Robert A Bonomo

Robert A Bonomo

UNVERIFIED PROFILE

Are you Robert A Bonomo?   Register this Author

Register author
Robert A Bonomo

Robert A Bonomo

Publications by authors named "Robert A Bonomo"

Are you Robert A Bonomo?   Register this Author

100Publications

1187Reads

17Profile Views

Ceftolozane/Tazobactam vs Polymyxin or Aminoglycoside-based Regimens for the Treatment of Drug-resistant Pseudomonas aeruginosa.

Clin Infect Dis 2020 Jul;71(2):304-310

Division of Infectious Diseases and HIV Medicine, Louis Stokes Cleveland VA Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cid/ciz816DOI Listing
July 2020

Molecular and clinical epidemiology of carbapenem-resistant Enterobacterales in the USA (CRACKLE-2): a prospective cohort study.

Lancet Infect Dis 2020 Jun 6;20(6):731-741. Epub 2020 Mar 6.

Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA; Departments of Pharmacology, Molecular Biology and Microbiology, Biochemistry, and Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, OH, USA; CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology, Cleveland, OH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1473-3099(19)30755-8DOI Listing
June 2020

Colistin resistance in China: from outer membrane to One Health.

Lancet Infect Dis 2020 Jun 4. Epub 2020 Jun 4.

Veterans Affairs (VA) Northeast Ohio Healthcare System, Cleveland, OH 44106, USA; Center for Antimicrobial Resistance and Epidemiology, Cleveland VA Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1473-3099(20)30242-5DOI Listing
June 2020

Shedding of multidrug-resistant gram-negative bacilli by colonized patients during procedures and patient care activities.

Am J Infect Control 2020 Jun 6. Epub 2020 Jun 6.

Geriatric Research, Education and Clinical Center, Louis Stokes Cleveland VA Medical Center, Cleveland, OH; Case Western Reserve University School of Medicine, Cleveland, OH. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajic.2020.06.004DOI Listing
June 2020

Core genome MLST and resistome analysis of Klebsiella pneumoniae using a clinically amenable workflow.

Diagn Microbiol Infect Dis 2020 May 21;97(1):114996. Epub 2020 Jan 21.

Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, MN; Division of Clinical Microbiology, Mayo Clinic, Rochester, MN.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.diagmicrobio.2020.114996DOI Listing
May 2020

Carbapenemases: Transforming into a Yet More Dangerous Menace.

Biomolecules 2020 May 6;10(5). Epub 2020 May 6.

Center for Applied Biotechnology Studies, Department of Biological Science, California State University Fullerton, Fullerton, CA 92831, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/biom10050720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277208PMC
May 2020

The Role of the Microbiota-Gut-Brain Axis and Antibiotics in ALS and Neurodegenerative Diseases.

Microorganisms 2020 May 23;8(5). Epub 2020 May 23.

Research Service, Louis Stokes Cleveland, Department of Veteran's Affairs Medical Center, Cleveland, OH 44106, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/microorganisms8050784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285349PMC
May 2020

Case Report: Successful Rescue Therapy of Extensively Drug-Resistant Osteomyelitis With Cefiderocol.

Open Forum Infect Dis 2020 May 5;7(5):ofaa150. Epub 2020 May 5.

Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ofid/ofaa150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252278PMC
May 2020

Distinct Mechanisms of Dissemination of NDM-1 Metallo-β-Lactamase in Species in Argentina.

Antimicrob Agents Chemother 2020 04 21;64(5). Epub 2020 Apr 21.

Center for Applied Biotechnology Studies, Department of Biological Science, College of Natural Sciences and Mathematics, California State University Fullerton, Fullerton, California, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.00324-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179578PMC
April 2020

Precision Medicine and Mysteries in Clinical Microbiology: Rationalizing Epidemiology, Genotype, and Phenotype To Guide Therapeutics.

Antimicrob Agents Chemother 2020 01 27;64(2). Epub 2020 Jan 27.

Medical and Research Services and Geriatrics Research, Education and Clinical Center (GRECC), VA Northeast Ohio Healthcare System and Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.02264-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985733PMC
January 2020

Reply to Vena, et al.

