Publications by authors named "Richie Soong"

100Publications

Next Generation Sequencing Reveals Novel Mutations in Mismatch Repair Genes and Other Cancer Predisposition Genes in Asian Patients with Suspected Lynch Syndrome.

Clin Colorectal Cancer 2019 12 7;18(4):e324-e334. Epub 2019 Jun 7.

Department of Hematology-Oncology, National University Cancer Institute, Singapore, Singapore; Cancer Science Institute, National University of Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.clcc.2019.05.007DOI Listing
December 2019

Somatic mutations and immune checkpoint biomarkers.

Respirology 2019 03 12;24(3):215-226. Epub 2019 Jan 12.

Department of Haematology-Oncology, National University Hospital, Singapore.

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http://doi.wiley.com/10.1111/resp.13463
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http://dx.doi.org/10.1111/resp.13463DOI Listing
March 2019

miREM: an expectation-maximization approach for prioritizing miRNAs associated with gene-set.

BMC Bioinformatics 2018 08 10;19(1):299. Epub 2018 Aug 10.

Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Dr, Singapore, 117599, Singapore.

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https://bmcbioinformatics.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/s12859-018-2292-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086043PMC
August 2018

Prognostic significance of immune cells in non-small cell lung cancer: meta-analysis.

Oncotarget 2018 May 15;9(37):24801-24820. Epub 2018 May 15.

Cancer Science Institute of Singapore, National University of Singapore, Singapore.

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http://dx.doi.org/10.18632/oncotarget.24835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973851PMC
May 2018

Finite-size effects in transcript sequencing count distribution: its power-law correction necessarily precedes downstream normalization and comparative analysis.

Biol Direct 2018 02 12;13(1). Epub 2018 Feb 12.

Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01, Matrix, Singapore, 138671, Singapore.

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https://biologydirect.biomedcentral.com/articles/10.1186/s13
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http://dx.doi.org/10.1186/s13062-018-0204-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809866PMC
February 2018

Immune checkpoint inhibitors in epidermal growth factor receptor mutant non-small cell lung cancer: Current controversies and future directions.

Lung Cancer 2018 01 13;115:12-20. Epub 2017 Nov 13.

Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea.

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http://dx.doi.org/10.1016/j.lungcan.2017.11.009DOI Listing
January 2018

Anti-tumor efficacy evaluation of a novel monoclonal antibody targeting neutral amino acid transporter ASCT2 using patient-derived xenograft mouse models of gastric cancer.

Am J Transl Res 2017 15;9(7):3399-3410. Epub 2017 Jul 15.

Singapore Translational Research Laboratory, Kyowa Hakko Kirin (Singapore) Pte. Ltd.11, Biopolis Way, 138667, #05-08 Helios, Singapore.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527254PMC
July 2017

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity.

Authors:
Simone Wahl Alexander Drong Benjamin Lehne Marie Loh William R Scott Sonja Kunze Pei-Chien Tsai Janina S Ried Weihua Zhang Youwen Yang Sili Tan Giovanni Fiorito Lude Franke Simonetta Guarrera Silva Kasela Jennifer Kriebel Rebecca C Richmond Marco Adamo Uzma Afzal Mika Ala-Korpela Benedetta Albetti Ole Ammerpohl Jane F Apperley Marian Beekman Pier Alberto Bertazzi S Lucas Black Christine Blancher Marc-Jan Bonder Mario Brosch Maren Carstensen-Kirberg Anton J M de Craen Simon de Lusignan Abbas Dehghan Mohamed Elkalaawy Krista Fischer Oscar H Franco Tom R Gaunt Jochen Hampe Majid Hashemi Aaron Isaacs Andrew Jenkinson Sujeet Jha Norihiro Kato Vittorio Krogh Michael Laffan Christa Meisinger Thomas Meitinger Zuan Yu Mok Valeria Motta Hong Kiat Ng Zacharoula Nikolakopoulou Georgios Nteliopoulos Salvatore Panico Natalia Pervjakova Holger Prokisch Wolfgang Rathmann Michael Roden Federica Rota Michelle Ann Rozario Johanna K Sandling Clemens Schafmayer Katharina Schramm Reiner Siebert P Eline Slagboom Pasi Soininen Lisette Stolk Konstantin Strauch E-Shyong Tai Letizia Tarantini Barbara Thorand Ettje F Tigchelaar Rosario Tumino Andre G Uitterlinden Cornelia van Duijn Joyce B J van Meurs Paolo Vineis Ananda Rajitha Wickremasinghe Cisca Wijmenga Tsun-Po Yang Wei Yuan Alexandra Zhernakova Rachel L Batterham George Davey Smith Panos Deloukas Bastiaan T Heijmans Christian Herder Albert Hofman Cecilia M Lindgren Lili Milani Pim van der Harst Annette Peters Thomas Illig Caroline L Relton Melanie Waldenberger Marjo-Riitta Järvelin Valentina Bollati Richie Soong Tim D Spector James Scott Mark I McCarthy Paul Elliott Jordana T Bell Giuseppe Matullo Christian Gieger Jaspal S Kooner Harald Grallert John C Chambers

