Publications by authors named "Rinse K Weersma"

100Publications

Gut microbiota in inflammatory bowel diseases: moving from basic science to clinical applications.

Hum Genet 2020 Aug 28. Epub 2020 Aug 28.

Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1007/s00439-020-02218-3DOI Listing
August 2020

Environmental factors associated with biological use and surgery in inflammatory bowel disease.

J Gastroenterol Hepatol 2020 Aug 24. Epub 2020 Aug 24.

Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1111/jgh.15223DOI Listing
August 2020

Latent cytomegalovirus infection does not influence long-term disease outcomes in inflammatory bowel disease, but is associated with later onset of disease.

Scand J Gastroenterol 2020 Aug 7;55(8):891-896. Epub 2020 Jul 7.

Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1080/00365521.2020.1786853DOI Listing
August 2020

Donor tobacco smoking is associated with postoperative thrombosis after primary liver transplantation.

J Thromb Haemost 2020 Jul 2. Epub 2020 Jul 2.

Department of Surgery, Section of Hepatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

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http://dx.doi.org/10.1111/jth.14983DOI Listing
July 2020

Understanding human gut diseases at single-cell resolution.

Hum Mol Genet 2020 Sep;29(R1):R51-R58

Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713GZ Groningen, The Netherlands.

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http://dx.doi.org/10.1093/hmg/ddaa130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530522PMC
September 2020

Identification of environmental risk factors associated with the development of Inflammatory Bowel Disease.

J Crohns Colitis 2020 Jun 23. Epub 2020 Jun 23.

Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, the Netherlands.

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http://dx.doi.org/10.1093/ecco-jcc/jjaa114DOI Listing
June 2020

TNFα-antagonist use and mucosal inflammation are associated with increased intestinal expression of SARS-CoV-2 host protease TMPRSS2 in patients with inflammatory bowel disease.

Gastroenterology 2020 Jun 15. Epub 2020 Jun 15.

Department of Gastroenterology and Hepatology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2020.05.091DOI Listing
June 2020

Interaction between drugs and the gut microbiome.

Gut 2020 Aug 14;69(8):1510-1519. Epub 2020 May 14.

Department of Genetics, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1136/gutjnl-2019-320204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398478PMC
August 2020

Predicted efficacy of a pharmacogenetic passport for inflammatory bowel disease.

Aliment Pharmacol Ther 2020 06 3;51(11):1105-1115. Epub 2020 May 3.

Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1111/apt.15762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318341PMC
June 2020

Habitual dietary intake of IBD patients differs from population controls: a case-control study.

Eur J Nutr 2020 Apr 24. Epub 2020 Apr 24.

Department of Gastroenterology and Hepatology, University Medical Centre Groningen and University of Groningen, Hanzeplein 1, P.O. box 30.001, 9700RB, Groningen, The Netherlands.

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http://dx.doi.org/10.1007/s00394-020-02250-zDOI Listing
April 2020

Tissue alarmins and adaptive cytokine induce dynamic and distinct transcriptional responses in tissue-resident intraepithelial cytotoxic T lymphocytes.

J Autoimmun 2020 03 4;108:102422. Epub 2020 Feb 4.

Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; K.G. Jebsen Coeliac Disease Research Centre, Department of Immunology, University of Oslo, Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2020.102422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049906PMC
March 2020

Characteristics and Dysbiosis of the Gut Microbiome in Renal Transplant Recipients.

J Clin Med 2020 Feb 1;9(2). Epub 2020 Feb 1.

Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.

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http://dx.doi.org/10.3390/jcm9020386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074359PMC
February 2020

Limited diagnostic accuracy and clinical impact of single-operator peroral cholangioscopy for indeterminate biliary strictures.

Endoscopy 2020 02 13;52(2):107-114. Epub 2019 Dec 13.

Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1055/a-1061-7067DOI Listing
February 2020

Diverticular disease: picking pockets and population biobanks.

Gut 2019 05 2;68(5):769-770. Epub 2019 Mar 2.

Gastroenterology Unit, Addenbrookes Hospital, Cambridge, UK.