Clin Infect Dis 2020 Jan 6. Epub 2020 Jan 6.

Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cid/ciaa004DOI Listing
January 2020

Cryo-electron Microscopy Structure of the Acinetobacter baumannii 70S Ribosome and Implications for New Antibiotic Development.

mBio 2020 01 21;11(1). Epub 2020 Jan 21.

Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/mBio.03117-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974574PMC
January 2020

Cefiderocol: A Novel Siderophore Cephalosporin Defeating Carbapenem-resistant Pathogens.

Authors:
Robert A Bonomo

Clin Infect Dis 2019 11;69(Suppl 7):S519-S520

Medical Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Case Western Reserve University, Cleveland, Ohio.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cid/ciz823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853757PMC
November 2019

Acinetobacter infections.

Clin Infect Dis 2019 Nov 17. Epub 2019 Nov 17.

Medicine, Education and Clinical Center, VA Northeast Ohio Healthcare System and Louis Stokes Cleveland VA Medical Center, Cleveland, OH.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cid/ciz1099DOI Listing
November 2019

Reply to Humphrey and Spafford.

Clin Infect Dis 2019 10;69(10):1831-1832

The Biostatistics Center and the Department of Epidemiology and Biostatistics, George Washington University, Rockville, Maryland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cid/ciz228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821162PMC
October 2019

Therapeutic Efficacy of LN-1-255 in Combination with Imipenem in Severe Infection Caused by Carbapenem-Resistant Acinetobacter baumannii.

Antimicrob Agents Chemother 2019 10 23;63(10). Epub 2019 Sep 23.

Servicio de Microbiología do Complexo Hospitalario Universitario da Coruña (CHUAC), Instituto de Investigación Biomédica da Coruña (INIBIC)-Centro de Investigacións Científicas Avanzadas (CICA), A Coruña, Spain

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.01092-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761515PMC
October 2019

Longitudinal Colonization With Streptococcus pneumoniae During the First Year of Life in a Healthy Newborn Cohort.

J Pediatric Infect Dis Soc 2019 Oct 31. Epub 2019 Oct 31.

Department of Medicine, Case Western Reserve School of Medicine, Cleveland, Ohio, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jpids/piz068DOI Listing
October 2019

A Primer on AmpC β-Lactamases: Necessary Knowledge for an Increasingly Multidrug-resistant World.

Clin Infect Dis 2019 09;69(8):1446-1455

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cid/ciz173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763639PMC
September 2019

Structural Insights into the Inhibition of the Extended-Spectrum β-Lactamase PER-2 by Avibactam.

Antimicrob Agents Chemother 2019 09 23;63(9). Epub 2019 Aug 23.

Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Microbiología, Inmunología y Biotecnología, Laboratorio de Resistencia Bacteriana, Buenos Aires, Argentina

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.00487-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709463PMC
September 2019

Multidrug-Resistant Gram-Negative Pathogens: The Urgent Need for 'Old' Polymyxins.

Adv Exp Med Biol 2019 ;1145:9-13

Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-3-030-16373-0_2DOI Listing
September 2019

Patient-to-Patient Transmission of Acinetobacter baumannii Gastrointestinal Colonization in the Intensive Care Unit.

Antimicrob Agents Chemother 2019 08 25;63(8). Epub 2019 Jul 25.

Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.00392-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658781PMC
August 2019

Protein determinants of dissemination and host specificity of metallo-β-lactamases.

Nat Commun 2019 08 9;10(1):3617. Epub 2019 Aug 9.

Instituto de Biología Molecular y Celular de Rosario (IBR, CONICET-UNR), S2000EZP, Rosario, Argentina.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-019-11615-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689000PMC
August 2019

Human Pleural Fluid Elicits Pyruvate and Phenylalanine Metabolism in to Enhance Cytotoxicity and Immune Evasion.

Front Microbiol 2019 17;10:1581. Epub 2019 Jul 17.

