Richard W Kriwacki

Richard W Kriwacki

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Richard W Kriwacki

Richard W Kriwacki

Publications by authors named "Richard W Kriwacki"

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C9orf72 Poly(PR) Dipeptide Repeats Disturb Biomolecular Phase Separation and Disrupt Nucleolar Function.

Mol Cell 2019 05 10;74(4):713-728.e6. Epub 2019 Apr 10.

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Sciences Center, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.03.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525025PMC
May 2019

Ion Mobility Mass Spectrometry Measures the Conformational Landscape of p27 and its Domains and how this is Modulated upon Interaction with Cdk2/cyclin A.

Angew Chem Int Ed Engl 2019 Mar 24;58(10):3114-3118. Epub 2019 Jan 24.

The Michael Barber Centre for Collaborative Mass Spectrometry, The School of Chemistry, Manchester Institute for Biotechnology, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1002/anie.201812697DOI Listing
March 2019

Ion Mobility Mass Spectrometry Uncovers the Impact of the Patterning of Oppositely Charged Residues on the Conformational Distributions of Intrinsically Disordered Proteins.

J Am Chem Soc 2019 Mar 12;141(12):4908-4918. Epub 2019 Mar 12.

The Michael Barber Centre for Collaborative Mass Spectrometry, The School of Chemistry, Manchester Institute for Biotechnology , University of Manchester , Manchester M13 9PL , U.K.

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http://dx.doi.org/10.1021/jacs.8b13483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488185PMC
March 2019

Methods for Physical Characterization of Phase-Separated Bodies and Membrane-less Organelles.

J Mol Biol 2018 11 24;430(23):4773-4805. Epub 2018 Jul 24.

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2018.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503534PMC
November 2018

Phase Separation in Biology and Disease.

J Mol Biol 2018 11 11;430(23):4603-4606. Epub 2018 Sep 11.

Department of Molecular Biology and Genetics, HHMI, School of Medicine, Johns Hopkins University, 725 N. Wolfe Street, Baltimore, MD 21205, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00222836183105
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http://dx.doi.org/10.1016/j.jmb.2018.09.006DOI Listing
November 2018

Linker histones as liquid-like glue for chromatin.

Proc Natl Acad Sci U S A 2018 11 2;115(47):11868-11870. Epub 2018 Nov 2.

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105;

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http://dx.doi.org/10.1073/pnas.1816936115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255204PMC
November 2018

Compositional adaptability in NPM1-SURF6 scaffolding networks enabled by dynamic switching of phase separation mechanisms.

Nat Commun 2018 11 29;9(1):5064. Epub 2018 Nov 29.

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1038/s41467-018-07530-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265330PMC
November 2018

Intrinsically Disordered Proteins: Structure, Function and Therapeutics.

J Mol Biol 2018 08 12;430(16):2275-2277. Epub 2018 Jun 12.

Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, United States; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Sciences Center, Memphis, TN 38105, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2018.06.012DOI Listing
August 2018

Regulation of apoptosis by an intrinsically disordered region of Bcl-xL.

Nat Chem Biol 2018 05 5;14(5):458-465. Epub 2018 Mar 5.

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1038/s41589-018-0011-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899648PMC
May 2018

Mapping Interactions between p27 and RhoA that Stimulate Cell Migration.

J Mol Biol 2018 03 1;430(6):751-758. Epub 2018 Feb 1.

Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2018.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965279PMC
March 2018

On the relationship status for Arf and NPM1 - it's complicated.

FEBS J 2018 03;285(5):828-831

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1111/febs.14407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965676PMC
March 2018

A Small Molecule Causes a Population Shift in the Conformational Landscape of an Intrinsically Disordered Protein.

J Am Chem Soc 2017 10 21;139(39):13692-13700. Epub 2017 Sep 21.

Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Sciences Center , Memphis, Tennessee 38105, United States.

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http://dx.doi.org/10.1021/jacs.7b01380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962290PMC
October 2017

Real-Time Analysis of Folding upon Binding of a Disordered Protein by Using Dissolution DNP NMR Spectroscopy.

Angew Chem Int Ed Engl 2017 06 16;56(25):7070-7073. Epub 2017 May 16.

