Publications by authors named "Ricky W Johnstone"

100Publications

Temporal Analysis of Brd4 Displacement in the Control of B Cell Survival, Proliferation, and Differentiation.

Cell Rep 2020 Oct;33(3):108290

Walter and Eliza Hall Institute of Medical Research, The University of Melbourne, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.108290DOI Listing
October 2020

Targeting the epigenetic regulation of antitumour immunity.

Nat Rev Drug Discov 2020 Nov 14;19(11):776-800. Epub 2020 Sep 14.

Translational Haematology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1038/s41573-020-0077-5DOI Listing
November 2020

IL-15 Preconditioning Augments CAR T Cell Responses to Checkpoint Blockade for Improved Treatment of Solid Tumors.

Mol Ther 2020 Nov 21;28(11):2379-2393. Epub 2020 Jul 21.

Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2020.07.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647667PMC
November 2020

Distinct and overlapping mechanisms of resistance to azacytidine and guadecitabine in acute myeloid leukemia.

Leukemia 2020 Dec 13;34(12):3388-3392. Epub 2020 Jul 13.

The Peter MacCallum Cancer Centre, Melbourne, 3000, VIC, Australia.

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http://dx.doi.org/10.1038/s41375-020-0973-zDOI Listing
December 2020

Efficient CRISPR/Cas9 Gene Editing in Uncultured Naive Mouse T Cells for In Vivo Studies.

J Immunol 2020 Apr 9;204(8):2308-2315. Epub 2020 Mar 9.

Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia; and

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http://dx.doi.org/10.4049/jimmunol.1901396DOI Listing
April 2020

Joseph F. Sambrook (1939-2019).

Nat Struct Mol Biol 2019 10;26(10):846-847

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY, USA.

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http://dx.doi.org/10.1038/s41594-019-0311-1DOI Listing
October 2019

Natural Killer Cells Suppress T Cell-Associated Tumor Immune Evasion.

Cell Rep 2019 Sep;28(11):2784-2794.e5

Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, VIC 3010, Australia; Department of Immunology, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.08.017DOI Listing
September 2019

Antagonism of IAPs Enhances CAR T-cell Efficacy.

Cancer Immunol Res 2019 02 16;7(2):183-192. Epub 2019 Jan 16.

Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1158/2326-6066.CIR-18-0428DOI Listing
February 2019

Down-regulation of a pro-apoptotic pathway regulated by PCAF/ADA3 in early stage gastric cancer.

Cell Death Dis 2018 05 1;9(5):442. Epub 2018 May 1.

Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia.

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http://dx.doi.org/10.1038/s41419-018-0470-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906598PMC
May 2018

A Comprehensive Protocol Resource for Performing Pooled shRNA and CRISPR Screens.

Methods Mol Biol 2018 ;1725:201-227

Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1007/978-1-4939-7568-6_17DOI Listing
January 2019

DOCK8 Drives Src-Dependent NK Cell Effector Function.

J Immunol 2017 Aug 9. Epub 2017 Aug 9.

Immune Defence Laboratory, Cancer Immunology Division, Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia;

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http://dx.doi.org/10.4049/jimmunol.1700751DOI Listing
August 2017

HDAC Inhibitor Panobinostat Engages Host Innate Immune Defenses to Promote the Tumoricidal Effects of Trastuzumab in HER2 Tumors.

Cancer Res 2017 05 1;77(10):2594-2606. Epub 2017 Mar 1.

Cancer Therapeutics Program, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre (VCCC), Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-2247DOI Listing
May 2017

A chemical probe toolbox for dissecting the cancer epigenome.

Nat Rev Cancer 2017 02;17(3):160-183

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/nrc.2016.148DOI Listing
February 2017

In the Midst of Life-Cell Death: What Is It, What Is It Good for, and How to Study It.

Cold Spring Harb Protoc 2016 12 1;2016(12). Epub 2016 Dec 1.

Peter MacCallum Cancer Centre, Melbourne, Victoria 3002, Australia.

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http://dx.doi.org/10.1101/pdb.top070508DOI Listing
December 2016

Constitutive IFNα/β signaling maintains expression of signaling intermediaries for efficient cytokine responses.

JAKSTAT 2016 18;5(1):e1173804. Epub 2016 May 18.

