Richard W Costello

Richard W Costello

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Richard W Costello

Richard W Costello

Publications by authors named "Richard W Costello"

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Personalized Biofeedback on Inhaler Adherence and Technique by Community Pharmacists: A Cluster Randomized Clinical Trial.

J Allergy Clin Immunol Pract 2019 Sep 27. Epub 2019 Sep 27.

Clinical Research Centre, Beaumont Hospital, RCSI, Dublin, Ireland; Department of Respiratory Medicine, RCSI, Dublin, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2019.09.008DOI Listing
September 2019

Personalizing medicine - could the smart inhaler revolutionize treatment for COPD and asthma patients?

Expert Opin Drug Deliv 2019 Jul 27;16(7):675-677. Epub 2019 Jun 27.

a Clinical Research Centre, Royal College of Surgeons in Ireland , RCSI Education & Research Centre, Smurfit Building, Beaumont Hospital , Dublin , Ireland.

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https://www.tandfonline.com/doi/full/10.1080/17425247.2019.1
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http://dx.doi.org/10.1080/17425247.2019.1628017DOI Listing
July 2019

Management of hypothalamic disease in patients with craniopharyngioma.

Clin Endocrinol (Oxf) 2019 04 11;90(4):506-516. Epub 2019 Feb 11.

Department of Endocrinology, St Vincent's University Hospital, Dublin, Ireland.

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http://doi.wiley.com/10.1111/cen.13929
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http://dx.doi.org/10.1111/cen.13929DOI Listing
April 2019

Reduction in exhaled nitric oxide tracks improved patient inhaler compliance in difficult asthma-a case study.

J Asthma 2018 12 26;55(12):1373-1375. Epub 2017 Dec 26.

b The Clinical Research Facility, University College , Cork , Ireland.

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http://dx.doi.org/10.1080/02770903.2017.1414237DOI Listing
December 2018

Digital technologies and adherence in respiratory diseases: the road ahead.

Eur Respir J 2018 11 22;52(5). Epub 2018 Nov 22.

RCSI Education and Research Centre, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.

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http://erj.ersjournals.com/lookup/doi/10.1183/13993003.01147
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http://dx.doi.org/10.1183/13993003.01147-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364097PMC
November 2018

Advances in Audio-Based Systems to Monitor Patient Adherence and Inhaler Drug Delivery.

Chest 2018 03 5;153(3):710-722. Epub 2017 Sep 5.

Trinity Centre for Bioengineering, Trinity College Dublin, The University of Dublin, Dublin, Ireland; School of Engineering, Trinity College Dublin, The University of Dublin, Dublin, Ireland; School of Medicine, Trinity College Dublin, The University of Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1016/j.chest.2017.08.1162DOI Listing
March 2018

Estimation of inhalation flow profile using audio-based methods to assess inhaler medication adherence.

PLoS One 2018 18;13(1):e0191330. Epub 2018 Jan 18.

Trinity Centre for Bioengineering, Trinity College Dublin, The University of Dublin, Dublin, Ireland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0191330PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773205PMC
February 2018

Objective Assessment of Patient Inhaler User Technique Using an Audio-Based Classification Approach.

Sci Rep 2018 02 1;8(1):2164. Epub 2018 Feb 1.

Trinity Centre for Bioengineering, Trinity College, The University of Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1038/s41598-018-20523-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794789PMC
February 2018

The Seven Stages of Man: The Role of Developmental Stage on Medication Adherence in Respiratory Diseases.

J Allergy Clin Immunol Pract 2016 Sep-Oct;4(5):813-20

Allergy and Respiratory Research Group, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1016/j.jaip.2016.04.002DOI Listing
October 2017

Irregular and Ineffective: A Quantitative Observational Study of the Time and Technique of Inhaler Use.

J Allergy Clin Immunol Pract 2016 Sep-Oct;4(5):900-909.e2

Department of Medicine, Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland; Respiratory Department, Clinical Research Centre, RCSI, Dublin, Ireland.

