Publications


Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy.
Nat Commun 2017 May 22;8:15338. Epub 2017 May 22.
Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.


Identification of definitive serum biomarkers associated with disease activity in primary Sjögren's syndrome.
Arthritis Res Ther 2016 May 14;18(1):106. Epub 2016 May 14.
Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.


Serum proteomic analysis identifies interleukin 16 as a biomarker for clinical response during early treatment of rheumatoid arthritis.
Cytokine 2016 Feb 14;78:87-93. Epub 2015 Dec 14.
Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8552, Japan. Electronic address:

Suppression of Th2 and Tfh immune reactions by Nr4a receptors in mature T reg cells.
J Exp Med 2015 Sep 24;212(10):1623-40. Epub 2015 Aug 24.
Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan Japan Science and Technology Agency (JST), Core Research for Evolutional Science and Technology, Chiyoda-ku, Tokyo 102-0075, Japan

Smad2 and Smad3 Inversely Regulate TGF-β Autoinduction in Clostridium butyricum-Activated Dendritic Cells.
Immunity 2015 Jul 30;43(1):65-79. Epub 2015 Jun 30.
Department of Microbiology and Immunology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan, and Japan Science and Technology Agency, CREST, Tokyo 102-0076, Japan. Electronic address:

Bruton's tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury.
Nat Commun 2015 Jun 10;6:7360. Epub 2015 Jun 10.
1] Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan [2] Japan Science and Technology Agency (JST), CREST, Chiyoda-ku, Tokyo 102-0075, Japan.

ETS transcription factor ETV2 directly converts human fibroblasts into functional endothelial cells.
Proc Natl Acad Sci U S A 2015 Jan 24;112(1):160-5. Epub 2014 Dec 24.
Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo 160-8582, Japan; Core Research for Evolutional Science and Technology Program, Japan Science and Technology Agency, Tokyo 102-0076, Japan;




Low dose CP-690,550 (tofacitinib), a pan-JAK inhibitor, accelerates the onset of experimental autoimmune encephalomyelitis by potentiating Th17 differentiation.
Biochem Biophys Res Commun 2012 Feb 9;418(2):234-40. Epub 2012 Jan 9.
Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.


Suppression of SOCS3 in macrophages prevents cancer metastasis by modifying macrophage phase and MCP2/CCL8 induction.
Cancer Lett 2011 Sep 31;308(2):172-80. Epub 2011 May 31.
Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.

SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-{gamma} and IL-17A production.
J Exp Med 2011 Sep 5;208(10):2055-67. Epub 2011 Sep 5.
Department of Microbiology and Immunology, Keio University School of Medicine, Shinjyuku-ku, Tokyo 160-8582, Japan.

Transcription factor Smad-independent T helper 17 cell induction by transforming-growth factor-β is mediated by suppression of eomesodermin.
Immunity 2011 May 19;34(5):741-54. Epub 2011 May 19.
Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan.



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