Rino Rappuoli

Rino Rappuoli

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Rino Rappuoli

Rino Rappuoli

Publications by authors named "Rino Rappuoli"

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Long noncoding RNAs are involved in multiple immunological pathways in response to vaccination.

Proc Natl Acad Sci U S A 2019 Aug 9;116(34):17121-17126. Epub 2019 Aug 9.

Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, 05508-000 São Paulo, Brazil;

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http://dx.doi.org/10.1073/pnas.1822046116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708379PMC
August 2019

Human monoclonal antibodies for discovery, therapy, and vaccine acceleration.

Curr Opin Immunol 2019 Aug 23;59:130-134. Epub 2019 Aug 23.

vAMRes Lab, Toscana Life Sciences, Siena, Italy; GSK, Siena, Italy; Imperial College, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2019.07.005DOI Listing
August 2019

Changing Priorities in Vaccinology: Antibiotic Resistance Moving to the Top.

Front Immunol 2018 30;9:1068. Epub 2018 May 30.

GSK Vaccines, Siena, Italy.

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http://dx.doi.org/10.3389/fimmu.2018.01068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992407PMC
July 2019

Transmission-Blocking Vaccines for Malaria: Time to Talk about Vaccine Introduction.

Trends Parasitol 2019 Jul 29;35(7):483-486. Epub 2019 May 29.

Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pt.2019.04.008DOI Listing
July 2019

Vaccine Evolution and Its Application to Fight Modern Threats.

Front Immunol 2019 25;10:1722. Epub 2019 Jul 25.

GlaxoSmithKline, Siena, Italy.

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http://dx.doi.org/10.3389/fimmu.2019.01722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669413PMC
July 2019

Vaccines and global health: In search of a sustainable model for vaccine development and delivery.

Sci Transl Med 2019 Jun;11(497)

Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaw2888DOI Listing
June 2019

Vaccines for Staphylococcus aureus and Target Populations.

Curr Top Microbiol Immunol 2017;409:491-528

GSK Vaccines, Research Center, Via Fiorentina 1, 53100, Siena, Italy.

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http://dx.doi.org/10.1007/82_2016_54DOI Listing
May 2019

Post-hoc analysis from phase III trials of human papillomavirus vaccines: considerations on impact on non-vaccine types.

Expert Rev Vaccines 2019 03 4;18(3):309-322. Epub 2019 Mar 4.

d Translational Science , GSK , Rixensart , Belgium.

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http://dx.doi.org/10.1080/14760584.2019.1579647DOI Listing
March 2019

Inhibiting neuraminidase can make the difference.

J Exp Med 2019 Feb 25;216(2):251-252. Epub 2019 Jan 25.

GlaxoSmithKline, Siena, Italy.

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http://www.jem.org/lookup/doi/10.1084/jem.20182245
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http://dx.doi.org/10.1084/jem.20182245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363436PMC
February 2019

Vaccines: An achievement of civilization, a human right, our health insurance for the future.

J Exp Med 2019 Jan 3;216(1):7-9. Epub 2018 Dec 3.

Humanitas Clinical and Research Center, Milan, Italy

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http://dx.doi.org/10.1084/jem.20182160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314523PMC
January 2019

On the mechanisms of conjugate vaccines.

Proc Natl Acad Sci U S A 2019 01 21;116(1):14-16. Epub 2018 Dec 21.

Private address, 53034 Colle Val d'Elsa (SI), Italy.

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http://dx.doi.org/10.1073/pnas.1819612116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320500PMC
January 2019

Meningococcal B vaccine (4CMenB): the journey from research to real world experience.

Expert Rev Vaccines 2018 12 5;17(12):1111-1121. Epub 2018 Dec 5.

d Vaccine Development Leader , Research and Development Centre , Rockville , MD , USA.

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https://www.tandfonline.com/doi/full/10.1080/14760584.2018.1
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http://dx.doi.org/10.1080/14760584.2018.1547637DOI Listing
December 2018

Vision for a systems architecture to integrate and transform population health.

Proc Natl Acad Sci U S A 2018 12;115(50):12595-12602

GlaxoSmithKline plc, 53100 Siena, Italy.

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http://dx.doi.org/10.1073/pnas.1809919115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294918PMC
December 2018

Technologies to address antimicrobial resistance.

Proc Natl Acad Sci U S A 2018 12;115(51):12887-12895

Research & Development Centre, GlaxoSmithKline, 53100 Siena, Italy.

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http://dx.doi.org/10.1073/pnas.1717160115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304975PMC
December 2018

Antimicrobial resistance and the role of vaccines.

