Publications by authors named "Rita Azevedo"

40Publications

Mesenchymal stromal cells induce regulatory T cells via epigenetic conversion of human conventional CD4 T cells in vitro.

Stem Cells 2020 08 30;38(8):1007-1019. Epub 2020 Apr 30.

Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal.

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http://dx.doi.org/10.1002/stem.3185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497276PMC
August 2020

Discovery of -(Indazol-3-yl)piperidine-4-carboxylic Acids as RORγt Allosteric Inhibitors for Autoimmune Diseases.

ACS Med Chem Lett 2020 Feb 9;11(2):114-119. Epub 2020 Jan 9.

Medicinal Chemistry, Discovery Biology, Discovery Process Chemistry, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Discovery Pharmaceutical Sciences, Modeling & Informatics, In Vitro and In Vivo Pharmacology, and Computational and Structural Chemistry, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.9b00431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025379PMC
February 2020

Protein Glycosylation and Tumor Microenvironment Alterations Driving Cancer Hallmarks.

Front Oncol 2019 14;9:380. Epub 2019 May 14.

Experimental Pathology and Therapeutics Group, Portuguese Institute of Oncology, Porto, Portugal.

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http://dx.doi.org/10.3389/fonc.2019.00380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530332PMC
May 2019

Molecular Markers Distinguishing T Cell Subtypes With TSDR Strand-Bias Methylation.

Front Immunol 2018 5;9:2540. Epub 2018 Nov 5.

Faculdade de Medicina da Universidade de Lisboa, Instituto de Medicina Molecular-João Lobo Antunes, Lisbon, Portugal.

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02540
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http://dx.doi.org/10.3389/fimmu.2018.02540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230625PMC
September 2019

Exploring sialyl-Tn expression in microfluidic-isolated circulating tumour cells: A novel biomarker and an analytical tool for precision oncology applications.

N Biotechnol 2019 Mar 28;49:77-87. Epub 2018 Sep 28.

Portuguese Institute of Oncology, Porto, Portugal; Institute of Biomedical Sciences Abel Salazar, University of Porto, Portugal; International Iberian Nanotechnology Laboratory (INL), Braga, Portugal; Glycobiology in Cancer, Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Portugal; Instituto de Investigação e Inovação em Saúde (I3S), University of Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.nbt.2018.09.004DOI Listing
March 2019

CD44 glycoprotein in cancer: a molecular conundrum hampering clinical applications.

Clin Proteomics 2018 27;15:22. Epub 2018 Jun 27.

1Experimental Pathology and Therapeutics Group, Portuguese Institute of Oncology, Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal.

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http://dx.doi.org/10.1186/s12014-018-9198-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020424PMC
June 2018

Glycan affinity magnetic nanoplatforms for urinary glycobiomarkers discovery in bladder cancer.

Talanta 2018 Jul 12;184:347-355. Epub 2018 Mar 12.

Experimental Pathology and Therapeutics Group, Research Centre, Portuguese Oncology Institute of Porto (IPO-Porto), R. Dr. António Bernardino de Almeida 62, 4200-162 Porto, Portugal; Institute of Biomedical Sciences Abel Salazar, University of Porto, R. Jorge de Viterbo Ferreira 228, 4050-013 Porto, Portugal; Institute for Research and Innovation in Health (i3S), University of Porto, R. Alfredo Allen, 4200-135 Porto, Portugal; Glycobiology in Cancer, Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), R. Júlio Amaral de Carvalho 45, 4200-135 Porto, Portugal; International Iberian Nanotechnology Laboratory (INL), Avda. Mestre José Veiga, 4715 Braga, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.talanta.2018.03.028DOI Listing
July 2018

Circulating tumor cells in bladder cancer: Emerging technologies and clinical implications foreseeing precision oncology.

Urol Oncol 2018 05 9;36(5):221-236. Epub 2018 Mar 9.

