Publications by authors named "Rieko Ueda"

12 Publications

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Factors Associated With the Acceleration of Patient Enrollment in Clinical Studies: A Cross-Sectional Study.

Front Pharmacol 2021 27;12:753067. Epub 2021 Oct 27.

Department of Cardiovascular Biology and Medicine, Juntendo University School of Medicine, Tokyo, Japan.

Under-recruitment in clinical trials is an issue worldwide. If the number of patients enrolled is lower than expected, based on the required sample size, then the reliability of the study results and their validation tend to be impaired. The current study therefore evaluated factors associated with accelerating patient enrollment using data from an ongoing multicenter prospective cohort study. The researchers encouraged research institutions to accelerate patient enrollment e-mail, newsletters, telephone calls, and site visits. We analyzed the relationship between several potential factors associated with acceleration of patient enrollment including site visits and patient enrollment in a real clinical study. Data were collected from 106 research institutions that participated in a multicenter prospective cohort study. Results showed that the following parameters differed in terms of patient enrollment and non-enrollment: urban area (47.2 vs. 67.6%, = 0.04), clinical research coordinator (CRC) participation in data input to electronic data capture (EDC) (41.7 vs. 11.8%, < 0.01), and site visit (38.9 vs. 11.8%, < 0.01). A multivariate analysis revealed that patient enrollment was significantly associated with urban area (odds ratio [OR] 0.33, 95% confidence interval [CI] 0.12-0.86, = 0.02), CRC participation in data input to EDC (OR 5.02; 95% CI 1.49-16.8; < 0.01), and site visit (OR 4.54, 95% CI 1.31-15.7, = 0.01). In conclusion, site visits and CRC participation in data input to EDC had a significant effect on patient enrollment promotion. Moreover, hospitals in rural areas were more effective in promoting patient enrollment than those in urban areas.
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http://dx.doi.org/10.3389/fphar.2021.753067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580154PMC
October 2021

The relationship between contributions of authors and author order.

J Gen Fam Med 2021 Nov 1;22(6):361-362. Epub 2021 Jun 1.

Clinical and Translational Research Center Kobe University Hospital Kobe Japan.

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http://dx.doi.org/10.1002/jgf2.466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561089PMC
November 2021

Nutritional intervention after an early assessment by a flexible endoscopic evaluation of swallowing is associated with a shorter hospital stay for patients with acute cerebral infarction: A retrospective study.

Asia Pac J Clin Nutr 2021 Jun;30(2):199-205

Nutrition Support Team, National Hospital Organization Takasaki General Medical Center, Takasaki, Gunma, Japan. Email:

Background And Objectives: It is important to evaluate the swallowing function of patients with acute cerebral infarction. The effects of nutritional intervention after an early assessment by a flexible endoscopic evaluation of swallowing (FEES) were evaluated.

Methods And Study Design: This retrospective study included 274 patients who were hospitalized for acute cerebral infarction and underwent a FEES between 2016 and 2018. The effects of early nutritional intervention after an assessment by a FEES within 48 h from admission were evaluated. The patients were divided into a shorter hospital stay group (<30 days) and a longer group (≥30 days). A multivariate analysis was performed to identify the predictive factors for a shorter hospital stay.

Results: The overall patient characteristics were as follows: 166 men; median age, 81 years old; and median body mass index (BMI), 21.1 kg/m2. No significant differences in the age, sex, or BMI were found between the shorter and longer hospital stay groups. A FEES within 48 h of admission (odds ratio [OR], 2.040; 95% confidence interval [CI], 1.120-3.700; p=0.019), FILS level ≥6 at admission (OR, 2.300; 95% CI, 1.190-4.440; p=0.013), and an administered energy dose of ≥18.5 kcal/kg on hospital day 3 (OR, 2.360; 95% CI, 1.180-4.690; p=0.015) were independently associated with a hospital stay <30 days.

Conclusions: Patients with acute cerebral infarction are more likely to have a shorter hospital stay (<30 days) if they undergo a FEES early after admission and receive optimal nutritional intervention.
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http://dx.doi.org/10.6133/apjcn.202106_30(2).0003DOI Listing
June 2021

Hospital characteristics preferred by medical students for their residency programs: A nationwide matching data analysis.

J Gen Fam Med 2020 Nov 26;21(6):242-247. Epub 2020 Aug 26.

Department of Medicine Muribushi Okinawa for Teaching Hospitals Okinawa Japan.

Background: In 2004, Japan introduced a mandatory 2-year postgraduate training program for graduating medical students with a super-rotation curriculum. A national matching system was established to determine the hospital residency programs best suited for the students. We examined the hospital characteristics preferred by applicants for residencies.

Methods: A nationwide cross-sectional study was conducted. Data on salaries, bonuses, and number of accepted ambulances were compiled from the Residency Electronic Information System. Information on the prefectural population, urban area, and number of senior residents (postgraduate years 3-5) for specialty training was extracted from data published on the web page. The ratio of the number of first-choice applicants to recruitment capacity (matching ratio) for each program was compared between the characteristics of the hospitals and prefectures.