Nature 2017 01 21;541(7635):81-86. Epub 2016 Dec 21.

Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.

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http://dx.doi.org/10.1038/nature20784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570525PMC
January 2017

The Warburg effect and drug resistance.

Br J Pharmacol 2016 Mar 18;173(6):970-9. Epub 2016 Feb 18.

Cancer Science Institute of Singapore, National University of Singapore, Singapore.

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http://dx.doi.org/10.1111/bph.13422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793921PMC
March 2016

Discovering and validating between-subject variations in plasma lipids in healthy subjects.

Sci Rep 2016 Jan 8;6:19139. Epub 2016 Jan 8.

NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore.

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http://dx.doi.org/10.1038/srep19139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705481PMC
January 2016

High-Throughput Mutation Profiling Changes before and 3 Weeks after Chemotherapy in Newly Diagnosed Breast Cancer Patients.

PLoS One 2015 2;10(12):e0142466. Epub 2015 Dec 2.

Department of Haematology-Oncology, National University Cancer Institute Singapore, National University Health System, Singapore, Singapore.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0142466PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667877PMC
June 2016

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.

Authors:
Norihiro Kato Marie Loh Fumihiko Takeuchi Niek Verweij Xu Wang Weihua Zhang Tanika N Kelly Danish Saleheen Benjamin Lehne Irene Mateo Leach Alexander W Drong James Abbott Simone Wahl Sian-Tsung Tan William R Scott Gianluca Campanella Marc Chadeau-Hyam Uzma Afzal Tarunveer S Ahluwalia Marc Jan Bonder Peng Chen Abbas Dehghan Todd L Edwards Tõnu Esko Min Jin Go Sarah E Harris Jaana Hartiala Silva Kasela Anuradhani Kasturiratne Chiea-Chuen Khor Marcus E Kleber Huaixing Li Zuan Yu Mok Masahiro Nakatochi Nur Sabrina Sapari Richa Saxena Alexandre F R Stewart Lisette Stolk Yasuharu Tabara Ai Ling Teh Ying Wu Jer-Yuarn Wu Yi Zhang Imke Aits Alexessander Da Silva Couto Alves Shikta Das Rajkumar Dorajoo Jemma C Hopewell Yun Kyoung Kim Robert W Koivula Jian'an Luan Leo-Pekka Lyytikäinen Quang N Nguyen Mark A Pereira Iris Postmus Olli T Raitakari Molly Scannell Bryan Robert A Scott Rossella Sorice Vinicius Tragante Michela Traglia Jon White Ken Yamamoto Yonghong Zhang Linda S Adair Alauddin Ahmed Koichi Akiyama Rasheed Asif Tin Aung Inês Barroso Andrew Bjonnes Timothy R Braun Hui Cai Li-Ching Chang Chien-Hsiun Chen Ching-Yu Cheng Yap-Seng Chong Rory Collins Regina Courtney Gail Davies Graciela Delgado Loi D Do Pieter A Doevendans Ron T Gansevoort Yu-Tang Gao Tanja B Grammer Niels Grarup Jagvir Grewal