Proc Natl Acad Sci U S A 2018 12;115(51):12868-12871

GlaxoSmithKline (GSK), 53100 Siena, Italy;

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http://dx.doi.org/10.1073/pnas.1717157115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305009PMC
December 2018

Correlates of adjuvanticity: A review on adjuvants in licensed vaccines.

Semin Immunol 2018 10 23;39:14-21. Epub 2018 May 23.

GSK, Rixensart, Belgium.

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http://dx.doi.org/10.1016/j.smim.2018.05.001DOI Listing
October 2018

Sustainable vaccine development: a vaccine manufacturer's perspective.

Curr Opin Immunol 2018 08 8;53:111-118. Epub 2018 May 8.

GSK, Rixensart, Belgium.

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http://dx.doi.org/10.1016/j.coi.2018.04.019DOI Listing
August 2018

Short-term and mid-term solutions for influenza vaccines.

Lancet Infect Dis 2018 08;18(8):832-833

GlaxoSmithKline, Siena, Italy. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(18)30404-3DOI Listing
August 2018

Glycoconjugate vaccines: Principles and mechanisms.

Authors:
Rino Rappuoli

Sci Transl Med 2018 08;10(456)

GlaxoSmithKline, Via Fiorentina 1, 53100 Siena, Italy.

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http://stm.sciencemag.org/lookup/doi/10.1126/scitranslmed.aa
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http://dx.doi.org/10.1126/scitranslmed.aat4615DOI Listing
August 2018

Role of O-Acetylation in the Immunogenicity of Bacterial Polysaccharide Vaccines.

Molecules 2018 Jun 2;23(6). Epub 2018 Jun 2.

External R&D, GSK Vaccines, 53100 Siena, Italy.

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http://dx.doi.org/10.3390/molecules23061340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100563PMC
June 2018

Deploy vaccines to fight superbugs.

Nature 2017 12;552(7684):165-167

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http://dx.doi.org/10.1038/d41586-017-08323-0DOI Listing
December 2017

Improving accountability in vaccine decision-making.

Expert Rev Vaccines 2017 11 9;16(11):1057-1066. Epub 2017 Oct 9.

c GSK Vaccines , Siena , Italy.

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http://dx.doi.org/10.1080/14760584.2017.1382358DOI Listing
November 2017

2. How is the economic assessment of vaccines performed today?

J Mark Access Health Policy 2017 31;5(1):1335163. Epub 2017 Aug 31.

Research & Development GSK, Siena, Italy.

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http://dx.doi.org/10.1080/20016689.2017.1335163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956288PMC
August 2017

3. How comprehensive can we be in the economic assessment of vaccines?

J Mark Access Health Policy 2017 31;5(1):1336044. Epub 2017 Aug 31.

Research & Development, Research Center, GSK, Siena, Italy.

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http://dx.doi.org/10.1080/20016689.2017.1336044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956290PMC
August 2017

Emerging experience with meningococcal serogroup B protein vaccines.

Expert Rev Vaccines 2017 May 10;16(5):433-451. Epub 2017 Apr 10.

d Research & Development, GSK , Siena , Italy.

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http://dx.doi.org/10.1080/14760584.2017.1308828DOI Listing
May 2017

Emerging infectious diseases: A proactive approach.

Proc Natl Acad Sci U S A 2017 04 10;114(16):4055-4059. Epub 2017 Apr 10.

GlaxoSmithKline Vaccines, 53100 Siena, Italy

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http://dx.doi.org/10.1073/pnas.1701410114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402424PMC
April 2017

Editorial overview: Preventive and therapeutic vaccines: Vaccination against viral disease - current advances and challenges.

Curr Opin Virol 2017 04;23:vi-viii

Ludwig-Maximilians-Universität München (LMU), Deutsches Zentrum für Infektionsforschung (DZIF), 80539 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.coviro.2017.06.001DOI Listing
April 2017

Beyond cost-effectiveness: Using systems analysis for infectious disease preparedness.

Vaccine 2017 01 22;35 Suppl 1:A46-A49. Epub 2016 Dec 22.

Gordon and Betty Moore Foundation, United States.

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http://dx.doi.org/10.1016/j.vaccine.2016.08.090DOI Listing
January 2017

Introduction to the vaccine supplement.

Authors:
Rino Rappuoli

Vaccine 2017 01 22;35 Suppl 1:A1. Epub 2016 Dec 22.