Results: A strong linear relationship was observed between the number of first-choice applications and the allocated number of resident positions (correlation coefficient, .72). The matching ratio was greater in community hospitals (2.10 times compared with university hospitals; 95% confidence interval [CI], 1.75-2.53), in hospitals with higher numbers of accepted ambulance cases (1.05 times per 1000 annually; 95% CI, 1.03-1.08), and in hospitals that served a larger prefectural population (1.05 times per million; 95% CI, 1.02-1.08).

Conclusions: Financial incentives do not seem to attract residency applicants. Applicants prefer non-university hospitals located in populous areas and those that accept larger number of ambulance cases. To recruit junior residents, an emergency department may need to have higher activity with larger numbers and variety of cases.
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http://dx.doi.org/10.1002/jgf2.370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689235PMC
November 2020

Performance Index for Types of Clinical Research Support Service Providers for Academic Research Organizations in Japan: A Cross-Sectional Survey.

Clin Transl Sci 2021 03 26;14(2):745-755. Epub 2020 Dec 26.

Department of Medical Innovation, Osaka University Hospital, Osaka, Japan.

The purpose of this study was to conduct a factual survey to evaluate the type of clinical research support offered by service providers (supporters) in Japanese academic research organizations (AROs). From September to October 2018, we conducted an online questionnaire targeting researchers and supporters of AROs, including individuals supporting research and development (R&D) planning, as well as those involved in study management, biostatistics, coordination, data management, monitoring, and auditing. The number of responses was tabulated for each survey item. For items with written descriptions, we compiled summaries using the inductive regression method of qualitative research. Responses were obtained from 124 researchers, 258 supporters, and 40 AROs. None of the institutions responded that they had a performance index for all types of service providers, whereas 47% of institutions had an index for 1-3 types of service providers, and 40% of institutions had no index. Many institutions responded that they had a performance index for coordinators and data management, but few responded that there was a performance index for individuals engaged in R&D and study management. Furthermore, for all evaluations of AROs and researchers, the level of supporter satisfaction was low at only 20%. There was a discrepancy between the levels of researcher expectations and the actual contribution of R&D in the process of research planning. Our survey revealed that there is currently no performance index for services supporting clinical research. In future studies, we need to examine a performance index that accurately reflects the researcher attitudes revealed in this study.
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http://dx.doi.org/10.1111/cts.12942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993270PMC
March 2021

Differences in author ranking: Development of SIGAPS scoring system for Japanese version.

J Gen Fam Med 2020 Sep 9;21(5):208-209. Epub 2020 Jul 9.

Department of Medical Innovation Osaka University Hospital Suita Japan.

Although the SIGAPS scoring system is extremely beneficial in evaluating the quality of academic papers and individual research achievement, values for author ranking may vary by country. If a SIGAPS scoring system outside of France is considered, the weighting by author ranking should also be reconsidered.
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http://dx.doi.org/10.1002/jgf2.359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521783PMC
September 2020

Importance of Quality Assessment in Clinical Research in Japan.

Front Pharmacol 2019 18;10:1228. Epub 2019 Oct 18.

Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.

: The number of papers published by an institution is acknowledged as an easy-to-understand research outcome. However, the quantity as well as the quality of research papers needs to be assessed. To determine the relation between the number of published papers and paper quality, a survey was conducted to assess publications focusing on interventional clinical trials reported by 11 core clinical research hospitals. A score was calculated for each paper using , scoring system, allowing for a clinical paper quality assessment independent of the field. Paper quality was defined as the relative Journal impact factor (IF) total score/number of papers. We surveyed 580 clinical trial papers. For each of the 11 medical institutions (a-k), respectively, the following was found: number of published papers: a:66, b:64, c:61, d:56, e:54, f:51, g:46, h:46, i:46, j:45, k:45 (median: 51, maximum: 66, minimum: 45); total Journal IF: a:204, b:252, c:207, d:225, e:257, f:164, g:216, h:190, i:156, j:179, k:219 (median: 207, maximum: 257, minimum: 156); relative Journal IF total score: a:244, b:272, c:260, d:299, e:268, f:215, g:225, h:208, i:189, j:223, k:218 (median: 225, maximum: 299, minimum: 189); and paper quality (relative Journal IF total score/number of papers): a:3.70, b:4.25, c:4.26, d:5.34, e:4.96, f:4.22, g:4.89, h:4.52, i:4.11, j:4.96, k:4.84 (median: 4.52, maximum: 5.34, minimum: 3.70). Additionally, no significant relation was found between the number of published papers and paper quality (correlation coefficient, -0.33, P = 0.32). The number of published papers does not correspond to paper quality. When assessing an institution's ability to perform clinical research, an assessment of paper quality should be included along with the number of published papers.
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http://dx.doi.org/10.3389/fphar.2019.01228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814083PMC
October 2019

Fabrication of Vertical Molecular Junction Devices with Conductive Polymer Contacts Using a Peeling Method.