Dongfeng Gu Gurpreet S Wander Anna-Liisa Hartikainen Stanley L Hazen Jing He Chew-Kiat Heng James E Hixson Albert Hofman Chris Hsu Wei Huang Lise L N Husemoen Joo-Yeon Hwang Sahoko Ichihara Michiya Igase Masato Isono Johanne M Justesen Tomohiro Katsuya Muhammad G Kibriya Young Jin Kim Miyako Kishimoto Woon-Puay Koh Katsuhiko Kohara Meena Kumari Kenneth Kwek Nanette R Lee Jeannette Lee Jiemin Liao Wolfgang Lieb David C M Liewald Tatsuaki Matsubara Yumi Matsushita Thomas Meitinger Evelin Mihailov Lili Milani Rebecca Mills Nina Mononen Martina Müller-Nurasyid Toru Nabika Eitaro Nakashima Hong Kiat Ng Kjell Nikus Teresa Nutile Takayoshi Ohkubo Keizo Ohnaka Sarah Parish Lavinia Paternoster Hao Peng Annette Peters Son T Pham Mohitha J Pinidiyapathirage Mahfuzar Rahman Hiromi Rakugi Olov Rolandsson Michelle Ann Rozario Daniela Ruggiero Cinzia F Sala Ralhan Sarju Kazuro Shimokawa Harold Snieder Thomas Sparsø Wilko Spiering John M Starr David J Stott Daniel O Stram Takao Sugiyama Silke Szymczak W H Wilson Tang Lin Tong Stella Trompet Väinö Turjanmaa Hirotsugu Ueshima André G Uitterlinden Satoshi Umemura Marja Vaarasmaki Rob M van Dam Wiek H van Gilst Dirk J van Veldhuisen Jorma S Viikari Melanie Waldenberger Yiqin Wang Aili Wang Rory Wilson Tien-Yin Wong Yong-Bing Xiang Shuhei Yamaguchi Xingwang Ye Robin D Young Terri L Young Jian-Min Yuan Xueya Zhou Folkert W Asselbergs Marina Ciullo Robert Clarke Panos Deloukas Andre Franke Paul W Franks Steve Franks Yechiel Friedlander Myron D Gross Zhirong Guo Torben Hansen Marjo-Riitta Jarvelin Torben Jørgensen J Wouter Jukema Mika Kähönen Hiroshi Kajio Mika Kivimaki Jong-Young Lee Terho Lehtimäki Allan Linneberg Tetsuro Miki Oluf Pedersen Nilesh J Samani Thorkild I A Sørensen Ryoichi Takayanagi Daniela Toniolo Habibul Ahsan Hooman Allayee Yuan-Tsong Chen John Danesh Ian J Deary Oscar H Franco Lude Franke Bastiaan T Heijman Joanna D Holbrook Aaron Isaacs Bong-Jo Kim Xu Lin Jianjun Liu Winfried März Andres Metspalu Karen L Mohlke Dharambir K Sanghera Xiao-Ou Shu Joyce B J van Meurs Eranga Vithana Ananda R Wickremasinghe Cisca Wijmenga Bruce H W Wolffenbuttel Mitsuhiro Yokota Wei Zheng Dingliang Zhu Paolo Vineis Soterios A Kyrtopoulos Jos C S Kleinjans Mark I McCarthy Richie Soong Christian Gieger James Scott Yik-Ying Teo Jiang He Paul Elliott E Shyong Tai Pim van der Harst Jaspal S Kooner John C Chambers

Nat Genet 2015 11 21;47(11):1282-1293. Epub 2015 Sep 21.

Department of Epidemiology and Biostatistics, Imperial College London, London, UK.

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http://dx.doi.org/10.1038/ng.3405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719169PMC
November 2015

Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study.

Lancet Diabetes Endocrinol 2015 Jul 18;3(7):526-534. Epub 2015 Jun 18.

