Rik Gijsbers

Rik Gijsbers

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Rik Gijsbers

Publications by authors named "Rik Gijsbers"

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Size and affinity kinetics of nanobodies influence targeting and penetration of solid tumours.

J Control Release 2020 Jan 14;317:34-42. Epub 2019 Nov 14.

Laboratory for In vivo Cellular and Molecular Imaging, ICMI-BEFY, Vrije Universiteit Brussel, Brussels, Belgium.

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http://dx.doi.org/10.1016/j.jconrel.2019.11.014DOI Listing
January 2020

Cytokines trigger disruption of endothelium barrier function and p38 MAP kinase activation in -silenced human lung microvascular endothelial cells.

Pulm Circ 2019 Oct-Dec;9(4):2045894019883607. Epub 2019 Oct 23.

Division of Respiratory Diseases, University Hospitals and Department of Chronic Diseases, Metabolism & Ageing (CHROMETA), KU Leuven - University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1177/2045894019883607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811766PMC
October 2019

AAV9-Mediated Overexpression of TRPM4 Increases the Incidence of Stress-Induced Ventricular Arrhythmias in Mice.

Front Physiol 2019 27;10:802. Epub 2019 Jun 27.

Laboratory of Ion Channel Research, TRP Research Platform Leuven, VIB Center for Brain and Disease, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.3389/fphys.2019.00802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610516PMC
June 2019

Impact of LEDGIN treatment during virus production on residual HIV-1 transcription.

Retrovirology 2019 04 2;16(1). Epub 2019 Apr 2.

Laboratory for Molecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Herestraat 49, Box 1023, 3000, Leuven, Flanders, Belgium.

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http://dx.doi.org/10.1186/s12977-019-0472-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444612PMC
April 2019

Growth Factor Screening in Dystrophic Muscles Reveals PDGFB/PDGFRB-Mediated Migration of Interstitial Stem Cells.

Int J Mol Sci 2019 Mar 5;20(5). Epub 2019 Mar 5.

Laboratory of Translational Cardiomyology, Department of Development and Regeneration, Stem Cell Research Institute, KU Leuven, 3000 Leuven, Belgium.

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http://dx.doi.org/10.3390/ijms20051118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429448PMC
March 2019

Targeted editing of the PSIP1 gene encoding LEDGF/p75 protects cells against HIV infection.

Sci Rep 2019 Feb 20;9(1):2389. Epub 2019 Feb 20.

Laboratory for Viral Vector Technology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000, Leuven, Belgium.

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http://dx.doi.org/10.1038/s41598-019-38718-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382798PMC
February 2019

Y-box-binding protein 1 supports the early and late steps of HIV replication.

PLoS One 2018 11;13(7):e0200080. Epub 2018 Jul 11.

Division of Molecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200080PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040738PMC
January 2019

A kindred with mutant IKAROS and autoimmunity.

J Allergy Clin Immunol 2018 08 27;142(2):699-702.e12. Epub 2018 Apr 27.

Department of Microbiology and Immunology, KUL - University of Leuven, Leuven, Belgium; VIB Center for Brain and Disease Research, Leuven, Belgium. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183061
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http://dx.doi.org/10.1016/j.jaci.2018.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541477PMC
August 2018

Analysis of HIV-1 infection in a controller-discordant couple.

J Virus Erad 2018 Jul 1;4(3):170-173. Epub 2018 Jul 1.

Molecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Belgium.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038135PMC
July 2018

Functional Evaluation of an IKBKG Variant Suspected to Cause Immunodeficiency Without Ectodermal Dysplasia.

J Clin Immunol 2017 Nov 10;37(8):801-810. Epub 2017 Oct 10.

Department of Microbiology and Immunology, Experimental Laboratory Immunology, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1007/s10875-017-0448-9DOI Listing
November 2017

Measles virus envelope pseudotyped lentiviral vectors transduce quiescent human HSCs at an efficiency without precedent.

Blood Adv 2017 Oct 24;1(23):2088-2104. Epub 2017 Oct 24.

International Center for Infectiology Research, Team Enveloped Viruses, Vectors and Innate Responses, INSERM, U1111, Université Claude Bernard Lyon 1, Centre National de la Recherche Scientifique, Unité Mixte de Recherche (UMR) 5308, Ecole Normale Supérieure de Lyon, Lyon, France.