Center for Applied Biotechnology Studies, Department of Biological Science, College of Natural Sciences and Mathematics, California State University, Fullerton, Fullerton, CA, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2019.01581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650585PMC
July 2019

Identification of Potential Virulence Factors in the Model Strain A118.

Front Microbiol 2019 23;10:1599. Epub 2019 Jul 23.

Department of Biological Science, Center for Applied Biotechnology Studies, California State University, Fullerton, Fullerton, CA, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2019.01599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663985PMC
July 2019

Carbapenem-resistant Enterobacteriaceae: global action required.

Lancet Infect Dis 2019 06 29;19(6):561-562. Epub 2019 Apr 29.

Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106, USA; Case Western Reserve University and Veterans Affairs Center for Antimicrobial Resistance and Epidemiology, Cleveland, OH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1473-3099(19)30210-5DOI Listing
June 2019

Cardiac Devices Enveloped with an Ounce of Prevention.

N Engl J Med 2019 05;380(20):1965-1966

From the Medical Service, Veterans Affairs Northeast Ohio Healthcare System, Case Western Reserve University Veterans Affairs Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), and the Department of Medicine, University Hospitals Cleveland Medical Center - all in Cleveland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMe1905678DOI Listing
May 2019

H, C, and N backbone resonance assignments for KPC-2, a class A serine-β-lactamase.

Biomol NMR Assign 2019 04 14;13(1):139-142. Epub 2018 Dec 14.

Department of Chemistry and Biochemistry, Miami University, 651 E. High St, Oxford, OH, 45056, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12104-018-9866-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440833PMC
April 2019

Interspecies DNA acquisition by a naturally competent Acinetobacter baumannii strain.

Int J Antimicrob Agents 2019 Apr 3;53(4):483-490. Epub 2019 Jan 3.

Center for Applied Biotechnology Studies, Department of Biological Science, College of Natural Sciences and Mathematics, California State University Fullerton, Fullerton, California, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijantimicag.2018.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456398PMC
April 2019

Polymyxins: To Combine or Not to Combine?

Antibiotics (Basel) 2019 Apr 10;8(2). Epub 2019 Apr 10.

Medicine Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/antibiotics8020038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627991PMC
April 2019

Human fluids alter DNA-acquisition in Acinetobacter baumannii.

Diagn Microbiol Infect Dis 2019 Mar 23;93(3):183-187. Epub 2018 Oct 23.

Center for Applied Biotechnology Studies, Department of Biological Science, College of Natural Sciences and Mathematics, California State University Fullerton, Fullerton, California, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07328893183048
Publisher Site
http://dx.doi.org/10.1016/j.diagmicrobio.2018.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372348PMC
March 2019

Shedding of methicillin-resistant Staphylococcus aureus by colonized patients during procedures and patient care activities.

Infect Control Hosp Epidemiol 2019 03 19;40(3):328-332. Epub 2019 Feb 19.

Geriatric Research, Education and Clinical Center, Louis Stokes Cleveland VA Medical Center,Cleveland, Ohio.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/ice.2018.342DOI Listing
March 2019

Rapid Replacement of Acinetobacter baumannii Strains Accompanied by Changes in Lipooligosaccharide Loci and Resistance Gene Repertoire.

mBio 2019 03 26;10(2). Epub 2019 Mar 26.

Department of Medicine, Case Western Reserve University and CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology, Cleveland, Ohio, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/mBio.00356-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437055PMC
March 2019

Ceftazidime/Avibactam, Meropenem/Vaborbactam, or Both? Clinical and Formulary Considerations.

Clin Infect Dis 2019 01;68(3):519-524

Department of Medicine, Division of Infectious Diseases, University of Michigan Medical School, Ann Arbor.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cid/ciy576DOI Listing
January 2019

New Treatment Options against Carbapenem-Resistant Infections.

Antimicrob Agents Chemother 2019 01 21;63(1). Epub 2018 Dec 21.

The University of Queensland Centre for Clinical Research, Royal Brisbane and Women's Hospital Campus, Brisbane, Queensland, Australia

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.01110-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325237PMC
January 2019

Antibiotic collateral sensitivity is contingent on the repeatability of evolution.