Department of Chemistry, Texas A&M University, College Station, TX, 77843, USA.

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http://dx.doi.org/10.1002/anie.201700464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674774PMC
June 2017

C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles.

Cell 2016 Oct;167(3):774-788.e17

Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Howard Hughes Medical Institute, Department of Cell and Molecular Biology, St Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079111PMC
http://dx.doi.org/10.1016/j.cell.2016.10.002DOI Listing
October 2016

Discoveries and controversies in BCL-2 protein-mediated apoptosis.

FEBS J 2016 07 27;283(14):2690-700. Epub 2015 Oct 27.

Department of Structural Biology, St Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1111/febs.13527DOI Listing
July 2016

Dynamic Protein Interaction Networks and New Structural Paradigms in Signaling.

Chem Rev 2016 06 29;116(11):6424-62. Epub 2016 Feb 29.

Molecular Structure & Function, The Hospital for Sick Children , Toronto, ON M5G 0A4, Canada.

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http://dx.doi.org/10.1021/acs.chemrev.5b00548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342629PMC
June 2016

Coexisting Liquid Phases Underlie Nucleolar Subcompartments.

Cell 2016 Jun 19;165(7):1686-1697. Epub 2016 May 19.

Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.04.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127388PMC
June 2016

Editorial Overview: Functional and Mechanistic Landscape of the Nuclear Pore Complex.

J Mol Biol 2016 05 5;428(10 Pt A):1947-8. Epub 2016 Apr 5.

Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, United States; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Sciences Center, Memphis, TN 38105, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00222836163002
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http://dx.doi.org/10.1016/j.jmb.2016.03.028DOI Listing
May 2016

Cryptic sequence features within the disordered protein p27Kip1 regulate cell cycle signaling.

Proc Natl Acad Sci U S A 2016 May 2;113(20):5616-21. Epub 2016 May 2.

Department of Biomedical Engineering and Center for Biological Systems Engineering, Washington University in St. Louis, St. Louis, MO 63130;

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http://dx.doi.org/10.1073/pnas.1516277113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878473PMC
May 2016

Monitoring Ligand-Induced Protein Ordering in Drug Discovery.

J Mol Biol 2016 Mar 23;428(6):1290-1303. Epub 2016 Jan 23.

Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Sciences Center, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2016.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826315PMC
March 2016

Asymmetric Modulation of Protein Order-Disorder Transitions by Phosphorylation and Partner Binding.

Angew Chem Int Ed Engl 2016 Jan 17;55(5):1675-9. Epub 2015 Dec 17.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92307, USA.

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http://dx.doi.org/10.1002/anie.201507728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752826PMC
January 2016

Phase separation in biology; functional organization of a higher order.

Cell Commun Signal 2016 Jan 5;14. Epub 2016 Jan 5.

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1186/s12964-015-0125-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700675PMC
January 2016

Pin1-Induced Proline Isomerization in Cytosolic p53 Mediates BAX Activation and Apoptosis.

Mol Cell 2015 Aug 30;59(4):677-84. Epub 2015 Jul 30.

Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Sciences Center, 920 Court Avenue, Memphis, TN 38163, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.06.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546541PMC
August 2015

The activity and stability of the intrinsically disordered Cip/Kip protein family are regulated by non-receptor tyrosine kinases.

J Mol Biol 2015 Jan 20;427(2):371-386. Epub 2014 Nov 20.

Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38103, USA.

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http://dx.doi.org/10.1016/j.jmb.2014.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297576PMC
January 2015

Protein dynamics: tuning disorder propensity in p53.

Nat Chem Biol 2014 Dec;10(12):987-8

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA, and the Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1038/nchembio.1692DOI Listing
December 2014

The DNA-binding domain mediates both nuclear and cytosolic functions of p53.

Nat Struct Mol Biol 2014 Jun 11;21(6):535-43. Epub 2014 May 11.

1] Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. [2] Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1038/nsmb.2829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134560PMC
June 2014

Many players in BCL-2 family affairs.

Trends Biochem Sci 2014 Mar 3;39(3):101-11. Epub 2014 Feb 3.

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2013.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005919PMC
March 2014

Structural polymorphism in the N-terminal oligomerization domain of NPM1.