​ (J C Chambers PhD, M Loh PhD, B Lehne PhD, W R Scott MRCP, W Zhang PhD, G Campanella MSc, M Chadeau-Hyam PhD, U Afzal MRCP, Prof P Froguel PhD, Prof P Vineis MD, Prof M-R Jarvelin PhD, Prof P Elliott PhD) (J C Chambers, Prof M-R Jarvelin, Prof P Elliott, Prof J S Kooner FRCP) (W R Scott, S-T Tan MRCP, Prof J Scott PhD, Prof J S Kooner) (J Abbott PhD) (J C Chambers, W Zhang, S-T Tan, U Afzal, Prof J S Kooner) (J C Chambers, P Punjabi FRCS, Prof J S Kooner) (M Loh) (C Blancher PhD) (A Drong PhD, Prof M I McCarthy MD) (Prof M I McCarthy) (J Kriebel PhD, S Wahl MSc, C Gieger PhD, H Grallert PhD) (C Gieger) (J Kriebel, S Wahl, C Gieger, B Thorand PhD, H Grallert) (H Prokisch PhD) (J Kriebel, S Wahl, B Thorand, H Grallert) (V Motta PhD, F Rota PhD, L Tarantini PhD, B Albetti PhD, Prof P A Bertazzi MD, V Bollati PhD) (Prof M Ala-Korpela PhD) (H R Elliott Dip Biol, R C Richmond BA, R Caiazzo PhD, T R Gaunt FRCP, Prof C L Relton PhD) (L Yengo PhD, Prof F Pattou PhD, R Caiazzo, S Cauchi PhD, Prof P Froguel) (L Yengo, S Cauchi, Prof P Froguel) (L Yengo, Prof F Pattou, S Cauchi, Prof P Froguel) (M Adamowicz-Brice PhD, Prof T J Aitman PhD) (K Bozaoglu PhD, R Caiazzo, J Jowett PhD) (Z Y Mok BSc, H K Ng BSc, M A Rozario BSc, R Soong PhD) (E-S Tai PhD) (E-S Tai) (Prof F Pattou) (H Prokisch) (Prof M Ala-Korpela, A J Kangas MSc, P Soininen PhD) (M Loh, Prof M-R Jarvelin) (Prof M-R Jarvelin) (Prof M Ala-Korpela, P Soininen) (Prof M-R Jarvelin) (Prof M Ala-Korpela) (Prof O Ammerpohl PhD) (Prof C Schafmayer MD) (Prof J Danesh FRCP) (Prof S de Lusignan PhD, Prof S Jones PhD) (Prof T Illig PhD) (S Jha MRCP) (A Kasturiratne MD, Prof A R Wickremasinghe PhD) (N Kato PhD) (N Kotea PhD) (S Kowlessur Dip Pub Health Admin) (J Pitkäniemi PhD) (Prof J Tuomilehto PhD) (J Pitkäniemi) (D Saleheen PhD) (D Saleheen) (D Saleheen) (E-S Tai) (Prof S A Kyrtopoulos PhD) (C Herder PhD) (C Herder) (Prof J Hampe MD) (R Soong) (Prof P Vineis) (Prof M I McCarthy).

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http://dx.doi.org/10.1016/S2213-8587(15)00127-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724884PMC
July 2015

Primary mucinous adenocarcinoma of the epididymis: report of a rare case with molecular genetic characterization including mutation analysis of the TP53 gene.

Appl Immunohistochem Mol Morphol 2015 Apr;23(4):308-12

*Department of Pathology, National University Health System †Cancer Science Institute, National University of Singapore, Singapore.

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http://dx.doi.org/10.1097/PAI.0b013e3182389663DOI Listing
April 2015

Technical reproducibility of single-nucleotide and size-based DNA biomarker assessment using DNA extracted from formalin-fixed, paraffin-embedded tissues.

J Mol Diagn 2015 May 4;17(3):242-50. Epub 2015 Mar 4.

Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School, Singapore, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore; Department of Cellular and Molecular Research, National Cancer Centre, Singapore, Singapore; Cancer Therapeutics and Stratified Oncology Group, Genome Institute of Singapore, Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2014.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411247PMC
May 2015

Expression of proteins associated with hypoxia and Wnt pathway activation is of prognostic significance in hepatocellular carcinoma.

Virchows Arch 2015 May 6;466(5):541-8. Epub 2015 Mar 6.

Cancer Science Institute, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1007/s00428-015-1745-4DOI Listing
May 2015

Feasibility of low-throughput next generation sequencing for germline DNA screening.

Clin Chem 2014 Dec 22;60(12):1549-57. Epub 2014 Oct 22.

Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Pathology, National University Health System, Singapore;

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http://www.clinchem.org/content/60/12/1549.full.pdf
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http://www.clinchem.org/cgi/doi/10.1373/clinchem.2014.227728
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http://dx.doi.org/10.1373/clinchem.2014.227728DOI Listing
December 2014

Postoperative serum methylation levels of TAC1 and SEPT9 are independent predictors of recurrence and survival of patients with colorectal cancer.

Cancer 2014 Oct 12;120(20):3131-41. Epub 2014 Jun 12.

Department of Medical Oncology, National Cancer Centre of Singapore, Singapore.

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http://dx.doi.org/10.1002/cncr.28802DOI Listing
October 2014

Immunotherapy in the treatment of non-small cell lung cancer.

Lung Cancer 2014 Aug 14;85(2):101-9. Epub 2014 May 14.

Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Surgery, University of Western Australia, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2014.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332778PMC
August 2014

Methodological aspects of whole-genome bisulfite sequencing analysis.

Brief Bioinform 2015 May 27;16(3):369-79. Epub 2014 May 27.

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http://dx.doi.org/10.1093/bib/bbu016DOI Listing
May 2015

Insights into the genetic structure and diversity of 38 South Asian Indians from deep whole-genome sequencing.

PLoS Genet 2014 May 15;10(5):e1004377. Epub 2014 May 15.

Saw Swee Hock School of Public Health, National University of Singapore, Singapore; NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore; Life Sciences Institute, National University of Singapore, Singapore; Department of Statistics and Applied Probability, National University of Singapore, Singapore.

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http://dx.doi.org/10.1371/journal.pgen.1004377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022468PMC
May 2014

Interleukin-4 and -8 gene polymorphisms and risk of gastric cancer in a population in Southwestern China.

Asian Pac J Cancer Prev 2014 ;15(7):2951-7

Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu, China E-mail :

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http://dx.doi.org/10.7314/apjcp.2014.15.7.2951DOI Listing
January 2015

Predicting HLA alleles from high-resolution SNP data in three Southeast Asian populations.

Hum Mol Genet 2014 Aug 3;23(16):4443-51. Epub 2014 Apr 3.

Saw Swee Hock School of Public Health, Life Sciences Institute, Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore, NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore 117456, Singapore and Agency for Science, Technology and Research, Genome Institute of Singapore, Singapore 138672, Singapore

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http://hmg.oxfordjournals.org/content/early/2014/04/03/hmg.d
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/ddu149
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http://dx.doi.org/10.1093/hmg/ddu149DOI Listing
August 2014

Patz1 regulates embryonic stem cell identity.

Stem Cells Dev 2014 May 25;23(10):1062-73. Epub 2014 Mar 25.

1 Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore , Singapore, Singapore .

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http://dx.doi.org/10.1089/scd.2013.0430DOI Listing
May 2014

CYP3A5*3 and bilirubin predict midazolam population pharmacokinetics in Asian cancer patients.

J Clin Pharmacol 2014 Feb 17;54(2):215-24. Epub 2013 Dec 17.

Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Defence Medical & Environmental Research Institute, DSO National Laboratories, Singapore, Singapore.

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http://dx.doi.org/10.1002/jcph.230DOI Listing
February 2014

Association of the IL-1B +3954 C/T polymorphism with the risk of gastric cancer in a population in Western China.

Eur J Cancer Prev 2014 Jan;23(1):35-42

Departments of aEpidemiology bChild and Adolescent Health, West China School of Public Health, Sichuan University, Chengdu cDepartment of Infectious Diseases, Hangzhou Center for Disease Control and Prevention, Hangzhou, China dCancer Science Institute of Singapore, National University of Singapore eDepartment of Pathology, National University Health System, Singapore, Singapore fSchool of Surgery, The University of Western Australia, Perth, Western Australia, Australia gDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK hInstitute of Health Sciences, University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.1097/CEJ.0b013e3283656380DOI Listing
January 2014

Phosphatidylinositol-3-kinase pathway aberrations in gastric and colorectal cancer: meta-analysis, co-occurrence and ethnic variation.

Int J Cancer 2014 Mar 17;134(5):1232-8. Epub 2013 Sep 17.

Cancer Science Institute of Singapore, National University of Singapore, Singapore.

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http://dx.doi.org/10.1002/ijc.28444DOI Listing
March 2014

Interleukin-10 gene promoter polymorphisms and risk of gastric cancer in a Chinese population: single nucleotide and haplotype analyses.

