Rita Bottino

Rita Bottino

UNVERIFIED PROFILE

Are you Rita Bottino?   Register this Author

Register author
Rita Bottino

Rita Bottino

Publications by authors named "Rita Bottino"

Are you Rita Bottino?   Register this Author

100Publications

2439Reads

10Profile Views

Immunological aspects of allogeneic pancreatic islet transplantation: a comparison between mouse and human.

Transpl Int 2019 09 15;32(9):903-912. Epub 2019 May 15.

Department of Surgery, Geneva University Hospitals and Medical Faculty, Geneva, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/tri.13445DOI Listing
September 2019

Is the renal subcapsular space the preferred site for clinical porcine islet xenotransplantation? Review article.

Int J Surg 2019 Sep 30;69:100-107. Epub 2019 Jul 30.

Xenotransplantation Program, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijsu.2019.07.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745254PMC
September 2019

Asparagine Synthetase Is Highly Expressed at Baseline in the Pancreas Through Heightened PERK Signaling.

Cell Mol Gastroenterol Hepatol 2019 Aug 14. Epub 2019 Aug 14.

Department of Pediatrics, Stanford University, Palo Alto, California. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcmgh.2019.08.003DOI Listing
August 2019

Xenotransplantation literature update, January/February 2019.

Xenotransplantation 2019 03 11;26(2):e12518. Epub 2019 Apr 11.

Department of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, Minnesota.

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/xen.12518
Publisher Site
http://dx.doi.org/10.1111/xen.12518DOI Listing
March 2019

A Method for Islet Transplantation to the Omentum in Mouse.

J Vis Exp 2019 Jan 7(143). Epub 2019 Jan 7.

Shenzhen Xenotransplantation Medical Engineering Research and Development Center, Institute of Translational Medicine, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen University School of Medicine, Shenzhen University Health Science Center;

View Article

Download full-text PDF

Source
https://www.jove.com/video/57160/a-method-for-islet-transpla
Publisher Site
http://dx.doi.org/10.3791/57160DOI Listing
January 2019

A Chromatin Basis for Cell Lineage and Disease Risk in the Human Pancreas.

Cell Syst 2018 09 22;7(3):310-322.e4. Epub 2018 Aug 22.

Department of Developmental Biology, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA; Department of Medicine, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA; Stanford Diabetes Research Center, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cels.2018.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347013PMC
September 2018

Discovering human diabetes-risk gene function with genetics and physiological assays.

Nat Commun 2018 09 21;9(1):3855. Epub 2018 Sep 21.

Department of Developmental Biology, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA, 94305, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-018-06249-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155000PMC
September 2018

Total pancreaticoduodenectomy with autologous islet transplantation 14 years after liver-contained composite visceral transplantation.

Am J Transplant 2018 08 14;18(8):2068-2074. Epub 2018 May 14.

Department of General Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ajt.14880DOI Listing
August 2018

The Future of Islet Transplantation Is Now.

Front Med (Lausanne) 2018 13;5:202. Epub 2018 Jul 13.

Institute of Cellular Therapeutics, Allegheny Health Network Research Institute, Allegheny Health Network, Pittsburgh, PA, United States.

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fmed.2018.00202/
Publisher Site
http://dx.doi.org/10.3389/fmed.2018.00202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053495PMC
July 2018

α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.

Cell Rep 2018 03;22(10):2667-2676

Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2018.02.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368357PMC
March 2018

Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling.

J Clin Invest 2017 Oct 18;127(10):3835-3844. Epub 2017 Sep 18.

Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI91761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617654PMC
October 2017

Single-Cell Analysis of Human Pancreas Reveals Transcriptional Signatures of Aging and Somatic Mutation Patterns.

Cell 2017 Oct 28;171(2):321-330.e14. Epub 2017 Sep 28.