Proc Natl Acad Sci U S A 2014 Mar 10;111(12):4466-71. Epub 2014 Mar 10.

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105.

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http://dx.doi.org/10.1073/pnas.1321007111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970533PMC
March 2014

pE-DB: a database of structural ensembles of intrinsically disordered and of unfolded proteins.

Nucleic Acids Res 2014 Jan 29;42(Database issue):D326-35. Epub 2013 Oct 29.

VIB Department of Structural Biology, Vrije Universiteit Brussel, Brussels, European Molecular Biology Laboratory, Hamburg Unit, EMBL c/o DESY, Hamburg, Germany, CEA, CNRS, UJF-Grenoble 1, Protein Dynamics and Flexibility, Institut de Biologie Structurale Jean-Pierre Ebel, 41 Rue Jules Horowitz, Grenoble 38027, France, Indiana University School of Medicine; Indianapolis, IN, USA, Department of Chemistry, Center of Magnetic Resonance (CERM), University of Florence, Sesto Fiorentino, Italy, Molecular Structure and Function Program, Hospital for Sick Children, Toronto, Ontario, Canada, Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada, Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA, Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel, Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA, Institute for Biological Instrumentation, Russian Academy of Sciences, Pushchino, Moscow Region, Russia, Department of Chemistry, University of Cambridge, Cambridge, UK, Departments of Biological Sciences and Computing Science, University of Alberta, Edmonton, AB T6G 2E8, Canada, Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest.

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http://dx.doi.org/10.1093/nar/gkt960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964940PMC
January 2014

Cryptic disorder: an order-disorder transformation regulates the function of nucleophosmin.

Pac Symp Biocomput 2012 :152-63

St. Jude Children's Research Hospital, Department of Structural Biology, Memphis, TN 38103, USA.

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December 2013

BID-induced structural changes in BAK promote apoptosis.

Nat Struct Mol Biol 2013 May 21;20(5):589-97. Epub 2013 Apr 21.

Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1038/nsmb.2563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683554PMC
May 2013

Regulated unfolding of proteins in signaling.

FEBS Lett 2013 Apr 20;587(8):1081-8. Epub 2013 Feb 20.

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://doi.wiley.com/10.1016/j.febslet.2013.02.024
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http://dx.doi.org/10.1016/j.febslet.2013.02.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898947PMC
April 2013

Cell signaling, post-translational protein modifications and NMR spectroscopy.

J Biomol NMR 2012 Nov 26;54(3):217-36. Epub 2012 Sep 26.

Department of NMR-Supported Structural Biology, Leibniz Institute of Molecular Pharmacology (FMP Berlin), In-cell NMR Group, Robert-Roessle Strasse 10, 13125 Berlin, Germany.

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http://dx.doi.org/10.1007/s10858-012-9674-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939263PMC
November 2012

Electrostatically accelerated coupled binding and folding of intrinsically disordered proteins.

J Mol Biol 2012 Oct 19;422(5):674-684. Epub 2012 Jun 19.

Department of Biochemistry, Kansas State University, Manhattan, KS 66506, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2012.06.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432731PMC
October 2012

Cell cycle regulation by the intrinsically disordered proteins p21 and p27.

Biochem Soc Trans 2012 Oct;40(5):981-8

St. Jude Children's Research Hospital, Department of Structural Biology, 262 Danny Thomas Place, Memphis TN, 38105, U.S.A.

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http://biochemsoctrans.org/lookup/doi/10.1042/BST20120092
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http://dx.doi.org/10.1042/BST20120092DOI Listing
October 2012

A short linear motif in BNIP3L (NIX) mediates mitochondrial clearance in reticulocytes.

Autophagy 2012 Sep 21;8(9):1325-32. Epub 2012 Aug 21.

Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.4161/auto.20764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442879PMC
September 2012

Structural biology. Versatility from protein disorder.

Science 2012 Sep;337(6101):1460-1

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1228775
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http://dx.doi.org/10.1126/science.1228775DOI Listing
September 2012

Intrinsic protein flexibility in regulation of cell proliferation: advantages for signaling and opportunities for novel therapeutics.

