Richard Zimmermann

Richard Zimmermann

UNVERIFIED PROFILE

Are you Richard Zimmermann?   Register this Author

Register author
Richard Zimmermann

Richard Zimmermann

Publications by authors named "Richard Zimmermann"

Are you Richard Zimmermann?   Register this Author

85Publications

1168Reads

35Profile Views

The signal peptide plus a cluster of positive charges in prion protein dictate chaperone-mediated Sec61 channel gating.

Biol Open 2019 Mar 5;8(3). Epub 2019 Mar 5.

Department of Medical Biochemistry and Molecular Biology, Saarland University, 66421 Homburg, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/bio.040691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451349PMC
March 2019

The kidney anion exchanger 1 affects tight junction properties via claudin-4.

Sci Rep 2019 Feb 28;9(1):3099. Epub 2019 Feb 28.

Department of Physiology and Membrane Protein Disease Research Group, University of Alberta, Edmonton, Alberta, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-39430-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395713PMC
February 2019

Treatment of SEC62 over-expressing tumors by Thapsigargin and Trifluoperazine.

Biomol Concepts 2018 May 19;9(1):53-63. Epub 2018 May 19.

Department of Medical Biochemistry and Molecular Biology, Saarland University, Homburg/Saar, saabrucken, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1515/bmc-2018-0006DOI Listing
May 2018

An Update on Sec61 Channel Functions, Mechanisms, and Related Diseases.

Front Physiol 2017 1;8:887. Epub 2017 Nov 1.

Competence Center for Molecular Medicine, Saarland University Medical School, Homburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphys.2017.00887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672155PMC
November 2017

hSnd2 protein represents an alternative targeting factor to the endoplasmic reticulum in human cells.

FEBS Lett 2017 10 14;591(20):3211-3224. Epub 2017 Sep 14.

Department of Medical Biochemistry and Molecular Biology, Saarland University, Homburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/1873-3468.12831DOI Listing
October 2017

Let's talk about Secs: Sec61, Sec62 and Sec63 in signal transduction, oncology and personalized medicine.

Signal Transduct Target Ther 2017 28;2:17002. Epub 2017 Apr 28.

Institute of Medical Biochemistry and Molecular Biology, Saarland University, Homburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sigtrans.2017.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661625PMC
April 2017

Dissecting the molecular organization of the translocon-associated protein complex.

Nat Commun 2017 02 20;8:14516. Epub 2017 Feb 20.

Department of Molecular Structural Biology, Max-Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms14516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321747PMC
February 2017

Organization of the native ribosome-translocon complex at the mammalian endoplasmic reticulum membrane.

Biochim Biophys Acta 2016 10 29;1860(10):2122-9. Epub 2016 Jun 29.

Max-Planck Institute of Biochemistry, Department of Molecular Structural Biology, D-82152 Martinsried, Germany; Cryo-Electron Microscopy, Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbagen.2016.06.024DOI Listing
October 2016

Components and Mechanisms of Import, Modification, Folding, and Assembly of Immunoglobulins in the Endoplasmic Reticulum.

J Clin Immunol 2016 05 29;36 Suppl 1:5-11. Epub 2016 Feb 29.

Competence Center for Molecular Medicine, Saarland University Medical School, Building 44, D-66421, Homburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10875-016-0250-0DOI Listing
May 2016

The use of virtual models to estimate the amount of grafting material: a case study.

Int J Oral Maxillofac Implants 2015 May-Jun;30(3):e43-4

View Article

Download full-text PDF

Source
http://dx.doi.org/10.11607/jomi.4101DOI Listing
March 2016

Expansion of a Predoctoral Surgical Implant Selective for Dental Students.

J Dent Educ 2016 Mar;80(3):328-33

Dr. Seitz is Assistant Clinical Professor of Comprehensive Dentistry, School of Dentistry, University of Texas Health Science Center at San Antonio; Dr. Zimmermann is Assistant Clinical Professor of Comprehensive Dentistry, School of Dentistry, University of Texas Health Science Center at San Antonio; Mr. Hendricson is Assistant Dean, Educational and Faculty Development, School of Dentistry, University of Texas Health Science Center at San Antonio.

View Article

Download full-text PDF

Source
March 2016

Structure of the mammalian oligosaccharyl-transferase complex in the native ER protein translocon.

Nat Commun 2014 ;5:3072

Department of Molecular Structural Biology, Max-Planck Institute of Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms4072DOI Listing
November 2015

Structure of the native Sec61 protein-conducting channel.

Nat Commun 2015 Sep 28;6:8403. Epub 2015 Sep 28.

