Robert A Beckman

Robert A Beckman

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Robert A Beckman

Robert A Beckman

Publications by authors named "Robert A Beckman"

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A roadmap to using historical controls in clinical trials - by Drug Information Association Adaptive Design Scientific Working Group (DIA-ADSWG).

Orphanet J Rare Dis 2020 Mar 12;15(1):69. Epub 2020 Mar 12.

Lombardi Comprehensive Cancer Center and Innovation Center for Biomedical Informatics, Georgetown University Medical Center, Washington, DC, 20007, USA.

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http://dx.doi.org/10.1186/s13023-020-1332-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069184PMC
March 2020

Multi-stage enrichment and basket trial designs with population selection.

Stat Med 2019 12 17;38(29):5470-5485. Epub 2019 Oct 17.

Departments of Oncology and of Biostatistics, Bioinformatics, and Biomathematics, Lombardi Comprehensive Cancer Center and Innovation Center for Biomedical Informatics, Georgetown University Medical Center, Washington, District of Columbia.

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http://dx.doi.org/10.1002/sim.8371DOI Listing
December 2019

Modelling bistable tumour population dynamics to design effective treatment strategies.

J Theor Biol 2019 Aug 9;474:88-102. Epub 2019 May 9.

Institute of Statistical Science, Academia Sinica, 128 Academia Rd, Sec 2, Nankang, 11529, Taipei, Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00225193193019
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http://dx.doi.org/10.1016/j.jtbi.2019.05.005DOI Listing
August 2019

Optimized adaptive enrichment designs.

Stat Methods Med Res 2019 07 18;28(7):2096-2111. Epub 2017 Dec 18.

1 Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Austria.

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http://journals.sagepub.com/doi/10.1177/0962280217747312
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http://dx.doi.org/10.1177/0962280217747312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613177PMC
July 2019

Patritumab with Cetuximab plus Platinum-Containing Therapy in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck: An Open-Label, Phase Ib Study.

Clin Cancer Res 2019 01 16;25(2):487-495. Epub 2018 Oct 16.

Royal Marsden Hospital/Institute of Cancer Research, National Institute of Health Research Biomedical Research Center, London, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-1539DOI Listing
January 2019

Adaptive expansion of biomarker populations in phase 3 clinical trials.

Contemp Clin Trials 2018 08 5;71:181-185. Epub 2018 Jul 5.

Departments of Oncology and of Biostatistics, Bioinformatics, and Biomathematics, Lombardi Comprehensive Cancer Center and Innovation Center for Biomedical Informatics, Georgetown University Medical Center, Washington, DC 20007, USA.

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http://dx.doi.org/10.1016/j.cct.2018.07.001DOI Listing
August 2018

How many tumor indications should be initially screened in development of next generation immunotherapies?

Contemp Clin Trials 2017 08 21;59:113-117. Epub 2017 Mar 21.

Department of Oncology, Lombardi Comprehensive Cancer Center, Innovation Center for Biomedical Informatics, Georgetown University Medical Center, 2115 Wisconsin Avenue, Suite 110, Washington, DC 20007, USA; Department of Biostatistics, Bioinformatics, and Biomathematics, Lombardi Comprehensive Cancer Center, Innovation Center for Biomedical Informatics, Georgetown University Medical Center, 2115 Wisconsin Avenue, Suite 110, Washington, DC 20007, USA.

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http://dx.doi.org/10.1016/j.cct.2017.03.012DOI Listing
August 2017

Evolutionary dynamics and significance of multiple subclonal mutations in cancer.

DNA Repair (Amst) 2017 08 9;56:7-15. Epub 2017 Jun 9.

Joseph Gottstein Memorial Cancer Research Laboratory, Departments of Pathology and Biochemistry, University of Washington School of Medicine, Seattle, WA, 98195 USA. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2017.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551892PMC
August 2017

Estimation of treatment effect in two-stage confirmatory oncology trials of personalized medicines.