Cancer Therapeutics Program, Peter MacCallum Cancer Center, East Melbourne, VIC, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Australia.

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http://dx.doi.org/10.1080/21623996.2016.1173804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964971PMC
August 2016

BET Inhibition Induces Apoptosis in Aggressive B-Cell Lymphoma via Epigenetic Regulation of BCL-2 Family Members.

Mol Cancer Ther 2016 09 12;15(9):2030-41. Epub 2016 Jul 12.

Gene Regulation Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0924DOI Listing
September 2016

Id2 and E Proteins Orchestrate the Initiation and Maintenance of MLL-Rearranged Acute Myeloid Leukemia.

Cancer Cell 2016 07 30;30(1):59-74. Epub 2016 Jun 30.

Cancer Therapeutics Program, Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, 3002 VIC, Australia; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, 3010 VIC, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.05.019DOI Listing
July 2016

CD271 Expression on Patient Melanoma Cells Is Unstable and Unlinked to Tumorigenicity.

Cancer Res 2016 07 20;76(13):3965-77. Epub 2016 Jun 20.

Cancer Development and Treatment Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Australia. Sir Peter MacCallum Department of Pathology, University of Melbourne, Parkville, Australia. Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Australia. Department of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2377DOI Listing
July 2016

How do tumor cells respond to HDAC inhibition?

FEBS J 2016 11 10;283(22):4032-4046. Epub 2016 May 10.

Cancer Therapeutics Program, The Peter MacCallum Cancer Centre, East Melbourne, Vic., Australia.

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http://doi.wiley.com/10.1111/febs.13746
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http://dx.doi.org/10.1111/febs.13746DOI Listing
November 2016

Long term, continuous exposure to panobinostat induces terminal differentiation and long term survival in the TH-MYCN neuroblastoma mouse model.

Int J Cancer 2016 Jul 10;139(1):194-204. Epub 2016 Mar 10.

Peter MacCallum Cancer Centre, Translational Research Laboratory, East Melbourne, VIC, Australia.

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http://dx.doi.org/10.1002/ijc.30056DOI Listing
July 2016

Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells.

Cell Rep 2016 Mar 18;14(8):1858-66. Epub 2016 Feb 18.

The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.01.059DOI Listing
March 2016

Serglycin determines secretory granule repertoire and regulates natural killer cell and cytotoxic T lymphocyte cytotoxicity.

FEBS J 2016 Mar 22;283(5):947-61. Epub 2016 Jan 22.

Cancer Cell Death/Killer Cell Biology Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/febs.13649DOI Listing
March 2016

The CDK9 Inhibitor Dinaciclib Exerts Potent Apoptotic and Antitumor Effects in Preclinical Models of MLL-Rearranged Acute Myeloid Leukemia.

Cancer Res 2016 Mar 1;76(5):1158-69. Epub 2015 Dec 1.

Gene Regulation Laboratory, Cancer Therapeutics Program, Peter MacCallum Cancer Centre, Melbourne, Australia. Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-1070DOI Listing
March 2016

Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma.

Cancer Discov 2016 Jan 21;6(1):59-70. Epub 2015 Oct 21.

Division of Research, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia. Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia. Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria, Australia. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1158/2159-8290.CD-14-0673DOI Listing
January 2016

Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies.

Blood 2015 Nov 7;126(21):2392-403. Epub 2015 Oct 7.

Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia;

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http://dx.doi.org/10.1182/blood-2015-03-632984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653767PMC
November 2015

Manipulation of B-cell responses with histone deacetylase inhibitors.

Nat Commun 2015 Apr 27;6:6838. Epub 2015 Apr 27.

1] Cancer Therapeutics Program, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria 3002, Australia [2] Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria 3010, Australia.

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http://dx.doi.org/10.1038/ncomms7838DOI Listing
April 2015

Combining the differentiating effect of panobinostat with the apoptotic effect of arsenic trioxide leads to significant survival benefit in a model of t(8;21) acute myeloid leukemia.

Clin Epigenetics 2015 22;7. Epub 2015 Jan 22.

Cancer Therapeutics Program, Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, 3002 VIC Australia ; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, 3010 VIC Australia.

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http://dx.doi.org/10.1186/s13148-014-0034-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308003PMC
January 2015

Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy.