Department of Molecular Structural Biology, Max-Planck Institute of Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/ncomms9403
Publisher Site
http://dx.doi.org/10.1038/ncomms9403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598622PMC
September 2015

Co-chaperones of the mammalian endoplasmic reticulum.

Subcell Biochem 2015 ;78:179-200

Medical Biochemistry & Molecular Biology, Saarland University, D-66421, Homburg, Germany,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-3-319-11731-7_9DOI Listing
April 2015

Guided Surgery in Pre-doctorate Clinic: A Case Study.

Tex Dent J 2015 Apr;132(4):254-61

View Article

Download full-text PDF

Source
April 2015

Protein transport into the human endoplasmic reticulum.

J Mol Biol 2015 Mar 23;427(6 Pt A):1159-75. Epub 2014 Jun 23.

Medical Biochemistry and Molecular Biology, Saarland University, 66421 Homburg, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmb.2014.06.011DOI Listing
March 2015

Increased water flux induced by an aquaporin-1/carbonic anhydrase II interaction.

Mol Biol Cell 2015 Mar 21;26(6):1106-18. Epub 2015 Jan 21.

Department of Physiology, University of Alberta, Edmonton, AB T6G 1C9, Canada Membrane Protein Disease Research Group, University of Alberta, Edmonton, AB T6G 1C9, Canada Department of Pediatrics, University of Alberta, Edmonton, AB T6G 1C9, Canada

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1091/mbc.E14-03-0812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357510PMC
March 2015

Interaction of Pseudomonas aeruginosa Exotoxin A with the human Sec61 complex suppresses passive calcium efflux from the endoplasmic reticulum.

Channels (Austin) 2014 2;8(1):76-83. Epub 2013 Oct 2.

Medical Biochemistry and Molecular Biology; Saarland University; Homburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/chan.26526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048345PMC
January 2015

Protein transport into the human ER and related diseases, Sec61-channelopathies.

Biochem Cell Biol 2014 Dec 27;92(6):499-509. Epub 2014 May 27.

Medical Biochemistry & Molecular Biology, Saarland University, Building 44, Kirrbergerstr, D-66421 Homburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1139/bcb-2014-0043DOI Listing
December 2014

Absence of BiP co-chaperone DNAJC3 causes diabetes mellitus and multisystemic neurodegeneration.

Am J Hum Genet 2014 Dec 20;95(6):689-97. Epub 2014 Nov 20.

Institute of Human Genetics, Technische Universität München, 81675 Munich, Germany; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajhg.2014.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259973PMC
December 2014

Secretion and immunogenicity of the meningioma-associated antigen TXNDC16.

J Immunol 2014 Sep 13;193(6):3146-54. Epub 2014 Aug 13.

Department of Human Genetics, Medical School, Saarland University, 66421 Homburg/Saar, Germany;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1303098DOI Listing
September 2014

The signal sequence influences post-translational ER translocation at distinct stages.

PLoS One 2013 9;8(10):e75394. Epub 2013 Oct 9.

Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom ; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0075394PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793985PMC
June 2014

Digital dentistry and implant dentistry--a case study.

Tex Dent J 2014 Apr;131(4):303-7

View Article

Download full-text PDF

Source
April 2014

Analysis of protein translocation into the endoplasmic reticulum of human cells.

Methods Mol Biol 2013 ;1033:285-99

Medical Biochemistry and Molecular Biology, Saarland University, Homburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-62703-487-6_18DOI Listing
March 2014

Using CAD/CAM technology to create a 10-unit zirconia fixed partial denture--a UTHSCSA dental school case report.

Tex Dent J 2013 Oct;130(10):1039-44

Comprehensive Dentistry, UTHSCSA Dental School, USA.

View Article

Download full-text PDF

Source
October 2013

CK2 phosphorylation of human Sec63 regulates its interaction with Sec62.

Biochim Biophys Acta 2013 Apr 31;1830(4):2938-45. Epub 2012 Dec 31.

Medizinische Biochemie und Molekularbiologie und Kompetenzzentrum Molekulare Medizin, Universität des Saarlandes, Gebäude 44, 66424 Homburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbagen.2012.12.020DOI Listing
April 2013

Why are investors not interested in my radiotracer? The industrial and regulatory constraints in the development of radiopharmaceuticals.

Nucl Med Biol 2013 Feb 4;40(2):155-66. Epub 2012 Dec 4.

Chrysalium Consulting SARL, 78470 Saint Rémy lès Chevreuse, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nucmedbio.2012.10.012DOI Listing
February 2013

CAD/CAM and lithium disilicate: an anterior esthetic case study.

Tex Dent J 2013 Feb;130(2):141-4

Department of Comprehensive Dentistry, University of Texas Health Science Center at San Antonio, Mail Code 7914, 7703 Floyd Curl Dr, San Antonio, TX 78229-3900, USA.

