Publications by authors named "Ritva Heljasvaara"

50Publications

Lack of collagen XVIII leads to lipodystrophy and perturbs hepatic glucose and lipid homeostasis.

J Physiol 2020 Aug 15;598(16):3373-3393. Epub 2020 Jun 15.

Oulu Center for Cell-Matrix Research, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.1113/JP279559DOI Listing
August 2020

Exploring the roles of MACIT and multiplexin collagens in stem cells and cancer.

Semin Cancer Biol 2020 05 31;62:134-148. Epub 2019 Aug 31.

Center for Cell-Matrix Research, Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Aapistie 7C, FI-90230, Oulu, Finland.

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http://dx.doi.org/10.1016/j.semcancer.2019.08.033DOI Listing
May 2020

Toward understanding scarless skin wound healing and pathological scarring.

F1000Res 2019 5;8. Epub 2019 Jun 5.

Oulu Center for Cell-Matrix Research, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.12688/f1000research.18293.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556993PMC
June 2020

Collagen XVIII Deposition in the Basement Membrane Zone beneath the Newly Forming Epidermis during Wound Healing in Mice.

Acta Med Okayama 2019 Apr;73(2):135-146

Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama 700-8558, Japan.

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http://dx.doi.org/10.18926/AMO/56649DOI Listing
April 2019

Matrix metalloproteinase 9 inhibits the motility of highly aggressive HSC-3 oral squamous cell carcinoma cells.

Exp Cell Res 2019 03 30;376(1):18-26. Epub 2019 Jan 30.

Cancer and Translational Medicine Research Unit, Faculty of Medicine, University of Oulu, Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland; Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland; HUSLAB, Department of Pathology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2019.01.018DOI Listing
March 2019

Human Tumor Tissue-Based 3D In Vitro Invasion Assays.

Methods Mol Biol 2018 ;1731:213-221

Cancer and Translational Medicine Research Unit, University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.1007/978-1-4939-7595-2_19DOI Listing
January 2019

Expression of a specific extracellular matrix signature is a favorable prognostic factor in acute myeloid leukemia.

Leuk Res Rep 2018 13;9:9-13. Epub 2017 Dec 13.

Centre of Excellence in Cell-Extracellular Matrix Research and Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.1016/j.lrr.2017.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735295PMC
December 2017

Understanding the extracellular matrix in acute myeloid leukemia.

Haematologica 2017 11;102(11):1807-1809

Centre of Excellence in Cell-Extracellular Matrix Research and Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Finland.

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http://www.haematologica.org/lookup/doi/10.3324/haematol.201
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http://dx.doi.org/10.3324/haematol.2017.174847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664384PMC
November 2017

Vanin 1 (VNN1) levels predict poor outcome in acute myeloid leukemia.

Am J Hematol 2018 01 23;93(1):E4-E7. Epub 2017 Oct 23.

Centre of Excellence in Cell-Extracellular Matrix Research and Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.1002/ajh.24925DOI Listing
January 2018

An extracellular matrix signature in leukemia precursor cells and acute myeloid leukemia.

Haematologica 2017 07 14;102(7):e245-e248. Epub 2017 Apr 14.

Centre of Excellence in Cell-Extracellular Matrix Research and Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Finland.

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http://dx.doi.org/10.3324/haematol.2017.167304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566047PMC
July 2017

Complement Component C3 and Complement Factor B Promote Growth of Cutaneous Squamous Cell Carcinoma.

Am J Pathol 2017 May 17;187(5):1186-1197. Epub 2017 Mar 17.

Department of Dermatology, University of Turku and Turku University Hospital, Turku, Finland; MediCity Research Laboratory, University of Turku, Turku, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2017.01.006DOI Listing
May 2017

Lack of collagen XV is protective after ischemic stroke in mice.

Cell Death Dis 2017 01 12;8(1):e2541. Epub 2017 Jan 12.

Department of Neurobiology, A. I. Virtanen Institute for Molecular Sciences, Biocenter Kuopio, University of Eastern Finland, Kuopio, Finland.

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http://dx.doi.org/10.1038/cddis.2016.456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386367PMC
January 2017

Collagen XVIII in tissue homeostasis and dysregulation - Lessons learned from model organisms and human patients.

