Rob Hooft van Huijsduijnen

Rob Hooft van Huijsduijnen

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Rob Hooft van Huijsduijnen

Rob Hooft van Huijsduijnen

Publications by authors named "Rob Hooft van Huijsduijnen"

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Two successful decades of Swiss collaborations to develop new anti-malarials.

Malar J 2019 Mar 22;18(1):94. Epub 2019 Mar 22.

Swiss Tropical & Public Health Institute, Socinstrasse 57, 4002, Basel, Switzerland.

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http://dx.doi.org/10.1186/s12936-019-2728-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431002PMC
March 2019

The antimalarial pipeline.

Curr Opin Pharmacol 2018 10 31;42:1-6. Epub 2018 May 31.

Medicines for Malaria Venture, 20 route de Pre-Bois, 1215 Geneva, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.coph.2018.05.006DOI Listing
October 2018

Malaria.

Nat Rev Dis Primers 2017 Aug 3;3:17050. Epub 2017 Aug 3.

Medicines for Malaria Venture, Geneva, Switzerland.

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http://dx.doi.org/10.1038/nrdp.2017.50DOI Listing
August 2017

Open data in drug discovery and development: lessons from malaria.

Nat Rev Drug Discov 2016 10 12;15(10):661-2. Epub 2016 Aug 12.

Medicines for Malaria Venture, 20 Route de Pré-Bois, Geneva 1215, Switzerland.

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http://dx.doi.org/10.1038/nrd.2016.154DOI Listing
October 2016

Efficacy of OZ439 (artefenomel) against early Plasmodium falciparum blood-stage malaria infection in healthy volunteers.

J Antimicrob Chemother 2016 09 5;71(9):2620-7. Epub 2016 Jun 5.

Department of Translational Medicine, Medicines for Malaria Venture, Route de Pré-Bois 20, 1215 Meyrin, Geneva, Switzerland

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http://dx.doi.org/10.1093/jac/dkw174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992851PMC
September 2016

Comprehensive protein tyrosine phosphatase mRNA profiling identifies new regulators in the progression of glioma.

Acta Neuropathol Commun 2016 09 1;4(1):96. Epub 2016 Sep 1.

Department of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 26, 6525, GA, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1186/s40478-016-0372-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009684PMC
September 2016

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Authors:
Wesley C Van Voorhis John H Adams Roberto Adelfio Vida Ahyong Myles H Akabas Pietro Alano Aintzane Alday Yesmalie Alemán Resto Aishah Alsibaee Ainhoa Alzualde Katherine T Andrews Simon V Avery Vicky M Avery Lawrence Ayong Mark Baker Stephen Baker Choukri Ben Mamoun Sangeeta Bhatia Quentin Bickle Lotfi Bounaadja Tana Bowling Jürgen Bosch Lauren E Boucher Fabrice F Boyom Jose Brea Marian Brennan Audrey Burton Conor R Caffrey Grazia Camarda Manuela Carrasquilla Dee Carter Maria Belen Cassera Ken Chih-Chien Cheng Worathad Chindaudomsate Anthony Chubb Beatrice L Colon Daisy D Colón-López Yolanda Corbett Gregory J Crowther Noemi Cowan Sarah D'Alessandro Na Le Dang Michael Delves Joseph L DeRisi Alan Y Du Sandra Duffy Shimaa Abd El-Salam El-Sayed Michael T Ferdig José A Fernández Robledo David A Fidock Isabelle Florent Patrick V T Fokou Ani Galstian Francisco Javier Gamo Suzanne Gokool Ben Gold Todd Golub Gregory M Goldgof Rajarshi Guha W Armand Guiguemde Nil Gural R Kiplin Guy Michael A E Hansen Kirsten K Hanson Andrew Hemphill Rob Hooft van Huijsduijnen Takaaki Horii Paul Horrocks Tyler B Hughes Christopher Huston Ikuo Igarashi Katrin Ingram-Sieber Maurice A Itoe Ajit Jadhav Amornrat Naranuntarat Jensen Laran T Jensen Rays H Y Jiang Annette Kaiser Jennifer Keiser Thomas Ketas Sebastien Kicka Sunyoung Kim Kiaran Kirk Vidya P Kumar Dennis E Kyle Maria Jose Lafuente Scott Landfear Nathan Lee Sukjun Lee Adele M Lehane Fengwu Li David Little Liqiong Liu Manuel Llinás Maria I Loza Aristea Lubar Leonardo Lucantoni Isabelle Lucet Louis Maes Dalu Mancama Nuha R Mansour Sandra March Sheena McGowan Iset Medina Vera Stephan Meister Luke Mercer Jordi Mestres Alvine N Mfopa Raj N Misra Seunghyun Moon John P Moore Francielly Morais Rodrigues da Costa Joachim Müller Arantza Muriana Stephen Nakazawa Hewitt Bakela Nare Carl Nathan Nathalie Narraidoo Sujeevi Nawaratna Kayode K Ojo Diana Ortiz Gordana Panic George Papadatos Silvia Parapini Kailash Patra Ngoc Pham Sarah Prats David M Plouffe Sally-Ann Poulsen Anupam Pradhan Celia Quevedo Ronald J Quinn Christopher A Rice Mohamed Abdo Rizk Andrea Ruecker Robert St Onge Rafaela Salgado Ferreira Jasmeet Samra Natalie G Robinett Ulrich Schlecht Marjorie Schmitt Filipe Silva Villela Francesco Silvestrini Robert Sinden Dennis A Smith Thierry Soldati Andreas Spitzmüller Serge Maximilian Stamm David J Sullivan William Sullivan Sundari Suresh Brian M Suzuki Yo Suzuki S Joshua Swamidass Donatella Taramelli Lauve R Y Tchokouaha Anjo Theron David Thomas Kathryn F Tonissen Simon Townson Abhai K Tripathi Valentin Trofimov Kenneth O Udenze Imran Ullah Cindy Vallieres Edgar Vigil Joseph M Vinetz Phat Voong Vinh Hoan Vu Nao-Aki Watanabe Kate Weatherby Pamela M White Andrew F Wilks Elizabeth A Winzeler Edward Wojcik Melanie Wree Wesley Wu Naoaki Yokoyama Paul H A Zollo Nada Abla Benjamin Blasco Jeremy Burrows Benoît Laleu Didier Leroy Thomas Spangenberg Timothy Wells Paul A Willis