PLoS Pathog 2014 Oct 13;10(10):e1004473. Epub 2014 Nov 13.

Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Victoria, Australia; Centre for Biomedical Research, Burnet Institute, Melbourne, Victoria, Australia; Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1371/journal.ppat.1004473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231123PMC
October 2014

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders.

Nat Rev Drug Discov 2014 Sep 18;13(9):673-91. Epub 2014 Aug 18.

1] Cancer Therapeutics Program, The Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne 3002, Victoria, Australia. [2] Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville 3052, Victoria, Australia.

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http://www.nature.com/articles/nrd4360
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http://dx.doi.org/10.1038/nrd4360DOI Listing
September 2014

Combination anti-CD137 and anti-CD40 antibody therapy in murine myc-driven hematological cancers.

Leuk Res 2014 Aug 2;38(8):948-54. Epub 2014 Jun 2.

Division of Cancer Research, Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne 3002, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville 3010, Australia; Department of Immunology, Monash University, Prahran 3181, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.leukres.2014.05.010DOI Listing
August 2014

The drug vehicle and solvent N-methylpyrrolidone is an immunomodulator and antimyeloma compound.

Cell Rep 2014 May 9;7(4):1009-19. Epub 2014 May 9.

Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC 3002, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC 3002, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.04.008DOI Listing
May 2014

Rational combination therapies targeting survival signaling in aggressive B-cell leukemia/lymphoma.

Curr Opin Hematol 2014 Jul;21(4):297-308

aCancer Therapeutics Program, Gene Regulation Laboratory, The Peter MacCallum Cancer Centre, Melbourne bMonash Haematology, Monash Medical Centre cSouthern Clinical School, Monash University, Faculty of Medicine, Dentistry and Health Sciences, Clayton dSir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.

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https://insights.ovid.com/crossref?an=00062752-201407000-000
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http://dx.doi.org/10.1097/MOH.0000000000000045DOI Listing
July 2014

Socrates: identification of genomic rearrangements in tumour genomes by re-aligning soft clipped reads.

Bioinformatics 2014 04 2;30(8):1064-1072. Epub 2014 Jan 2.

Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Department of Medical Biology, University of Melbourne, Victoria 3010, Melanoma Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Department of Pathology, The University of Melbourne, Victoria 3010, NICTA Victoria Laboratory, The University of Melbourne, Victoria 3010, Department of Computing and Information Systems, University of Melbourne, Victoria 3010, Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Sir Peter MacCallum Department of Oncology, The University of Melbourne, Victoria 3010, Department of Mathematics and Statistics, The University of Melbourne, Victoria 3010 and Bioinformatics and Cancer Genomics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Department of Medical Biology, University of Melbourne, Victoria 3010, Melanoma Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Department of Pathology, The University of Melbourne, Victoria 3010, NICTA Victoria Laboratory, The University of Melbourne, Victoria 3010, Department of Computing and Information Systems, University of Melbourne, Victoria 3010, Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Sir Peter MacCallum Department of Oncology, The University of Melbourne, Victoria 3010, Department of Mathematics and Statistics, The University of Melbourne, Victoria 3010 and Bioinformatics and Cancer Genomics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Department of Medical Biology, University of Melbourne, Victoria 3010, Melanoma Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Department of Pathology, The University of Melbourne, Victoria 3010, NICTA Victoria Laboratory, The University of Melbourne, Victoria 3010, Department of Computing and Information Systems, University of Melbourne, Victoria 3010, Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Sir Peter MacCallum Department of Oncology, The University of Melbourne, Victoria 3010, Department of Mathematics and Statistics, The University of Melbourne, Victoria 3010 and Bioinformatics and Cancer Genomics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Department of Medical Biology, University of Melbourne, Victoria 3010, Melanoma Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Department of Pathology, The University of Melbourne, Victoria 3010, NICTA Victoria Laboratory, The University of Melbourne, Victoria 3010, Department of Computing and Information Systems, University of Melbourne, Victoria 3010, Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Sir Peter MacCallum Department of Oncology, The University of Melbourne, Victoria 3010, Department of Mathematics and Statistics, The University of Melbourne, Victoria 3010 and Bioinformatics and Cancer Genomics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia.

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http://dx.doi.org/10.1093/bioinformatics/btt767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982158PMC
April 2014

Id2 represses E2A-mediated activation of IL-10 expression in T cells.