Matrix Biol 2017 01 13;57-58:55-75. Epub 2016 Oct 13.

Oulu Center for Cell-Matrix Research, Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu, FIN-90014 Oulu, Finland.

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http://dx.doi.org/10.1016/j.matbio.2016.10.002DOI Listing
January 2017

Elevated VEGF-D Modulates Tumor Inflammation and Reduces the Growth of Carcinogen-Induced Skin Tumors.

Neoplasia 2016 07;18(7):436-46

Oulu Center for Cell-Matrix Research, Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, FIN-90014, University of Oulu, Oulu, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2016.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954931PMC
July 2016

Redox-fibrosis: Impact of TGFβ1 on ROS generators, mediators and functional consequences.

Redox Biol 2015 Dec 28;6:344-352. Epub 2015 Aug 28.

Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, Oulu, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2015.08.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565043PMC
December 2015

Endostatin induces proliferation of oral carcinoma cells but its effect on invasion is modified by the tumor microenvironment.

Exp Cell Res 2015 Aug 22;336(1):130-40. Epub 2015 Jun 22.

Research Group of Cancer and Translational Medicine, Faculty of Medicine, University of Oulu, Finland; Medical Research Center, Oulu University Hospital, Oulu, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2015.06.012DOI Listing
August 2015

EphB2 Promotes Progression of Cutaneous Squamous Cell Carcinoma.

J Invest Dermatol 2015 Jul 19;135(7):1882-1892. Epub 2015 Mar 19.

Department of Dermatology, University of Turku and Turku University Hospital, Turku, Finland; MediCity Research Laboratory, University of Turku, Turku, Finland. Electronic address:

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http://dx.doi.org/10.1038/jid.2015.104DOI Listing
July 2015

Collagen XVIII short isoform is critical for retinal vascularization, and overexpression of the Tsp-1 domain affects eye growth and cataract formation.

Invest Ophthalmol Vis Sci 2013 Nov 13;54(12):7450-62. Epub 2013 Nov 13.

Oulu Center for Cell-Matrix Research, Department of Medical Biochemistry and Molecular Biology, University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.1167/iovs.13-13039DOI Listing
November 2013

Expression of VEGF and collagen XVIII in meningiomas: correlations with histopathological and MRI characteristics.

Acta Neurochir (Wien) 2013 Jun 20;155(6):989-96; discussion 996. Epub 2013 Apr 20.

Department of Neurosurgery, Institute of Clinical Medicine, University of Oulu, Oulu, P.O. Box 21, 90029 OYS, Finland.

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http://dx.doi.org/10.1007/s00701-013-1699-8DOI Listing
June 2013

ADAMTS-12 metalloprotease is necessary for normal inflammatory response.

J Biol Chem 2012 Nov 27;287(47):39554-63. Epub 2012 Sep 27.

Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain.

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http://dx.doi.org/10.1074/jbc.M112.408625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501021PMC
November 2012

Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth.

Cancer Res 2012 Jul 16;72(14):3512-21. Epub 2012 May 16.

Molecular/Cancer Biology Program, Institute for Molecular Medicine Finland and Helsinki University Central Hospital, Research Programs Unit, Biomedicum Helsinki, Finland.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-1070DOI Listing
July 2012

Novel pathogenic mutations and skin biopsy analysis in Knobloch syndrome.

Mol Vis 2009 23;15:801-9. Epub 2009 Apr 23.

Centro de Estudos do Genoma Humano, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brazil.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671584PMC
August 2009

Type XVIII collagen degradation products in acute lung injury.

Crit Care 2009 9;13(2):R52. Epub 2009 Apr 9.

Lung Injury and Fibrosis Treatment Program (LIFT), Department of Medical Sciences, The Medical School University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.

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http://ccforum.biomedcentral.com/articles/10.1186/cc7779
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http://dx.doi.org/10.1186/cc7779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689499PMC
September 2009

Lack of collagen XVIII accelerates cutaneous wound healing, while overexpression of its endostatin domain leads to delayed healing.

