Rob C van Wijk

Rob C van Wijk

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Rob C van Wijk

Rob C van Wijk

Publications by authors named "Rob C van Wijk"

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Mechanistic and Quantitative Understanding of Pharmacokinetics in Zebrafish Larvae through Nanoscale Blood Sampling and Metabolite Modeling of Paracetamol.

J Pharmacol Exp Ther 2019 Oct 1;371(1):15-24. Epub 2019 Aug 1.

Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research (R.C.v.W., E.H.J.K., V.K., T.K., A.C.H., T.H., P.H.v.d.G.) and Animal Sciences and Health, Institute of Biology Leiden (A.O., H.P.S.), Leiden University, Leiden, The Netherlands; and Certara QSP, Canterbury, United Kingdom (P.H.v.d.G.)

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http://dx.doi.org/10.1124/jpet.119.260299DOI Listing
October 2019

Impact of post-hatching maturation on the pharmacokinetics of paracetamol in zebrafish larvae.

Sci Rep 2019 Feb 15;9(1):2149. Epub 2019 Feb 15.

Animal Sciences and Health, Institute of Biology Leiden (IBL), Leiden University, Leiden, The Netherlands.

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http://www.nature.com/articles/s41598-019-38530-w
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http://dx.doi.org/10.1038/s41598-019-38530-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377609PMC
February 2019

Outside-In Systems Pharmacology Combines Innovative Computational Methods With High-Throughput Whole Vertebrate Studies.

CPT Pharmacometrics Syst Pharmacol 2018 05 25;7(5):285-287. Epub 2018 Apr 25.

Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/psp4.12297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980533PMC
May 2018

Development of a population pharmacokinetic model to predict brain distribution and dopamine D2 receptor occupancy of raclopride in non-anesthetized rat.

Eur J Pharm Sci 2018 Jan 5;111:514-525. Epub 2017 Nov 5.

Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2017.10.031DOI Listing
January 2018

Pharmacokinetic Modeling of Paracetamol Uptake and Clearance in Zebrafish Larvae: Expanding the Allometric Scale in Vertebrates with Five Orders of Magnitude.

Zebrafish 2016 12 15;13(6):504-510. Epub 2016 Sep 15.

1 Division of Analytical Biosciences, Systems Pharmacology Cluster, Leiden Academic Centre for Drug Research, Leiden University , Leiden, The Netherlands .

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http://dx.doi.org/10.1089/zeb.2016.1313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124745PMC
December 2016

Integration of PKPD relationships into benefit-risk analysis.

Br J Clin Pharmacol 2015 Nov 29;80(5):979-91. Epub 2015 Jul 29.

Division of Pharmacology, Leiden Academic Centre for Drug Research, the Netherlands.

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http://dx.doi.org/10.1111/bcp.12674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631171PMC
November 2015