Stat Med 2017 05 17;36(12):1843-1861. Epub 2017 Mar 17.

Departments of Oncology and of Biostatistics, Bioinformatics, and Biomathematics, Lombardi Comprehensive Cancer Center and Innovation Center for Biomedical Informatics, Georgetown University Medical Center, 2115 Wisconsin Avenue, Suite 110, Washington, DC, 20007, U.S.A.

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http://dx.doi.org/10.1002/sim.7272DOI Listing
May 2017

Long range personalized cancer treatment strategies incorporating evolutionary dynamics.

Biol Direct 2016 10 22;11(1):56. Epub 2016 Oct 22.

Departments of Oncology and of Biostatistics, Bioinformatics, and Biomathematics, Lombardi Comprehensive Cancer Center and Innovation Center for Biomedical Informatics, Georgetown University Medical Center, Washington, DC, USA.

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http://dx.doi.org/10.1186/s13062-016-0153-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075220PMC
October 2016

Optimizing Trial Designs for Targeted Therapies.

PLoS One 2016;11(9):e0163726. Epub 2016 Sep 29.

Section for Medical Statistics, Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Austria.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0163726PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042421PMC
September 2016

Translating predictive biomarkers within oncology clinical development programs.

Biomark Med 2015 2;9(9):851-62. Epub 2015 Sep 2.

Biostatistics & Research Decision Sciences, Merck Research Laboratories, Rahway, NJ, USA.

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http://dx.doi.org/10.2217/bmm.15.56DOI Listing
July 2016

Efficient, Adaptive Clinical Validation of Predictive Biomarkers in Cancer Therapeutic Development.

Adv Exp Med Biol 2015 ;867:81-90

Biostatistics and Research Decision Sciences, Merck Research Laboratories, Rahway, NJ, USA.

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http://dx.doi.org/10.1007/978-94-017-7215-0_6DOI Listing
March 2016

Phase I Imaging and Pharmacodynamic Trial of CS-1008 in Patients With Metastatic Colorectal Cancer.

J Clin Oncol 2015 Aug 29;33(24):2609-16. Epub 2015 Jun 29.

Marika Ciprotti, Niall C. Tebbutt, Fook-Thean Lee, Sze-Ting Lee, Hui K. Gan, Wendie Hopkins, Fiona E. Scott, Andrew M. Scott, Ludwig Institute for Cancer Research; David C. McKee, Graeme J. O'Keefe, Sylvia J. Gong, Geoffrey Chong, Bridget Chappell, Andrew M. Scott, Austin Health, Melbourne, Australia; Martin W. Brechbiel, National Cancer Institute, Bethesda, MD; Archie N. Tse, Jonathan Greenberg, Daiichi Sankyo Co., Ltd, Parsippany, NJ; Mendel Jansen, Daiichi Sankyo Development Ltd, Gerrards Cross, Buckinghamshire, United Kingdom; Manabu Matsumura, Masakatsu Kotsuma, Rira Watanabe, Daiichi Sankyo Co., Ltd, Tokyo, Japan; Robert A. Beckman, Georgetown University Medical Center and Ralph Venhaus, Ludwig Institute for Cancer Research, New York, NY.

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http://ascopubs.org/doi/10.1200/JCO.2014.60.4256
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http://dx.doi.org/10.1200/JCO.2014.60.4256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881374PMC
August 2015

Nonstandard personalized medicine strategies for cancer may lead to improved patient outcomes.

Per Med 2014 Sep;11(7):705-719

Institute of Statistical Science, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei, Taiwan.

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http://dx.doi.org/10.2217/pme.14.57DOI Listing
September 2014

Maximizing return on socioeconomic investment in phase II proof-of-concept trials.

Clin Cancer Res 2014 Apr 13;20(7):1730-4. Epub 2014 Feb 13.