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http://dx.doi.org/10.1136/gutjnl-2019-318231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580773PMC
May 2019

Shared gut, but distinct oral microbiota composition in primary Sjögren's syndrome and systemic lupus erythematosus.

J Autoimmun 2019 02 9;97:77-87. Epub 2018 Nov 9.

Department of Rheumatology & Clinical Immunology, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700 RB, Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.jaut.2018.10.009DOI Listing
February 2019

Single-Cell RNA Sequencing of Blood and Ileal T Cells From Patients With Crohn's Disease Reveals Tissue-Specific Characteristics and Drug Targets.

Gastroenterology 2019 02 2;156(3):812-815.e22. Epub 2018 Nov 2.

Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2018.10.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759855PMC
February 2019

Multiomics Analyses to Deliver the Most Effective Treatment to Every Patient With Inflammatory Bowel Disease.

Gastroenterology 2018 11 2;155(5):e1-e4. Epub 2018 Aug 2.

Genomics plc, Oxford, United Kingdom.

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http://dx.doi.org/10.1053/j.gastro.2018.07.039DOI Listing
November 2018

Pharmacomicrobiomics: a novel route towards personalized medicine?

Protein Cell 2018 05 28;9(5):432-445. Epub 2018 Apr 28.

Departments of Genetics, University Medical Center Groningen, PO Box 30001, 9700 RB, Groningen, The Netherlands.

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http://dx.doi.org/10.1007/s13238-018-0547-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960471PMC
May 2018

Reduced salivary secretion contributes more to changes in the oral microbiome of patients with primary Sjögren's syndrome than underlying disease.

Ann Rheum Dis 2018 10 23;77(10):1542-1544. Epub 2018 Mar 23.

Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1136/annrheumdis-2018-213026DOI Listing
October 2018

DNA polymorphisms predict time to progression from uncomplicated to complicated Crohn's disease.

Eur J Gastroenterol Hepatol 2018 04;30(4):447-455

Center for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine.

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http://dx.doi.org/10.1097/MEG.0000000000001055DOI Listing
April 2018

Prevalence of- and risk factors for work disability in Dutch patients with inflammatory bowel disease.

World J Gastroenterol 2017 Dec;23(46):8182-8192

Department of Gastroenterology and Hepatology, University of Groningen and University Medical Centre Groningen, Groningen, 9700 RB Groningen, the Netherlands.

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http://dx.doi.org/10.3748/wjg.v23.i46.8182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739924PMC
December 2017

Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis.

Gut 2018 08 4;67(8):1517-1524. Epub 2017 Aug 4.

Department of Gastroenterology and Hepatology, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1136/gutjnl-2016-313598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797498PMC
August 2018

Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis.

Gastroenterology 2017 06 6;152(8):1975-1984.e8. Epub 2017 Mar 6.

Norwegian PSC Research Center and Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.02.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546611PMC
June 2017

The influence of proton pump inhibitors and other commonly used medication on the gut microbiota.

Gut Microbes 2017 07 24;8(4):351-358. Epub 2017 Jan 24.

a University of Groningen and University Medical Center Groningen , Department of Gastroenterology and Hepatology , Groningen , the Netherlands.

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http://dx.doi.org/10.1080/19490976.2017.1284732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570416PMC
July 2017

Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease.

Nat Genet 2017 Feb 19;49(2):269-273. Epub 2016 Dec 19.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.

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http://dx.doi.org/10.1038/ng.3745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540332PMC
February 2017

The genetic background of inflammatory bowel disease: from correlation to causality.

J Pathol 2017 Jan 15;241(2):146-158. Epub 2016 Nov 15.

Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1002/path.4817DOI Listing
January 2017

Drug Repositioning in Inflammatory Bowel Disease Based on Genetic Information.

Inflamm Bowel Dis 2016 11;22(11):2562-2570

Department of Gastroenterology and Hepatology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.

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http://dx.doi.org/10.1097/MIB.0000000000000912DOI Listing
November 2016

Shifting Paradigms: What Is the True Prevalence and Clinical Course of Primary Sclerosing Cholangitis?