PLoS Pathog 2016 07 28;12(7):e1005763. Epub 2016 Jul 28.

Medicines for Malaria Venture, Geneva, Switzerland.

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http://dx.doi.org/10.1371/journal.ppat.1005763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965013PMC
July 2016

Ferroquine: welcome to the next generation of antimalarials.

Lancet Infect Dis 2015 Dec 3;15(12):1365-6. Epub 2015 Sep 3.

Medicines for Malaria Venture, 1215 Geneva 15, Switzerland.

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http://dx.doi.org/10.1016/S1473-3099(15)00148-6DOI Listing
December 2015

Profile of William C. Campbell, Satoshi Ōmura, and Youyou Tu, 2015 Nobel Laureates in Physiology or Medicine.

Proc Natl Acad Sci U S A 2015 Dec 22;112(52):15773-6. Epub 2015 Dec 22.

Medicines for Malaria Venture, 1215 Geneva, Switzerland.

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http://dx.doi.org/10.1073/pnas.1520952112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702971PMC
December 2015

Hit and lead criteria in drug discovery for infectious diseases of the developing world.

Nat Rev Drug Discov 2015 Nov 5;14(11):751-8. Epub 2015 Oct 5.

Global Health Innovative Technology (GHIT) Fund, Ark Hills, Sengokuyama Mori Tower (25F), 1-9-10 Roppongi, Minato-ku, Tokyo 106-0032, Japan.

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http://dx.doi.org/10.1038/nrd4683DOI Listing
November 2015

Malaria medicines: a glass half full?

Nat Rev Drug Discov 2015 Jun 22;14(6):424-42. Epub 2015 May 22.

1] Medicines for Malaria Venture, 20 Route de Pré-Bois, 1215 Geneva 15, Switzerland. [2] Division of Allergy and Infectious Diseases, Department of Medicine and Departments of Global Health and Microbiology, University of Washington, 750 Republican Street, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1038/nrd4573DOI Listing
June 2015

Inhibition of protein tyrosine phosphatases enhances cerebral collateral growth in rats.

J Mol Med (Berl) 2014 Sep 27;92(9):983-94. Epub 2014 May 27.

Center for Cardiovascular Research (CCR), Department of Internal Medicine/Cardiology, Richard-Thoma-Laboratories for Arteriogenesis, Charité-University Medicine Berlin, Hessische Str. 3-4, 10115, Berlin, Germany.

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http://dx.doi.org/10.1007/s00109-014-1164-zDOI Listing
September 2014

Designing the next generation of medicines for malaria control and eradication.

Malar J 2013 Jun 6;12:187. Epub 2013 Jun 6.

Medicines for Malaria Venture-MMV, PO Box 1826, Route de Pré-Bois 20, Geneva 151215, Switzerland.

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http://dx.doi.org/10.1186/1475-2875-12-187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685552PMC
June 2013

Characterization of protein tyrosine phosphatase H1 knockout mice in animal models of local and systemic inflammation.

J Inflamm (Lond) 2010 Mar 30;7:16. Epub 2010 Mar 30.

MerckSerono Ivrea, In vivo Pharmacology Department, via ribes 5, 10010 Colleretto G, (TO) Italy.

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http://dx.doi.org/10.1186/1476-9255-7-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873500PMC
March 2010

Protein tyrosine phosphatases in glioma biology.

Acta Neuropathol 2010 Feb 21;119(2):157-75. Epub 2009 Nov 21.

Department of Cell Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, 6525 GA Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s00401-009-0614-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808538PMC
February 2010

Protein tyrosine phosphatases: dual-specificity phosphatases in health and disease.

FEBS J 2008 Mar;275(5):848-66

Centro de Investigación Príncipe Felipe, Valencia, Spain.