Experimental Pathology and Therapeutics Group, Research Centre, Portuguese Oncology Institute of Porto (IPO-Porto), R. Dr. António Bernardino de Almeida 62, 4200-162 Porto, Portugal; Institute of Biomedical Sciences Abel Salazar, University of Porto, R. Jorge de Viterbo Ferreira 228, 4050-013 Porto, Portugal; Institute for Research and Innovation in Health (i3S), University of Porto, R. Alfredo Allen, 4200-135 Porto, Portugal; Glycobiology in Cancer, Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), R. Júlio Amaral de Carvalho 45, 4200-135 Porto, Portugal; Porto Comprehensive Cancer Centre (P.ccc), R. Dr. António Bernardino de Almeida 62, 4200-162 Porto, Portugal; International Iberian Nanotechnology Laboratory (INL), Avda. Mestre José Veiga, 4715 Braga, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.urolonc.2018.02.004DOI Listing
May 2018

Over forty years of bladder cancer glycobiology: Where do glycans stand facing precision oncology?

Oncotarget 2017 Oct 21;8(53):91734-91764. Epub 2017 Jul 21.

Experimental Pathology and Therapeutics Group, Portuguese Institute of Oncology, Porto, Portugal.

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http://dx.doi.org/10.18632/oncotarget.19433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710962PMC
October 2017

Sialyl-Tn identifies muscle-invasive bladder cancer basal and luminal subtypes facing decreased survival, being expressed by circulating tumor cells and metastases.

Urol Oncol 2017 12 12;35(12):675.e1-675.e8. Epub 2017 Sep 12.

Experimental Pathology and Therapeutics Group, Research Center, Portuguese Institute of Oncology, Porto, Portugal; Abel Salazar Institute of Biomedical Sciences, University of Porto, Porto, Portugal; International Iberian Nanotechnology Laboratory, Braga, Portugal; Institute for Research and Innovation in Health, University of Porto, Porto, Portugal; Glycobiology in Cancer, Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal; Porto Comprehensive Cancer Center (P.ccc), Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.urolonc.2017.08.012DOI Listing
December 2017

In silico approaches for unveiling novel glycobiomarkers in cancer.

J Proteomics 2018 01 4;171:95-106. Epub 2017 Aug 4.

Experimental Pathology and Therapeutics Group, Research Centre, Portuguese Institute of Oncology of Porto (IPO-Porto), Porto, Portugal; Institute of Biomedical Sciences Abel Salazar, University of Porto, Porto, Portugal; Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal; Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal; Porto Comprehensive Cancer Center (P.ccc), Porto, Portugal; International Iberian Nanotechnology Laboratory (INL), Braga, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2017.08.004DOI Listing
January 2018

Moving toward personalized medicine in rheumatoid arthritis: SNPs in methotrexate intracellular pathways are associated with methotrexate therapeutic outcome.

Pharmacogenomics 2016 10 27;17(15):1649-1674. Epub 2016 Sep 27.

Molecular Oncology & Viral Pathology Group - Research Center, Portuguese Institute of Oncology of Porto (IPO-Porto), Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal.

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https://www.futuremedicine.com/doi/10.2217/pgs-2016-0067
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http://dx.doi.org/10.2217/pgs-2016-0067DOI Listing
October 2016

Emerging antibody-based therapeutic strategies for bladder cancer: A systematic review.

J Control Release 2015 Sep 18;214:40-61. Epub 2015 Jul 18.

Experimental Pathology and Therapeutics Group - Research Center, Portuguese Institute of Oncology of Porto (IPO-Porto), Rua Dr. António Bernardino de Almeida, 4200-072, Porto, Portugal; Health School of University of Fernando Pessoa, Praça 9 de Abril 349, 4249-004 Porto, Portugal; Department of Surgical Oncology, Portuguese Institute of Oncology of Porto (IPO-Porto), Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2015.07.002DOI Listing
September 2015

Pharmacogenomics of Methotrexate Membrane Transport Pathway: Can Clinical Response to Methotrexate in Rheumatoid Arthritis Be Predicted?

