Publications by authors named "Richard W Tothill"

45Publications

A xenograft and cell line model of SDH-deficient pheochromocytoma derived from Sdhb+/- rats.

Endocr Relat Cancer 2020 Oct;27(10):X9-X10

Department of Pathology and Laboratory Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1530/ERC-19-0474eDOI Listing
October 2020

Wet or Dry? Do Liquid Biopsy Techniques Compete with or Complement PET for Disease Monitoring in Oncology?

J Nucl Med 2017 06 27;58(6):869-870. Epub 2017 Apr 27.

Peter MacCallum Cancer Center, Melbourne, Victoria, Australia; and

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http://dx.doi.org/10.2967/jnumed.117.190116DOI Listing
June 2017

(68)Ga-DOTATATE and (18)F-FDG PET/CT in Paraganglioma and Pheochromocytoma: utility, patterns and heterogeneity.

Cancer Imaging 2016 Aug 17;16(1):22. Epub 2016 Aug 17.

Cancer Imaging, Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, VIC, 3000, Australia.

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http://dx.doi.org/10.1186/s40644-016-0084-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989291PMC
August 2016

Serous ovarian and primary peritoneal cancers: A comparative analysis of clinico-pathological features, molecular subtypes and treatment outcome.

Gynecol Oncol 2016 Sep 18;142(3):458-64. Epub 2016 Jul 18.

The Westmead Institute for Medical Research, The University of Sydney, Sydney, NSW, Australia; Department of Gynecological Oncology, Westmead Hospital, Sydney, NSW, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2016.06.023DOI Listing
September 2016

BET Inhibition Induces Apoptosis in Aggressive B-Cell Lymphoma via Epigenetic Regulation of BCL-2 Family Members.

Mol Cancer Ther 2016 09 12;15(9):2030-41. Epub 2016 Jul 12.

Gene Regulation Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0924DOI Listing
September 2016

Long term, continuous exposure to panobinostat induces terminal differentiation and long term survival in the TH-MYCN neuroblastoma mouse model.

Int J Cancer 2016 Jul 10;139(1):194-204. Epub 2016 Mar 10.

Peter MacCallum Cancer Centre, Translational Research Laboratory, East Melbourne, VIC, Australia.

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http://dx.doi.org/10.1002/ijc.30056DOI Listing
July 2016

Pheo-Type: A Diagnostic Gene-expression Assay for the Classification of Pheochromocytoma and Paraganglioma.

J Clin Endocrinol Metab 2016 Mar 21;101(3):1034-43. Epub 2016 Jan 21.

The Peter MacCallum Cancer Centre (A.F., A.H., P.J., A.T., R.J.H., R.W.T.), East Melbourne, Victoria, 3002 Australia; The Department of Pathology (R.W.T., A.F.), University of Melbourne, Parkville, Victoria 3010, Australia; Cancer Genetics (T.D., D.B., R.C.-B.), Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales 2065, Australia; University of Sydney (T.D., D.B., A.J.G., R.C.-B.), Sydney, New South Wales 2006, Australia; The University of Queensland Diamantina Institute, Translational Research Institute (J.H., E.L.D.), Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia; The Tumor Bank (L.Z., D.C.), Children's Cancer Research Unit, The Children's Hospital at Westmead, St Westmead, New South Wales 2145, Australia; The Sir Peter MacCallum Department of Oncology (P.J., A.T., R.J.H.), University of Melbourne, Parkville, Victoria 3010, Australia; Department of Endocrinology (E.L.D.), Royal Brisbane and Women's Hospital, Brisbane, Queensland 4029, Australia; Royal Melbourne Hospital and Department of Medicine (A.T.), University of Melbourne, Parkville, Victoria 3010, Australia; and Cancer Diagnosis and Pathology Group (A.J.G.), Kolling Institute of Medical Research and the Department of Anatomical Pathology, Royal North Shore Hospital, Sydney, New South Wales 2065, Australia.

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http://dx.doi.org/10.1210/jc.2015-3889DOI Listing
March 2016

Loss of heterozygosity: what is it good for?

BMC Med Genomics 2015 Aug 1;8:45. Epub 2015 Aug 1.

Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1186/s12920-015-0123-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522148PMC
August 2015

Whole-genome characterization of chemoresistant ovarian cancer.

