Publications by authors named "Rita Sattler"

34Publications

Generation of two induced pluripotent stem cell (iPSC) lines from an ALS patient with simultaneous mutations in KIF5A and MATR3 genes.

Authors:
David X Medina Ashley Boehringer Marissa Dominick Ileana Lorenzini Sara Saez-Atienzar Erik P Pioro Rita Sattler Bryan Traynor Robert Bowser

Stem Cell Res 2020 Dec 24;50:102141. Epub 2020 Dec 24.

Department of Neurobiology, Gregory W Fulton ALS Research Center, Barrow Neurological Institute, 350 W Thomas Road, Phoenix, AZ 85013, USA.

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December 2020

The M1311V variant of ATP7A is associated with impaired trafficking and copper homeostasis in models of motor neuron disease.

Authors:
Nadine Bakkar Alexander Starr Benjamin E Rabichow Ileana Lorenzini Zachary T McEachin Robert Kraft Matthew Chaung Sam Macklin-Isquierdo Taylor Wingfield Briggs Carhart Nathan Zahler Wen-Hsuan Chang Gary J Bassell Alexandre Betourne Nicholas Boulis Samuel V Alworth Justin K Ichida Paul R August Daniela C Zarnescu Rita Sattler Robert Bowser

Neurobiol Dis 2020 Dec 24;149:105228. Epub 2020 Dec 24.

Department of Neurobiology, Barrow Neurological Institute, Phoenix, AZ 85013, USA. Electronic address:

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December 2020

The Hitchhiker's Guide to Nucleocytoplasmic Trafficking in Neurodegeneration.

Authors:
Stephen Moore Benjamin E Rabichow Rita Sattler

Neurochem Res 2020 Jun 21;45(6):1306-1327. Epub 2020 Feb 21.

Department of Neurobiology, Barrow Neurological Institute, 350 W Thomas Road, Phoenix, AZ, 85013, USA.

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June 2020

Correction to: ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD.

Authors:
Stephen Moore Eric Alsop Ileana Lorenzini Alexander Starr Benjamin E Rabichow Emily Mendez Jennifer L Levy Camelia Burciu Rebecca Reiman Jeannie Chew Veronique V Belzil Dennis Dickson Janice Robertson Kim A Staats Justin K Ichida Leonard Petrucelli Kendall Van Keuren-Jensen Rita Sattler

Acta Neuropathol 2019 Nov;138(5):883-884

Department of Neurobiology, Barrow Neurological Institute, 355 W Thomas Road, Phoenix, AZ, 85013, USA.

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November 2019

Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS.

Authors:
Ernesto Manzo Ileana Lorenzini Dianne Barrameda Abigail G O'Conner Jordan M Barrows Alexander Starr Tina Kovalik Benjamin E Rabichow Erik M Lehmkuhl Dakotah D Shreiner Archi Joardar Jean-Charles Liévens Robert Bowser Rita Sattler Daniela C Zarnescu

Elife 2019 06 10;8. Epub 2019 Jun 10.

Department of Molecular and Cellular Biology, University of Arizona, Tucson, United States.

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June 2019

ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD.

Authors:
Stephen Moore Eric Alsop Ileana Lorenzini Alexander Starr Benjamin E Rabichow Emily Mendez Jennifer L Levy Camelia Burciu Rebecca Reiman Jeannie Chew Veronique V Belzil Dennis W Dickson Janice Robertson Kim A Staats Justin K Ichida Leonard Petrucelli Kendall Van Keuren-Jensen Rita Sattler

Acta Neuropathol 2019 07 3;138(1):49-65. Epub 2019 Apr 3.

Department of Neurobiology, Barrow Neurological Institute, 350 W Thomas Road, Phoenix, AZ, 85013, USA.

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July 2019

Reactivation of nonsense-mediated mRNA decay protects against C9orf72 dipeptide-repeat neurotoxicity.

Authors:
Wangchao Xu Puhua Bao Xin Jiang Haifang Wang Meiling Qin Ruiqi Wang Tao Wang Yi Yang Ileana Lorenzini Lujian Liao Rita Sattler Jin Xu

Brain 2019 05;142(5):1349-1364

Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

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May 2019

Molecularly defined cortical astroglia subpopulation modulates neurons via secretion of Norrin.