Authors' Affiliations: Biostatistics and Research Decision Sciences, Merck Research Laboratories (MRL), Upper Gwynedd, Pennsylvania; Center for Evolution and Cancer, Helen Diller Family Cancer Center, University of California at San Francisco, San Francisco, California; and Oncology Clinical Research, Daiichi Sankyo Pharmaceutical Development, Edison, New Jersey.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2312DOI Listing
April 2014

Molecular imaging of death receptor 5 occupancy and saturation kinetics in vivo by humanized monoclonal antibody CS-1008.

Clin Cancer Res 2013 Nov 17;19(21):5984-93. Epub 2013 Sep 17.

Authors' Affiliations: Tumour Targeting Laboratory and Oncogenic Transcription Laboratory, Ludwig Institute for Cancer Research; Department of Nuclear Medicine and Centre for PET, Austin Health, Melbourne, Australia; Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, Cancer Research Centre, Bethesda, Maryland; Clinical Development-Oncology, Daiichi Sankyo Pharmaceutical Development, Edison, New Jersey; and Global Project Management Department, Daiichi Sankyo Co. Ltd., Tokyo, Japan.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-3104DOI Listing
November 2013

New evidence-based adaptive clinical trial methods for optimally integrating predictive biomarkers into oncology clinical development programs.

Chin J Cancer 2013 May 15;32(5):233-41. Epub 2013 Mar 15.

Daiichi Sankyo Pharmaceutical Development, Edison, NJ 08837, USA.

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http://dx.doi.org/10.5732/cjc.012.10248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845554PMC
May 2013

Impact of genetic dynamics and single-cell heterogeneity on development of nonstandard personalized medicine strategies for cancer.

Proc Natl Acad Sci U S A 2012 Sep 13;109(36):14586-91. Epub 2012 Aug 13.

Simons Center for Systems Biology, School of Natural Sciences, Institute for Advanced Study, Princeton, NJ 08540, USA.

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http://dx.doi.org/10.1073/pnas.1203559109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437850PMC
September 2012

Integrating predictive biomarkers and classifiers into oncology clinical development programmes.

Nat Rev Drug Discov 2011 Sep 30;10(10):735-48. Epub 2011 Sep 30.

Clinical Research Oncology, Daiichi-Sankyo Pharmaceutical Development, 399 Thornall Street, Edison, New Jersey 08837, USA.

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http://dx.doi.org/10.1038/nrd3550DOI Listing
September 2011

Monoclonal antibody dose determination and biodistribution into solid tumors.

Ther Deliv 2011 Mar;2(3):333-44

Oncology Clinical Research, Daiichi Sankyo Pharmaceutical Development, 399 Thornall Street, Edison, NJ 08837, USA.

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http://dx.doi.org/10.4155/tde.10.91DOI Listing
March 2011

Efficiency of carcinogenesis: is the mutator phenotype inevitable?

Authors:
Robert A Beckman

Semin Cancer Biol 2010 Oct 8;20(5):340-52. Epub 2010 Oct 8.

Department of Oncology Clinical Research, Daiichi Sankyo Pharmaceutical Development, Edison, NJ 08837, USA.

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http://dx.doi.org/10.1016/j.semcancer.2010.10.004DOI Listing
October 2010

Reply: Is There Any Genetic Instability in Human Cancer?

DNA Repair (Amst) 2010 Aug 29;9(8):859-860. Epub 2010 Jun 29.

Department of Pathology Box 357705, School of Medicine, K-072 HSB, University of Washington.

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http://dx.doi.org/10.1016/j.dnarep.2010.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914197PMC
August 2010

How can we improve antibody-based cancer therapy?

MAbs 2009 Jan-Feb;1(1):67-70

Clinical and Quantitative Sciences, North Wales, Pennsylvania, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715179PMC
http://dx.doi.org/10.4161/mabs.1.1.7359DOI Listing
April 2010

Optimal cost-effective designs of Phase II proof of concept trials and associated go-no go decisions.