View Article

Download full-text PDF

Source
February 2013

Structure and 3D arrangement of endoplasmic reticulum membrane-associated ribosomes.

Structure 2012 Sep 19;20(9):1508-18. Epub 2012 Jul 19.

Department of Molecular Structural Biology, Max-Planck Institute of Biochemistry, D-82152 Martinsried, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.str.2012.06.010DOI Listing
September 2012

TRC40 can deliver short secretory proteins to the Sec61 translocon.

J Cell Sci 2012 Aug 14;125(Pt 15):3612-20. Epub 2012 Apr 14.

Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/jcs.102608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445324PMC
August 2012

Sec62 bridges the gap from 3q amplification to molecular cell biology in non-small cell lung cancer.

Am J Pathol 2012 Feb 21;180(2):473-83. Epub 2011 Dec 21.

Department of Medical Biochemistry and Molecular Biology, Saarland University, Homburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajpath.2011.10.039DOI Listing
February 2012

Calmodulin regulation of the calcium-leak channel Sec61 is unique to vertebrates.

Channels (Austin) 2011 Jul-Aug;5(4):293-8. Epub 2011 Jul 1.

Osnabrück University, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/chan.5.4.16160DOI Listing
January 2012

Functional characterization of the essential tail anchor of the herpes simplex virus type 1 nuclear egress protein pUL34.

J Gen Virol 2011 Dec 10;92(Pt 12):2734-45. Epub 2011 Aug 10.

Max von Pettenkofer-Institut, Ludwig-Maximilians-Universität München, Pettenkoferstr. 9a, 80336 München, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/vir.0.032730-0DOI Listing
December 2011

Sec61 complexes form ubiquitous ER Ca2+ leak channels.

Channels (Austin) 2011 May-Jun;5(3):228-35. Epub 2011 May 1.

Medical Biochemistry and Molecular Biology, Saarland University, Homburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/chan.5.3.15314DOI Listing
October 2011

Introduction of an implant surgical selective into a predoctoral dental curriculum.

J Dent Educ 2011 Sep;75(9):1256-62

Comprehensive Dentistry, Dental School, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, USA.

View Article

Download full-text PDF

Source
September 2011

Sec62 protein level is crucial for the ER stress tolerance of prostate cancer.

Prostate 2011 Jul 12;71(10):1074-83. Epub 2011 Jan 12.

Department of Medical Biochemistry and Molecular Biology, Saarland University, Homburg/Saar, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pros.21324DOI Listing
July 2011

Protein translocation across the ER membrane.

Biochim Biophys Acta 2011 Mar 27;1808(3):912-24. Epub 2010 Jun 27.

Medical Biochemistry & Molecular Biology, Saarland University, D-66041 Homburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbamem.2010.06.015DOI Listing
March 2011

An interaction between human Sec63 and nucleoredoxin may provide the missing link between the SEC63 gene and polycystic liver disease.

FEBS Lett 2011 Feb 18;585(4):596-600. Epub 2011 Jan 18.

Medical Biochemistry and Molecular Biology, Saarland University, Homburg, Germany.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1016/j.febslet.2011.01.024
Publisher Site
http://dx.doi.org/10.1016/j.febslet.2011.01.024DOI Listing
February 2011

BiP modulates the affinity of its co-chaperone ERj1 for ribosomes.

J Biol Chem 2010 Nov 23;285(47):36427-33. Epub 2010 Sep 23.

Department of Medical Biochemistry and Molecular Biology, Saarland University, 66421 Homburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M110.143263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978572PMC
November 2010

The mammalian and yeast translocon complexes comprise a characteristic Sec61 channel.

Biochem Biophys Res Commun 2010 Jun 5;396(3):714-20. Epub 2010 May 5.

Biophysik, Universität Osnabrück, FB Biologie/Chemie, 49076 Osnabrück, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2010.04.168DOI Listing
June 2010

The ER-membrane-resident Hsp40 ERj1 is a novel substrate for protein kinase CK2.

Biochem Biophys Res Commun 2009 Oct 3;388(4):637-42. Epub 2009 Aug 3.

Medizinische Biochemie und Molekularbiologie, Universität des Saarlandes, 66421 Homburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2009.07.146DOI Listing
October 2009

Lanthanum ions inhibit the mammalian Sec61 complex in its channel dynamics and protein transport activity.

FEBS Lett 2009 Jul 24;583(14):2359-64. Epub 2009 Jun 24.

Biophysik, Universität Osnabrück, FB Biologie/Chemie, D-49034 Osnabrück, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.febslet.2009.06.032DOI Listing
July 2009

A novel twist to protein secretion in eukaryotes.

