Rickie Patani

Rickie Patani

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Rickie Patani

Rickie Patani

Publications by authors named "Rickie Patani"

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Delineating Astrocytic Cytokine Responses in a Human Stem Cell Model of Neural Trauma.

J Neurotrauma 2019 Aug 27. Epub 2019 Aug 27.

University of Cambridge, 2152, Division of Neurosurgery, Department of Clinical Neurosciences, Cambridge, Cambridgeshire, United Kingdom of Great Britain and Northern Ireland;

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http://dx.doi.org/10.1089/neu.2019.6480DOI Listing
August 2019

Gene expression analysis reveals early dysregulation of disease pathways and links Chmp7 to pathogenesis of spinal and bulbar muscular atrophy.

Sci Rep 2019 Mar 5;9(1):3539. Epub 2019 Mar 5.

Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, Queen Square, London, WC1N 3BG, UK.

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http://dx.doi.org/10.1038/s41598-019-40118-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401132PMC
March 2019

Harnessing cellular aging in human stem cell models of amyotrophic lateral sclerosis.

Aging Cell 2019 Feb 19;18(1):e12862. Epub 2018 Dec 19.

The Institute of Neurology, University College London, London, UK.

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http://dx.doi.org/10.1111/acel.12862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351881PMC
February 2019

A Liquid to Solid Phase Transition Underlying Pathological Huntingtin Exon1 Aggregation.

Mol Cell 2018 05 10;70(4):588-601.e6. Epub 2018 May 10.

Institute of Structural and Molecular Biology, Birkbeck College and University College London, London, WC1E 7HX, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971205PMC
May 2018

Kir4.1-Dependent Astrocyte-Fast Motor Neuron Interactions Are Required for Peak Strength.

Neuron 2018 04 5;98(2):306-319.e7. Epub 2018 Apr 5.

Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Departments of Pediatrics and Neurosurgery, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Paediatrics and Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB20QQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919779PMC
April 2018

Concise Review: The Cellular Conspiracy of Amyotrophic Lateral Sclerosis.

Stem Cells 2018 03 27;36(3):293-303. Epub 2017 Dec 27.

Department of Molecular Neuroscience, Institute of Neurology, University College London, London, United Kingdom.

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http://dx.doi.org/10.1002/stem.2758DOI Listing
March 2018

Elucidating Pro-Inflammatory Cytokine Responses after Traumatic Brain Injury in a Human Stem Cell Model.

J Neurotrauma 2018 01 3;35(2):341-352. Epub 2017 Nov 3.

1 Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge , Cambridge, United Kingdom .

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http://dx.doi.org/10.1089/neu.2017.5155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784793PMC
January 2018

A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models.

Nat Commun 2017 10 27;8(1):1164. Epub 2017 Oct 27.

John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, E.D. Adrian Building, Forvie Site, Robinson Way, Cambridge, CB2 0PY, UK.

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http://dx.doi.org/10.1038/s41467-017-01283-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660125PMC
October 2017

The translational potential of human induced pluripotent stem cells for clinical neurology : The translational potential of hiPSCs in neurology.

Cell Biol Toxicol 2017 04 3;33(2):129-144. Epub 2016 Dec 3.

Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N3BG, UK.

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http://dx.doi.org/10.1007/s10565-016-9372-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325844PMC
April 2017

Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging.

Cell Rep 2017 01;18(2):557-570

Institute of Neurology, University College London, London WC1N 3BG, UK; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5263238PMC
January 2017

In vitro prion-like behaviour of TDP-43 in ALS.

Neurobiol Dis 2016 Dec 30;96:236-247. Epub 2016 Aug 30.

Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square House, Queen Square, London WC1N 3BG, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2016.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113659PMC
December 2016

Using human induced pluripotent stem cells to model cerebellar disease: hope and hype.

J Neurogenet 2015 27;29(2-3):95-102. Epub 2015 Aug 27.

a National Hospital for Neurology and Neurosurgery, UCL Institute of Neurology , London , UK.

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http://dx.doi.org/10.3109/01677063.2015.1053478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673530PMC
August 2016

Human Stem Cell-Derived Astrocytes: Specification and Relevance for Neurological Disorders.

Curr Stem Cell Rep 2016;2:236-247. Epub 2016 Jun 3.

Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, WC1N 3BG London, UK ; Addenbrooke's Hospital, Cambridge University Hospitals, Hills Rd, Cambridge, CB2 0QQ UK ; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK ; Euan MacDonald Centre for MND, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1007/s40778-016-0049-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972864PMC
June 2016

Neural Conversion and Patterning of Human Pluripotent Stem Cells: A Developmental Perspective.

Stem Cells Int 2016 16;2016:8291260. Epub 2016 Mar 16.

Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK; National Hospital for Neurology and Neurosurgery, UCL Institute of Neurology, 33 Queen Square, London WC1N 3BG, UK; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK; Euan MacDonald Centre for MND, University of Edinburgh, Edinburgh EH16 4SB, UK.

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http://dx.doi.org/10.1155/2016/8291260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812494PMC
April 2016

Quo vadis motor neuron disease?

World J Methodol 2016 Mar 26;6(1):56-64. Epub 2016 Mar 26.

Rubika Balendra, Department of Neurodegenerative Disease, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom.

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http://dx.doi.org/10.5662/wjm.v6.i1.56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804252PMC
March 2016

Generating Diverse Spinal Motor Neuron Subtypes from Human Pluripotent Stem Cells.

Authors:
Rickie Patani

Stem Cells Int 2016 28;2016:1036974. Epub 2015 Dec 28.

Department of Molecular Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, UK; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK; University of Edinburgh, Edinburgh EH16 4SB, UK.