Adv Exp Med Biol 2012 ;725:27-49

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1007/978-1-4614-0659-4_3DOI Listing
April 2012

Disorder-function relationships for the cell cycle regulatory proteins p21 and p27.

Biol Chem 2012 Apr;393(4):259-74

Department of Structural Biology, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38103, USA.

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http://dx.doi.org/10.1515/hsz-2011-0254DOI Listing
April 2012

Incomplete folding upon binding mediates Cdk4/cyclin D complex activation by tyrosine phosphorylation of inhibitor p27 protein.

J Biol Chem 2011 Aug 29;286(34):30142-51. Epub 2011 Jun 29.

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1074/jbc.M111.244095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191053PMC
August 2011

Cell biology. Fishing in the nuclear pore.

Science 2011 Jul;333(6038):44-5

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1126/science.1208568DOI Listing
July 2011

A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases.

Nat Struct Mol Biol 2011 Jul 17;18(8):947-9. Epub 2011 Jul 17.

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1038/nsmb.2086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245743PMC
July 2011

The role of the LH subdomain in the function of the Cip/Kip cyclin-dependent kinase regulators.

Biophys J 2011 May;100(10):2486-94

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1016/j.bpj.2011.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093569PMC
May 2011

Intrinsic disorder mediates the diverse regulatory functions of the Cdk inhibitor p21.

Nat Chem Biol 2011 Apr 27;7(4):214-21. Epub 2011 Feb 27.

Departments of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1038/nchembio.536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124363PMC
April 2011

The orderly chaos of proteins.

Sci Am 2011 Apr;304(4):68-73

Indiana University School of Medicine, Center for Computational Biology and Bioinformatics, USA.

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http://dx.doi.org/10.1038/scientificamerican0411-68DOI Listing
April 2011

A dual E3 mechanism for Rub1 ligation to Cdc53.

Mol Cell 2010 Sep;39(5):784-96

Howard Hughes Medical Institute, St Jude Children's Research Hospital, Memphis, TN 38105, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10972765100064
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http://dx.doi.org/10.1016/j.molcel.2010.08.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001161PMC
September 2010

Quantification of the vitamin D receptor-coregulator interaction.

Biochemistry 2009 Feb;48(7):1454-61

Endocrine Unit, University of California, San Francisco, San Francisco, California 94121, USA.

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http://dx.doi.org/10.1021/bi801874nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654718PMC
February 2009

Intrinsically unstructured domains of Arf and Hdm2 form bimolecular oligomeric structures in vitro and in vivo.

J Mol Biol 2008 Dec 16;384(1):240-54. Epub 2008 Sep 16.

Department of Structural Biology, St. Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.jmb.2008.09.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612038PMC
December 2008

Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins.

Proc Natl Acad Sci U S A 2008 Dec 12;105(51):20327-32. Epub 2008 Dec 12.

Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1073/pnas.0808036105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629294PMC
December 2008

Regulation of cell division by intrinsically unstructured proteins: intrinsic flexibility, modularity, and signaling conduits.

Biochemistry 2008 Jul;47(29):7598-609

Department of Structural Biology, St. Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1021/bi8006803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2580775PMC
July 2008

Role of intrinsic flexibility in signal transduction mediated by the cell cycle regulator, p27 Kip1.

J Mol Biol 2008 Feb 14;376(3):827-38. Epub 2007 Dec 14.

Department of Structural Biology, St. Jude Children's Research Hospital, 332 North Lauderdale St., Memphis, TN 38105, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00222836070162
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http://dx.doi.org/10.1016/j.jmb.2007.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2350195PMC
February 2008

Peptide design and structural characterization of a GPCR loop mimetic.

Biopolymers 2007 Jul;86(4):298-310

Department of Chemistry and Computational Research on Materials Institute, The University of Memphis, Memphis, TN 38152, USA.

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http://dx.doi.org/10.1002/bip.20745DOI Listing
July 2007

Negative regulation of ASK1 by p21Cip1 involves a small domain that includes Serine 98 that is phosphorylated by ASK1 in vivo.

Mol Cell Biol 2007 May 26;27(9):3530-41. Epub 2007 Feb 26.

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis, TN 38105-2794, USA.