J Nanosci Nanotechnol 2016 Apr;16(4):3307-11

Unlabelled: We present a simple technique for patterning Au top electrodes in vertical molecular junction devices that have the conductive polymer, poly(3,4-ethylene dioxythiophene)-poly(4-styrene sulfonate) (

Pedot: PSS), as a contact layer between the self-assembled monolayer and the Au top electrode. In this method, a thermally curable photoresist of SU-8 is used to define the areas where the top electrodes are formed. The hydrophobicity and low surface energy of the cured SU-8 facilitates selective deposition of

Pedot: PSS onto the defined top electrode areas of the device through solution dewetting, and also enables the physical peeling of the Au top electrodes deposited on the SU-8 layers using an adhesion tape. Through this approach, vertical molecular junctions with patterned Au top electrodes can be fabricated without employing the shadow mask evaporation process used in the conventional approach. We processed vertical molecular tunneling devices based on self-assembled alkanedithiol monolayers with an active area of 100 µm2.
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http://dx.doi.org/10.1166/jnn.2016.12278DOI Listing
April 2016

Enhanced Photocurrent Generation from Bacteriorhodopsin Photocells Using Grating-Structured Transparent Conductive Oxide Electrodes.

J Nanosci Nanotechnol 2016 Apr;16(4):3206-12

We fabricated a grating-structured electrode made of indium-doped zinc oxide (IZO) with a high refractive index (approximately 2) for a bacteriorhodopsin (bR) photocell. We investigated the photocurrent characteristics of the bR photocell and demonstrated that the photocurrent values from the bR/IZO electrode with the grating structure with a grating period of 340 nm were more than 3.5-4 times larger than those without the grating structure. The photocurrent enhancement was attributed to the resonance effect due to light coupling to the grating structure as well as the scattering effect based on the experimental results and analysis using the photonic band structure determined using finite-difference time-domain (FDTD) simulations. The refractive index of the bR film in electrolyte solution (1.40) used in the FDTD simulations was estimated by analyzing the extinction peak wavelength of 20-nm gold colloids in the bR film. Our results indicate that the grating- or photonic-crystal-structured transparent conductive oxide (TCO) electrodes can increase the light use efficiency of various bR devices such as artificial photosynthetic devices, solar cells, and light-sensing devices.
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http://dx.doi.org/10.1166/jnn.2016.12310DOI Listing
April 2016

Controlled spontaneous emission of single molecules in a two-dimensional photonic band gap.

J Am Chem Soc 2013 Jan 27;135(1):106-9. Epub 2012 Dec 27.

National Institute of Information and Communications Technology, 588-2 Iwaoka, Nishi-ku, Kobe 651-2492, Japan.

We have established a new platform to control the rate of spontaneous emission (SE) of organic molecules in the visible-light region using a combination of a two-dimensional (2D) photonic crystal (PC) slab made of TiO(2) and a single-molecule measurement method. The SE from single molecules of a perylenediimide derivative was effectively inhibited via a radiation field controlled by the 2D PC slab, which has a photonic band gap (PBG) for transverse-electric (TE)-polarized light. The fluorescence lifetimes of the single molecules were extended up to 5.5 times (28.6 ns) by the PBG effect. This result appears to be the first demonstration of drastic lifetime elongation for single molecules due to a PBG effect.
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http://dx.doi.org/10.1021/ja3115357DOI Listing
January 2013

Fabrication of two-dimensional Ta2O5 photonic crystal slabs with ultra-low background emission toward highly sensitive fluorescence spectroscopy.

Opt Express 2011 Jan;19(2):1422-8

Kobe Advanced ICT Research Center, National Institute of Information and Communications Technology, Nishi-Ku, Kobe, Japan.

A two-dimensional tantalum pentoxide (Ta2O5) photonic crystal (PC) slab with low-background emission was fabricated and a 12-fold enhancement of fluorescence from the organic dyes of perylene diimide adsorbed on the surface of the PCs was observed. The background emissions of the Ta2O5 substrates with and without the PCs after thermal annealing at 600°C with oxygen gas were comparable to that of a well-cleaned cover glass. This is to date the lowest level of background emissions of two-dimensional PCs using materials with a high refractive index (>2). The results reported here provide new insights into the fabrication of the photonic devices that enable highly sensitive fluorescence microscopy or optical detections.
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http://dx.doi.org/10.1364/OE.19.001422DOI Listing
January 2011

Dynamics of spontaneous emission from SiN with two-dimensional photonic crystals.

Opt Lett 2008 Aug;33(15):1768-70

Kobe Advanced Research Center, National Institute of Information and Communications Technology, 588-2 Iwaoka, Nishi-Ku, Kobe 651-2492, Japan.

We investigated the dynamics of spontaneous emission from a photonic crystal etched into a SiN slab. After fitting the decay curves of the emission to double exponential functions, we divided the dynamic process of the spontaneous emission into a fast process and a slow process. It was observed that the presence of the photonic crystal increased the proportion of the fast decay component, and consequently, the emission rate and time-integrated emission intensity were also enhanced. These enhancements were a result of the coupling of the guide modes to the leaky modes of the photonic crystal slab waveguide.
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http://dx.doi.org/10.1364/ol.33.001768DOI Listing
August 2008
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