Department of Bioengineering and Applied Physics, Stanford University, Stanford, CA 94305, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA; Institute of Cellular Therapeutics, Allegheny Health Network, 320 East North Avenue, Pittsburgh, PA 15212, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2017.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047899PMC
October 2017

Safe use of anti-CD154 monoclonal antibody in pig islet xenotransplantation in monkeys.

Xenotransplantation 2017 01 6;24(1). Epub 2017 Jan 6.

Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/xen.12283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332295PMC
January 2017

Spontaneous Hypoglycemia After Islet Autotransplantation for Chronic Pancreatitis.

J Clin Endocrinol Metab 2016 10 22;101(10):3669-3675. Epub 2016 Aug 22.

Department of Endocrinology, Diabetes, and Metabolism (Y.K.L., C.F., P.C.J., B.A.H.), Endocrinology and Metabolism Institute, Departments of General Surgery (R.M.W.) and Gastroenterology and Hepatology (T.S.), Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio 44195; and Islet Isolation Laboratory (R.B.), Institute of Cellular Therapeutics, Allegheny Health Network, Pittsburgh, Pennsylvania 15212.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2016-2111DOI Listing
October 2016

Clinical Islet Xenotransplantation: A Step Forward.

EBioMedicine 2016 Oct 24;12:22-23. Epub 2016 Sep 24.

Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ebiom.2016.09.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078620PMC
October 2016

Recent advances in understanding xenotransplantation: implications for the clinic.

Expert Rev Clin Immunol 2015 1;11(12):1379-90. Epub 2015 Sep 1.

b 2 Institute of Cellular Therapeutics, Allegheny-Singer Research Institute, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1586/1744666X.2015.1083861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879962PMC
August 2016

In vitro exposure of pig neonatal isletlike cell clusters to human blood.

Xenotransplantation 2015 Jul-Aug;22(4):317-24. Epub 2015 Jul 14.

Division of Immunogenetics, Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/xen.12178DOI Listing
May 2016

Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function.

Cell Metab 2016 05 28;23(5):909-20. Epub 2016 Apr 28.

Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine (Oncology Division), Stanford University School of Medicine, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmet.2016.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864151PMC
May 2016

FoxO1 Plays an Important Role in Regulating β-Cell Compensation for Insulin Resistance in Male Mice.

Endocrinology 2016 Mar 4;157(3):1055-70. Epub 2016 Jan 4.

Division of Pediatric Endocrinology (T.Z., D.H.K., S.L., Z.G., R.M., V.C.-N., J.Y., H.H.D.), Department of Pediatrics, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224; Molecular Inflammation Research Center for Aging Intervention (D.H.K.), College of Pharmacy, Pusan National University, Busan, 609-735 Korea; Division of Pediatric Surgery (X.X., G.G.), Department of Surgery, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224; Laboratory for Molecular Design of Pharmaceutics (J.Y., H.H.), Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, 060-0812 Japan; Department of Physiology and Pharmacology (R.W.), University of Western Ontario, London, Ontario, N6C 2V5 Canada; Institute of Cellular Therapeutics (R.B.), Allegheny Health Network, Pittsburgh, Pennsylvania 15212; and Diabetes, Obesity and Metabolism Institute (J.C.A.-P., A.G.-O.), Division of Endocrinology, Diabetes and Bone Disease, Department of Medicine, Icahn School of Medicine Mt Sinai, New York, New York 10029.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2015-1852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769368PMC
March 2016

The pathobiology of pig-to-primate xenotransplantation: a historical review.

Xenotransplantation 2016 03 27;23(2):83-105. Epub 2016 Jan 27.

Institute for Cellular Therapeutics, Allegheny-Singer Research Institute, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/xen.12219DOI Listing
March 2016

Initial in vitro studies on tissues and cells from GTKO/CD46/NeuGcKO pigs.

Xenotransplantation 2016 03 14;23(2):137-50. Epub 2016 Mar 14.

Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/xen.12229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842123PMC
March 2016

Islet xenotransplantation: what is the optimal age of the islet-source pig?

