Publications by authors named "Ritu Aneja"

100Publications

Quadruple-negative breast cancer: novel implications for a new disease.

Breast Cancer Res 2020 Nov 19;22(1):127. Epub 2020 Nov 19.

Department of Biology, Georgia State University, 100 Piedmont Ave, Atlanta, GA, 30303, USA.

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November 2020

SARS-CoV-2 Infection in Cancer Patients: Effects on Disease Outcomes and Patient Prognosis.

Cancers (Basel) 2020 Nov 5;12(11). Epub 2020 Nov 5.

Department of Biology, College of Arts and Sciences, Georgia State University, Atlanta, GA 30303, USA.

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November 2020

Adrenal gland fine needle aspiration: a multi-institutional analysis of 139 cases.

J Am Soc Cytopathol 2020 Aug 13. Epub 2020 Aug 13.

Department of Pathology, Emory University Hospital, Atlanta, Georgia. Electronic address:

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August 2020

HER2 immunohistochemistry staining positivity is strongly predictive of tumor response to neoadjuvant chemotherapy in HER2 positive breast cancer.

Pathol Res Pract 2020 Nov 10;216(11):153155. Epub 2020 Aug 10.

Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, United States. Electronic address:

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November 2020

Protein Conformational Changes in Breast Cancer Sera Using Infrared Spectroscopic Analysis.

Cancers (Basel) 2020 Jun 27;12(7). Epub 2020 Jun 27.

Department of Physics and Astronomy, Georgia State University, Atlanta, GA 30303, USA.

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June 2020

A novel prognostic two-gene signature for triple negative breast cancer.

Mod Pathol 2020 11 13;33(11):2208-2220. Epub 2020 May 13.

Nottingham Breast Cancer Research Centre, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham, UK.

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November 2020

Quadruple-Negative Breast Cancer: An Uneven Playing Field.

JCO Glob Oncol 2020 02;6:233-237

Department of Biology, Georgia State University, Atlanta, GA.

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February 2020

Spotlighting the hypoxia-centrosome amplification axis.

Med Res Rev 2020 Jul 10;40(4):1508-1513. Epub 2020 Feb 10.

Department of Biology, Georgia State University, Atlanta, Georgia.

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July 2020

Clinicopathologic Factors Associated With Response to Neoadjuvant Anti-HER2-Directed Chemotherapy in HER2-Positive Breast Cancer.

Clin Breast Cancer 2020 02 18;20(1):19-24. Epub 2019 Sep 18.

Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA. Electronic address:

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February 2020

Roles of p38α and p38β mitogen‑activated protein kinase isoforms in human malignant melanoma A375 cells.

Int J Mol Med 2019 Dec 24;44(6):2123-2132. Epub 2019 Oct 24.

Department of Biological Science and Technology, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung 404, Taiwan, R.O.C.

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December 2019

Panoptic View of Prognostic Models for Personalized Breast Cancer Management.

Cancers (Basel) 2019 Sep 7;11(9). Epub 2019 Sep 7.

Department of Biology, Georgia State University, Atlanta, GA 30303, USA.

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September 2019

Prognostic significance of cathepsin V (CTSV/CTSL2) in breast ductal carcinoma in situ.

J Clin Pathol 2020 Feb 23;73(2):76-82. Epub 2019 Aug 23.

Histopathology, University of Nottingham School of Medicine, Nottingham, UK.

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February 2020

Monitoring the dynamics of hemeoxygenase-1 activation in head and neck cancer cells in real-time using plasmonically enhanced Raman spectroscopy.

Chem Sci 2019 May 22;10(18):4876-4882. Epub 2019 Mar 22.

Laser Dynamics Laboratory , School of Chemistry and Biochemistry , Georgia Institute of Technology , Atlanta , Georgia 30332 , USA . Email:

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May 2019

Collagen (XI) alpha-1 chain is an independent prognostic factor in breast ductal carcinoma in situ.

Mod Pathol 2019 10 7;32(10):1460-1472. Epub 2019 Jun 7.

Nottingham Breast Cancer Research Centre, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham City Hospital, Nottingham, UK.

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October 2019

Geometric characteristics of collagen have independent prognostic significance in breast ductal carcinoma in situ: an image analysis study.