Glaxosmithkline Vaccines, Siena, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2016.11.038DOI Listing
January 2017

Core values for vaccine evaluation.

Vaccine 2017 01 22;35 Suppl 1:A57-A62. Epub 2016 Dec 22.

GSK Vaccines, Via Fiorentina, 1, 53100 SI, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2016.11.034DOI Listing
January 2017

Compare voting systems to improve them.

Nature 2017 01;541(7636):151-153

GlaxoSmithKline Vaccines, Siena, Italy.

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http://dx.doi.org/10.1038/541151aDOI Listing
January 2017

Future Challenges for Vaccinologists.

Methods Mol Biol 2016 ;1403:41-55

GSK Vaccines, Siena, 53100, Italy.

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http://dx.doi.org/10.1007/978-1-4939-3387-7_2DOI Listing
December 2016

Meningococcal B Vaccine during a University Outbreak.

Authors:
Rino Rappuoli

N Engl J Med 2016 10;375(16):1594-5

GSK Vaccines, Siena, Italy

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http://dx.doi.org/10.1056/NEJMc1610666DOI Listing
October 2016

Editorial overview: Vaccines: novel technologies for vaccine development.

Curr Opin Immunol 2016 08 4;41:v-vii. Epub 2016 Aug 4.

GlaxoSmithKline Vaccines, Siena, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2016.07.001DOI Listing
August 2016

Multicriteria decision analysis and core values for enhancing vaccine-related decision-making.

Sci Transl Med 2016 06;8(345):345ps14

GSK Vaccines, Via Fiorentina 1, 53100 Siena, Italy.

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http://dx.doi.org/10.1126/scitranslmed.aaf0756DOI Listing
June 2016

Influence of Statins on Influenza Vaccine Response in Elderly Individuals.

J Infect Dis 2016 Apr 28;213(8):1224-8. Epub 2015 Oct 28.

Novartis Vaccines, Siena, Italy.

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http://dx.doi.org/10.1093/infdis/jiv456DOI Listing
April 2016

Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design.

J Exp Med 2016 Apr 28;213(4):469-81. Epub 2016 Mar 28.

GlaxoSmithKline Vaccines S.r.l., 53100 Siena, Italy.

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http://dx.doi.org/10.1084/jem.20151960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821650PMC
April 2016

Self-assembling protein nanoparticles in the design of vaccines.

Comput Struct Biotechnol J 2016 26;14:58-68. Epub 2015 Nov 26.

GlaxoSmithKline Vaccines S.r.l., Via Fiorentina 1, 53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.csbj.2015.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706605PMC
February 2016

Phagocyte subsets and lymphocyte clonal deletion behind ineffective immune response to Staphylococcus aureus.

FEMS Microbiol Rev 2015 Sep 19;39(5):750-63. Epub 2015 May 19.

Novartis Vaccines, Research Center, via Fiorentina 1, 53100 Siena, Italy

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http://dx.doi.org/10.1093/femsre/fuv024DOI Listing
September 2015

Prevention and control of meningococcal outbreaks: The emerging role of serogroup B meningococcal vaccines.

Vaccine 2015 Jul 17;33(31):3628-35. Epub 2015 Jun 17.

Center for Global Health Cincinnati Children's Hospital, 3333 Burnett Avenue, Cincinnati, OH 45229, USA. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2015.06.046DOI Listing
July 2015

Introduction to the supplement.

Authors:
Rino Rappuoli

Vaccine 2015 Jun;33 Suppl 2:B1-2

Novartis Vaccines, Siena, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2015.02.072DOI Listing
June 2015

Lessons from Reverse Vaccinology for viral vaccine design.

Curr Opin Virol 2015 Apr 29;11:89-97. Epub 2015 Mar 29.

Novartis Vaccines, Siena, Italy; Department of Biology, University of Naples 'Federico II', Naples, Italy.

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http://dx.doi.org/10.1016/j.coviro.2015.03.001DOI Listing
April 2015

Developing vaccines for an aging population.

Sci Transl Med 2015 Apr;7(281):281ps8

Novartis Vaccines, Siena, Italy.

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http://dx.doi.org/10.1126/scitranslmed.aaa0722DOI Listing
April 2015

Inactivated and adjuvanted influenza vaccines.

Curr Top Microbiol Immunol 2015 ;386:151-80

Research and Development, Novartis Vaccines, Via Fiorentina 1, 53100, Siena, Italy,

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http://dx.doi.org/10.1007/82_2014_406DOI Listing
March 2015

What are affordable vaccines?