Xenotransplantation 2015 Jan-Feb;22(1):7-19. Epub 2014 Aug 11.

Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/xen.12130DOI Listing
January 2016

Glucose metabolism in pigs expressing human genes under an insulin promoter.

Xenotransplantation 2015 Jan-Feb;22(1):70-9. Epub 2014 Nov 10.

Thomas E. Starzl Transplantation Institute, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/xen.12145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329053PMC
January 2016

Use of genetically-engineered pig donors in islet transplantation.

World J Transplant 2015 Dec;5(4):243-50

Rita Bottino, Massimo Trucco, Institute of Cellular Therapeutics, Allegheny-Singer Research Institute, Allegheny Health Network, Pittsburgh, PA 15212-4772, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5500/wjt.v5.i4.243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689934PMC
December 2015

Current status of islet xenotransplantation.

Int J Surg 2015 Nov 4;23(Pt B):261-266. Epub 2015 Aug 4.

The Centre for Transplant & Renal Research, Westmead Research Institute, Westmead, NSW, Australia; Department of Surgery, University of Sydney at Westmead Hospital, Westmead, NSW, Australia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijsu.2015.07.703DOI Listing
November 2015

Generation of antigen-specific Foxp3+ regulatory T-cells in vivo following administration of diabetes-reversing tolerogenic microspheres does not require provision of antigen in the formulation.

Clin Immunol 2015 Sep 12;160(1):103-23. Epub 2015 Mar 12.

Institute of Cellular Therapeutics, 11th Floor South Tower, Allegheny Health Network, 320 East North Avenue, Pittsburgh, PA, 15212, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2015.03.004DOI Listing
September 2015

Exposure to Radiocontrast Agents Induces Pancreatic Inflammation by Activation of Nuclear Factor-κB, Calcium Signaling, and Calcineurin.

Gastroenterology 2015 Sep 14;149(3):753-64.e11. Epub 2015 May 14.

Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2015.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550538PMC
September 2015

Clinical implementation of islet transplantation: A current assessment.

Pediatr Diabetes 2015 Sep 18;16(6):393-401. Epub 2015 Jun 18.

Institute of Cellular Therapeutics, Allegheny Health Network, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12287DOI Listing
September 2015

Streptozotocin-associated lymphopenia in cynomolgus monkeys.

Islets 2014 ;6(3):e944441

Division of Immunogenetics; Department of Pediatrics; Children's Hospital of Pittsburgh; University of Pittsburgh Medical Center ; Pittsburgh , PA USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/19382014.2014.944441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292713PMC
June 2015

Factors associated with islet yield and insulin independence after total pancreatectomy and islet cell autotransplantation in patients with chronic pancreatitis utilizing off-site islet isolation: Cleveland Clinic experience.

J Clin Endocrinol Metab 2015 May 17;100(5):1765-70. Epub 2015 Mar 17.

Department of Endocrinology, Diabetes and Metabolism (P.C.J., Y.K.L., C.F., B.A.H.), and Department of General Surgery, Digestive Disease Institute (R.M.W.), Cleveland Clinic, Cleveland, Ohio, 44195; Department of Pediatrics (R.B., M.T.), Division of Immunogenetics, University of Pittsburgh, Pittsburgh, Pennsylvania 15213; and Department of Gastroenterology and Hepatology, Digestive Disease Institute (T.K.S.), and Department of Biostatistics, Quantitative Health Sciences (J.B.), Cleveland Clinic, Cleveland, Ohio, 44195.

View Article

Download full-text PDF

Source
https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
Publisher Site
http://dx.doi.org/10.1210/jc.2014-4298DOI Listing
May 2015

Islet xenotransplantation from genetically engineered pigs.

Curr Opin Organ Transplant 2013 Dec;18(6):695-702

aThomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center bDivision of Immunogenetics, Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MOT.0000000000000020DOI Listing
December 2013

Limitations of the pig-to-non-human primate islet transplantation model.