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http://dx.doi.org/10.1128/MCB.00086-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1899956PMC
May 2007

Proteomic studies of the intrinsically unstructured mammalian proteome.

J Proteome Res 2006 Oct;5(10):2839-48

Department of Structural Biology, St. Jude Children's Research Hospital, and Department of Molecular Sciences, University of Tennessee Health Sciences Center, Memphis, Tennessee 38163, USA.

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http://dx.doi.org/10.1021/pr060328cDOI Listing
October 2006

Three-dimensional 13C-detected CH3-TOCSY using selectively protonated proteins: facile methyl resonance assignment and protein structure determination.

J Am Chem Soc 2006 Jul;128(28):9119-28

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1021/ja058587aDOI Listing
July 2006

Thermodynamic characterization of interactions between p27(Kip1) and activated and non-activated Cdk2: intrinsically unstructured proteins as thermodynamic tethers.

Biochim Biophys Acta 2006 Feb 11;1764(2):182-9. Epub 2006 Jan 11.

Department of Structural Biology, St. Jude Children's Research Hospital, 332 North Lauderdale St., Memphis, TN 38105, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S157096390500448
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http://dx.doi.org/10.1016/j.bbapap.2005.12.016DOI Listing
February 2006

Disruption of an intermonomer salt bridge in the p53 tetramerization domain results in an increased propensity to form amyloid fibrils.

Protein Sci 2005 Dec 31;14(12):2993-3003. Epub 2005 Oct 31.

Department of Structural Biology, St. Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1110/ps.051622005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2253254PMC
December 2005

Disordered p27Kip1 exhibits intrinsic structure resembling the Cdk2/cyclin A-bound conformation.

J Mol Biol 2005 Nov 20;353(5):1118-28. Epub 2005 Sep 20.

Department of Structural Biology, St. Jude Children's Research Hospital, 332 North Lauderdale St., Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.jmb.2005.08.074DOI Listing
November 2005

Molecular basis for the specificity of p27 toward cyclin-dependent kinases that regulate cell division.

J Mol Biol 2005 Jun 26;349(4):764-73. Epub 2005 Apr 26.

Department of Structural Biology, St Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.jmb.2005.04.019DOI Listing
June 2005

p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding.

Nat Struct Mol Biol 2004 Apr 14;11(4):358-64. Epub 2004 Mar 14.

Department of Structural Biology, St. Jude Children's Research Hospital, 332, North Lauderdale Street, Memphis, Tennessee 38105, USA.

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http://www.nature.com/articles/nsmb746
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http://dx.doi.org/10.1038/nsmb746DOI Listing
April 2004

P21Waf1/Cip1 dysfunction in neuroblastoma: a novel mechanism of attenuating G0-G1 cell cycle arrest.

Cancer Res 2003 Jul;63(13):3840-4

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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July 2003

Structure, activity, and distribution of fish osteocalcin.

J Biol Chem 2003 Apr 6;278(14):11843-8. Epub 2003 Jan 6.

Molecular Sciences Department, University of Tennessee, Health Science Center, Memphis, Tennessee 38163, USA.

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http://dx.doi.org/10.1074/jbc.M211449200DOI Listing
April 2003

Peptides derived from two dynamically disordered proteins self-assemble into amyloid-like fibrils.

J Am Chem Soc 2003 Mar;125(11):3200-1

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://pubs.acs.org/doi/abs/10.1021/ja028265w
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http://dx.doi.org/10.1021/ja028265wDOI Listing
March 2003

Reversible amyloid formation by the p53 tetramerization domain and a cancer-associated mutant.

J Mol Biol 2003 Mar;327(3):699-709

Department of Structural Biology, St Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/s0022-2836(03)00175-xDOI Listing
March 2003

Structure and dynamics of thioguanine-modified duplex DNA.

J Biol Chem 2003 Jan 24;278(2):1005-11. Epub 2002 Oct 24.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M204243200
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January 2003

A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer.

Nat Struct Biol 2002 Jan;9(1):12-6

Department of Structural Biology, St. Jude Children's Research Hospital, 332 N. Lauderdale St., Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1038/nsb730DOI Listing
January 2002