Authors:
Rino Rappuoli

Lancet 2015 Mar;385(9974):1177-8

Novartis Vaccines, Siena 53100, Italy. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(15)60627-4DOI Listing
March 2015

Neisseria meningitidis: pathogenesis and immunity.

Curr Opin Microbiol 2015 Feb 22;23:68-72. Epub 2014 Nov 22.

Novartis Vaccines, Siena, Italy.

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http://dx.doi.org/10.1016/j.mib.2014.11.006DOI Listing
February 2015

Cost effectiveness has its place, but so does common sense.

BMJ 2014 Nov 13;349:g6759. Epub 2014 Nov 13.

Novartis Vaccines and Diagnostics Limited, Frimley, UK.

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http://dx.doi.org/10.1136/bmj.g6759DOI Listing
November 2014

Vaccines, emerging viruses, and how to avoid disaster.

Authors:
Rino Rappuoli

BMC Biol 2014 Nov 29;12:100. Epub 2014 Nov 29.

Novartis Vaccines, Siena 53100, Italy.

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http://dx.doi.org/10.1186/s12915-014-0100-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247664PMC
November 2014

Changing route: aerosol vaccine against tuberculosis.

Authors:
Rino Rappuoli

Lancet Infect Dis 2014 Oct 20;14(10):901-2. Epub 2014 Aug 20.

Novartis Vaccines, Via Fiorentina 1, 53100 Siena, Italy. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(14)70886-2DOI Listing
October 2014

Big science for vaccine development.

Vaccine 2014 Aug 25;32(37):4705-7. Epub 2014 Jun 25.

Laboratorio di Microbiologia Molecolare e Biotecnologia (LA.M.M.B.), Dipartimento di Biotecnologie Mediche, Università di Siena, Siena, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2014.06.071DOI Listing
August 2014

Vaccines, new opportunities for a new society.

Proc Natl Acad Sci U S A 2014 Aug 18;111(34):12288-93. Epub 2014 Aug 18.

Novartis Vaccines, 53100 Siena, Italy.

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http://dx.doi.org/10.1073/pnas.1402981111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151714PMC
August 2014

Inner Workings: 1885, the first rabies vaccination in humans.

Authors:
Rino Rappuoli

Proc Natl Acad Sci U S A 2014 Aug 26;111(34):12273. Epub 2014 Aug 26.

Novartis Vaccines and Diagnostics, 53100 Siena, Italy

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http://dx.doi.org/10.1073/pnas.1414226111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151773PMC
August 2014

Vaccines: science, health, longevity, and wealth.

Authors:
Rino Rappuoli

Proc Natl Acad Sci U S A 2014 Aug;111(34):12282

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151739PMC
http://dx.doi.org/10.1073/pnas.1413559111DOI Listing
August 2014

From empiricism to rational design: a personal perspective of the evolution of vaccine development.

Nat Rev Immunol 2014 07 13;14(7):505-14. Epub 2014 Jun 13.

Novartis Vaccines, Via Fiorentina 1, 53100 Siena, Italy.

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http://dx.doi.org/10.1038/nri3694DOI Listing
July 2014

Designing vaccines for the twenty-first century society.

Front Immunol 2014 23;5:12. Epub 2014 Jan 23.

Research Center, Novartis Vaccines and Diagnostics , Siena , Italy.

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http://dx.doi.org/10.3389/fimmu.2014.00012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899546PMC
June 2014

Vaccines for the 21st century.

EMBO Mol Med 2014 Jun 6;6(6):708-20. Epub 2014 Apr 6.

Novartis Vaccines, Siena, Italy

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http://embomolmed.embopress.org/cgi/doi/10.1002/emmm.2014038
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http://dx.doi.org/10.1002/emmm.201403876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203350PMC
June 2014

Variability of genes encoding surface proteins used as vaccine antigens in meningococcal endemic and epidemic strain panels from Norway.

Vaccine 2014 May 12;32(23):2722-31. Epub 2014 Mar 12.

Division of Infectious Disease Control, Norwegian Institute of Public Health, Oslo, Norway; Section for International Health, Faculty of Medicine, University of Oslo, Oslo, Norway.

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X140029
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http://dx.doi.org/10.1016/j.vaccine.2014.02.068DOI Listing
May 2014

A priority-setting aid for new vaccine candidates.

Proc Natl Acad Sci U S A 2014 Mar;111(9):3199-200

Departments of Economics and Public Health Sciences, University of Rochester, Rochester, NY 14627.

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http://dx.doi.org/10.1073/pnas.1400945111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948234PMC
March 2014