Publications by authors named "Riekelt H Houtkooper"

100Publications

IgG Subclasses Shape Cytokine Responses by Human Myeloid Immune Cells through Differential Metabolic Reprogramming.

J Immunol 2020 Nov 13. Epub 2020 Nov 13.

Amsterdam Rheumatology and Immunology Center, Department of Rheumatology and Clinical Immunology, Amsterdam University Medical Centers, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands;

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http://dx.doi.org/10.4049/jimmunol.2000263DOI Listing
November 2020

Mitochondrial Fatty Acid Oxidation Disorders: Laboratory Diagnosis, Pathogenesis, and the Complicated Route to Treatment.

J Lipid Atheroscler 2020 Sep 22;9(3):313-333. Epub 2020 Sep 22.

Laboratory Genetic Metabolic Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology and Metabolism, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.

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http://dx.doi.org/10.12997/jla.2020.9.3.313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521971PMC
September 2020

Exploring the metabolic fate of medium-chain triglycerides in healthy individuals using a stable isotope tracer.

Clin Nutr 2020 Sep 4. Epub 2020 Sep 4.

Amsterdam UMC, University of Amsterdam, Laboratory Genetic Metabolic Diseases, Amsterdam Cardiovascular Sciences, Amsterdam Gastroenterology Endocrinology and Metabolism, Meibergdreef 9, 1105, AZ, Amsterdam, the Netherlands; Section Metabolic Diseases, Wilhelmina Children's Hospital, University Medical Center Utrecht, Lundlaan 6, 3584, EA, Utrecht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.clnu.2020.08.032DOI Listing
September 2020

Enzyme engineering to fight mitochondrial diseases.

Nat Metab 2020 Mar;2(3):215-216

Laboratory of Genetic Metabolic Diseases, Amsterdam Gastroenterology and Metabolism, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1038/s42255-020-0177-xDOI Listing
March 2020

Identification of longevity compounds with minimized probabilities of side effects.

Biogerontology 2020 Dec 19;21(6):709-719. Epub 2020 Jun 19.

Laboratory Genetic Metabolic Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology and Metabolism, Amsterdam Cardiovascular Sciences, Meibergdreef 9, 1105, AZ, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10522-020-09887-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541369PMC
December 2020

Confounding factors from inducible systems for spatiotemporal gene expression regulation.

J Cell Biol 2020 Jul;219(7)

Laboratory for Integrative Systems Physiology, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1083/jcb.202003031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337492PMC
July 2020

Mitochondrial cross-compartmental signalling to maintain proteostasis and longevity.

Philos Trans R Soc Lond B Biol Sci 2020 06 4;375(1801):20190414. Epub 2020 May 4.

Laboratory Genetic Metabolic Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology and Metabolism, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1098/rstb.2019.0414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209959PMC
June 2020

Skeletal muscle in healthy humans exhibits a day-night rhythm in lipid metabolism.

Mol Metab 2020 07 6;37:100989. Epub 2020 Apr 6.

Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, P.O. Box 616, 6200 MD Maastricht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2020.100989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217992PMC
July 2020

Mitochondrial translation and dynamics synergistically extend lifespan in C. elegans through HLH-30.

J Cell Biol 2020 Jun;219(6)

Laboratory Genetic Metabolic Diseases, Amsterdam Gastroenterology and Metabolism, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1083/jcb.201907067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265311PMC
June 2020

A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways.

Cell Metab 2020 03 20;31(3):549-563.e7. Epub 2020 Feb 20.

Laboratory Genetic Metabolic Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology and Metabolism, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2020.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214782PMC
March 2020

Prediction of VLCAD deficiency phenotype by a metabolic fingerprint in newborn screening bloodspots.

Biochim Biophys Acta Mol Basis Dis 2020 06 19;1866(6):165725. Epub 2020 Feb 19.

Section Metabolic Diagnostics, Department of Genetics, University Medical Center Utrecht, Utrecht University, Lundlaan 6, 3584 EA Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2020.165725DOI Listing
June 2020

Mitochondrial fission and fusion: A dynamic role in aging and potential target for age-related disease.

Mech Ageing Dev 2020 03 1;186:111212. Epub 2020 Feb 1.

Laboratory Genetic Metabolic Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology and Metabolism, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.mad.2020.111212DOI Listing
March 2020

A reduced form of nicotinamide riboside defines a new path for NAD biosynthesis and acts as an orally bioavailable NAD precursor.

Mol Metab 2019 12 3;30:192-202. Epub 2019 Oct 3.