Mod Pathol 2019 10 7;32(10):1473-1485. Epub 2019 Jun 7.

Nottingham Breast Cancer Research Centre, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham City Hospital, Nottingham, UK.

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October 2019

Disadvantaged neighborhoods and racial disparity in breast cancer outcomes: the biological link.

Cancer Causes Control 2019 Jul 20;30(7):677-686. Epub 2019 May 20.

Department of Biology, Georgia State University, Atlanta, GA, 30303, USA.

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July 2019

Time will tell: Circadian clock dysregulation in triple negative breast cancer.

Front Biosci (Schol Ed) 2019 03 1;11:178-192. Epub 2019 Mar 1.

Department of Biology, International Consortium for Advancing Research on Triple Negative Breast Cancer, Georgia State University, Atlanta, GA 30303, USA,

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March 2019

Targeting risk factors for reducing the racially disparate burden in breast cancer.

Front Biosci (Schol Ed) 2019 03 1;11:136-160. Epub 2019 Mar 1.

Department of Biology, International Consortium for Advancing Research on Triple Negative Breast Cancer, Georgia State University, Atlanta, GA 30303, USA,

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March 2019

The persisting puzzle of racial disparity in triple negative breast cancer: looking through a new lens.

Front Biosci (Schol Ed) 2019 03 1;11:75-88. Epub 2019 Mar 1.

Department of Biology, International Consortium for Advancing Research on Triple Negative Breast Cancer, Georgia State University, Atlanta, GA 30303, USA,

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March 2019

ROS- and HIF1α-dependent IGFBP3 upregulation blocks IGF1 survival signaling and thereby mediates high-glucose-induced cardiomyocyte apoptosis.

J Cell Physiol 2019 08 19;234(8):13557-13570. Epub 2019 Jan 19.

Department of Biological Science and Technology, China Medical University, Taichung, Taiwan.

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August 2019

Comparing breast biomarker status between routine immunohistochemistry and FISH studies and Oncotype DX testing, a study of 610 cases.

Breast J 2018 11 19;24(6):889-893. Epub 2018 Sep 19.

Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia.

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November 2018

Pkcδ Activation is Involved in ROS-Mediated Mitochondrial Dysfunction and Apoptosis in Cardiomyocytes Exposed to Advanced Glycation End Products (Ages).

Aging Dis 2018 Aug 1;9(4):647-663. Epub 2018 Aug 1.

1Department of Biological Science and Technology, College of Biopharmaceutical and Food Sciences, China Medical University, Taiwan.

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August 2018

Panoptic Overview of Triple-Negative Breast Cancer in Nigeria: Current Challenges and Promising Global Initiatives.

J Glob Oncol 2018 07;4:1-20

Nikita Wright, Padmashree Rida, Emad Rakha, Ayodeji Agboola, and Ritu Aneja, Georgia State University, Atlanta, GA; Emad Rakha, University of Nottingham and Nottingham University Hospitals National Health Service Trust, Nottingham, United Kingdom; and Ayodeji Agboola, Olabisi Onabanjo University, Sagamu, Nigeria.

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July 2018

Prognostic significance of tumor-infiltrating lymphocytes in ductal carcinoma in situ of the breast.

Mod Pathol 2018 08 20;31(8):1226-1236. Epub 2018 Mar 20.

Academic Pathology, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham, UK.

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August 2018

Diallyl trisulfide suppresses doxorubicin-induced cardiomyocyte apoptosis by inhibiting MAPK/NF-κB signaling through attenuation of ROS generation.

Environ Toxicol 2018 Jan 31;33(1):93-103. Epub 2017 Oct 31.

Department of Biological Science and Technology, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan, 404, Republic of China.

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January 2018

Galangin suppresses H O -induced aging in human dermal fibroblasts.

Environ Toxicol 2017 Dec 18;32(12):2419-2427. Epub 2017 Aug 18.

Department of Biological Science and Technology, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan, ROC.

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December 2017

50 years on … the discovery of tubulin continues to advance cancer treatment.

Endocr Relat Cancer 2017 09;24(9):E3-E5

Department of BiologyGeorgia State University, Atlanta, Georgia, USA

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September 2017

Centrosome amplification: a suspect in breast cancer and racial disparities.

