Rita C R Perlingeiro

Rita C R Perlingeiro

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Rita C R Perlingeiro

Rita C R Perlingeiro

Publications by authors named "Rita C R Perlingeiro"

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Gene Correction of LGMD2A Patient-Specific iPSCs for the Development of Targeted Autologous Cell Therapy.

Mol Ther 2019 12 28;27(12):2147-2157. Epub 2019 Aug 28.

Lillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA; Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2019.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904833PMC
December 2019

Transplantation studies reveal internuclear transfer of toxic RNA in engrafted muscles of myotonic dystrophy 1 mice.

EBioMedicine 2019 Sep 21;47:553-562. Epub 2019 Aug 21.

Lillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis, MN, USA; Stem Cell Institute, University of Minnesota, Minneapolis, MN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.08.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796515PMC
September 2019

Pluripotent Stem Cell-Based Therapeutics for Muscular Dystrophies.

Trends Mol Med 2019 Sep;25(9):803-816

Lillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis, MN, USA; Stem Cell Institute, University of Minnesota, Minneapolis, MN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2019.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721995PMC
September 2019

Pax3 cooperates with Ldb1 to direct local chromosome architecture during myogenic lineage specification.

Nat Commun 2019 05 24;10(1):2316. Epub 2019 May 24.

Department of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis, MN, 55455, USA.

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http://dx.doi.org/10.1038/s41467-019-10318-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534668PMC
May 2019

Pluripotent stem cell-derived myogenic progenitors remodel their molecular signature upon in vivo engraftment.

Proc Natl Acad Sci U S A 2019 Mar 13;116(10):4346-4351. Epub 2019 Feb 13.

Lillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis, MN 55455;

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http://dx.doi.org/10.1073/pnas.1808303116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410870PMC
March 2019

Serial transplantation reveals a critical role for endoglin in hematopoietic stem cell quiescence.

Blood 2019 02 28;133(7):688-696. Epub 2018 Dec 28.

Lillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis, MN.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2018-09
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http://dx.doi.org/10.1182/blood-2018-09-874677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376279PMC
February 2019

Nanotopography-responsive myotube alignment and orientation as a sensitive phenotypic biomarker for Duchenne Muscular Dystrophy.

Biomaterials 2018 11 21;183:54-66. Epub 2018 Aug 21.

Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA; Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA; Institute for Engineering in Medicine, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01429612183060
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http://dx.doi.org/10.1016/j.biomaterials.2018.08.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239205PMC
November 2018

Recapitulating muscle disease phenotypes with myotonic dystrophy 1 induced pluripotent stem cells: a tool for disease modeling and drug discovery.

Dis Model Mech 2018 07 18;11(7). Epub 2018 Jul 18.

Lillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA

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http://dx.doi.org/10.1242/dmm.034728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078411PMC
July 2018

Skeletal Muscle Stem Cells from PSC-Derived Teratomas Have Functional Regenerative Capacity.

Cell Stem Cell 2018 Jul;23(1):74-85.e6

Lillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA; Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909183029
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http://dx.doi.org/10.1016/j.stem.2018.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752207PMC
July 2018

Myogenic Progenitors from Mouse Pluripotent Stem Cells for Muscle Regeneration.

Methods Mol Biol 2016 ;1460:191-208

Department of Medicine, Lillehei Heart Institute, University of Minnesota, 4-128 CCRB, 2231 6th St. SE, Minneapolis, MN, 55455, USA.

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http://dx.doi.org/10.1007/978-1-4939-3810-0_14DOI Listing
January 2018

The DUX4 homeodomains mediate inhibition of myogenesis and are functionally exchangeable with the Pax7 homeodomain.

J Cell Sci 2017 Nov 21;130(21):3685-3697. Epub 2017 Sep 21.

Lillehei Heart Institute, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55014, USA

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http://dx.doi.org/10.1242/jcs.205427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702055PMC
November 2017

Generation of skeletal myogenic progenitors from human pluripotent stem cells using non-viral delivery of minicircle DNA.

Stem Cell Res 2017 08 12;23:87-94. Epub 2017 Jul 12.

Lillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis, MN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2017.07.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582001PMC
August 2017

Expansion and Purification Are Critical for the Therapeutic Application of Pluripotent Stem Cell-Derived Myogenic Progenitors.

Stem Cell Reports 2017 07 18;9(1):12-22. Epub 2017 May 18.