Gastroenterology 2016 10 30;151(4):590-3. Epub 2016 Aug 30.

College of Health Solutions, Arizona State University and Mayo Clinic Arizona, Phoenix, Arizona.

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http://dx.doi.org/10.1053/j.gastro.2016.08.046DOI Listing
October 2016

A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis.

Nat Commun 2016 08 9;7:12342. Epub 2016 Aug 9.

Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.

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http://dx.doi.org/10.1038/ncomms12342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980482PMC
August 2016

Multi-locus genetic risk score predicts risk for Crohn's disease in Slovenian population.

World J Gastroenterol 2016 Apr;22(14):3777-84

Katarina Zupančič, Kristijan Skok, Katja Repnik, Uroš Potočnik, Center for Human Genetics and Pharmacogenomics, Medical Faculty of Maribor, University of Maribor, 2000 Maribor, Slovenia.

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http://dx.doi.org/10.3748/wjg.v22.i14.3777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814740PMC
April 2016

Alkaline phosphatase at diagnosis of primary sclerosing cholangitis and 1 year later: evaluation of prognostic value.

Liver Int 2016 12 4;36(12):1867-1875. Epub 2016 Apr 4.

Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1111/liv.13110DOI Listing
December 2016

A large variety of clinical features and concomitant disorders in celiac disease - A cohort study in the Netherlands.

Dig Liver Dis 2016 May 18;48(5):499-505. Epub 2016 Jan 18.

Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands; Department of Genetics, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.dld.2016.01.006DOI Listing
May 2016

HSPA6 is an ulcerative colitis susceptibility factor that is induced by cigarette smoke and protects intestinal epithelial cells by stabilizing anti-apoptotic Bcl-XL.

Biochim Biophys Acta 2016 04 26;1862(4):788-796. Epub 2016 Jan 26.

Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2016.01.020DOI Listing
April 2016

Endoscopic assessment of primary sclerosing cholangitis.

Minerva Gastroenterol Dietol 2016 Mar 7;62(1):49-62. Epub 2015 Oct 7.

Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands -

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March 2016

Identification of Clinical and Genetic Parameters Associated with Hidradenitis Suppurativa in Inflammatory Bowel Disease.

Inflamm Bowel Dis 2016 Jan;22(1):106-13

*Departments of Dermatology, †Gastroenterology and Hepatology, and ‡Genetics, University of Groningen, University Medical Center Groningen, the Netherlands.

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http://dx.doi.org/10.1097/MIB.0000000000000579DOI Listing
January 2016

The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids.

Circ Res 2015 Oct 10;117(9):817-24. Epub 2015 Sep 10.

From the Department of Pediatrics (J.F., E.B., M.H.H.), Department of Genetics (J.F., M.J.B., M.C.C., E.F.T., A.M., J.A.M.D., J.M., L.F., C.W., A.Z.), and Department of Gastroenterology and Hepatology (F.I., R.K.W.), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Top Institute Food and Nutrition, Wageningen, The Netherlands (E.F.T., J.A.M.D., A.Z.); Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland (J.M.); Broad Institute of MIT and Harvard, Cambridge, MA (T.W.P., R.J.X., D.G.); and Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease (R.J.X.) and Center for Computational and Integrative Biology (R.J.X.), Massachusetts General Hospital and Harvard Medical School, Boston.

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http://dx.doi.org/10.1161/CIRCRESAHA.115.306807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596485PMC
October 2015

Genetic polymorphism in ATG16L1 gene influences the response to adalimumab in Crohn's disease patients.

Pharmacogenomics 2015 ;16(3):191-204

University Medical Centre Maribor, Ljubljanska 5, Maribor, Slovenia.

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http://dx.doi.org/10.2217/pgs.14.172DOI Listing
November 2015

Distinctive inflammatory bowel disease phenotype in primary sclerosing cholangitis.