Xenotransplantation 2013 Jan-Feb;20(1):2-4. Epub 2013 Jan 9.

Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/xen.12017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778665PMC
September 2013

Toward clinical islet xenotransplantation - are revisions to the IXA guidelines warranted?

Xenotransplantation 2013 Mar-Apr;20(2):68-74. Epub 2013 Jan 16.

Department of Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/xen.12015DOI Listing
September 2013

Pancreatic acinar cell nuclear factor κB activation because of bile acid exposure is dependent on calcineurin.

J Biol Chem 2013 Jul 6;288(29):21065-73. Epub 2013 Jun 6.

Department of Pediatrics, Children’s Hospital of Pittsburgh of the University of Pittsburgh Medical Center and the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224, USA.

View Article

Download full-text PDF

Source
http://www.jbc.org/content/288/29/21065.full.pdf
Web Search
http://www.jbc.org/cgi/doi/10.1074/jbc.M113.471425
Publisher Site
http://dx.doi.org/10.1074/jbc.M113.471425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774373PMC
July 2013

The potential of genetically-engineered pigs in providing an alternative source of organs and cells for transplantation.

J Biomed Res 2013 Jul 12;27(4):249-53. Epub 2013 Jun 12.

Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7555/JBR.27.20130063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721033PMC
July 2013

Early islet damage after direct exposure of pig islets to blood: has humoral immunity been underestimated?

Cell Transplant 2012 5;21(8):1791-802. Epub 2012 Jul 5.

Division of Immunogenetics, Department of Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/full/10.3727/096368912X65301
Publisher Site
http://dx.doi.org/10.3727/096368912X653011DOI Listing
April 2013

Increased yield and improved transplantation outcome of mouse islets with bovine serum albumin.

J Transplant 2012 9;2012:856386. Epub 2012 Dec 9.

Division of Immunogenetics, Department of Pediatrics, John G. Rangos Research Center, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15201, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2012/856386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523609PMC
January 2013

A syndrome of severe hypoglycemia and acidosis in young immunosuppressed diabetic monkeys and pigs-association with sepsis.

Transplantation 2012 Dec;94(12):1187-91

Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/TP.0b013e318272210cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529756PMC
December 2012

Clinical islet xenotransplantation: how close are we?

Diabetes 2012 Dec;61(12):3046-55

Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db12-0033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501885PMC
December 2012

Isolation of human islets for autologous islet transplantation in children and adolescents with chronic pancreatitis.

J Transplant 2012 8;2012:642787. Epub 2012 Feb 8.

Division of Immunogenetics, Department of Pediatrics, Rangos Research Center, Children's Hospital of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA 15224, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2012/642787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306977PMC
August 2012

Cytokine and chemokine production by human pancreatic islets upon enterovirus infection.

Diabetes 2012 Aug 17;61(8):2030-6. Epub 2012 May 17.

1Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db11-1547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402326PMC
August 2012

Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT.

Dev Cell 2012 Jul;23(1):21-34

Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.devcel.2012.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587727PMC
July 2012

Essential roles of insulin expression in Aire+ tolerogenic dendritic cells in maintaining peripheral self-tolerance of islet β-cells.

Cell Immunol 2012 12;273(2):115-23. Epub 2012 Jan 12.

Division of Immunogenetics, Department of Pediatrics, University of Pittsburgh School of Medicine, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cellimm.2011.12.010DOI Listing
April 2012

Clinical xenotransplantation: the next medical revolution?

Lancet 2012 Feb 20;379(9816):672-83. Epub 2011 Oct 20.

Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0140-6736(11)61091-XDOI Listing
February 2012

Pig-to-nonhuman primates pancreatic islet xenotransplantation: an overview.

Curr Diab Rep 2011 Oct;11(5):402-12

Division of Immunogenetics, Department of Pediatrics, Rangos Research Center, Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11892-011-0213-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167044PMC
October 2011

PDGF signalling controls age-dependent proliferation in pancreatic β-cells.