Trends Parasitol 2009 Apr 5;25(4):147-50. Epub 2009 Mar 5.

Medical Biochemistry and Molecular Biology, Saarland University, 66421 Homburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pt.2009.01.002DOI Listing
April 2009

The heat shock protein 70 molecular chaperone network in the pancreatic endoplasmic reticulum - a quantitative approach.

FEBS J 2007 Oct 10;274(19):5175-87. Epub 2007 Sep 10.

Medizinische Biochemie und Molekularbiologie, Universität des Saarlandes, Homburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1742-4658.2007.06039.xDOI Listing
October 2007

Protein transport into the endoplasmic reticulum: mechanisms and pathologies.

Trends Mol Med 2006 Dec 30;12(12):567-73. Epub 2006 Oct 30.

Medizinische Biochemie & Molekularbiologie and Klinik für Urologie & Kinderurologie, Universität des Saarlandes, D-66421 Homburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molmed.2006.10.004DOI Listing
December 2006

The nucleotide exchange factor activity of Grp170 may explain the non-lethal phenotype of loss of Sil1 function in man and mouse.

FEBS Lett 2006 Oct 5;580(22):5237-40. Epub 2006 Sep 5.

Medizinische Biochemie und Molekularbiologie, Universität des Saarlandes, D-66421 Homburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.febslet.2006.08.055DOI Listing
October 2006

ERj1p uses a universal ribosomal adaptor site to coordinate the 80S ribosome at the membrane.

Nat Struct Mol Biol 2005 Nov;12(11):1015-6

Institut für Biochemie der Charité, University Medical School Berlin, Monbijoustr. 2, 10117 Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nsmb998DOI Listing
November 2005

ERj1p has a basic role in protein biogenesis at the endoplasmic reticulum.

Nat Struct Mol Biol 2005 Nov;12(11):1008-14

Medizinische Biochemie und Molekularbiologie, Universität des Saarlandes, D-66421 Homburg, Germany.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nsmb1007
Publisher Site
http://dx.doi.org/10.1038/nsmb1007DOI Listing
November 2005

Specific detection and semi-quantitative analysis of TRPC4 protein expression by antibodies.

Pflugers Arch 2005 Oct 18;451(1):81-6. Epub 2005 Jun 18.

Experimentelle und Klinische Pharmakologie und Toxikologie, Medizinische Fakultät, Universität des Saarlandes, 66421 Homburg, Deutschland.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00424-005-1443-1
Publisher Site
http://dx.doi.org/10.1007/s00424-005-1443-1DOI Listing
October 2005

Not all J domains are created equal: implications for the specificity of Hsp40-Hsp70 interactions.

Protein Sci 2005 Jul;14(7):1697-709

Department of Biochemistry, Microbiology and Biotechnology, Rhodes University, Grahamstown, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1110/ps.051406805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2253343PMC
July 2005

Protein transport into canine pancreatic microsomes: a quantitative approach.

Eur J Biochem 2004 Aug;271(15):3200-7

Medizinische Biochemie und Molekularbiologie, Universität des Saarlandes, Homburg, Germany.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1432-1033.2004.04252.x
Publisher Site
http://dx.doi.org/10.1111/j.1432-1033.2004.04252.xDOI Listing
August 2004

Characterization of pancreatic ERj3p, a homolog of yeast DnaJ-like protein Scj1p.

Biol Chem 2004 May;385(5):389-95

Medizinische Biochemie and Molekularbiologie, Universität des Saarlandes, D-66421 Homburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1515/BC.2004.043DOI Listing
May 2004

The Sec61p complex is a dynamic precursor activated channel.

Mol Cell 2003 Jul;12(1):261-8

Biophysik, Universität Osnabrück, FB Biologie/Chemie, D-49034 Osnabrück, Germany.

View Article

Download full-text PDF

Source
July 2003

Tail-anchored and signal-anchored proteins utilize overlapping pathways during membrane insertion.

J Biol Chem 2003 Feb 2;278(8):5669-78. Epub 2002 Dec 2.

School of Biological Sciences, University of Manchester, 2.205 Stopford Building, Oxford Road, Manchester M13 9PT, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M209968200DOI Listing
February 2003

Tetratricopeptide repeat motif-mediated Hsc70-mSTI1 interaction. Molecular characterization of the critical contacts for successful binding and specificity.

J Biol Chem 2003 Feb 13;278(9):6896-904. Epub 2002 Dec 13.

Department of Biochemistry, Microbiology and Biotechnology, Rhodes University, Grahamstown 6140, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M206867200DOI Listing
February 2003