Blood 2014 May 10;123(22):3420-8. Epub 2014 Apr 10.

Division of Molecular Immunology Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia; Department of Medical Biology, University of Melbourne, Melbourne, Australia;

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http://dx.doi.org/10.1182/blood-2014-03-561456DOI Listing
May 2014

The anticancer effects of HDAC inhibitors require the immune system.

Oncoimmunology 2014 Jan;3(1):e27414

Cancer Therapeutics Program; The Peter MacCallum Cancer Centre; East Melbourne, VIC Australia ; Sir Peter MacCallum Department of Oncology; University of Melbourne; Parkville, VIC Australia.

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http://www.tandfonline.com/doi/abs/10.4161/onci.27414
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http://dx.doi.org/10.4161/onci.27414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962507PMC
January 2014

Lethal giant larvae 1 tumour suppressor activity is not conserved in models of mammalian T and B cell leukaemia.

PLoS One 2014 27;9(1):e87376. Epub 2014 Jan 27.

Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia ; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia ; Centre for Micro-Photonics, Swinburne University of Technology, Hawthorn, Victoria, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087376PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903681PMC
September 2014

Response of BRAF-mutant melanoma to BRAF inhibition is mediated by a network of transcriptional regulators of glycolysis.

Cancer Discov 2014 Apr 27;4(4):423-33. Epub 2014 Jan 27.

1Molecular Oncology Laboratory, Oncogenic Signaling and Growth Control Program, 2Translational Research Laboratory, Cancer Therapeutics Program, 3Bioinformatics Core Facility, 4The Cancer Signalling Laboratory, Oncogenic Signaling and Growth Control Program, 5Gene Regulation Laboratory, Cancer Therapeutics Program, 6Molecular Imaging and Targeted Therapeutics Laboratory, Cancer Therapeutics Program, 7Department of Cancer Imaging, Peter MacCallum Cancer Centre, East Melbourne; 8Sir Peter MacCallum Department of Oncology, Departments of 9Biochemistry and Molecular Biology, and 10Pathology, University of Melbourne, Parkville; 11Metabolic Remodelling Laboratory, Metabolic Research Unit, School of Medicine, Deakin University, Waurn Ponds; 12Department of Medicine, St Vincent's Hospital, University of Melbourne, Fitzroy, Victoria; 13Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead; 14Department of Tissue Pathology & Diagnostic Oncology, Royal Prince Alfred Hospital; 15Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia; 16Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah; and 17Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110245PMC
April 2014

New and emerging HDAC inhibitors for cancer treatment.

J Clin Invest 2014 Jan 2;124(1):30-9. Epub 2014 Jan 2.

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http://dx.doi.org/10.1172/JCI69738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871231PMC
January 2014

Genome-wide functional genomic and transcriptomic analyses for genes regulating sensitivity to vorinostat.

Sci Data 2014 8;1:140017. Epub 2014 Jul 8.

Victorian Centre for Functional Genomics, The Peter MacCallum Cancer Centre , St Andrews Place, East Melbourne, Victoria 3002, Australia ; Sir Peter MacCallum Department of Oncology, The University of Melbourne , Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1038/sdata.2014.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322586PMC
November 2015

Growth differentiating factor 15 enhances the tumor-initiating and self-renewal potential of multiple myeloma cells.

Blood 2014 Jan 17;123(5):725-33. Epub 2013 Dec 17.

Division of Hematologic Malignancies, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD;

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http://dx.doi.org/10.1182/blood-2013-08-524025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907757PMC
January 2014

An intact immune system is required for the anticancer activities of histone deacetylase inhibitors.

Cancer Res 2013 Dec 24;73(24):7265-76. Epub 2013 Oct 24.

Authors' Affiliations: Cancer Therapeutics Program, and Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria; The University of Queensland Diamantina Institute, Translational Research Institute, Woolloongabba; Queensland Institute of Medical Research; and School of Medicine, University of Queensland, Herston, Queensland, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0890DOI Listing
December 2013

Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors.

Eur J Cancer 2013 Dec 3;49(18):3936-44. Epub 2013 Sep 3.

Oncogenic Signalling and Growth Control Program, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett St, Melbourne, Victoria 8006, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria 3010, Australia; Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria 3010, Australia.