Endocr Relat Cancer 2017 09 17;24(9):T47-T64. Epub 2017 May 17.

Department of BiologyGeorgia State University, Atlanta, Georgia, USA

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September 2017

Immunohistochemical Classification of Ampullary Carcinomas: Critical Reappraisal Fails to Confirm Prognostic Relevance for Recently Proposed Panels, and Highlights MUC5AC as a Strong Prognosticator.

Am J Surg Pathol 2017 Jul;41(7):865-876

*Department of Pathology, Emory University School of Medicine Departments of †Mathematics and Statistics ¶Biology, Georgia State University, Atlanta, GA ‡Department of Pathology, University of California San Francisco, San Francisco, CA §Department of Pathology, Tokai University Hachioji Hospital, Tokyo ∥Department of Pathology, Showa University Fujigaoka Hospital, Yokohama, Japan.

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July 2017

Tackling intra- and inter-tumor heterogeneity to combat triple negative breast cancer.

Front Biosci (Landmark Ed) 2017 06 1;22:1549-1580. Epub 2017 Jun 1.

Department of Biology, Georgia State University, Atlanta, GA 30303, USA,

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June 2017

Absorption, Metabolic Stability, and Pharmacokinetics of Ginger Phytochemicals.

Molecules 2017 Mar 30;22(4). Epub 2017 Mar 30.

Department of Biology, Georgia State University, Atlanta, GA 30303, USA.

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March 2017

Prognostic value of CA20, a score based on centrosome amplification-associated genes, in breast tumors.

Sci Rep 2017 03 21;7(1):262. Epub 2017 Mar 21.

Department of Biology, Georgia State University, Atlanta, GA, USA.

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March 2017

The more the messier: centrosome amplification as a novel biomarker for personalized treatment of colorectal cancers.

J Biomed Res 2016 Nov 10;30(6):441-451. Epub 2015 Nov 10.

Department of Biology, Georgia State University, Atlanta, GA 30303, USA.

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November 2016

Targeted drugs and diagnostic assays: Companions in the race to combat ethnic disparity.

Front Biosci (Landmark Ed) 2017 01 1;22:193-211. Epub 2017 Jan 1.

Department of Biology, Georgia State University, Atlanta, GA 30303,

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January 2017

Diverse roles of HDAC6 in viral infection: Implications for antiviral therapy.

Pharmacol Ther 2016 08 23;164:120-5. Epub 2016 Apr 23.

State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China; Institute of Biomedical Sciences, College of Life Sciences, Key Laboratory of Animal Resistance of Shandong Province, Key Laboratory of Molecular and Nano Probes of the Ministry of Education, Shandong Normal University, Jinan 250014, China. Electronic address:

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August 2016

Ginger augmented chemotherapy: A novel multitarget nontoxic approach for cancer management.

Mol Nutr Food Res 2016 06 11;60(6):1364-73. Epub 2016 Mar 11.

Department of Biology, Georgia State University, Atlanta, GA, USA.

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June 2016

How to be good at being bad: centrosome amplification and mitotic propensity drive intratumoral heterogeneity.

Cancer Metastasis Rev 2015 Dec;34(4):703-13

Department of Biology, Georgia State University, Atlanta, GA, 30303, USA.

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December 2015

Microtubule-Binding Proteins as Promising Biomarkers of Paclitaxel Sensitivity in Cancer Chemotherapy.

Med Res Rev 2016 Mar 1;36(2):300-12. Epub 2015 Sep 1.

State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, 300071, China.

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March 2016

Preclinical Evaluation of DMA, a Bisbenzimidazole, as Radioprotector: Toxicity, Pharmacokinetics, and Biodistribution Studies in Balb/c Mice.

Mol Pharmacol 2015 Oct 3;88(4):768-78. Epub 2015 Aug 3.

Chemical Biology Research Laboratory, Special Center for Molecular Medicine, Jawaharlal Nehru University, Delhi, India (V.Ta.); Department of Chemistry, University of Delhi, Delhi, India (H.N., V.Ti., V.Ta.); Department of Biology, Georgia State University, Atlanta, Georgia (C.Y., S.R.G., R.A.); Dr. Ambedkar Center for Biomedical Research, University of Delhi, Delhi, India (A.K.); Division of Cyclotron and Radiopharmaceutical Sciences, Institute of Nuclear Medicine and Allied Sciences, Delhi, India (K.C., P.P.H., A.K.M.); and Pharmacokinetics and Metabolism Division, Council of Scientific and Industrial Research-Central Drug Research Institute, Lucknow, India (A.S., J.L.)