Matrix Biol 2008 Jul 1;27(6):535-46. Epub 2008 Apr 1.

Biocenter Oulu, Collagen Research Unit, University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.1016/j.matbio.2008.03.003DOI Listing
July 2008

Endostatin overexpression inhibits lymphangiogenesis and lymph node metastasis in mice.

Cancer Res 2007 Dec;67(24):11528-35

Collagen Research Unit, Biocenter Oulu and Department of Medical Biochemistry and Molecular Biology, University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-1458DOI Listing
December 2007

The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway.

J Cell Sci 2007 Oct 25;120(Pt 20):3544-52. Epub 2007 Sep 25.

Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncologia, Universidad de Oviedo, 33006-Oviedo, Asturias, Spain.

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http://dx.doi.org/10.1242/jcs.005751DOI Listing
October 2007

Collagen XVIII/endostatin shows a ubiquitous distribution in human ocular tissues and endostatin-containing fragments accumulate in ocular fluid samples.

Graefes Arch Clin Exp Ophthalmol 2007 Jan 13;245(1):74-81. Epub 2006 Apr 13.

Department of Ophthalmology, Helsinki University Central Hospital, P.O. Box 220, 00029 Helsinki, HUS, Finland.

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http://dx.doi.org/10.1007/s00417-006-0281-yDOI Listing
January 2007

Collagen XVIII/endostatin is associated with the epithelial-mesenchymal transformation in the atrioventricular valves during cardiac development.

Dev Dyn 2006 Jan;235(1):132-42

Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.

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http://dx.doi.org/10.1002/dvdy.20556DOI Listing
January 2006

Generation of biologically active endostatin fragments from human collagen XVIII by distinct matrix metalloproteases.

Exp Cell Res 2005 Jul;307(2):292-304

Collagen Research Unit, Biocenter Oulu and Department of Medical Biochemistry and Molecular Biology, University of Oulu, PO Box 5000, FIN-90014 Oulu, Finland.

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http://dx.doi.org/10.1016/j.yexcr.2005.03.021DOI Listing
July 2005

Expression of collagen XVIII and MMP-20 in developing teeth and odontogenic tumors.

Matrix Biol 2004 Jun;23(3):153-61

Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, P.O. Box 5281, 90014 Oulu, Finland.

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http://dx.doi.org/10.1016/j.matbio.2004.04.003DOI Listing
June 2004

Endostatin inhibits human tongue carcinoma cell invasion and intravasation and blocks the activation of matrix metalloprotease-2, -9, and -13.

J Biol Chem 2003 Jun 10;278(25):22404-11. Epub 2003 Apr 10.

Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, FIN-90014 Oulu, Finland.

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http://dx.doi.org/10.1074/jbc.M210325200DOI Listing
June 2003

Matrix metalloproteinases process the laminin-5 gamma 2-chain and regulate epithelial cell migration.

Biochem Biophys Res Commun 2003 Apr;303(4):1012-7

Department of Clinical Veterinary Sciences, Faculty of Veterinary Medicine, Helsinki University Central Hospital (HUCH), Institute of Dentistry, University of Helsinki, Finland.

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http://dx.doi.org/10.1016/s0006-291x(03)00452-2DOI Listing
April 2003

Collagen XVIII, a basement membrane heparan sulfate proteoglycan, interacts with L-selectin and monocyte chemoattractant protein-1.

J Biol Chem 2003 Apr 28;278(15):13069-76. Epub 2003 Jan 28.

Laboratory of Molecular and Cellular Recognition, Osaka University Graduate School of Medicine, 2-2, Yamada-oka, Suita 565-0871, Japan.

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http://dx.doi.org/10.1074/jbc.M212244200DOI Listing
April 2003

A heterologous prime-boost regime using DNA and recombinant vaccinia virus expressing the Leishmania infantum P36/LACK antigen protects BALB/c mice from cutaneous leishmaniasis.

Vaccine 2002 Jan;20(7-8):1226-31

Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología, Universidad Autónoma Campus de Cantoblanco, CSIC, 28049, Madrid, Spain.

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http://dx.doi.org/10.1016/s0264-410x(01)00427-3DOI Listing
January 2002