Nestlé Institute of Health Sciences, Nestlé Research, EPFL Innovation Park, 1015, Lausanne, Switzerland; School of Life Sciences, EPFL, Lausanne, 1015, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2019.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6807296PMC
December 2019

A uniparental isodisomy event introducing homozygous pathogenic variants drives a multisystem metabolic disorder.

Cold Spring Harb Mol Case Stud 2019 12 13;5(6). Epub 2019 Dec 13.

Laboratory of Genetic Metabolic Diseases, Amsterdam Gastroenterology and Metabolism, Immunology and Infectious Diseases, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, Netherlands.

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http://dx.doi.org/10.1101/mcs.a004457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913148PMC
December 2019

Mitochondrial Dysfunction Underlies Cardiomyocyte Remodeling in Experimental and Clinical Atrial Fibrillation.

Cells 2019 10 5;8(10). Epub 2019 Oct 5.

Department of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences, 1081 HV Amsterdam, The Netherlands.

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http://dx.doi.org/10.3390/cells8101202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829298PMC
October 2019

Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy.

Cell 2019 09 29;178(6):1299-1312.e29. Epub 2019 Aug 29.

MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK; Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK; Institute of Structural and Molecular Biology, University College London and Birkbeck, London WC1E 6BT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736778PMC
September 2019

The role of glycolysis and mitochondrial respiration in the formation and functioning of endothelial tip cells during angiogenesis.

Sci Rep 2019 08 30;9(1):12608. Epub 2019 Aug 30.

Ocular Angiogenesis Group, Department of Ophthalmology, Amsterdam Cardiovascular Sciences and Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41598-019-48676-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717205PMC
August 2019

A single day of high-fat diet feeding induces lipid accumulation and insulin resistance in brown adipose tissue in mice.

Am J Physiol Endocrinol Metab 2019 11 6;317(5):E820-E830. Epub 2019 Aug 6.

Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1152/ajpendo.00123.2019DOI Listing
November 2019

From molecular promise to preclinical results: HDAC inhibitors in the race for healthy aging drugs.

EMBO Mol Med 2019 09 1;11(9):e9854. Epub 2019 Aug 1.

Laboratory Genetic Metabolic Diseases, Amsterdam UMC, Amsterdam Gastroenterology and Metabolism, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.15252/emmm.201809854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728603PMC
September 2019

Underpowered or negative? A crucial distinction. Reply to Dollerup OL, Treebak JT, Jessen N [letter].

Diabetologia 2019 06 13;62(6):1096. Epub 2019 Apr 13.

Department of Nutrition and Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University, Universiteitssingel 50, P.O. Box 616, 6200 MD, Maastricht, the Netherlands.

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http://dx.doi.org/10.1007/s00125-019-4868-3DOI Listing
June 2019

Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion.

PLoS Genet 2019 03 7;15(3):e1007633. Epub 2019 Mar 7.

Laboratory Genetic Metabolic Diseases, Amsterdam Gastroenterology and Metabolism, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.

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http://dx.plos.org/10.1371/journal.pgen.1007633
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http://dx.doi.org/10.1371/journal.pgen.1007633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424468PMC
March 2019

NAD metabolism as a target for metabolic health: have we found the silver bullet?

Diabetologia 2019 06 16;62(6):888-899. Epub 2019 Feb 16.

Department of Nutrition and Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University, Universiteitssingel 50, P.O. Box 616, 6200 MD, Maastricht, the Netherlands.

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http://dx.doi.org/10.1007/s00125-019-4831-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509089PMC
June 2019

Translational Metabolism: A multidisciplinary approach towards precision diagnosis of inborn errors of metabolism in the omics era.

J Inherit Metab Dis 2019 03 5;42(2):197-208. Epub 2019 Feb 5.

Laboratory Genetic Metabolic Diseases, Department of Clinical Chemistry, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/jimd.12008DOI Listing
March 2019

COmplexome Profiling ALignment (COPAL) reveals remodeling of mitochondrial protein complexes in Barth syndrome.

Bioinformatics 2019 09;35(17):3083-3091

CMBI, Radboud Centre for Mitochondrial Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1093/bioinformatics/btz025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735710PMC
September 2019

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia.

Cell Rep 2018 11;25(8):2044-2052.e5

Amsterdam UMC, University of Amsterdam, Department of Medical Biochemistry, Experimental Vascular Biology, Amsterdam Cardiovascular Sciences, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Molecular Cell Biology and Immunology, Amsterdam Cardiovascular Sciences, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HZ Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.10.092DOI Listing
November 2018

Identification of key pathways and metabolic fingerprints of longevity in C. elegans.