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http://dx.doi.org/10.1016/j.ejca.2013.08.007DOI Listing
December 2013

Modulation of antitumour immune responses by intratumoural Stat1 expression.

Immunol Cell Biol 2013 Oct 20;91(9):556-67. Epub 2013 Aug 20.

1] Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia [2] Deptartment of Pathology, University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1038/icb.2013.41DOI Listing
October 2013

Histone deacetylase inhibitors reduce glycoprotein VI expression and platelet responses to collagen related peptide.

Thromb Res 2013 Jun 2;131(6):514-20. Epub 2013 May 2.

Cancer Research Division, The Peter MacCallum Cancer Centre, St. Andrew's Place, East Melbourne 3002, Victoria, Australia.

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http://dx.doi.org/10.1016/j.thromres.2013.02.013DOI Listing
June 2013

A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance.

Blood 2013 Apr 25;121(17):3459-68. Epub 2013 Feb 25.

Department of Experimental Oncology at the IFOM-IEO Campus, European Institute of Oncology, via Adamello 16, Milan, Italy.

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http://dx.doi.org/10.1182/blood-2012-10-461988DOI Listing
April 2013

AKT signalling is required for ribosomal RNA synthesis and progression of Eμ-Myc B-cell lymphoma in vivo.

FEBS J 2013 Nov 13;280(21):5307-16. Epub 2013 Feb 13.

Division of Research, Peter MacCallum Cancer Centre, East Melbourne, Vic., Australia.

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http://dx.doi.org/10.1111/febs.12135DOI Listing
November 2013

Enhancing the antitumor effects of radiotherapy with combinations of immunostimulatory antibodies.

Oncoimmunology 2012 Dec;1(9):1629-1631

Division of Cell Biology II; The Netherlands Cancer Institute; Amsterdam, The Netherlands.

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http://dx.doi.org/10.4161/onci.21652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525626PMC
December 2012

Oncogenes in cell survival and cell death.

Cold Spring Harb Perspect Biol 2012 Dec 1;4(12). Epub 2012 Dec 1.

Cancer Therapeutics Program, Gene Regulation Laboratory, Peter MacCallum Cancer Centre, East Melbourne 3002, Victoria, Australia.

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http://cshperspectives.cshlp.org/lookup/doi/10.1101/cshpersp
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http://dx.doi.org/10.1101/cshperspect.a009829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504432PMC
December 2012

Intrinsic and extrinsic apoptotic pathway signaling as determinants of histone deacetylase inhibitor antitumor activity.

Adv Cancer Res 2012 ;116:165-97

Cancer Therapeutics Program, Gene Regulation Laboratory, The Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1016/B978-0-12-394387-3.00005-7DOI Listing
March 2013

The combination of histone deacetylase inhibitors with immune-stimulating antibodies has potent anti-cancer effects.

Oncoimmunology 2012 May;1(3):377-379

Cancer Therapeutics; The Peter MacCallum Cancer Centre; East Melbourne, Australia ; Cancer Immunology Program; The Peter MacCallum Cancer Centre; East Melbourne, Australia.

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http://dx.doi.org/10.4161/onci.18804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382866PMC
May 2012

Regulating the TRAIL of destruction: how A20 protects glioblastomas from TRAIL-mediated death.

Cancer Discov 2012 Feb;2(2):112-4

Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1158/2159-8290.CD-11-0350DOI Listing
February 2012

Radiotherapy increases the permissiveness of established mammary tumors to rejection by immunomodulatory antibodies.

Cancer Res 2012 Jul 8;72(13):3163-74. Epub 2012 May 8.

Cancer Therapeutics Program, Sir Donald and Lady Trescowthick Laboratories, Department of Physical Sciences, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-0210DOI Listing
July 2012

Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor.

Immunity 2012 Apr 5;36(4):561-71. Epub 2012 Apr 5.

Structural Immunobiology Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0430, USA.

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http://dx.doi.org/10.1016/j.immuni.2012.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334467PMC
April 2012

Promises and challenges of anticancer drugs that target the epigenome.

Epigenomics 2011 Oct;3(5):547-65

Cancer Therapeutics Program, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne 3002, Victoria, Australia.

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http://dx.doi.org/10.2217/epi.11.82DOI Listing
October 2011