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http://dx.doi.org/10.1182/bloodadvances.2017007773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728281PMC
October 2017

Inhibition of MicroRNA-146a and Overexpression of Its Target Dihydrolipoyl Succinyltransferase Protect Against Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction.

Circulation 2017 Aug 13;136(8):747-761. Epub 2017 Jun 13.

From Center for Molecular and Vascular Research, Leuven, Belgium (W.H., A.P., S.D., Pa.C., P.P., A.S.W., S.J., S.H.); Center for Heart Failure Research, Department of Cardiology, CARIM School for Cardiovascular Diseases, Maastricht University, The Netherlands (W.H., A.P., S.D., Pa.C., W.V., R.v.L., B.S., M.v.B., S.H.); Cardiovascular Research Center, OLV Hospital, Aalst, Belgium (W.H.); Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, Department of Oncology, Leuven, Belgium (A.Q., G.E., S.S., S.V., Pe.C.); Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, Leuven, Belgium (A.Q., G.E., S.S., S.V., Pe.C.); Amsterdam Medical Center, Amsterdam University, The Netherlands (S.A., I.E., Y.P.); Laboratory for Viral Vector Technology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences (R.G., C.V.D.H.), Laboratory for Neurobiology and Gene Therapy, Department of Neurosciences (R.G., C.V.D.H.), Leuven Viral Vector Core, Belgium (R.G., C.V.D.H.); and Klinik für Innere Medezin III, Universitätsklinikum des Saarlandes, Homburg, Germany (A.N., C.M.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.024171DOI Listing
August 2017

A novel kindred with inherited STAT2 deficiency and severe viral illness.

J Allergy Clin Immunol 2017 06 10;139(6):1995-1997.e9. Epub 2017 Jan 10.

Department of Immunology and Microbiology, Autoimmune Genetics Laboratory, Vlaams Instituut Biotechnologie and KU Leuven, Leuven, Flanders, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.10.033DOI Listing
June 2017

Engineering Next-Generation BET-Independent MLV Vectors for Safer Gene Therapy.

Mol Ther Nucleic Acids 2017 Jun 12;7:231-245. Epub 2017 Apr 12.

Laboratory for Viral Vector Technology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium; Leuven Viral Vector Core, KU Leuven, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.omtn.2017.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415309PMC
June 2017

Evaluation of WGA-Cre-dependent topological transgene expression in the rodent brain.

Brain Struct Funct 2017 03 3;222(2):717-733. Epub 2016 Jun 3.

Department of Neurosciences, Laboratory for Neurobiology and Gene Therapy, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1007/s00429-016-1241-xDOI Listing
March 2017

Insight into HIV-2 latency may disclose strategies for a cure for HIV-1 infection.

J Virus Erad 2017 Jan 1;3(1):7-14. Epub 2017 Jan 1.

Laboratory for Molecular Virology and Gene Therapy , Department of Pharmaceutical and Pharmacological Sciences , KU Leuven , Belgium.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337426PMC
January 2017

Dynamic Oligomerization of Integrase Orchestrates HIV Nuclear Entry.

Sci Rep 2016 11 10;6:36485. Epub 2016 Nov 10.

Laboratory for Molecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, 3000, Belgium.

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http://dx.doi.org/10.1038/srep36485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103197PMC
November 2016

LEDGIN-mediated Inhibition of Integrase-LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV.

EBioMedicine 2016 Jun 13;8:248-264. Epub 2016 May 13.

Laboratory of Molecular Virology and Gene Therapy, Department of Pharmacological and Pharmaceutical Sciences, KU Leuven, Kapucijnenvoer 33 VTCB +5, 3000 Leuven, Flanders, Belgium. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S23523964163018
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http://dx.doi.org/10.1016/j.ebiom.2016.04.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919729PMC
June 2016

Comparative Analysis of HIV-1 and Murine Leukemia Virus Three-Dimensional Nuclear Distributions.

J Virol 2016 May 29;90(10):5205-5209. Epub 2016 Apr 29.

Laboratory of Molecular Virology, University of Trento, Centre for Integrative Biology, Trento, Italy

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http://dx.doi.org/10.1128/JVI.03188-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859700PMC
May 2016

Noninvasive Imaging Reveals Stable Transgene Expression in Mouse Airways After Delivery of a Nonintegrating Recombinant Adeno-Associated Viral Vector.

Hum Gene Ther 2016 01 21;27(1):60-71. Epub 2015 Dec 21.

1 Laboratory for Molecular Virology and Gene Therapy , Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Flanders, Belgium.