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http://dx.doi.org/10.1016/j.jaip.2016.07.009DOI Listing
October 2017

The INCA (Inhaler Compliance Assessment): A comparison with established measures of adherence.

Psychol Health 2017 Oct 28;32(10):1266-1287. Epub 2017 Feb 28.

a Department of Psychology, Division of Population Sciences , Royal College of Surgeons in Ireland , Dublin , Ireland.

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http://dx.doi.org/10.1080/08870446.2017.1290243DOI Listing
October 2017

The use of multiple respiratory inhalers requiring different inhalation techniques has an adverse effect on COPD outcomes.

Int J Chron Obstruct Pulmon Dis 2017 21;12:59-71. Epub 2016 Dec 21.

Observational and Pragmatic Research Institute Pte Ltd, Singapore; Academic Primary Care, University of Aberdeen, Aberdeen, UK.

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http://dx.doi.org/10.2147/COPD.S117196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191843PMC
August 2017

Targeting patients with asthma for omalizumab therapy: choosing the right patient to get the best value for money.

Ther Adv Chronic Dis 2017 Feb 1;8(2-3):31-45. Epub 2017 Feb 1.

Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland.

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http://journals.sagepub.com/doi/10.1177/2040622317690494
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http://dx.doi.org/10.1177/2040622317690494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354131PMC
February 2017

Monitoring Inhaler Inhalations Using an Acoustic Sensor Proximal to Inhaler Devices.

J Aerosol Med Pulm Drug Deliv 2016 Oct 9;29(5):439-446. Epub 2016 Feb 9.

1 Trinity Centre for Bioengineering, Trinity College Dublin , Dublin, Ireland .

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http://dx.doi.org/10.1089/jamp.2015.1276DOI Listing
October 2016

A risk stratification tool for exacerbations of COPD: time to switch to DECAF.

Thorax 2016 06 16;71(6):489-90. Epub 2016 Feb 16.

Department of Respiratory Medicine, Royal College of Surgeons in Ireland (RCSI), Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1136/thoraxjnl-2015-208053DOI Listing
June 2016

Acoustic Analysis of Inhaler Sounds From Community-Dwelling Asthmatic Patients for Automatic Assessment of Adherence.

IEEE J Transl Eng Health Med 2014 11;2:2700210. Epub 2014 Mar 11.

Trinity College Dublin Trinity Centre for Bioengineering Dublin Ireland 2.

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http://dx.doi.org/10.1109/JTEHM.2014.2310480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848061PMC
May 2016

Predicting asthma exacerbations employing remotely monitored adherence.

Healthc Technol Lett 2016 Mar 23;3(1):51-5. Epub 2016 Mar 23.

Clinical Research Centre, Beaumont Hospital, Royal College of Surgeons in Ireland, Dublin, Ireland; Department of Medicine, Beaumont Hospital, Royal College of Surgeons in Ireland, Dublin, Ireland.

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http://dx.doi.org/10.1049/htl.2015.0058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814807PMC
March 2016

An Acoustic-Based Method to Detect and Quantify the Effect of Exhalation into a Dry Powder Inhaler.

J Aerosol Med Pulm Drug Deliv 2015 Aug 13;28(4):247-53. Epub 2014 Nov 13.

1 Trinity Centre for Bioengineering, Trinity College Dublin , Ireland .

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http://dx.doi.org/10.1089/jamp.2014.1169DOI Listing
August 2015

Mechanism of sphingosine 1-phosphate- and lysophosphatidic acid-induced up-regulation of adhesion molecules and eosinophil chemoattractant in nerve cells.

Int J Mol Sci 2011 17;12(5):3237-49. Epub 2011 May 17.

Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland; E-Mails: (R.W.C.); (M.M.); (M.A.).

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http://dx.doi.org/10.3390/ijms12053237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116188PMC
January 2015

A nurse-led intervention study: Promoting compliance with Diskus Inhaler use in asthma patients.