World J Gastroenterol 2015 Feb;21(6):1956-71

A Boudewijn de Vries, Marcel Janse, Hans Blokzijl, Rinse K Weersma, Department of Gastroenterology and Hepatology, University Medical Centre Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.

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http://dx.doi.org/10.3748/wjg.v21.i6.1956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323476PMC
February 2015

Complex host genetics influence the microbiome in inflammatory bowel disease.

Genome Med 2014 2;6(12):107. Epub 2014 Dec 2.

Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142 USA ; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114 USA ; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114 USA.

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http://dx.doi.org/10.1186/s13073-014-0107-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292994PMC
January 2015

Down the line from genome-wide association studies in inflammatory bowel disease: the resulting clinical benefits and the outlook for the future.

Expert Rev Clin Immunol 2015 Jan 10;11(1):33-44. Epub 2014 Dec 10.

Department of Gastroenterology and Hepatology, University of Groningen and University Medical Centre Groningen, 9700 RB Groningen, The Netherlands.

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http://dx.doi.org/10.1586/1744666X.2015.990439DOI Listing
January 2015

Performance of the Montreal classification for inflammatory bowel diseases.

World J Gastroenterol 2014 Nov;20(41):15374-81

Lieke M Spekhorst, Marijn C Visschedijk, Rudi Alberts, Eleonora A Festen, Gerard Dijkstra, Rinse K Weersma, Department of Gastroenterology and Hepatology, University of Groningen and University Medical Centre Groningen, 9700 RB Groningen, The Netherlands.

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http://www.wjgnet.com/1007-9327/full/v20/i41/15374.htm
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http://dx.doi.org/10.3748/wjg.v20.i41.15374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223272PMC
November 2014

The ATG16L1-T300A allele impairs clearance of pathosymbionts in the inflamed ileal mucosa of Crohn's disease patients.

Gut 2015 Oct 24;64(10):1546-52. Epub 2014 Sep 24.

Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1136/gutjnl-2014-307289DOI Listing
October 2015

Completion rate of small bowel capsule endoscopy is higher after erythromycin compared to domperidone.

BMC Gastroenterol 2014 Sep 19;14:162. Epub 2014 Sep 19.

Department of Gastroenterology and Hepatology, University Medical Centre Groningen, University of Groningen, PO Box 30001 9700 RB Groningen, The Netherlands.

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http://dx.doi.org/10.1186/1471-230X-14-162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177765PMC
September 2014

Non-small-bowel abnormalities identified during small bowel capsule endoscopy.

World J Gastroenterol 2014 Apr;20(14):4025-9

Reinier A Hoedemaker, Jessie Westerhof, Rinse K Weersma, Jan J Koornstra, Department of Gastroenterology and Hepatology, University Medical Centre Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.

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http://dx.doi.org/10.3748/wjg.v20.i14.4025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983458PMC
April 2014

Extraintestinal manifestations and complications in inflammatory bowel disease: from shared genetics to shared biological pathways.

Inflamm Bowel Dis 2014 Jun;20(6):987-94

Departments of *Genetics, and †Gastroenterology and Hepatology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.

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http://dx.doi.org/10.1097/MIB.0000000000000032DOI Listing
June 2014

Correlation of genetic risk and messenger RNA expression in a Th17/IL23 pathway analysis in inflammatory bowel disease.

Inflamm Bowel Dis 2014 May;20(5):777-82

Departments of *Genetics, and †Gastroenterology and Hepatology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.

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http://dx.doi.org/10.1097/MIB.0000000000000013DOI Listing
May 2014

MMP-2 is a disease-modifying gene in primary sclerosing cholangitis.

Liver Int 2014 Feb 28;34(2):274-80. Epub 2013 Jun 28.

Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1111/liv.12237DOI Listing
February 2014

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.

Nat Genet 2013 Jun 21;45(6):670-5. Epub 2013 Apr 21.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

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http://petercroucher.com/wp-content/uploads/2013/10/51_Natur
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http://www.nature.com/doifinder/10.1038/ng.2616
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http://dx.doi.org/10.1038/ng.2616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667736PMC
June 2013