Nature 2011 Oct 12;478(7369):349-55. Epub 2011 Oct 12.

Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature10502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503246PMC
October 2011

Hemoglobin A1C Percentage in Nonhuman Primates: A Useful Tool to Monitor Diabetes before and after Porcine Pancreatic Islet Xenotransplantation.

J Transplant 2011 17;2011:965605. Epub 2011 Apr 17.

Division of Immunogenetics, Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, 4401 Penn Avenue, Pittsburgh, PA 15224, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2011/965605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087943PMC
July 2011

Insulin secretion and glucose metabolism in alpha 1,3-galactosyltransferase knock-out pigs compared to wild-type pigs.

Xenotransplantation 2010 Mar-Apr;17(2):131-9

Division of Immunogenetics, Department of Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1399-3089.2010.00572.xDOI Listing
September 2010

Redox modulation protects islets from transplant-related injury.

Diabetes 2010 Jul 22;59(7):1731-8. Epub 2010 Apr 22.

Division of Immunogenetics, Department of Pediatrics, University of Pittsburgh School of Medicine, Rangos Research Center, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db09-0588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889773PMC
July 2010

Recovery of endogenous beta-cell function in nonhuman primates after chemical diabetes induction and islet transplantation.

Diabetes 2009 Feb 10;58(2):442-7. Epub 2008 Nov 10.

Division of Immunogenetics, Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db08-1127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628618PMC
February 2009

Islet xenotransplantation: the pig-to-non-human primate model.

Xenotransplantation 2008 Mar-Apr;15(2):104-6

Division of Immunogenetics, Department of Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh, PA 15213, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1399-3089.2008.00463.xDOI Listing
October 2008

Safe induction of diabetes by high-dose streptozotocin in pigs.

Pancreas 2008 Jan;36(1):31-8

Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA.

View Article

Download full-text PDF

Source
http://pdfs.journals.lww.com/pancreasjournal/2008/01000/Safe
Web Search
http://dx.doi.org/10.1097/mpa.0b013e3181452886DOI Listing
January 2008

Angiopoietin-1 production in islets improves islet engraftment and protects islets from cytokine-induced apoptosis.

Diabetes 2007 Sep 27;56(9):2274-83. Epub 2007 Jun 27.

Department of Pediatrics, Rangos Research Center, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db07-0371DOI Listing
September 2007

Antidiabetic sulfonylurea stimulates insulin secretion independently of plasma membrane KATP channels.

Am J Physiol Endocrinol Metab 2007 Jul 3;293(1):E293-301. Epub 2007 Apr 3.

Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, 3500 Terrace St., Pittsburgh, PA 15261, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpendo.00016.2007DOI Listing
July 2007

Rapid loss of intraportally transplanted islets: an overview of pathophysiology and preventive strategies.

Xenotransplantation 2007 Jul;14(4):288-97

Department of Pediatrics, Division of Immunogenetics, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1399-3089.2007.00419.xDOI Listing
July 2007

Gene therapy for type 1 diabetes: is it ready for the clinic?

Immunol Res 2006 ;36(1-3):83-9

Diabetes Institute, Children's Hospital of Pittsburgh, Pittsburgh 15213, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1385/IR:36:1:83DOI Listing
May 2007

Acute gastric dilatation after porcine islet transplantation in a cynomolgus monkey - case history and review of the literature.

Xenotransplantation 2007 May;14(3):265-70

Division of Immunogenetics, Department of Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1399-3089.2007.00406.xDOI Listing
May 2007

Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity.

Ann N Y Acad Sci 2007 Apr 21;1103:90-3. Epub 2007 Mar 21.

Diabetes Division, University of Massachusetts Medical School, 373 Plantation Street, Suite 218, Worcester, MA 01605, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1196/annals.1394.011DOI Listing
April 2007

Isolation outcome and functional characteristics of young and adult pig pancreatic islets for transplantation studies.