J Biopharm Stat 2009 ;19(3):424-36

Biostatistics and Research Decision Sciences, Merck Research Laboratories (MRL), Upper Gwynedd, PA 19454, USA.

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http://dx.doi.org/10.1080/10543400902800478DOI Listing
July 2009

Mutator mutations enhance tumorigenic efficiency across fitness landscapes.

Authors:
Robert A Beckman

PLoS One 2009 Jun 10;4(6):e5860. Epub 2009 Jun 10.

Simons Center for Systems Biology, Institute for Advanced Study, Princeton, NJ, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0005860PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2690659PMC
June 2009

Antibody-based therapy for solid tumors.

Cancer J 2008 May-Jun;14(3):178-83

Clinical and Quantitative Sciences, Merck Research Laboratories, North Wales, Pennsylvania 19454-1099, USA.

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http://dx.doi.org/10.1097/PPO.0b013e318172d71aDOI Listing
September 2008

Cancers exhibit a mutator phenotype: clinical implications.

Cancer Res 2008 May;68(10):3551-7; discussion 3557

Department of Pathology, University of Washington School of Medicine, Seattle, Washington, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-5835DOI Listing
May 2008

Genetic instability is not a requirement for tumor development.

Cancer Res 2008 May;68(10):3558-60; discussion 3560-1

Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-6544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2563138PMC
May 2008

Antibody constructs in cancer therapy: protein engineering strategies to improve exposure in solid tumors.

Cancer 2007 Jan;109(2):170-9

Clinical Hematology-Oncology, Centocor Research and Development, Inc., Malvern, Pennsylvania 19355, USA.

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http://dx.doi.org/10.1002/cncr.22402DOI Listing
January 2007

Efficiency of carcinogenesis with and without a mutator mutation.

Proc Natl Acad Sci U S A 2006 Sep 11;103(38):14140-5. Epub 2006 Sep 11.

Department of Clinical Research and Development, Hematology/Oncology, Centocor, Inc., Malvern, PA 19355-1307, USA.

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http://dx.doi.org/10.1073/pnas.0606271103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1599925PMC
September 2006

RNA unrestrained molecular dynamics ensemble improves agreement with experimental NMR data compared to single static structure: a test case.

J Comput Aided Mol Des 2006 May 28;20(5):263-79. Epub 2006 Sep 28.

Discovery Research Informatics, Computer-Assisted Drug Design, Pfizer Global Research and Development, Ann Arbor, MI 48105, USA.

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http://dx.doi.org/10.1007/s10822-006-9049-zDOI Listing
May 2006

Genetic instability in cancer: theory and experiment.

Semin Cancer Biol 2005 Dec;15(6):423-35

Department of Clinical Research and Development, Hematology/Oncology, Centocor Inc., Malvern, PA 19355-1307, USA.

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http://dx.doi.org/10.1016/j.semcancer.2005.06.007DOI Listing
December 2005

Negative clonal selection in tumor evolution.

Genetics 2005 Dec 2;171(4):2123-31. Epub 2005 Sep 2.

Dept. of Clinical Research and Development, Hematology/Oncology, Centocor, Malvern, PA 19355-1307, USA.

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http://dx.doi.org/10.1534/genetics.105.040840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1456124PMC
December 2005

Pharmacogenetics and pharmacogenomics in oncology therapeutic antibody development.

Biotechniques 2005 Oct;39(4):565-8

Hematology and Oncology, Clinical Research and Development, Centocor Research & Development, Inc, Wayne, PA 19087, USA.

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October 2005

Self-assembled, deterministic carbon nanotube wiring networks.

Angew Chem Int Ed Engl 2002 Jan;41(2):353-6

University of California, Los Angeles, Department of Chemistry and Biochemistry, 607 Charles E. Young Dr., 90095-1569, USA.

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http://dx.doi.org/10.1002/1521-3773(20020118)41:2<353::aid-anie353>3.0.co;2-yDOI Listing
January 2002