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http://dx.doi.org/10.1089/hum.2015.109DOI Listing
January 2016

Sodium Iodide Symporter PET and BLI Noninvasively Reveal Mesoangioblast Survival in Dystrophic Mice.

Stem Cell Reports 2015 Dec 28;5(6):1183-1195. Epub 2015 Nov 28.

Department of Imaging and Pathology, Nuclear Medicine and Molecular Imaging, KU Leuven, Leuven 3000, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2015.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682284PMC
December 2015

The dark side of ID8-Luc2: pitfalls for luciferase tagged murine models for ovarian cancer.

J Immunother Cancer 2015 15;3:57. Epub 2015 Dec 15.

Department of Gynaecology and Obstetrics, UZ Leuven, Leuven, Belgium ; Department of Oncology, Laboratory of Gynaecologic Oncology, KU Leuven, Leuven Cancer Institute, Leuven, Belgium.

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http://dx.doi.org/10.1186/s40425-015-0102-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678634PMC
December 2015

Cardiac Niche Influences the Direct Reprogramming of Canine Fibroblasts into Cardiomyocyte-Like Cells.

Stem Cells Int 2016 23;2016:4969430. Epub 2015 Nov 23.

Translational Cardiomyology Laboratory, Stem Cell Biology and Embryology Unit, Department of Development and Regeneration, KU Leuven, Herestraat 49 O&N4 Bus 814, 3000 Leuven, Belgium ; Human Anatomy Unit, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Via Forlanini 8, 27100 Pavia, Italy.

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http://downloads.hindawi.com/journals/sci/2016/4969430.pdf
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http://www.hindawi.com/journals/sci/2016/4969430/
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http://dx.doi.org/10.1155/2016/4969430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670879PMC
December 2015

Retroviral integration: Site matters: Mechanisms and consequences of retroviral integration site selection.

Bioessays 2015 Nov 21;37(11):1202-14. Epub 2015 Aug 21.

Department of Pharmaceutical and Pharmacological Sciences, Laboratory for Molecular Virology and Drug Discovery, KU Leuven-University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1002/bies.201500051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053271PMC
November 2015

Evaluation of the expression pattern of rAAV2/1, 2/5, 2/7, 2/8, and 2/9 serotypes with different promoters in the mouse visual cortex.

J Comp Neurol 2015 Oct 19;523(14):2019-42. Epub 2015 Jun 19.

KU Leuven, Laboratory of Neuroplasticity and Neuroproteomics, Department of Biology, Leuven, Belgium.

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http://dx.doi.org/10.1002/cne.23819DOI Listing
October 2015

Serotype-dependent transduction efficiencies of recombinant adeno-associated viral vectors in monkey neocortex.

Neurophotonics 2015 Jul 1;2(3):031209. Epub 2015 Oct 1.

KU Leuven, Laboratory of Neuro- and Psychophysiology, Department of Neurosciences, O&N2 Herestraat 49 bus 10.21, 3000 Leuven, Belgium; Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, 149 13th street, Charlestown, Massachusetts 02129, United States; Harvard Medical School, Department of Radiology, 149 13th street, Charlestown, Massachusetts 02129, United States.

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http://neurophotonics.spiedigitallibrary.org/data/Journals/N
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http://neurophotonics.spiedigitallibrary.org/article.aspx?do
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http://dx.doi.org/10.1117/1.NPh.2.3.031209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729112PMC
July 2015

FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an α-synuclein-based rat model for Parkinson's disease.

Neurobiol Aging 2015 Mar 21;36(3):1559-68. Epub 2015 Jan 21.

Laboratory for Neurobiology and Gene Therapy, Department of Neurosciences, KU Leuven, Flanders, Belgium; Leuven Viral Vector Core, KU Leuven, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.01.014DOI Listing
March 2015

Host factors for retroviral integration site selection.

Trends Biochem Sci 2015 Feb 31;40(2):108-16. Epub 2014 Dec 31.

Laboratory for Molecular Virology and Gene Therapy, KU Leuven, Leuven 3000, Flanders, Belgium.

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http://dx.doi.org/10.1016/j.tibs.2014.12.001DOI Listing
February 2015

Controlling and monitoring stem cell safety in vivo in an experimental rodent model.

Stem Cells 2014 Nov;32(11):2833-44

Biomedical MRI, Department of Imaging and Pathology, KU Leuven, Belgium; Molecular Small Animal Imaging Center, KU Leuven, Belgium.