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http://dx.doi.org/10.1111/j.1742-4658.2008.06250.xDOI Listing
March 2008

Growth hormone signalling: sprouting links between pathways, human genetics and therapeutic options.

Trends Endocrinol Metab 2007 Jan-Feb;18(1):12-8. Epub 2006 Nov 28.

Serono Pharmaceutical Research Institute, 14, Chemin des Aulx, 1228 Plan-les-Ouates, Geneva, Switzerland.

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http://dx.doi.org/10.1016/j.tem.2006.11.004DOI Listing
April 2007

Improvement of peripheral endothelial dysfunction by protein tyrosine phosphatase inhibitors in heart failure.

Circulation 2006 Dec 13;114(23):2498-507. Epub 2006 Nov 13.

INSERM U644, Federate Institute for Multidisciplinary Research on Peptides, Rouen University Medical School, Rouen, France.

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.106.6
Publisher Site
http://dx.doi.org/10.1161/CIRCULATIONAHA.106.630129DOI Listing
December 2006

Decompartmentalizing target validation-thinking outside the pipeline boxes.

J Mol Med (Berl) 2006 Oct 5;84(10):802-13. Epub 2006 Aug 5.

Serono Pharmaceutical Research Institute, Serono International S.A., 14, Chemin des Aulx, 1228, Plan-les-Ouates, Geneva, Switzerland.

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http://dx.doi.org/10.1007/s00109-006-0080-2DOI Listing
October 2006

Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPrho/PTPRT).

Brain Res 2006 Oct 14;1116(1):50-7. Epub 2006 Sep 14.

Department of Pharmacology, The Ohio State University, 333 W 10th Ave., Columbus, OH 43210, USA.

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http://dx.doi.org/10.1016/j.brainres.2006.07.122DOI Listing
October 2006

Sap-1/PTPRH activity is regulated by reversible dimerization.

Biochem Biophys Res Commun 2005 Jun;331(2):497-502

Serono Pharmaceutical Research Institute, 14, chemin des Aulx, Plan-les-Ouates/Geneva, Switzerland.

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http://dx.doi.org/10.1016/j.bbrc.2005.03.196DOI Listing
June 2005

Applying the SPOT peptide synthesis procedure to the study of protein tyrosine phosphatase substrate specificity: probing for the heavenly match in vitro.

Methods 2005 Jan;35(1):64-72

Sanofi-Synthelabo, Labège Innopole voie 1, BP 137, 31676 Labège, France.

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http://dx.doi.org/10.1016/j.ymeth.2004.07.009DOI Listing
January 2005

Involvement of phosphoinositide 3-kinase gamma, Rac, and PAK signaling in chemokine-induced macrophage migration.

J Biol Chem 2004 Oct 29;279(41):43273-84. Epub 2004 Jul 29.

Serono Pharmaceutical Research Institute, Serono International S.A., 14 Chemin des Aulx, CH 1228 Plan-les-Ouates, Geneva, Switzerland.

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http://dx.doi.org/10.1074/jbc.M402924200DOI Listing
October 2004

Prospects for inhibitors of protein tyrosine phosphatase 1B as antidiabetic drugs.

J Med Chem 2004 Aug;47(17):4142-6

Serono Pharmaceutical Research Institute, Chemin des Aulx 14, 1228 Plan-les-Ouates, Geneva, Switzerland.

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http://dx.doi.org/10.1021/jm030629nDOI Listing
August 2004

Probing protein-tyrosine phosphatase substrate specificity using a phosphotyrosine-containing phage library.

J Biol Chem 2004 Jan 24;279(1):311-8. Epub 2003 Oct 24.

Serono Pharmaceutical Research Institute, CH-1228 Geneva, Switzerland.

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http://dx.doi.org/10.1074/jbc.M307617200DOI Listing
January 2004

Mapping of synergistic components of weakly interacting protein-protein motifs using arrays of paired peptides.

J Biol Chem 2003 Apr 27;278(17):15162-7. Epub 2003 Jan 27.

Serono Pharmaceutical Research Institute, Geneva 1228, Switzerland.

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http://dx.doi.org/10.1074/jbc.M211887200DOI Listing
April 2003

Protein tyrosine phosphatases as drug targets: PTP1B and beyond.

Expert Opin Ther Targets 2002 Dec;6(6):637-47

Serono Pharmaceutical Research Institute, 14, chemin des Aulx, Plan-les-Ouates/Geneva, Switzerland.

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http://dx.doi.org/10.1517/14728222.6.6.637DOI Listing
December 2002

The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities.

Protein Sci 2002 Oct;11(10):2326-34

Serono Pharmaceutical Research Institute, 14, chemin des Aulx, 1228 Plan-Les-Ouates, Geneva, Switzerland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373693PMC
http://dx.doi.org/10.1110/ps.0213402DOI Listing
October 2002

Selecting protein tyrosine phosphatases as drug targets.

Drug Discov Today 2002 Oct;7(19):1013-9

Serono Pharmaceutical Research Institute, 14 Chemin des Aulx, 1228 Plan-les-Ouates, Geneva, Switzerland.

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http://dx.doi.org/10.1016/s1359-6446(02)02438-8DOI Listing
October 2002