Authors:
Sean J Miller Thomas Philips Namho Kim Raha Dastgheyb Zhuoxun Chen Yi-Chun Hsieh J Gavin Daigle Malika Datta Jeannie Chew Svetlana Vidensky Jacqueline T Pham Ethan G Hughes Michael B Robinson Rita Sattler Raju Tomer Jung Soo Suk Dwight E Bergles Norman Haughey Mikhail Pletnikov Justin Hanes Jeffrey D Rothstein

Nat Neurosci 2019 05 1;22(5):741-752. Epub 2019 Apr 1.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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May 2019

RNA Editing Deficiency in Neurodegeneration.

Authors:
Ileana Lorenzini Stephen Moore Rita Sattler

Adv Neurobiol 2018 ;20:63-83

Department of Neurobiology and Neurology, Dignityhealth St. Joseph's Hospital, Barrow Neurological Institute, Phoenix, AZ, USA.

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October 2018

Representing Diversity in the Dish: Using Patient-Derived Models to Recreate the Heterogeneity of Neurological Disease.

Authors:
Layla T Ghaffari Alexander Starr Andrew T Nelson Rita Sattler

Front Neurosci 2018 9;12:56. Epub 2018 Feb 9.

Department of Neurobiology, Barrow Neurological Institute, Dignity Health-St. Joseph's Hospital and Medical Center, Phoenix, AZ, United States.

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February 2018

Synaptic dysfunction and altered excitability in C9ORF72 ALS/FTD.

Authors:
Alexander Starr Rita Sattler

Brain Res 2018 08 14;1693(Pt A):98-108. Epub 2018 Feb 14.

Division of Neurobiology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013, United States. Electronic address:

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August 2018

TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD.

Authors:
Ching-Chieh Chou Yi Zhang Mfon E Umoh Spencer W Vaughan Ileana Lorenzini Feilin Liu Melissa Sayegh Paul G Donlin-Asp Yu Han Chen Duc M Duong Nicholas T Seyfried Maureen A Powers Thomas Kukar Chadwick M Hales Marla Gearing Nigel J Cairns Kevin B Boylan Dennis W Dickson Rosa Rademakers Yong-Jie Zhang Leonard Petrucelli Rita Sattler Daniela C Zarnescu Jonathan D Glass Wilfried Rossoll

Nat Neurosci 2018 02 8;21(2):228-239. Epub 2018 Jan 8.

Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, USA.

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February 2018

Artificial intelligence in neurodegenerative disease research: use of IBM Watson to identify additional RNA-binding proteins altered in amyotrophic lateral sclerosis.

Authors:
Nadine Bakkar Tina Kovalik Ileana Lorenzini Scott Spangler Alix Lacoste Kyle Sponaugle Philip Ferrante Elenee Argentinis Rita Sattler Robert Bowser

Acta Neuropathol 2018 02 13;135(2):227-247. Epub 2017 Nov 13.

Department of Neurobiology, Barrow Neurological Institute, 350 W Thomas Road, Phoenix, AZ, 85013, USA.

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February 2018

Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS.

Authors:
Alyssa N Coyne Ileana Lorenzini Ching-Chieh Chou Meaghan Torvund Robert S Rogers Alexander Starr Benjamin L Zaepfel Jennifer Levy Jeffrey Johannesmeyer Jacob C Schwartz Hiroshi Nishimune Konrad Zinsmaier Wilfried Rossoll Rita Sattler Daniela C Zarnescu

Cell Rep 2017 Oct;21(1):110-125

Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA; Department of Neuroscience, University of Arizona, Tucson, AZ 85721, USA; Department of Neurology, University of Arizona, Tucson, AZ 85721, USA. Electronic address:

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October 2017

The transcription factor Pax6 contributes to the induction of GLT-1 expression in astrocytes through an interaction with a distal enhancer element.

Authors:
Mausam Ghosh Meredith Lane Elizabeth Krizman Rita Sattler Jeffrey D Rothstein Michael B Robinson

J Neurochem 2016 Jan 24;136(2):262-75. Epub 2015 Nov 24.

Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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January 2016

The C9orf72 repeat expansion disrupts nucleocytoplasmic transport.

Authors:
Ke Zhang Christopher J Donnelly Aaron R Haeusler Jonathan C Grima James B Machamer Peter Steinwald Elizabeth L Daley Sean J Miller Kathleen M Cunningham Svetlana Vidensky Saksham Gupta Michael A Thomas Ingie Hong Shu-Ling Chiu Richard L Huganir Lyle W Ostrow Michael J Matunis Jiou Wang Rita Sattler Thomas E Lloyd Jeffrey D Rothstein

Nature 2015 Sep 26;525(7567):56-61. Epub 2015 Aug 26.