Nature 2015 May;521(7553):489-94

1] Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia [2] Department of Pathology, University of Melbourne, Parkville, Victoria 3052, Australia [3] Sir Peter MacCallum Cancer Centre Department of Oncology, University of Melbourne, Parkville, Victoria 3052, Australia [4] Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London W12 0HS, UK [5] Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1038/nature14410DOI Listing
May 2015

The genomic landscape of phaeochromocytoma.

J Pathol 2015 May 2;236(1):78-89. Epub 2015 Feb 2.

The Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia; The Department of Pathology, University of Melbourne, Parkville, VIC, Australia.

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http://dx.doi.org/10.1002/path.4503DOI Listing
May 2015

Development and validation of a gene expression tumour classifier for cancer of unknown primary.

Pathology 2015 Jan;47(1):7-12

1Peter MacCallum Cancer Centre, East Melbourne 2National (ICT) Australia, The University of Melbourne, Parkville 3Healthscope Pathology, Clayton 4Circadian Technologies Limited, Toorak 5The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville 6The Department of Pathology, University of Melbourne, Parkville 7The Department of Biochemistry, University of Melbourne, Parkville, Vic, Australia.

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http://dx.doi.org/10.1097/PAT.0000000000000194DOI Listing
January 2015

Cohesin Rad21 mediates loss of heterozygosity and is upregulated via Wnt promoting transcriptional dysregulation in gastrointestinal tumors.

Cell Rep 2014 Dec 20;9(5):1781-1797. Epub 2014 Nov 20.

Differentiation and Transcription Laboratory, Peter MacCallum Cancer Centre (PMCC), East Melbourne, VIC 3002, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3000, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.10.059DOI Listing
December 2014

Socrates: identification of genomic rearrangements in tumour genomes by re-aligning soft clipped reads.

Bioinformatics 2014 04 2;30(8):1064-1072. Epub 2014 Jan 2.

Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Department of Medical Biology, University of Melbourne, Victoria 3010, Melanoma Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Department of Pathology, The University of Melbourne, Victoria 3010, NICTA Victoria Laboratory, The University of Melbourne, Victoria 3010, Department of Computing and Information Systems, University of Melbourne, Victoria 3010, Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Sir Peter MacCallum Department of Oncology, The University of Melbourne, Victoria 3010, Department of Mathematics and Statistics, The University of Melbourne, Victoria 3010 and Bioinformatics and Cancer Genomics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Department of Medical Biology, University of Melbourne, Victoria 3010, Melanoma Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Department of Pathology, The University of Melbourne, Victoria 3010, NICTA Victoria Laboratory, The University of Melbourne, Victoria 3010, Department of Computing and Information Systems, University of Melbourne, Victoria 3010, Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Sir Peter MacCallum Department of Oncology, The University of Melbourne, Victoria 3010, Department of Mathematics and Statistics, The University of Melbourne, Victoria 3010 and Bioinformatics and Cancer Genomics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Department of Medical Biology, University of Melbourne, Victoria 3010, Melanoma Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Department of Pathology, The University of Melbourne, Victoria 3010, NICTA Victoria Laboratory, The University of Melbourne, Victoria 3010, Department of Computing and Information Systems, University of Melbourne, Victoria 3010, Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Sir Peter MacCallum Department of Oncology, The University of Melbourne, Victoria 3010, Department of Mathematics and Statistics, The University of Melbourne, Victoria 3010 and Bioinformatics and Cancer Genomics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Department of Medical Biology, University of Melbourne, Victoria 3010, Melanoma Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Department of Pathology, The University of Melbourne, Victoria 3010, NICTA Victoria Laboratory, The University of Melbourne, Victoria 3010, Department of Computing and Information Systems, University of Melbourne, Victoria 3010, Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Sir Peter MacCallum Department of Oncology, The University of Melbourne, Victoria 3010, Department of Mathematics and Statistics, The University of Melbourne, Victoria 3010 and Bioinformatics and Cancer Genomics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia.

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http://dx.doi.org/10.1093/bioinformatics/btt767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982158PMC
April 2014

A signature predicting poor prognosis in gastric and ovarian cancer represents a coordinated macrophage and stromal response.

Clin Cancer Res 2014 May 21;20(10):2761-72. Epub 2014 Mar 21.