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http://dx.doi.org/10.1155/2016/1036974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707335PMC
January 2016

Hypothermic Preconditioning Reverses Tau Ontogenesis in Human Cortical Neurons and is Mimicked by Protein Phosphatase 2A Inhibition.

EBioMedicine 2016 Jan 12;3:141-154. Epub 2015 Dec 12.

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, Midlothian EH16 4SB, United Kingdom; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, Midlothian EH16 4UU, United Kingdom; Euan MacDonald Centre for MND Research, University of Edinburgh, Edinburgh, Midlothian EH16 4SB, United Kingdom; The Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, Midlothian EH16 4SB, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S23523964153024
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http://dx.doi.org/10.1016/j.ebiom.2015.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739435PMC
January 2016

Hypothermic Preconditioning of Human Cortical Neurons Requires Proteostatic Priming.

EBioMedicine 2015 Jun 11;2(6):528-35. Epub 2015 Apr 11.

Centre for Clinical Brain Sciences, University of Edinburgh, Midlothian EH16 4SB, United Kingdom ; MRC Centre for Regenerative Medicine, University of Edinburgh, Midlothian EH16 4SB, United Kingdom ; The Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Midlothian EH16 4SB, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S23523964150009
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http://dx.doi.org/10.1016/j.ebiom.2015.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534756PMC
June 2015

Lymphomatosis cerebri: a treatable cause of rapidly progressive dementia.

J Neurol Neurosurg Psychiatry 2015 Feb 20;86(2):238-40. Epub 2014 May 20.

Department of Neuroinflammation, The National Hospital for Neurology and Neurosurgery, London, UK.

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http://jnnp.bmj.com/cgi/doi/10.1136/jnnp-2013-307327
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http://dx.doi.org/10.1136/jnnp-2013-307327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316841PMC
February 2015

TS or not TS?

Pract Neurol 2013 Aug 13;13(4):268-70. Epub 2013 Mar 13.

Department of Neurology, Essex Centre for Neurological Sciences, Queen's Hospital, Romford, Essex, UK.

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http://dx.doi.org/10.1136/practneurol-2012-000371DOI Listing
August 2013

Flexor hallucis brevis spasm.

Muscle Nerve 2013 Jun 26;47(6):939. Epub 2013 Mar 26.

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http://dx.doi.org/10.1002/mus.23796DOI Listing
June 2013

Voltage-gated potassium channelopathy: an expanding spectrum of clinical phenotypes.

BMJ Case Rep 2013 Jan 10;2013. Epub 2013 Jan 10.

Department of Neurology, Queen's Hospital, Essex Centre for Neurological Sciences, London, UK.

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http://dx.doi.org/10.1136/bcr-2012-007742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603777PMC
January 2013

Experimental and therapeutic opportunities for stem cells in multiple sclerosis.

Int J Mol Sci 2012 Nov 8;13(11):14470-91. Epub 2012 Nov 8.

Anne McLaren Laboratory for Regenerative Medicine, Stem Cell Institute, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 0SZ, UK.

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http://dx.doi.org/10.3390/ijms131114470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509592PMC
November 2012

Using human pluripotent stem cells to study post-transcriptional mechanisms of neurodegenerative diseases.

Brain Res 2012 Jun 5;1462:129-38. Epub 2012 Jan 5.

Anne McLaren Laboratory for Regenerative Medicine, University of Cambridge, Forvie Site, Robinson Way, Cambridge, UK.

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http://dx.doi.org/10.1016/j.brainres.2011.12.057DOI Listing
June 2012

Using induced pluripotent stem cells (iPSC) to model human neuromuscular connectivity: promise or reality?

J Anat 2012 Feb 2;220(2):122-30. Epub 2011 Dec 2.

Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1111/j.1469-7580.2011.01459.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275767PMC
February 2012

Integrin activation promotes axon growth on inhibitory chondroitin sulfate proteoglycans by enhancing integrin signaling.

J Neurosci 2011 Apr;31(17):6289-95

Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, United Kingdom.

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http://dx.doi.org/10.1523/JNEUROSCI.0008-11.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116378PMC
April 2011

Human stem cell-derived neurons: a system to study human tau function and dysfunction.

PLoS One 2010 Nov 11;5(11):e13947. Epub 2010 Nov 11.

Department of Clinical Neurosciences, Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013947PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978712PMC
November 2010

Human embryonic stem cell-derived neurons as a tool for studying neuroprotection and neurodegeneration.

Mol Neurobiol 2010 Aug 30;42(1):97-102. Epub 2010 Apr 30.

Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH89XD, UK.

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http://dx.doi.org/10.1007/s12035-010-8136-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948543PMC
August 2010

Abnormal tau phosphorylation in primary progressive multiple sclerosis.

Acta Neuropathol 2010 May 21;119(5):591-600. Epub 2010 Mar 21.

Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Forvie Site, Robinson Way, Cambridge, UK.

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http://link.springer.com/10.1007/s00401-010-0671-4
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http://dx.doi.org/10.1007/s00401-010-0671-4DOI Listing
May 2010

Activin/Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity.

PLoS One 2009 Oct 6;4(10):e7327. Epub 2009 Oct 6.

Anne McLaren Laboratory for Regenerative Medicine & Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007327PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752165PMC
October 2009

Evidence for abnormal tau phosphorylation in early aggressive multiple sclerosis.

Acta Neuropathol 2009 May 14;117(5):583-9. Epub 2009 Mar 14.

Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Forvie Site, Robinson Way, Cambridge, UK.

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http://dx.doi.org/10.1007/s00401-009-0515-2DOI Listing
May 2009