/pnas.0700720104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1857229PMC
May 2007

The role of spermidine/spermine N1-acetyltransferase in determining response to chemotherapeutic agents in colorectal cancer cells.

Mol Cancer Ther 2007 Jan;6(1):128-37

Department of Oncology, Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast City Hospital, University Floor, Belfast City Hospital, Lisburn Road, Belfast, BT9 7AB, Northern Ireland.

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http://dx.doi.org/10.1158/1535-7163.MCT-06-0303DOI Listing
January 2007

Tumor necrosis factor-alpha increases reactive oxygen species by inducing spermine oxidase in human lung epithelial cells: a potential mechanism for inflammation-induced carcinogenesis.

Cancer Res 2006 Dec;66(23):11125-30

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-3174DOI Listing
December 2006

Tumor necrosis factor alpha induces spermidine/spermine N1-acetyltransferase through nuclear factor kappaB in non-small cell lung cancer cells.

J Biol Chem 2006 Aug 6;281(34):24182-92. Epub 2006 Jun 6.

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1074/jbc.M601871200DOI Listing
August 2006

Polyamine analogues down-regulate estrogen receptor alpha expression in human breast cancer cells.

J Biol Chem 2006 Jul 4;281(28):19055-63. Epub 2006 May 4.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1074/jbc.M600910200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623667PMC
July 2006

Mammalian polyamine catabolism: a therapeutic target, a pathological problem, or both?

J Biochem 2006 Jan;139(1):17-25

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, Maryland, 21231, USA.

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http://dx.doi.org/10.1093/jb/mvj021DOI Listing
January 2006

Significance of targeting polyamine metabolism as an antineoplastic strategy: unique targets for polyamine analogues.

Proc West Pharmacol Soc 2005 ;48:24-30

Johns Hopkins University School of Medicine, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21231, USA.

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January 2006

Significance of targeting polyamine metabolism as an antineoplastic strategy: unique targets for polyamine analogues.

Proc West Pharmacol Soc 2005 ;48:24-30

Johns Hopkins University School of Medicine, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21231, USA.

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January 2006

Induction of spermidine/spermine N1-acetyltransferase (SSAT) by aspirin in Caco-2 colon cancer cells.

Biochem J 2006 Feb;394(Pt 1):317-24

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1042/BJ20051298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1386030PMC
February 2006