Publications by authors named "Riika Rontu"

2 Publications

  • Page 1 of 1

Neuregulin-1 genotype moderates the association between job strain and early atherosclerosis in young men.

Ann Behav Med 2007 Apr;33(2):148-55

Department of Psychology, University of Helsinki, Finland.

Background: Although it is known that a given level of strain does not induce a corresponding CHD risk in all individuals, factors that predict groups at risk have remained unclear. Neuregulin-1 (NRG-1) has various roles in the development and function of the heart and autonomic nervous system.

Purpose: We examined whether polymorphic variation in NRG-1 moderates the association between job strain and early atherosclerosis.

Methods: The participants (M age = 32.5) were 349 women and 357 men derived from the population-based Cardiovascular Risk in Young Finns study. Job strain was defined as the joint effect of job demands and job control. Preclinical atherosclerosis was measured using carotid intima-media thickness (IMT) ultrasound.

Results: NRG-1 single nucleotide polymorphism SNP8NRG221533 (T to C) was found to moderate the association between job strain and IMT in men (p = .04). Job strain was significantly associated with increased IMT among men with T/T genotype but not among the others. A direct association between NRG-1 and IMT was found in women.

Conclusions: Our results suggest that the effect of job strain on early atherosclerosis is dependent on NRG-1 genotype in men. Gene x Environment Interaction approach seems to offer important additional information in stress research.
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http://dx.doi.org/10.1007/BF02879896DOI Listing
April 2007

No association between the brain-derived neurotrophic factor 196 G>A or 270 C>T polymorphisms and Alzheimer's or Parkinson's disease.

Folia Neuropathol 2006 ;44(1):12-6

Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Center for Laboratory Medicine, Tampere University, Tampere, Finland.

The brain-derived neurotrophic factor (BDNF) promotes survival, differentiation and maintenance of neurons in the central nervous system. BDNF 196 G>A and 270 C>T polymorphisms have previously been associated with Alzheimer's disease (AD) and with Parkinson's disease (PD). To study the role of BDNF 196 G>A and 270 C>T polymorphisms in Finnish AD and PD patients we genotyped BDNF 196 G>A and 270 C>T polymorphisms in 97 sporadic AD patients, 52 PD patients and 101 control subjects with polymerase chain reaction. No associations were found between the genotypes studied and AD or PD in Finnish patients. Moreover, no interaction between either BDNF polymorphism and the epsilon 4 allele of apolipoprotein E was found. In conclusion, it seems that the BDNF gene does not contribute significantly to the risk of AD or PD in Finnish patients.
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June 2006
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