Asian Pac J Cancer Prev 2013 ;14(4):2577-82

Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu, Sichuan, China.

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http://dx.doi.org/10.7314/apjcp.2013.14.4.2577DOI Listing
October 2013

GBSA: a comprehensive software for analysing whole genome bisulfite sequencing data.

Nucleic Acids Res 2013 Feb 24;41(4):e55. Epub 2012 Dec 24.

Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.

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http://dx.doi.org/10.1093/nar/gks1281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575794PMC
February 2013

Localized sclerotic bone response demonstrated reduced nanomechanical creep properties.

J Mech Behav Biomed Mater 2013 Jan 15;17:198-208. Epub 2012 Sep 15.

Department of Bioengineering, 9 Engineering Drive 1, National University of Singapore, and Department of Orthopaedic Surgery, National University Hospital, 117576 Singapore, Singapore.

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http://dx.doi.org/10.1016/j.jmbbm.2012.09.002DOI Listing
January 2013

Targeting ROS1 with anaplastic lymphoma kinase inhibitors: a promising therapeutic strategy for a newly defined molecular subset of non-small-cell lung cancer.

J Thorac Oncol 2012 Nov;7(11):1625-30

Cancer Science Institute of Singapore, National University of Singapore, Singapore.

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http://dx.doi.org/10.1097/JTO.0b013e31826baf83DOI Listing
November 2012

The topography of DNA methylation in the non-neoplastic colonic mucosa surrounding colorectal cancers.

Mol Carcinog 2014 Feb 21;53(2):98-108. Epub 2012 Aug 21.

Department of Pathology, National University Health System, National University of Singapore, Singapore, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1002/mc.21951DOI Listing
February 2014

ADPRT Val762Ala and XRCC1 Arg194Trp polymorphisms and risk of gastric cancer in Sichuan of China.

Asian Pac J Cancer Prev 2012 ;13(5):2139-44

Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu, China.

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http://dx.doi.org/10.7314/apjcp.2012.13.5.2139DOI Listing
January 2013

RUNX3 downregulation in human lung adenocarcinoma is independent of p53, EGFR or KRAS status.

Pathol Oncol Res 2012 Oct 24;18(4):783-92. Epub 2012 Jun 24.

Cancer Science Institute of Singapore, Centre for Translational Medicine, National University of Singapore, #12-01, 14 Medical Drive, Singapore, 117599, Singapore.

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http://dx.doi.org/10.1007/s12253-011-9485-5DOI Listing
October 2012

Clinical potential of DNA methylation in gastric cancer: a meta-analysis.

PLoS One 2012 27;7(4):e36275. Epub 2012 Apr 27.

Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0036275PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338684PMC
September 2012

Gene discovery in familial cancer syndromes by exome sequencing: prospects for the elucidation of familial colorectal cancer type X.

Mod Pathol 2012 Aug 20;25(8):1055-68. Epub 2012 Apr 20.

Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.

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http://www.nature.com/articles/modpathol201262
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http://dx.doi.org/10.1038/modpathol.2012.62DOI Listing
August 2012

Differences in outcome and toxicity between Asian and caucasian patients with lung cancer treated with systemic therapy.

Future Oncol 2012 Apr;8(4):451-62

Cancer Science Institute of Singapore, National University of Singapore, Singapore.

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http://dx.doi.org/10.2217/fon.12.25DOI Listing
April 2012

Exome versus transcriptome sequencing in identifying coding region variants.

Expert Rev Mol Diagn 2012 Apr;12(3):241-51

Cancer Science Institute of Singapore, #12-01, MD6, Centre for Translational Medicine, NUS Yong Loo Lin School of Medicine, National University of Singapore, 14 Medical Drive, 117599, Singapore.

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http://dx.doi.org/10.1586/erm.12.10DOI Listing
April 2012

Protein arginine methyltransferase 6 regulates embryonic stem cell identity.

Stem Cells Dev 2012 Sep 8;21(14):2613-22. Epub 2012 May 8.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1089/scd.2011.0330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729635PMC
September 2012

Technological advances in DNA sequence enrichment and sequencing for germline genetic diagnosis.