Exp Gerontol 2018 11 6;113:128-140. Epub 2018 Oct 6.

Laboratory Genetic Metabolic Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology & Metabolism, 1105 AZ Amsterdam, the Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S05315565183011
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http://dx.doi.org/10.1016/j.exger.2018.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224709PMC
November 2018

Barth syndrome cells display widespread remodeling of mitochondrial complexes without affecting metabolic flux distribution.

Biochim Biophys Acta Mol Basis Dis 2018 11 1;1864(11):3650-3658. Epub 2018 Sep 1.

Laboratory Genetic Metabolic Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology & Metabolism, Amsterdam Cardiovascular Sciences, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2018.08.041DOI Listing
November 2018

Mitochondrial ubiquinone-mediated longevity is marked by reduced cytoplasmic mRNA translation.

Life Sci Alliance 2018 Aug;1(5)

Laboratory Genetic Metabolic Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology & Metabolism, Meibergdreef 9, Amsterdam, The Netherlands.

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http://dx.doi.org/10.26508/lsa.201800082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126614PMC
August 2018

Natural genetic variation in identified genomic loci controlling metabolite levels.

Genome Res 2018 09 14;28(9):1296-1308. Epub 2018 Aug 14.

Laboratory Genetic Metabolic Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology and Metabolism, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1101/gr.232322.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120624PMC
September 2018

Preface - Animal models for aging.

Biochim Biophys Acta Mol Basis Dis 2018 09 22;1864(9 Pt A):2679. Epub 2018 Jun 22.

Laboratory Genetic Metabolic Diseases, Academic Medical Center, Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2018.06.015DOI Listing
September 2018

Disorders of mitochondrial long-chain fatty acid oxidation and the carnitine shuttle.

Rev Endocr Metab Disord 2018 03;19(1):93-106

Dutch Fatty Acid Oxidation Expertise Center, Laboratory Genetic Metabolic Diseases, Departments of Clinical Chemistry and Pediatrics, Emma Children's Hospital, Academic Medical Center, Meibergdreef 9, 1105, AZ, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s11154-018-9448-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208583PMC
March 2018

Quercetin Lowers Plasma Triglycerides Accompanied by White Adipose Tissue Browning in Diet-Induced Obese Mice.

Int J Mol Sci 2018 06 16;19(6). Epub 2018 Jun 16.

Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Post Zone C7Q, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.3390/ijms19061786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032193PMC
June 2018

Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease.

Endocr Rev 2018 08;39(4):489-517

Laboratory of Genetic Metabolic Diseases, Academic Medical Center, AZ Amsterdam, Netherlands.

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https://academic.oup.com/edrv/article/39/4/489/4982126
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http://dx.doi.org/10.1210/er.2017-00211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093334PMC
August 2018

Increased cardiac fatty acid oxidation in a mouse model with decreased malonyl-CoA sensitivity of CPT1B.

Cardiovasc Res 2018 08;114(10):1324-1334

Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, Box 1498, New York, NY, USA.

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http://dx.doi.org/10.1093/cvr/cvy089DOI Listing
August 2018

Platelet Toll-like receptor expression and activation induced by lipopolysaccharide and sepsis.

Platelets 2019 12;30(3):296-304. Epub 2018 Mar 12.

a Center for Experimental and Molecular Medicine, Academic Medical Center , University of Amsterdam , Amsterdam , The Netherlands.

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https://www.tandfonline.com/doi/full/10.1080/09537104.2018.1
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http://dx.doi.org/10.1080/09537104.2018.1445841DOI Listing
April 2019

Ethnic differences in metabolite signatures and type 2 diabetes: a nested case-control analysis among people of South Asian, African and European origin.

Nutr Diabetes 2017 Dec 19;7(12):300. Epub 2017 Dec 19.

Laboratory Genetic Metabolic Diseases, Academic Medical Centre, I. van Valkengoed, Meibergdreef 9, J2-209, 1105 AZ, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41387-017-0003-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865542PMC
December 2017

Forward and reverse genetics approaches to uncover metabolic aging pathways in Caenorhabditis elegans.

Biochim Biophys Acta Mol Basis Dis 2018 09 15;1864(9 Pt A):2697-2706. Epub 2017 Sep 15.

Laboratory Genetic Metabolic Diseases, Academic Medical Center of Amsterdam, 1105 AZ Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2017.09.006DOI Listing
September 2018

AMC-Bio-Artificial Liver culturing enhances mitochondrial biogenesis in human liver cell lines: The role of oxygen, medium perfusion and 3D configuration.