Int J Mol Sci 2015 Jun 16;16(6):13760-80. Epub 2015 Jun 16.

Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde (IINFACTS), 4585-116 Gandra PRD, Portugal.

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http://dx.doi.org/10.3390/ijms160613760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490522PMC
June 2015

Smartphone application for rheumatoid arthritis self-management: cross-sectional study revealed the usefulness, willingness to use and patients' needs.

Rheumatol Int 2015 Oct 24;35(10):1675-85. Epub 2015 Apr 24.

Molecular Oncology Group CI, Portuguese Institute of Oncology of Porto (IPO-Porto), Rua Dr. António Bernardino de Almeida, 4200-072, Porto, Portugal.

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http://dx.doi.org/10.1007/s00296-015-3270-9DOI Listing
October 2015

Genetic polymorphisms in low-dose methotrexate transporters: current relevance as methotrexate therapeutic outcome biomarkers.

Pharmacogenomics 2014 ;15(12):1611-35

CESPU, Institute of Research & Advanced Training in Health Sciences & Technologies, Department of Pharmaceutical Sciences, Higher Institute of Health Sciences - North (ISCS-N), Rua Central de Gandra 1317, 4585-116, Gandra PRD, Portugal.

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http://dx.doi.org/10.2217/pgs.14.116DOI Listing
June 2015

Role of key TYMS polymorphisms on methotrexate therapeutic outcome in portuguese rheumatoid arthritis patients.

PLoS One 2014 3;9(10):e108165. Epub 2014 Oct 3.

Molecular Oncology Group CI, Portuguese Institute of Oncology of Porto (IPO-Porto), Porto, Portugal; Abel Salazar Institute for the Biomedical Sciences (ICBAS) of University of Porto, Porto, Portugal; Virology Service, Portuguese Institute of Oncology of Porto (IPO-Porto), Porto, Portugal; Research Department-Portuguese League Against Cancer (LPCC-NRNorte), Porto, Portugal.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108165PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184792PMC
July 2015

SLC19A1, SLC46A1 and SLCO1B1 polymorphisms as predictors of methotrexate-related toxicity in Portuguese rheumatoid arthritis patients.

Toxicol Sci 2014 Nov 14;142(1):196-209. Epub 2014 Aug 14.

CESPU, Institute of Research and Advanced Training in Health Sciences and Technologies, Department of Pharmaceutical Sciences, Higher Institute of Health Sciences-North (ISCS-N), Rua Central de Gandra 1317, 4585-116 Gandra PRD, Portugal.

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http://academic.oup.com/toxsci/article/142/1/196/1707453/SLC
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http://dx.doi.org/10.1093/toxsci/kfu162DOI Listing
November 2014

Prediction of methotrexate clinical response in Portuguese rheumatoid arthritis patients: implication of MTHFR rs1801133 and ATIC rs4673993 polymorphisms.

Biomed Res Int 2014 21;2014:368681. Epub 2014 May 21.

Molecular Oncology Group CI, Portuguese Institute of Oncology of Porto (IPO-Porto), Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal ; Abel Salazar Institute for the Biomedical Sciences (ICBAS), University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal ; Virology Service, Portuguese Institute of Oncology of Porto (IPO-Porto), Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal ; Research Department-Portuguese League Against Cancer (LPCC-NRNorte), Estrada Interior da Circunvalação 6657, 4200-177 Porto, Portugal.

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http://www.hindawi.com/journals/bmri/2014/368681/
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http://dx.doi.org/10.1155/2014/368681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055378PMC
February 2015

SLC19A1 80G allele as a biomarker of methotrexate-related gastrointestinal toxicity in Portuguese rheumatoid arthritis patients.

Pharmacogenomics 2014 Apr 18;15(6):807-20. Epub 2013 Dec 18.