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October 2015

Docetaxel-induced polyploidization may underlie chemoresistance and disease relapse.

Cancer Lett 2015 Oct 13;367(2):89-92. Epub 2015 Jul 13.

Department of Biology, Georgia State University, Atlanta, GA 30303, USA; Institute of Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA. Electronic address:

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October 2015

The Noscapine Chronicle: A Pharmaco-Historic Biography of the Opiate Alkaloid Family and its Clinical Applications.

Med Res Rev 2015 Sep 14;35(5):1072-96. Epub 2015 Jul 14.

Department of Biology, Georgia State University, Atlanta, GA, 30303, USA.

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September 2015

Wheat germ agglutinin anchored chitosan microspheres of reduced brominated derivative of noscapine ameliorated acute inflammation in experimental colitis.

Colloids Surf B Biointerfaces 2015 Aug 21;132:225-35. Epub 2015 May 21.

Department of Pharmaceutics, Chandigarh College of Pharmacy, Mohali, Panjab, India. Electronic address:

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August 2015

Noscapine recirculates enterohepatically and induces self-clearance.

Eur J Pharm Sci 2015 Sep 28;77:90-9. Epub 2015 May 28.

Department of Biology, Georgia State University, Atlanta, GA 30303, United States. Electronic address:

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September 2015

Turning the headlights on novel cancer biomarkers: Inspection of mechanics underlying intratumor heterogeneity.

Mol Aspects Med 2015 Nov 27;45:3-13. Epub 2015 May 27.

Department of Biology, Georgia State University, Atlanta, GA 30303, USA; Institute of Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA. Electronic address:

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November 2015

Synergistic interactions among flavonoids and acetogenins in Graviola (Annona muricata) leaves confer protection against prostate cancer.

Carcinogenesis 2015 Jun 11;36(6):656-65. Epub 2015 Apr 11.

Department of Biology, Georgia State University, Atlanta, GA-30303, USA, Drug Metabolism, Pharmacokinetics & Clinical Pharmacology, Advinus Therapeutics, Karnataka, 560058, India; Department of Pharmaceutical Sciences, Manipal University, Karnataka, 576104, India and Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA

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June 2015

Die-hard survivors: heterogeneity in apoptotic thresholds may underlie chemoresistance.

Expert Rev Anticancer Ther 2015 Mar 19;15(3):277-81. Epub 2015 Feb 19.

Department of Biology, Georgia State University, Atlanta, GA 30303, USA.

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March 2015

Cyclodextrin complexes of reduced bromonoscapine in guar gum microspheres enhance colonic drug delivery.

Mol Pharm 2014 Dec 18;11(12):4339-49. Epub 2014 Nov 18.

Department of Biology and §Department of Chemistry, Georgia State University , Atlanta, Georgia 30303, United States.

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December 2014

CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6.

Cell Res 2014 Nov 24;24(11):1342-53. Epub 2014 Oct 24.

State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China.

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November 2014

Hydroxychavicol, a betel leaf component, inhibits prostate cancer through ROS-driven DNA damage and apoptosis.

Toxicol Appl Pharmacol 2014 Oct 23;280(1):86-96. Epub 2014 Jul 23.

Department of Biology, Georgia State University, Atlanta, GA 30303, USA. Electronic address:

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October 2014

Enhanced noscapine delivery using estrogen-receptor-targeted nanoparticles for breast cancer therapy.

Anticancer Drugs 2014 Jul;25(6):704-16

aDepartment of Biology, Georgia State University, Atlanta, Georgia, USA bDepartment of Pharmaceutics, Chandigarh College of Pharmacy cDepartment of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Mohali, Punjab dDr. B.R Ambedkar Center for Biomedical Research, University of Delhi, Delhi, India.

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July 2014

Synthesis and evaluation of antiproliferative activity of a novel series of hydroxychavicol analogs.

Eur J Med Chem 2014 Mar 21;75:1-10. Epub 2014 Jan 21.