Mitochondrion 2018 03 24;39:30-42. Epub 2017 Aug 24.

Tytgat Institute for Liver and Intestinal Research, Academic Medical Center (AMC), University of Amsterdam, Postbus 22660, 1100 DD Amsterdam, The Netherlands; Surgical Laboratory, Academic Medical Center (AMC), University of Amsterdam, Postbus 22660, 1100 DD Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.mito.2017.08.011DOI Listing
March 2018

Acute detachment of hexokinase II from mitochondria modestly increases oxygen consumption of the intact mouse heart.

Metabolism 2017 07 21;72:66-74. Epub 2017 Apr 21.

Laboratory of Experimental Intensive Care and Anesthesiology, Department of Anesthesiology, Academic Medical Center, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2017.04.008DOI Listing
July 2017

The gut microbiota as a modulator of innate immunity during melioidosis.

PLoS Negl Trop Dis 2017 04 19;11(4):e0005548. Epub 2017 Apr 19.

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1371/journal.pntd.0005548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411098PMC
April 2017

Identification of enzymes involved in oxidation of phenylbutyrate.

J Lipid Res 2017 05 9;58(5):955-961. Epub 2017 Mar 9.

Laboratory Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands

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http://dx.doi.org/10.1194/jlr.M075317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408614PMC
May 2017

Microbial stimulation of different Toll-like receptor signalling pathways induces diverse metabolic programmes in human monocytes.

Nat Microbiol 2016 Dec 19;2:16246. Epub 2016 Dec 19.

Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/nmicrobiol.2016.246DOI Listing
December 2016

Ketones and inborn errors of metabolism: old friends revisited.

J Inherit Metab Dis 2017 01;40(1):3-4

Laboratory Genetic Metabolic Diseases, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10545-016-9997-yDOI Listing
January 2017

A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans.

Nat Protoc 2016 10 1;11(10):1798-816. Epub 2016 Sep 1.

Laboratory Genetic Metabolic Diseases, Academic Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1038/nprot.2016.106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040492PMC
October 2016

Commentaries on Viewpoint: The rigorous study of exercise adaptations: Why mRNA might not be enough.

J Appl Physiol (1985) 2016 08;121(2):597-600

University of Wisconsin-MadisonYork UniversityUniversity of KentuckyAustralian Catholic UniversityAustralian Catholic University, Liverpool John Moores UniversityKarolinska InstitutetPennsylvania State UniversityAcademic Medical Center, University of Amsterdam.

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http://dx.doi.org/10.1152/japplphysiol.00509.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142615PMC
August 2016

Sirtuin activation as a therapeutic approach against inborn errors of metabolism.

J Inherit Metab Dis 2016 07 4;39(4):565-72. Epub 2016 May 4.

Laboratory Genetic Metabolic Diseases, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10545-016-9939-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920849PMC
July 2016

The impact of altered carnitine availability on acylcarnitine metabolism, energy expenditure and glucose tolerance in diet-induced obese mice.

Biochim Biophys Acta 2016 08 22;1862(8):1375-82. Epub 2016 Apr 22.

Department of Clinical Chemistry, Laboratory Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands; Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, Box 1498, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2016.04.012DOI Listing
August 2016

Tetracycline antibiotics impair mitochondrial function and its experimental use confounds research.

Cancer Res 2015 Nov 16;75(21):4446-9. Epub 2015 Oct 16.

Laboratory Genetic Metabolic Diseases, Academic Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-1626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631686PMC
November 2015

Type 5 adenylyl cyclase disruption leads to enhanced exercise performance.

Aging Cell 2015 Dec 1;14(6):1075-84. Epub 2015 Oct 1.

Department of Cell Biology & Molecular Medicine, New Jersey Medical School, Rutgers University, Newark, NJ, USA.

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http://dx.doi.org/10.1111/acel.12401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693460PMC
December 2015

Antibiotic use and abuse: a threat to mitochondria and chloroplasts with impact on research, health, and environment.

Bioessays 2015 Oct 8;37(10):1045-53. Epub 2015 Sep 8.

Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1002/bies.201500071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698130PMC
October 2015

Mitochondrial quality control pathways as determinants of metabolic health.

Bioessays 2015 Aug 26;37(8):867-76. Epub 2015 May 26.

Laboratory Genetic Metabolic Diseases, Academic Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1002/bies.201500013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053262PMC
August 2015

Fatty acid oxidation flux predicts the clinical severity of VLCAD deficiency.