CESPU, Institute of Research & Advanced Training in Health Sciences & Technologies, Department of Pharmaceutical Sciences, Higher Institute of Health Sciences (ISCS-N), Rua Central de Gandra 1317, 4585-116, Gandra PRD, Portugal and Molecular Oncology Group CI, Portuguese Institute of Oncology of Porto (IPO-Porto), Rua Dr. António Bernardino de Almeida, 4200-072, Porto, Portugal and Abel Salazar Institute for the Biomedical Sciences (ICBAS), University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313, Porto, Portugal.

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http://dx.doi.org/10.2217/pgs.13.244DOI Listing
April 2014

Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: a template-based approach.

Bioorg Med Chem Lett 2013 Nov 7;23(22):6178-82. Epub 2013 Sep 7.

Department of Chemical Research, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2013.08.110DOI Listing
November 2013

Current approaches for TYMS polymorphisms and their importance in molecular epidemiology and pharmacogenetics.

Pharmacogenomics 2013 Aug;14(11):1337-51

CESPU, Health Sciences Research Center-CICS, Department of Pharmaceutical Sciences, Higher Institute of Health Sciences-North-ISCS-N, Rua Central de Gandra 1317, 4585-116 Gandra PRD, Portugal.

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http://dx.doi.org/10.2217/pgs.13.118DOI Listing
August 2013

Long-term immune reconstitution of naive and memory t cell pools after haploidentical hematopoietic stem cell transplantation.

Biol Blood Marrow Transplant 2013 May 8;19(5):703-12. Epub 2013 Feb 8.

Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.

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http://dx.doi.org/10.1016/j.bbmt.2013.01.017DOI Listing
May 2013

Identification of novel bacterial M.SssI DNA methyltransferase inhibitors.

J Biomol Screen 2013 Mar 25;18(3):348-55. Epub 2012 Oct 25.

Department of Cell and Applied Biology, Radboud University Nijmegen, Nijmegen, 6525 AJ, Netherlands.

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http://dx.doi.org/10.1177/1087057112465009DOI Listing
March 2013

X-ray structure of p38α bound to TAK-715: comparison with three classic inhibitors.

Acta Crystallogr D Biol Crystallogr 2012 Aug 17;68(Pt 8):1041-50. Epub 2012 Jul 17.

Merck Research Laboratories, MSD, PO Box 20, 5340 BH Oss, The Netherlands.

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http://scripts.iucr.org/cgi-bin/paper?S090744491201997X
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http://dx.doi.org/10.1107/S090744491201997XDOI Listing
August 2012

Reversible senescence in human CD4+CD45RA+CD27- memory T cells.

J Immunol 2011 Sep 25;187(5):2093-100. Epub 2011 Jul 25.

Division of Infection and Immunity, University College London, London W1T 4JF, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.1100978DOI Listing
September 2011

A molecular informatics view on best practice in multi-parameter compound optimization.

Drug Discov Today 2011 Jul 13;16(13-14):555-68. Epub 2011 May 13.

Department of Molecular Design & Informatics, Merck Research Laboratories, Oss, The Netherlands.

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http://dx.doi.org/10.1016/j.drudis.2011.05.005DOI Listing
July 2011

IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner.

Blood 2009 Mar 13;113(13):2999-3007. Epub 2008 Nov 13.

Unidade de Imunologia Clínica, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.

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http://dx.doi.org/10.1182/blood-2008-07-166223DOI Listing
March 2009

[Macrophage migration inhibitory factor and interleukin-6 in crush syndrome: analogy with severity? Case reports].

Rev Bras Ter Intensiva 2007 Dec;19(4):499-503

Departamento de Clínica Médica, FM, UFRJ.

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December 2007

[Poisoning syndrome due to 2,000 stings of africanized honeybees].

Rev Bras Ter Intensiva 2006 Mar;18(1):99-103

AMIB.

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March 2006