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http://dx.doi.org/10.1002/stem.1819DOI Listing
November 2014

HIV-1 integrase variants retarget viral integration and are associated with disease progression in a chronic infection cohort.

Cell Host Microbe 2014 Nov 12;16(5):651-62. Epub 2014 Nov 12.

Laboratory for Molecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven-University of Leuven, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2014.09.016DOI Listing
November 2014

Bioluminescence imaging of stroke-induced endogenous neural stem cell response.

Neurobiol Dis 2014 Sep 27;69:144-55. Epub 2014 May 27.

KU Leuven, Laboratory for Neurobiology and Gene Therapy, Department of Neurosciences, 3000 Leuven, Flanders, Belgium; KU Leuven, Molecular Small Animal Imaging Center, MOSAIC, KU Leuven, 3000 Leuven, Flanders, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2014.05.014DOI Listing
September 2014

The HIV-1 integrase mutant R263A/K264A is 2-fold defective for TRN-SR2 binding and viral nuclear import.

J Biol Chem 2014 Sep 25;289(36):25351-61. Epub 2014 Jul 25.

From the Laboratory for Molecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, Katholieke Universiteit Leuven, 3000, Leuven, Belgium

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http://dx.doi.org/10.1074/jbc.M113.533281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155696PMC
September 2014

BET-independent MLV-based Vectors Target Away From Promoters and Regulatory Elements.

Mol Ther Nucleic Acids 2014 Jul 29;3:e179. Epub 2014 Jul 29.

1] KU Leuven Laboratory for Molecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, Leuven, Belgium [2] KU Leuven, Leuven Viral Vector Core, Leuven, Belgium.

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http://dx.doi.org/10.1038/mtna.2014.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121521PMC
July 2014

Viral vectors expressing a single microRNA-based short-hairpin RNA result in potent gene silencing in vitro and in vivo.

J Biotechnol 2014 Jan 16;169:71-81. Epub 2013 Nov 16.

KU Leuven, Laboratory for Neurobiology and Gene Therapy, Department of Neurosciences, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.jbiotec.2013.11.004DOI Listing
January 2014

Recipient leukocyte infusion enhances the local and systemic graft-versus-neuroblastoma effect of allogeneic bone marrow transplantation in mice.

Cancer Immunol Immunother 2013 Nov 1;62(11):1733-44. Epub 2013 Oct 1.

Laboratory of Experimental Transplantation, KU Leuven, Herestraat 49, box 811, 3000, Leuven, Belgium,

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http://dx.doi.org/10.1007/s00262-013-1479-6DOI Listing
November 2013

Long-term miR-669a therapy alleviates chronic dilated cardiomyopathy in dystrophic mice.

J Am Heart Assoc 2013 Aug 20;2(4):e000284. Epub 2013 Aug 20.

Translational Cardiomyology Lab, Stem Cell Biology and Embryology, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1161/JAHA.113.000284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828786PMC
August 2013

1,25-Dihydroxyvitamin D3 and the aging-related forkhead box O and sestrin proteins in osteoblasts.

J Steroid Biochem Mol Biol 2013 Jul 16;136:112-9. Epub 2012 Sep 16.

Laboratory for Clinical and Experimental Endocrinology, KU Leuven, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.jsbmb.2012.09.011DOI Listing
July 2013

PEAR1 attenuates megakaryopoiesis via control of the PI3K/PTEN pathway.

Blood 2013 Jun 10;121(26):5208-17. Epub 2013 May 10.

Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1182/blood-2012-10-462887DOI Listing
June 2013

Quantitation of HIV DNA integration: effects of differential integration site distributions on Alu-PCR assays.

J Virol Methods 2013 Apr 21;189(1):53-7. Epub 2013 Jan 21.

University of Pennsylvania Perelman School of Medicine, Department of Microbiology, 3610 Hamilton Walk, Philadelphia, PA 19104-6076, United States.

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http://dx.doi.org/10.1016/j.jviromet.2013.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608829PMC
April 2013

Single-cell imaging of HIV-1 provirus (SCIP).

Proc Natl Acad Sci U S A 2013 Apr 19;110(14):5636-41. Epub 2013 Mar 19.

Laboratory of Neurobiology, Scuola Normale Superiore, 56124 Pisa, Italy.

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http://dx.doi.org/10.1073/pnas.1216254110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619299PMC
April 2013

Transient Expression of an LEDGF/p75 Chimera Retargets Lentivector Integration and Functionally Rescues in a Model for X-CGD.