Brain Science Institute, School of Medicine, Johns Hopkins University.

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September 2015

Generation of GFAP::GFP astrocyte reporter lines from human adult fibroblast-derived iPS cells using zinc-finger nuclease technology.

Authors:
Ping-Wu Zhang Amanda M Haidet-Phillips Jacqueline T Pham Youngjin Lee Yuqing Huo Pentti J Tienari Nicholas J Maragakis Rita Sattler Jeffrey D Rothstein

Glia 2016 Jan 21;64(1):63-75. Epub 2015 Aug 21.

Department of Neurology, Johns Hopkins University, Rangos 2-248, Baltimore, Maryland.

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January 2016

High-Throughput Assay Development for Cystine-Glutamate Antiporter (xc-) Highlights Faster Cystine Uptake than Glutamate Release in Glioma Cells.

Authors:
Ajit G Thomas Rita Sattler Karen Tendyke Kara A Loiacono Hans Hansen Vishal Sahni Yutaka Hashizume Camilo Rojas Barbara S Slusher

PLoS One 2015 7;10(8):e0127785. Epub 2015 Aug 7.

Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, United States of America; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, United States of America; Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, United States of America; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, United States of America.

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May 2016

A comprehensive library of familial human amyotrophic lateral sclerosis induced pluripotent stem cells.

Authors:
Ying Li Umamahesw Balasubramanian Devon Cohen Ping-Wu Zhang Elizabeth Mosmiller Rita Sattler Nicholas J Maragakis Jeffrey D Rothstein

PLoS One 2015 11;10(3):e0118266. Epub 2015 Mar 11.

Department of Neurology, Johns Hopkins University, School of Medicine, Baltimore, Maryland, 21205, United States of America; Brain Science Institute, Johns Hopkins University, Baltimore, Maryland, 21205, United States of America; Department of Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, Maryland, 21205, United States of America.

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December 2015

Aberrant RNA homeostasis in amyotrophic lateral sclerosis: potential for new therapeutic targets?

Authors:
Christopher J Donnelly Jonathan C Grima Rita Sattler

Neurodegener Dis Manag 2014 ;4(6):417-37

Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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August 2015

Biomarker development for C9orf72 repeat expansion in ALS.

Authors:
Emily F Mendez Rita Sattler

Brain Res 2015 May 27;1607:26-35. Epub 2014 Sep 27.

Brain Science Institute and Department of Neurology, Johns Hopkins University School of Medicine, 855N Wolfe Street, Rangos 2-223, Baltimore, MD 21205, USA. Electronic address:

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May 2015

Mutant disrupted-in-schizophrenia 1 in astrocytes: focus on glutamate metabolism.

Authors:
Sofya Abazyan Eun Ju Yang Bagrat Abazyan Meng Xia Chunxia Yang Camilo Rojas Barbara Slusher Rita Sattler Mikhail Pletnikov

J Neurosci Res 2014 Dec 8;92(12):1659-68. Epub 2014 Aug 8.

Departments of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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December 2014

C9orf72 nucleotide repeat structures initiate molecular cascades of disease.

Authors:
Aaron R Haeusler Christopher J Donnelly Goran Periz Eric A J Simko Patrick G Shaw Min-Sik Kim Nicholas J Maragakis Juan C Troncoso Akhilesh Pandey Rita Sattler Jeffrey D Rothstein Jiou Wang

Nature 2014 Mar 5;507(7491):195-200. Epub 2014 Mar 5.

1] Department of Biochemistry and Molecular Biology, Johns Hopkins University Baltimore, Maryland 21205, USA [2] Department of Neuroscience, Johns Hopkins University Baltimore, Maryland 21205, USA.

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March 2014

RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention.

Authors:
Christopher J Donnelly Ping-Wu Zhang Jacqueline T Pham Aaron R Haeusler Aaron R Heusler Nipun A Mistry Svetlana Vidensky Elizabeth L Daley Erin M Poth Benjamin Hoover Daniel M Fines Nicholas Maragakis Pentti J Tienari Leonard Petrucelli Bryan J Traynor Jiou Wang Frank Rigo C Frank Bennett Seth Blackshaw Rita Sattler Jeffrey D Rothstein

Neuron 2013 Oct;80(2):415-28

Department of Neurology, Johns Hopkins University, 855 N Wolfe Street, Rangos 2-270, Baltimore, MD 21205, USA; Brain Science Institute, Johns Hopkins University, 855 N Wolfe Street, Rangos 2-270, Baltimore, MD 21205, USA.