Department of Chemistry, Georgia State University, Petit Science Center, 100 Piedmont Avenue SE, Atlanta, GA 30303, USA; The Center for Diagnostics and Therapeutics, Georgia State University, Petit Science Center, 100 Piedmont Avenue SE, Atlanta, GA 30303, USA; The Center for Biotechnology and Drug Design, Georgia State University, Petit Science Center, 100 Piedmont Avenue SE, Atlanta, GA 30303, USA. Electronic address:

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March 2014

Piper betel leaf: a reservoir of potential xenohormetic nutraceuticals with cancer-fighting properties.

Cancer Prev Res (Phila) 2014 May 21;7(5):477-86. Epub 2014 Jan 21.

Department of Biology, Georgia State University, Atlanta, GA 30303.

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May 2014

Enterohepatic recirculation of bioactive ginger phytochemicals is associated with enhanced tumor growth-inhibitory activity of ginger extract.

Carcinogenesis 2014 Jun 15;35(6):1320-9. Epub 2014 Jan 15.

Department of Biology, Georgia State University, Atlanta, GA 30303, USA, Advinus Therapeutics, Bangalore, Karnataka 560058, India, Department of Chemistry, University of Delhi, Delhi 110007, India and Department of Biomedical Engineering, McGill University, Montreal, Quebec H3G 1Y6, Canada

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June 2014

Interphase microtubules: chief casualties in the war on cancer?

Drug Discov Today 2014 Jul 4;19(7):824-9. Epub 2013 Nov 4.

Department of Biology, Georgia State University, Atlanta, GA 30303, USA. Electronic address:

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July 2014

Sterically stabilized gelatin microassemblies of noscapine enhance cytotoxicity, apoptosis and drug delivery in lung cancer cells.

Colloids Surf B Biointerfaces 2013 Jul 24;107:235-44. Epub 2013 Feb 24.

Department of Biology, Georgia State University, Atlanta, GA 30303, USA.

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July 2013

Ginger phytochemicals exhibit synergy to inhibit prostate cancer cell proliferation.

Nutr Cancer 2013 ;65(2):263-72

Department of Biology, Georgia State University, Atlanta, Georgia 30303, USA.

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December 2013

Heading off with the herd: how cancer cells might maneuver supernumerary centrosomes for directional migration.

Cancer Metastasis Rev 2013 Jun;32(1-2):269-87

Department of Biology, Georgia State University, Atlanta, GA 30303, USA.

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June 2013

DMA, a bisbenzimidazole, offers radioprotection by promoting NFκB transactivation through NIK/IKK in human glioma cells.

PLoS One 2012 22;7(6):e39426. Epub 2012 Jun 22.

Dr B. R. Ambedkar Center for Biomedical Research, University of Delhi, Delhi, India.

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November 2012

Cep70 contributes to angiogenesis by modulating microtubule rearrangement and stimulating cell polarization and migration.

Cell Cycle 2012 Apr 15;11(8):1554-63. Epub 2012 Apr 15.

State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, China.

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April 2012

Near infrared active heptacyanine dyes with unique cancer-imaging and cytotoxic properties.

Bioorg Med Chem Lett 2012 Jan 28;22(2):1242-6. Epub 2011 Nov 28.

Georgia State University, Department of Chemistry, Petit Science Center, 100 Piedmont Ave., Atlanta, GA 30303, USA.

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January 2012

In silico inspired design and synthesis of a novel tubulin-binding anti-cancer drug: folate conjugated noscapine (Targetin).

J Comput Aided Mol Des 2012 Feb 15;26(2):233-47. Epub 2011 Dec 15.

Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA.

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February 2012

Benefits of whole ginger extract in prostate cancer.

Br J Nutr 2012 Feb 18;107(4):473-84. Epub 2011 Aug 18.

Department of Biology, Georgia State University, Atlanta, GA 30303, USA.

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February 2012

CEP70 protein interacts with γ-tubulin to localize at the centrosome and is critical for mitotic spindle assembly.

J Biol Chem 2011 Sep 27;286(38):33401-8. Epub 2011 Jul 27.

Department of Genetics and Cell Biology, Tianjin Key Laboratory of Protein Science, College of Life Sciences, Nankai University, Tianjin 300071, China.

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September 2011