Mol Ther Nucleic Acids 2013 Mar 5;2:e77. Epub 2013 Mar 5.

Department of Pharmaceutical and Pharmacological Sciences, Laboratory of Molecular Virology and Gene Therapy, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1038/mtna.2013.4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615818PMC
March 2013

Long-term reversal of diabetes in non-obese diabetic mice by liver-directed gene therapy.

J Gene Med 2013 Jan;15(1):28-41

School of Medical & Molecular Biosciences, University of Technology Sydney, Sydney, Australia.

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http://dx.doi.org/10.1002/jgm.2692DOI Listing
January 2013

Phage display-directed discovery of LEDGF/p75 binding cyclic peptide inhibitors of HIV replication.

Mol Ther 2012 Nov 24;20(11):2064-75. Epub 2012 Jul 24.

Laboratory for Molecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, K.U.Leuven and IRC Kulak, Flanders, Belgium.

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http://dx.doi.org/10.1038/mt.2012.132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498793PMC
November 2012

HRP-2 determines HIV-1 integration site selection in LEDGF/p75 depleted cells.

Retrovirology 2012 Oct 9;9:84. Epub 2012 Oct 9.

Division of Molecular Medicine, Katholieke Universiteit Leuven, Leuven, Flanders, Belgium.

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http://dx.doi.org/10.1186/1742-4690-9-84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485173PMC
October 2012

Pathway specific gene expression profiling reveals oxidative stress genes potentially regulated by transcription co-activator LEDGF/p75 in prostate cancer cells.

Prostate 2012 May 27;72(6):597-611. Epub 2011 Jul 27.

Center for Health Disparities and Molecular Medicine, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, California 92350, USA.

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http://dx.doi.org/10.1002/pros.21463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227744PMC
May 2012

Regulator of G-protein signaling 18 controls megakaryopoiesis and the cilia-mediated vertebrate mechanosensory system.

FASEB J 2012 May 3;26(5):2125-36. Epub 2012 Feb 3.

Center for Molecular and Vascular Biology, KU Leuven, Campus Gasthuisberg, O&N1, Herestraat 49, Box 911, 3000 Leuven, Belgium.

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http://www.fasebj.org/doi/10.1096/fj.11-198739
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http://dx.doi.org/10.1096/fj.11-198739DOI Listing
May 2012

Interplay between HIV entry and transportin-SR2 dependency.

Retrovirology 2011 Jan 30;8. Epub 2011 Jan 30.

Laboratory of Molecular Virology and Gene Therapy, Katholieke Universiteit Leuven, Kapucijnenvoer 33, VCTB+5, B-3000 Leuven, Flanders, Belgium.

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http://dx.doi.org/10.1186/1742-4690-8-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041740PMC
January 2011

High-resolution profiling of the LEDGF/p75 chromatin interaction in the ENCODE region.

Nucleic Acids Res 2010 Oct 19;38(18):6135-47. Epub 2010 May 19.

Laboratory for Molecular Virology and Gene Therapy, KULeuven and IRC KULAK, Kapucijnenvoer 33, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1093/nar/gkq410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952859PMC
October 2010

LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin.

Mol Ther 2010 Mar 5;18(3):552-60. Epub 2010 Jan 5.

Division of Molecular Medicine, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1038/mt.2010.36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839429PMC
March 2010

Immunohistochemical detection of transgene expression in the brain using small epitope tags.

BMC Biotechnol 2010 Feb 18;10:16. Epub 2010 Feb 18.

Laboratory for Neurobiology and Gene Therapy, Division of Molecular Medicine, Department of Molecular and Cellular Medicine, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1186/1472-6750-10-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831034PMC
February 2010

State-of-the-art lentiviral vectors for research use: risk assessment and biosafety recommendations.

Curr Gene Ther 2009 Dec;9(6):459-74

Scientific Institute of Public Health, Division of Biosafety and Biotechnology, B-1050 Brussels, Belgium.

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https://www.wiv-isp.be/pdf/pauwels_cgt_vol9_issue6_2009.pdf
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http://dx.doi.org/10.2174/156652309790031120DOI Listing
December 2009

Synthesis and biological evaluation of (11)C-labeled beta-galactosyl triazoles as potential PET tracers for in vivo LacZ reporter gene imaging.

Bioorg Med Chem 2009 Jul 29;17(14):5117-25. Epub 2009 May 29.