Authors' Affiliations: Cancer Genetics and Genomics Laboratory; Molecular Genomics Core Facility; Department of Pathology, Peter MacCallum Cancer Centre, East Melbourne; Sir Peter MacCallum Department of Oncology; Department of Medicine, Royal Melbourne Hospital; National ICT Australia (NICTA); Department of Pathology, The University of Melbourne, Parkville, Australia; Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School; Cellular and Molecular Research, National Cancer Centre; Cancer Science Institute of Singapore, National University of Singapore; Genome Institute of Singapore, Singapore; and Faculty of Medicine in the Galilee, Bar Ilan University, Zfat, IsraelAuthors' Affiliations: Cancer Genetics and Genomics Laboratory; Molecular Genomics Core Facility; Department of Pathology, Peter MacCallum Cancer Centre, East Melbourne; Sir Peter MacCallum Department of Oncology; Department of Medicine, Royal Melbourne Hospital; National ICT Australia (NICTA); Department of Pathology, The University of Melbourne, Parkville, Australia; Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School; Cellular and Molecular Research, National Cancer Centre; Cancer Science Institute of Singapore, National University of Singapore; Genome Institute of Singapore, Singapore; and Faculty of Medicine in the Galilee, Bar Ilan University, Zfat, IsraelAuthors' Affiliations: Cancer Genetics and Genomics Laboratory; Molecular Genomics Core Facility; Department of Pathology, Peter MacCallum Cancer Centre, East Melbourne; Sir Peter MacCallum Department of Oncology; Department of Medicine, Royal Melbourne Hospital; National ICT Australia (NICTA); Department of Pathology, The University of Melbourne, Parkville, Australia; Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School; Cellular and Molecular Research, National Cancer Centre; Cancer Science Institute of Singapore, National University of Singapore; Genome Institute of Singapore, Singapore; and Fa

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http://clincancerres.aacrjournals.org/content/early/2014/04/
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http://clincancerres.aacrjournals.org/content/early/2014/03/
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-13-3049DOI Listing
May 2014

Navigating the challenge of tumor heterogeneity in cancer therapy.

Cancer Discov 2014 Feb;4(2):146-8

1Cancer Therapeutics Program, Division of Cancer Research, Peter MacCallum Cancer Centre, East Melbourne; 2Sir Peter MacCallum Department of Oncology and 3Department of Pathology, University of Melbourne, Parkville; and 4Department of Medicine, St Vincent's Hospital, University of Melbourne, Fitzroy, Victoria, Australia.

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http://dx.doi.org/10.1158/2159-8290.CD-13-1042DOI Listing
February 2014

Targeted-capture massively-parallel sequencing enables robust detection of clinically informative mutations from formalin-fixed tumours.

Sci Rep 2013 Dec 13;3:3494. Epub 2013 Dec 13.

1] Molecular Pathology Research and Development Laboratory, Department of Pathology, Peter MacCallum Cancer Centre, East Melbourne, Victoria, 3002, Australia [2] Department of Pathology, The University of Melbourne, Parkville, Victoria, 3010, Australia [3] Translational Genomics and Epigenomics Laboratory, Ludwig Institute for Cancer Research, The Olivia Newton-John Cancer and Wellness Centre, Heidelberg, Victoria, 3084, Australia.

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http://dx.doi.org/10.1038/srep03494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861801PMC
December 2013

Massively-parallel sequencing assists the diagnosis and guided treatment of cancers of unknown primary.

J Pathol 2013 Dec;231(4):413-23

The Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia; The Department of Pathology, University of Melbourne, Parkville, VIC, Australia.

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http://dx.doi.org/10.1002/path.4251DOI Listing
December 2013

CONTRA: copy number analysis for targeted resequencing.

Bioinformatics 2012 May 2;28(10):1307-13. Epub 2012 Apr 2.

Bioinformatics Core Facility, Peter MacCallum Cancer Centre, VIC 3002, Australia.

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http://dx.doi.org/10.1093/bioinformatics/bts146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348560PMC
May 2012

Next-generation sequencing for cancer diagnostics: a practical perspective.

Clin Biochem Rev 2011 Nov;32(4):177-95

Molecular Pathology, Hunter Area Pathology Service, Newcastle, NSW 2310;

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219767PMC
November 2011

Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells.

Genome Res 2011 Oct 2;21(10):1601-15. Epub 2011 Sep 2.

Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia.

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http://dx.doi.org/10.1101/gr.116095.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202278PMC
October 2011

Options available--from start to finish--for obtaining data from DNA microarrays II.

Nat Genet 2002 Dec;32 Suppl:481-9

The Ian Potter Foundation Centre for Cancer Genomics and Predictive Medicine and The Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, Locked Bag 1, A'Beckett Street, Melbourne 8006, Victoria, Australia.

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http://dx.doi.org/10.1038/ng1030DOI Listing
December 2002