Nurs Open 2014 Dec 28;1(1):42-52. Epub 2014 Nov 28.

School of Nursing & Midwifery Royal College of Surgeons in Ireland Adliya Bahrain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047302PMC
http://dx.doi.org/10.1002/nop2.10DOI Listing
December 2014

Eosinophil peroxidase induces expression of cholinergic genes via cell surface neural interactions.

Mol Immunol 2014 Nov 14;62(1):37-45. Epub 2014 Jun 14.

Department of Medicine, Royal College of Surgeons in Ireland, Smurfit Building, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.1016/j.molimm.2014.05.014DOI Listing
November 2014

Physiological levels of lipoxin A4 inhibit ENaC and restore airway surface liquid height in cystic fibrosis bronchial epithelium.

Physiol Rep 2014 Aug 7;2(8). Epub 2014 Aug 7.

Department of Molecular Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.14814/phy2.12093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246599PMC
August 2014

Asthma and cystic fibrosis: a tangled web.

Pediatr Pulmonol 2014 Mar 13;49(3):205-13. Epub 2014 Jan 13.

Department of Respiratory Medicine, Adelaide & Meath Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1002/ppul.22934DOI Listing
March 2014

Automatic identification and accurate temporal detection of inhalations in asthma inhaler recordings.

Conf Proc IEEE Eng Med Biol Soc 2012 ;2012:2595-8

Trinity Center for Bioengineering, Trinity College Dublin, Dublin 2, Ireland.

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http://dx.doi.org/10.1109/EMBC.2012.6346495DOI Listing
August 2013

A method of estimating inspiratory flow rate and volume from an inhaler using acoustic measurements.

Physiol Meas 2013 Aug 26;34(8):903-14. Epub 2013 Jul 26.

Trinity Centre for Bioengineering, Trinity College Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1088/0967-3334/34/8/903DOI Listing
August 2013

Eosinophil recruitment to nasal nerves after allergen challenge in allergic rhinitis.

Clin Immunol 2013 Apr 27;147(1):50-57. Epub 2013 Feb 27.

Department of Medicine, Royal College of Surgeons in Ireland, Smurfit Building, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.1016/j.clim.2013.02.008DOI Listing
April 2013

Short term and long term effects of pulmonary rehabilitation on physical activity in COPD.

Respir Med 2012 Dec 12;106(12):1671-9. Epub 2012 Oct 12.

Department of Respiratory Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1016/j.rmed.2012.08.016DOI Listing
December 2012

Long-term follow-up of non-calcified pulmonary nodules (<10 mm) identified during low-dose CT screening for lung cancer.

Eur Radiol 2012 Sep 27;22(9):1923-8. Epub 2012 Apr 27.

Department of Radiology, Beaumont Hospital, Beaumont Road, Dublin, Ireland.

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http://dx.doi.org/10.1007/s00330-012-2443-0DOI Listing
September 2012

Acupuncture as an adjunct to pulmonary rehabilitation.

J Cardiopulm Rehabil Prev 2011 Nov-Dec;31(6):392-9

Department of Respiratory Medicine, Beaumont Hospital and the associated Education and Research Centre, University College of Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1097/HCR.0b013e31822f0f61DOI Listing
April 2012

Eosinophil peroxidase signals via epidermal growth factor-2 to induce cell proliferation.

Am J Respir Cell Mol Biol 2011 Nov 31;45(5):946-52. Epub 2011 Mar 31.

Department of Medicine, Education and Research Centre, Royal College of Surgeons in Ireland, Dublin, Ireland.

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http://dx.doi.org/10.1165/rcmb.2010-0454OCDOI Listing
November 2011

Lung function changes following methacholine inhalation in COPD.

Respir Med 2009 Apr 10;103(4):535-41. Epub 2008 Dec 10.

Division of Infection and Immunity, School of Clinical Sciences, University of Liverpool, University Hospital Aintree, Liverpool, UK.