Laboratory for Radiopharmacy, Faculty of Pharmaceutical Sciences, Katholieke Universiteit Leuven, Herestraat 49 bus 821, BE-3000 Leuven, Belgium.

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https://linkinghub.elsevier.com/retrieve/pii/S09680896090052
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http://dx.doi.org/10.1016/j.bmc.2009.05.056DOI Listing
July 2009

Lens epithelium-derived growth factor/p75 interacts with the transposase-derived DDE domain of PogZ.

J Biol Chem 2009 Apr 25;284(17):11467-77. Epub 2009 Feb 25.

Laboratory for Molecular Virology and Gene Therapy, Division of Molecular Medicine, Katholieke Universiteit Leuven, Kapucijnenvoer 33, Flanders, Belgium.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M807781200
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http://dx.doi.org/10.1074/jbc.M807781200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670152PMC
April 2009

Diffusion of myelin oligodendrocyte glycoprotein in living OLN-93 cells investigated by raster-scanning image correlation spectroscopy (RICS).

J Fluoresc 2008 Sep 18;18(5):813-9. Epub 2008 Jan 18.

Laboratory for Biomolecular Dynamics, Catholic University Leuven, Celestijnenlaan 200G, 3001, Heverlee, Belgium.

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http://dx.doi.org/10.1007/s10895-007-0308-8DOI Listing
September 2008

Transportin-SR2 imports HIV into the nucleus.

Curr Biol 2008 Aug;18(16):1192-202

Laboratory for Molecular Virology and Gene Therapy, KU Leuven and IRC, Kapucijnenvoer 33, B-3000 Leuven, Flanders, Belgium.

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http://dx.doi.org/10.1016/j.cub.2008.07.079DOI Listing
August 2008

Synthesis and evaluation of 18F- and 11C-labeled phenyl-galactopyranosides as potential probes for in vivo visualization of LacZ gene expression using positron emission tomography.

Bioconjug Chem 2008 Feb 8;19(2):441-9. Epub 2008 Jan 8.

Laboratory for Radiopharmacy, Faculty of Pharmaceutical Sciences, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1021/bc700216dDOI Listing
February 2008

A p-[18F]fluoroethoxyphenyl bicyclic nucleoside analogue as a potential positron emission tomography imaging agent for varicella-zoster virus thymidine kinase gene expression.

J Med Chem 2007 Dec 30;50(26):6627-37. Epub 2007 Nov 30.

Molecular Small Animal Imaging Center, Laboratory for Radiopharmacy-Faculty of Pharmaceutical Sciences, Department of Nuclear Medicine, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium.

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http://dx.doi.org/10.1021/jm700971pDOI Listing
December 2007

Differential interaction of HIV-1 integrase and JPO2 with the C terminus of LEDGF/p75.

J Mol Biol 2007 Sep 12;372(2):407-21. Epub 2007 Jul 12.

Molecular Medicine, KULeuven and IRC KULAK, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.jmb.2007.06.090DOI Listing
September 2007

Parkin protects against neurotoxicity in the 6-hydroxydopamine rat model for Parkinson's disease.

Mol Ther 2006 Nov 17;14(5):716-23. Epub 2006 Aug 17.

Laboratory for Neurobiology and Gene Therapy, Molecular Medicine, K.U. Leuven, Kapucijnenvoer 33 VCTB+5, B-3000 Leuven, Flanders, Belgium.

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http://dx.doi.org/10.1016/j.ymthe.2006.06.009DOI Listing
November 2006

Noninvasive monitoring of long-term lentiviral vector-mediated gene expression in rodent brain with bioluminescence imaging.

Mol Ther 2006 Sep 3;14(3):423-31. Epub 2006 Jul 3.

Molecular Small Animal Imaging Center (MoSAIC) and Department of Nuclear Medicine, University Hospital Leuven, Belgium.

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http://dx.doi.org/10.1016/j.ymthe.2006.05.007DOI Listing
September 2006

Comparison of lentiviral vector titration methods.

BMC Biotechnol 2006 Jul 12;6:34. Epub 2006 Jul 12.

Laboratory for Molecular Virology and Gene Therapy, K.U.Leuven and IRC KULAK, Flanders, Belgium.

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http://bmcbiotechnol.biomedcentral.com/articles/10.1186/1472
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http://dx.doi.org/10.1186/1472-6750-6-34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1534021PMC
July 2006