Genet Med 2015 Dec 2;17(12):989-94. Epub 2015 Apr 2.

Department of Paediatric Gastroenterology and Metabolic Diseases, Wilhelmina Children's Hospital, UMC Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1038/gim.2015.22DOI Listing
December 2015

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research.

Cell Rep 2015 Mar 12;10(10):1681-1691. Epub 2015 Mar 12.

Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.02.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565776PMC
March 2015

Laminar shear stress inhibits endothelial cell metabolism via KLF2-mediated repression of PFKFB3.

Arterioscler Thromb Vasc Biol 2015 Jan 30;35(1):137-45. Epub 2014 Oct 30.

From the Institute for Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University, Frankfurt am Main, Germany (A.D., K.M.M., Y.M., T.L., S.D., R.A.B.); The Laboratory Genetic Metabolic Diseases, Academic Medical Center, Amsterdam, The Netherlands (R.H.H.); The Max-Delbrück-Center, Berlin, Germany (X.Y., W.C.); Department of Cardiology, Internal Medicine III, Goethe University Hospital Frankfurt, Frankfurt am Main, Germany (A.M.Z.); Angiogenesis and Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany (M.P.); and German Center for Cardiovascular Research (DZHK), Partner Site RheinMain, Frankfurt am Main, Germany (A.M.Z., S.D.).

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http://dx.doi.org/10.1161/ATVBAHA.114.304277DOI Listing
January 2015

The two-faced progeria gene and its implications in aging and metabolism.

EMBO Rep 2014 May 10;15(5):470-1. Epub 2014 Apr 10.

Laboratory Genetic Metabolic Diseases, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/embr.201438776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210100PMC
May 2014

Mitochondrial response to nutrient availability and its role in metabolic disease.

EMBO Mol Med 2014 May;6(5):580-9

Laboratory Genetic Metabolic Diseases, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/emmm.201303782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023882PMC
May 2014

Mitochondrial fission: firing up mitochondria in brown adipose tissue.

EMBO J 2014 Mar 30;33(5):401-2. Epub 2014 Jan 30.

Laboratory Genetic Metabolic Diseases, Academic Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1002/embj.201487798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989620PMC
March 2014

NAD⁺ metabolism: a therapeutic target for age-related metabolic disease.

Crit Rev Biochem Mol Biol 2013 Jul-Aug;48(4):397-408. Epub 2013 Jun 6.

Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

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http://dx.doi.org/10.3109/10409238.2013.789479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858599PMC
February 2014

Pharmacological approaches to restore mitochondrial function.

Nat Rev Drug Discov 2013 Jun 13;12(6):465-83. Epub 2013 May 13.

Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1038/nrd4023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896945PMC
June 2013

Exploring the therapeutic space around NAD+.

J Cell Biol 2012 Oct;199(2):205-9

Laboratory Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.

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http://www.jcb.org/lookup/doi/10.1083/jcb.201207019
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http://dx.doi.org/10.1083/jcb.201207019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471225PMC
October 2012

Systems genetics of metabolism: the use of the BXD murine reference panel for multiscalar integration of traits.

Cell 2012 Sep 30;150(6):1287-99. Epub 2012 Aug 30.

Laboratory of Integrative and Systems Physiology, School of Life Sciences, École Polytechnique Fédérale de Lausanne 1015, Switzerland.

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http://dx.doi.org/10.1016/j.cell.2012.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604687PMC
September 2012

Cholestasis is associated with hepatic microvascular dysfunction and aberrant energy metabolism before and during ischemia-reperfusion.

Antioxid Redox Signal 2012 Oct 7;17(8):1109-23. Epub 2012 Jun 7.

Department of Experimental Surgery, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1089/ars.2011.4291DOI Listing
October 2012

Sirtuins as regulators of metabolism and healthspan.

Nat Rev Mol Cell Biol 2012 Mar 7;13(4):225-238. Epub 2012 Mar 7.

Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1038/nrm3293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872805PMC
March 2012

The metabolic footprint of aging in mice.

Sci Rep 2011 31;1:134. Epub 2011 Oct 31.

Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fe´de´rale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1038/srep00134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216615PMC
September 2013

Cardiac and skeletal muscle defects in a mouse model of human Barth syndrome.

J Biol Chem 2011 Jan 9;286(2):899-908. Epub 2010 Nov 9.

Department of Pediatrics, Cincinnati Children's Hospital Medical Center and the University of Cincinnati, Cincinnati, Ohio 45229, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.171439
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http://dx.doi.org/10.1074/jbc.M110.171439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020775PMC
January 2011