Expert Rev Mol Diagn 2012 Mar;12(2):159-73

Cancer Science Institute of Singapore, National University of Singapore, Singapore.

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http://dx.doi.org/10.1586/erm.11.95DOI Listing
March 2012

Exome sequencing: dual role as a discovery and diagnostic tool.

Ann Neurol 2012 Jan;71(1):5-14

Cancer Science Institute of Singapore, National University of Singapore, Singapore.

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http://dx.doi.org/10.1002/ana.22647DOI Listing
January 2012

Human genetics and genomics a decade after the release of the draft sequence of the human genome.

Hum Genomics 2011 Oct;5(6):577-622

Centre for Molecular Epidemiology, Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525251PMC
http://dx.doi.org/10.1186/1479-7364-5-6-577DOI Listing
October 2011

Challenges and pitfalls in the introduction of pharmacogenetics for cancer.

Ann Acad Med Singap 2011 Aug;40(8):369-74

Cancer Science Institute of Singapore, National University of Singapore, Singapore.

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August 2011

Clinical and therapeutic relevance of PIM1 kinase in gastric cancer.

Gastric Cancer 2012 Apr 13;15(2):188-97. Epub 2011 Oct 13.

Department of Pathology, National University Health System, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074, Singapore.

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http://dx.doi.org/10.1007/s10120-011-0097-2DOI Listing
April 2012

Gemcitabine and platinum pathway pharmacogenetics in Asian breast cancer patients.

Cancer Genomics Proteomics 2011 Sep-Oct;8(5):255-9

Department of Hematology-Oncology, National University Cancer Institute of Singapore.

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February 2012

Studying the epigenome using next generation sequencing.

J Med Genet 2011 Nov 8;48(11):721-30. Epub 2011 Aug 8.

Cancer Science Institute of Singapore, National University of Singapore, Singapore.

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http://dx.doi.org/10.1136/jmedgenet-2011-100242DOI Listing
November 2011

Low cytosine triphosphate synthase 2 expression renders resistance to 5-fluorouracil in colorectal cancer.

Cancer Biol Ther 2011 Mar 15;11(6):599-608. Epub 2011 Mar 15.

Cancer Science Institute of Singapore, Center for Life Sciences, National University of Singapore, Singapore.

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http://dx.doi.org/10.4161/cbt.11.6.14670DOI Listing
March 2011

Comparison of the pharmacokinetics and pharmacodynamics of S-1 between Caucasian and East Asian patients.

Cancer Sci 2011 Feb 10;102(2):478-83. Epub 2010 Dec 10.

Department of Hematology-Oncology, National University Health System, Cancer Sciences Institute of Singapore, National University of Singapore, Singapore.

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http://dx.doi.org/10.1111/j.1349-7006.2010.01793.xDOI Listing
February 2011

Impact of sample heterogeneity on methylation analysis.

Diagn Mol Pathol 2010 Dec;19(4):243-7

Cancer Science Institute of Singapore, National University of Singapore, Singapore.

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http://dx.doi.org/10.1097/PDM.0b013e3181de4396DOI Listing
December 2010

MicroRNA-130b regulates the tumour suppressor RUNX3 in gastric cancer.

Eur J Cancer 2010 May 20;46(8):1456-63. Epub 2010 Feb 20.

Cancer Science Institute of Singapore, Centre for Life Sciences #02-15, 28 Medical Drive, National University of Singapore, Singapore 117456, Singapore.

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http://dx.doi.org/10.1016/j.ejca.2010.01.036DOI Listing
May 2010

CD133 expression predicts for non-response to chemotherapy in colorectal cancer.

Mod Pathol 2010 Mar 15;23(3):450-7. Epub 2010 Jan 15.

Department of Pathology, National University Health System & Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

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http://www.nature.com/articles/modpathol2009181
Publisher Site
http://dx.doi.org/10.1038/modpathol.2009.181DOI Listing
March 2010

Response to a novel multitargeted tyrosine kinase inhibitor pazopanib in metastatic Merkel cell carcinoma.

J Clin Oncol 2009 Sep 29;27(26):e97-100. Epub 2009 Jun 29.

Department of Haematology/Oncology, National University Health System, Singapore, Singapore.

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http://dx.doi.org/10.1200/JCO.2009.21.8149DOI Listing
September 2009