Nat Commun 2019 01 18;10(1):334. Epub 2019 Jan 18.

Center for Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41467-018-08098-6
Publisher Site
http://dx.doi.org/10.1038/s41467-018-08098-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338734PMC
January 2019

Human serum albumin alters specific genes that can play a role in survival and persistence in Acinetobacter baumannii.

Sci Rep 2018 10 3;8(1):14741. Epub 2018 Oct 3.

Center for Applied Biotechnology Studies, Department of Biological Science, College of Natural Sciences and Mathematics, California State University Fullerton, Fullerton, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-33072-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170387PMC
October 2018

Epidemiology of Carbapenem-Resistant Enterobacteriaceae at a Long-term Acute Care Hospital.

Open Forum Infect Dis 2018 Oct 3;5(10):ofy224. Epub 2018 Oct 3.

Division of Infectious Diseases, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan.

View Article

Download full-text PDF

Source
https://academic.oup.com/ofid/article/doi/10.1093/ofid/ofy22
Publisher Site
http://dx.doi.org/10.1093/ofid/ofy224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168706PMC
October 2018

Ceftazidime/avibactam versus standard-of-care agents against carbapenem-resistant Enterobacteriaceae harbouring blaKPC in a one-compartment pharmacokinetic/pharmacodynamic model.

J Antimicrob Chemother 2018 09;73(9):2405-2410

Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jac/dky213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927864PMC
September 2018

Activity of Ceftazidime-Avibactam against Carbapenem-Resistant and Hypervirulent Klebsiella pneumoniae Isolates.

Antimicrob Agents Chemother 2018 08 27;62(8). Epub 2018 Jul 27.

Public Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.01031-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105775PMC
August 2018

: Defining the Role of Efflux Pumps in Resistance to Antimicrobial Therapy, Surface Motility, and Biofilm Formation.

Front Microbiol 2018 21;9:1902. Epub 2018 Aug 21.

Research Service, Atlanta Veterans Affairs Medical Center, Decatur, GA, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2018.01902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111201PMC
August 2018

The Continuing Challenge of Metallo-β-Lactamase Inhibition: Mechanism Matters.

Trends Pharmacol Sci 2018 07 18;39(7):635-647. Epub 2018 Apr 18.

Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tips.2018.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005755PMC
July 2018

Ibrutinib Therapy and Skin and Soft Tissue Infection.

Open Forum Infect Dis 2018 Jul 18;5(7):ofy168. Epub 2018 Jul 18.

Infectious Diseases Section, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ofid/ofy168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065501PMC
July 2018

Defining Substrate Specificity in the CTX-M Family: the Role of Asp240 in Ceftazidime Hydrolysis.

Antimicrob Agents Chemother 2018 06 25;62(6). Epub 2018 May 25.

Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Microbiología, Inmunología y Biotecnología, Laboratorio de Resistencia Bacteriana, Buenos Aires, Argentina.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.00116-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971610PMC
June 2018

It's too soon to pull the plug on antibiotic cycling.

Lancet Infect Dis 2018 05;18(5):493

Center for Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, OH, USA; Departments of Translational Hematology and Oncology Research and Radiation Oncology, Cleveland Clinic, Cleveland, OH 44040, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1473-3099(18)30214-7DOI Listing
May 2018

A Comparison of Cefazolin Versus Ceftriaxone for the Treatment of Methicillin-Susceptible Bacteremia in a Tertiary Care VA Medical Center.

Open Forum Infect Dis 2018 May 18;5(5):ofy089. Epub 2018 May 18.

Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ofid/ofy089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961173PMC
May 2018

Exploring Additional Dimensions of Complexity in Inhibitor Design for Serine β-Lactamases: Mechanistic and Intra- and Inter-molecular Chemistry Approaches.

Front Microbiol 2018 5;9:622. Epub 2018 Apr 5.

Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH, United States.

View Article

Download full-text PDF

Source
http://journal.frontiersin.org/article/10.3389/fmicb.2018.00
Publisher Site
http://dx.doi.org/10.3389/fmicb.2018.00622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895744PMC
April 2018