Department of Medicine, Lillehei Heart Institute, University of Minnesota, 4-128 CCRB, 2231 6th Street South East, Minneapolis, MN 55455, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.04.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511038PMC
July 2017

Derivation of Skeletal Myogenic Precursors from Human Pluripotent Stem Cells Using Conditional Expression of PAX7.

Methods Mol Biol 2016 ;1357:423-39

Department of Medicine, Lillehei Heart Institute, University of Minnesota, CCRB 4-128, 2231 6th St. SE, Minneapolis, MN, 55455, USA.

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http://dx.doi.org/10.1007/7651_2014_134DOI Listing
October 2016

Treatment with rGDF11 does not improve the dystrophic muscle pathology of mdx mice.

Skelet Muscle 2016 14;6:21. Epub 2016 Jun 14.

Lillehei Heart Institute, Department of Medicine, University of Minnesota, 4-128 CCRB, 2231 6th St. SE, Minneapolis, MN 55455 USA.

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http://dx.doi.org/10.1186/s13395-016-0092-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906773PMC
October 2016

Endoglin integrates BMP and Wnt signalling to induce haematopoiesis through JDP2.

Nat Commun 2016 10 7;7:13101. Epub 2016 Oct 7.

Department of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota 55455, USA.

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http://dx.doi.org/10.1038/ncomms13101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059784PMC
October 2016

Coaxing stem cells for skeletal muscle repair.

Adv Drug Deliv Rev 2015 Apr 15;84:198-207. Epub 2014 Jul 15.

Lillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis, MN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.addr.2014.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295015PMC
April 2015

Dominant lethal pathologies in male mice engineered to contain an X-linked DUX4 transgene.

Cell Rep 2014 Sep 28;8(5):1484-96. Epub 2014 Aug 28.

Lillehei Heart Institute, University of Minnesota, 2231 6th Street SE, Minneapolis, MN 55455, USA; Department of Pediatrics, University of Minnesota, 2231 6th Street SE, Minneapolis, MN 55455, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.07.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188423PMC
September 2014

Stem cells for skeletal muscle regeneration: therapeutic potential and roadblocks.

Transl Res 2014 Apr 14;163(4):409-17. Epub 2013 Nov 14.

Department of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis, Minn. Electronic address:

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http://dx.doi.org/10.1016/j.trsl.2013.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976768PMC
April 2014

A new immuno-, dystrophin-deficient model, the NSG-mdx(4Cv) mouse, provides evidence for functional improvement following allogeneic satellite cell transplantation.

Stem Cells 2013 Aug;31(8):1611-20

Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota, USA; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.

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http://dx.doi.org/10.1002/stem.1402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767774PMC
August 2013

A Perspective on the Potential of Human iPS Cell-Based Therapies for Muscular Dystrophies: Advancements so far and Hurdles to Overcome.

J Stem Cell Res Ther 2013 May;3

Lillehei Heart Institute, Department of Medicine, University of Minnesota, 312 Church Street SE, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.4172/2157-7633.1000e113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220265PMC
May 2013

Functional dissection of Pax3 in paraxial mesoderm development and myogenesis.

Stem Cells 2013 Jan;31(1):59-70

Department of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota 55455, USA.

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http://dx.doi.org/10.1002/stem.1254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528848PMC
January 2013

Effect of endoglin overexpression during embryoid body development.

Exp Hematol 2012 Oct 19;40(10):837-46. Epub 2012 Jun 19.

Lillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.

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http://dx.doi.org/10.1016/j.exphem.2012.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447113PMC
October 2012

A critical role for endoglin in the emergence of blood during embryonic development.

Blood 2012 Jun 24;119(23):5417-28. Epub 2012 Apr 24.

Department of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1182/blood-2011-11-391896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369678PMC
June 2012

Engraftment of ES-Derived Myogenic Progenitors in a Severe Mouse Model of Muscular Dystrophy.

J Stem Cell Res Ther 2012 Jan;10(1)

Lillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis, MN.

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http://dx.doi.org/10.4172/2157-7633.S10-001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593119PMC
January 2012

Functional myogenic engraftment from mouse iPS cells.

Stem Cell Rev Rep 2011 Nov;7(4):948-57

Lillehei Heart Institute, Department of Medicine, University of Minnesota, 4-124 Nils Hasselmo Hall, 312 Church St. S.E., Minneapolis, 55455 MN, USA.