Xenotransplantation 2007 Jan;14(1):74-82

Division of Immunogenetics, Department of Pediatrics, Children's Hospital of Pittsburgh, Rangos Research Center, Pittsburgh, PA 15213, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1399-3089.2006.00374.xDOI Listing
January 2007

Reduction of early graft loss after intraportal porcine islet transplantation in monkeys.

Transplantation 2007 Jan;83(2):202-10

Division of Immunogenetics, Department of Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/01.tp.0000250680.36942.c6DOI Listing
January 2007

Induction of diabetes in cynomolgus monkeys with high-dose streptozotocin: adverse effects and early responses.

Pancreas 2006 Oct;33(3):287-92

Division of Immunogenetics, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/01.mpa.0000235307.04110.a2DOI Listing
October 2006

Sirolimus is associated with reduced islet engraftment and impaired beta-cell function.

Diabetes 2006 Sep;55(9):2429-36

Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db06-0173DOI Listing
September 2006

Prospective and challenges of islet transplantation for the therapy of autoimmune diabetes.

Pancreas 2006 Apr;32(3):231-43

Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/01.mpa.0000203961.16630.2fDOI Listing
April 2006

Facilitating physiologic self-regeneration: a step beyond islet cell replacement.

Pharm Res 2006 Feb 1;23(2):227-42. Epub 2006 Jan 1.

Division of Immunogenetics, Department of Pediatrics, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11095-005-9095-6DOI Listing
February 2006

Multifaceted therapeutic approaches for a multigenic disease.

Diabetes 2005 Dec;54 Suppl 2:S79-86

Division of Immunogenetics, Department of Pediatrics, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh, 3460 Fifth Ave., Pittsburgh, Pennsylvania 15213, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/diabetes.54.suppl_2.s79DOI Listing
December 2005

Harmful delayed effects of exogenous isolation enzymes on isolated human islets: relevance to clinical transplantation.

Am J Transplant 2005 Nov;5(11):2671-81

Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1600-6143.2005.01078.x
Publisher Site
http://dx.doi.org/10.1111/j.1600-6143.2005.01078.xDOI Listing
November 2005

Gene transfer of constitutively active Akt markedly improves human islet transplant outcomes in diabetic severe combined immunodeficient mice.

Diabetes 2005 Jun;54(6):1664-75

Division of Endocrinology, BST-E-1140, University of Pittsburgh, 200 Lothrop St., Pittsburgh, PA 15261, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/diabetes.54.6.1664DOI Listing
June 2005

Recovery of the endogenous beta cell function in the NOD model of autoimmune diabetes.

Stem Cells 2003 ;21(4):377-88

Division of Immunogenetics, Department of Pediatrics, University of Pittsburgh, School of Medicine, Pennsylvania 15213, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1634/stemcells.21-4-377DOI Listing
February 2004

Induction of beta-cell proliferation and retinoblastoma protein phosphorylation in rat and human islets using adenovirus-mediated transfer of cyclin-dependent kinase-4 and cyclin D1.

Diabetes 2004 Jan;53(1):149-59

Division of Endocrinology and Metabolism, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/diabetes.53.1.149DOI Listing
January 2004

Flexible management of enzymatic digestion improves human islet isolation outcome from sub-optimal donor pancreata.

Am J Transplant 2003 Sep;3(9):1135-42

Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
September 2003

Protection of islets by in situ peptide-mediated transduction of the Ikappa B kinase inhibitor Nemo-binding domain peptide.

J Biol Chem 2003 Mar 9;278(11):9862-8. Epub 2003 Jan 9.

Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M207700200DOI Listing
March 2003

Islet/pancreas transplantation: challenges for pediatrics.

Pediatr Diabetes 2002 Dec;3(4):210-23

Diabetes Institute, Rangos Research Center, Children's Hospital of Pittsburgh, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1034/j.1399-5448.2002.30408.xDOI Listing
December 2002