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October 2013

Human stem cell-derived spinal cord astrocytes with defined mature or reactive phenotypes.

Authors:
Laurent Roybon Nuno J Lamas Alejandro D Garcia Eun Ju Yang Rita Sattler Vernice J Lewis Yoon A Kim C Alan Kachel Jeffrey D Rothstein Serge Przedborski Hynek Wichterle Christopher E Henderson

Cell Rep 2013 Sep 29;4(5):1035-1048. Epub 2013 Aug 29.

Project A.L.S./Jenifer Estess Laboratory for Stem Cell Research, New York, NY 10032, USA.

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September 2013

Increased expression of glutamate transporter GLT-1 in peritumoral tissue associated with prolonged survival and decreases in tumor growth in a rat model of experimental malignant glioma.

Authors:
Rita Sattler Betty Tyler Benjamin Hoover Luke T Coddington Violette Recinos Lee Hwang Henry Brem Jeffrey D Rothstein

J Neurosurg 2013 Oct 2;119(4):878-86. Epub 2013 Aug 2.

Department of Neurology.

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October 2013

Human nasal olfactory epithelium as a dynamic marker for CNS therapy development.

Authors:
Rita Sattler Yoko Ayukawa Luke Coddington Akira Sawa David Block Richard Chipkin Jeffrey D Rothstein

Exp Neurol 2011 Dec 16;232(2):203-11. Epub 2011 Sep 16.

Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA.

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December 2011

Inhibition of xc⁻ transporter-mediated cystine uptake by sulfasalazine analogs.

Authors:
Krupa Shukla Ajit G Thomas Dana V Ferraris Niyada Hin Rita Sattler Jesse Alt Camilo Rojas Barbara S Slusher Takashi Tsukamoto

Bioorg Med Chem Lett 2011 Oct 12;21(20):6184-7. Epub 2011 Aug 12.

Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA.

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October 2011

Genetic and functional studies of a missense variant in a glutamate transporter, SLC1A3, in Tourette syndrome.

Authors:
Abby Adamczyk Colin D Gause Rita Sattler Svetlana Vidensky Jeffery D Rothstein Harvey Singer Tao Wang

Psychiatr Genet 2011 Apr;21(2):90-7

McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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April 2011

Harmine, a natural beta-carboline alkaloid, upregulates astroglial glutamate transporter expression.

Authors:
Yun Li Rita Sattler Eun Ju Yang Alice Nunes Yoko Ayukawa Sadia Akhtar Grace Ji Ping-Wu Zhang Jeffrey D Rothstein

Neuropharmacology 2011 Jun 27;60(7-8):1168-75. Epub 2010 Oct 27.

Department of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.

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June 2011

GluR1 controls dendrite growth through its binding partner, SAP97.

Authors:
Weiguo Zhou Lei Zhang Xiong Guoxiang Jelena Mojsilovic-Petrovic Kogo Takamaya Rita Sattler Richard Huganir Robert Kalb

J Neurosci 2008 Oct;28(41):10220-33

Department of Pediatrics, Division of Neurology, Joseph Stokes Jr. Research Institute, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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October 2008

Targeting an old mechanism in a new disease-protection of glutamatergic dysfunction in depression.

Authors:
Rita Sattler Jeffrey D Rothstein

Biol Psychiatry 2007 Jan;61(2):137-8

Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA.

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January 2007

Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1.

Authors:
Chong-Hyun Kim Kogo Takamiya Ronald S Petralia Rita Sattler Sandy Yu Weiguo Zhou Robert Kalb Robert Wenthold Richard Huganir

Nat Neurosci 2005 Aug 10;8(8):985-7. Epub 2005 Jul 10.

Department of Neuroscience and Howard Hughes Medical Institute, The Johns Hopkins University, Baltimore, Maryland 21205, USA.

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August 2005

Formation of polypyrrole from 2,5-bis(2-pyrrolyl)pyrrolidine.

Authors:
Arnd Garsuch Rita R Sattler Peter G Pickup

Chem Commun (Camb) 2004 Feb 13(3):344-5. Epub 2004 Jan 13.

Department of Chemistry, Memorial University of Newfoundland, St. John's, Newfoundland, Canada A1B 3X7.

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February 2004