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http://dx.doi.org/10.1007/s12015-011-9258-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465364PMC
November 2011

Modulation of TGF-β signaling by endoglin in murine hemangioblast development and primitive hematopoiesis.

Blood 2011 Jul 20;118(1):88-97. Epub 2011 May 20.

Department of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis, MN, USA.

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http://dx.doi.org/10.1182/blood-2010-12-325019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139390PMC
July 2011

Clonal analysis reveals a common progenitor for endothelial, myeloid, and lymphoid precursors in umbilical cord blood.

Circ Res 2010 Dec 14;107(12):1460-9. Epub 2010 Oct 14.

Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, USA.

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http://dx.doi.org/10.1161/CIRCRESAHA.110.223669DOI Listing
December 2010

Engraftment of embryonic stem cell-derived myogenic progenitors in a dominant model of muscular dystrophy.

Exp Neurol 2009 Nov 13;220(1):212-6. Epub 2009 Aug 13.

Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1016/j.expneurol.2009.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761496PMC
November 2009

Engraftment of mesenchymal stem cells into dystrophin-deficient mice is not accompanied by functional recovery.

Exp Cell Res 2009 Sep 19;315(15):2624-36. Epub 2009 May 19.

Department of Developmental Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9133, USA.

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http://dx.doi.org/10.1016/j.yexcr.2009.05.009DOI Listing
September 2009

Prospective isolation of skeletal muscle stem cells with a Pax7 reporter.

Stem Cells 2008 Dec 18;26(12):3194-204. Epub 2008 Sep 18.

Lillehei Heart Institute and Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.

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http://dx.doi.org/10.1634/stemcells.2007-1017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372243PMC
December 2008

Mesodermal patterning activity of SCL.

Exp Hematol 2008 Dec 21;36(12):1593-603. Epub 2008 Sep 21.

Lillehei Heart Institute and Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1016/j.exphem.2008.07.005DOI Listing
December 2008

The therapeutic potential of embryonic and adult stem cells for skeletal muscle regeneration.

Stem Cell Rev 2008 Sep 8;4(3):217-25. Epub 2008 Jul 8.

Department of Developmental Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9133, USA.

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http://link.springer.com/10.1007/s12015-008-9023-3
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http://dx.doi.org/10.1007/s12015-008-9023-3DOI Listing
September 2008

Lineage-specific reprogramming as a strategy for cell therapy.

Cell Cycle 2008 Jun 11;7(12):1732-7. Epub 2008 Jun 11.

Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.4161/cc.7.12.6159DOI Listing
June 2008

Pax3 activation promotes the differentiation of mesenchymal stem cells toward the myogenic lineage.

Exp Cell Res 2008 May 5;314(8):1721-33. Epub 2008 Mar 5.

Department of Developmental Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9133, USA.

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http://dx.doi.org/10.1016/j.yexcr.2008.02.016DOI Listing
May 2008

Functional skeletal muscle regeneration from differentiating embryonic stem cells.

Nat Med 2008 Feb 20;14(2):134-43. Epub 2008 Jan 20.

Department of Developmental Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9133, USA.

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http://dx.doi.org/10.1038/nm1705DOI Listing
February 2008

Endoglin is required for hemangioblast and early hematopoietic development.

Development 2007 Aug 18;134(16):3041-8. Epub 2007 Jul 18.

Department of Developmental Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9133, USA.

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http://dx.doi.org/10.1242/dev.002907DOI Listing
August 2007

SSEA-4 identifies mesenchymal stem cells from bone marrow.

Blood 2007 Feb 24;109(4):1743-51. Epub 2006 Oct 24.

Center for Developmental Biology, University of Texas Southwestern Medical Center, Dallas 75390-9133, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2005-11-01
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http://dx.doi.org/10.1182/blood-2005-11-010504DOI Listing
February 2007

A role for thrombopoietin in hemangioblast development.

Stem Cells 2003 ;21(3):272-80

Whitehead Institute, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1634/stemcells.21-3-272DOI Listing
February 2004

Enhanced hematopoietic differentiation of embryonic stem cells conditionally expressing Stat5.

Proc Natl Acad Sci U S A 2003 Sep 20;100 Suppl 1:11904-10. Epub 2003 Aug 20.

Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1073/pnas.1734140100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC304105PMC
September 2003

HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors.

Cell 2002 Apr;109(1):29-37

Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1016/s0092-8674(02)00680-3DOI Listing
April 2002