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http://dx.doi.org/10.1016/j.rmed.2008.11.002DOI Listing
April 2009

Role of the muscarinic M2 receptor in human nasal mucosa.

Rhinology 2007 Sep;45(3):229-34

Department of Otolaryngology, Royal College of Surgeons in Ireland, Dublin, Ireland.

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September 2007

Subjects with non-allergic non-infectious perennial rhinitis do not show nasal hyper-responsiveness to bradykinin.

Eur Arch Otorhinolaryngol 2007 Jan 17;264(1):33-7. Epub 2006 Oct 17.

Department of Otolaryngology-Head and Neck Surgery, Royal College of Surgeons in Ireland, Dublin, Ireland.

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http://dx.doi.org/10.1007/s00405-006-0161-4DOI Listing
January 2007

Eosinophil-mediated cholinergic nerve remodeling.

Am J Respir Cell Mol Biol 2006 Jun 2;34(6):775-86. Epub 2006 Feb 2.

Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1165/rcmb.2005-0196OCDOI Listing
June 2006

Hyperresponsiveness of congestive nasal reflexes in allergic rhinitis.

Rhinology 2006 Mar;44(1):68-73

Department of Otorhinolaryngology, Royal College of Surgeons in Ireland, Dublin, Ireland.

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March 2006

Neutrophil sphingosine 1-phosphate and lysophosphatidic acid receptors in pneumonia.

Am J Respir Cell Mol Biol 2006 Feb 13;34(2):233-41. Epub 2005 Oct 13.

Department of Medicine, RCSI, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.1165/rcmb.2005-0126OCDOI Listing
February 2006

Lung mechanics and dyspnea during exacerbations of chronic obstructive pulmonary disease.

Am J Respir Crit Care Med 2005 Dec 15;172(12):1510-6. Epub 2005 Sep 15.

Department of Medicine, Clinical Sciences Centre, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, UK.

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http://dx.doi.org/10.1164/rccm.200504-595OCDOI Listing
December 2005

Extending a home from hospital care programme for COPD exacerbations to include pulmonary rehabilitation.

Respir Med 2005 Oct 31;99(10):1297-302. Epub 2005 Mar 31.

Department of Medicine, Royal College of Surgeons in Ireland, Smurfit Building, Beaumont Hospial, Dublin, Ireland.

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http://dx.doi.org/10.1016/j.rmed.2005.02.033DOI Listing
October 2005

Diverse effects of eosinophil cationic granule proteins on IMR-32 nerve cell signaling and survival.

Am J Respir Cell Mol Biol 2005 Aug 28;33(2):169-77. Epub 2005 Apr 28.

Department of Medicine, RCSI, Beaumont Hospital, Dublin 9, Ireland, and Department of Dermatology, University of Utah, Salt Lake City, USA.

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http://dx.doi.org/10.1165/rcmb.2005-0056OCDOI Listing
August 2005

Mechanism of eosinophil induced signaling in cholinergic IMR-32 cells.

Am J Physiol Lung Cell Mol Physiol 2005 Feb 1;288(2):L326-32. Epub 2004 Oct 1.

Department of Medicine, RCSI, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.1152/ajplung.00254.2004DOI Listing
February 2005

Use of Sniff nasal-inspiratory force to predict survival in amyotrophic lateral sclerosis.

Am J Respir Crit Care Med 2005 Feb 29;171(3):269-74. Epub 2004 Oct 29.

Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.1164/rccm.200403-314OCDOI Listing
February 2005

Eosinophil adhesion to cholinergic IMR-32 cells protects against induced neuronal apoptosis.

J Immunol 2004 Nov;173(10):5963-70

Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.4049/jimmunol.173.10.5963DOI Listing
November 2004

Effect of eosinophil adhesion on intracellular signaling in cholinergic nerve cells.

Am J Respir Cell Mol Biol 2004 Mar 10;30(3):333-41. Epub 2003 Jul 10.

Department of Medicine, RCSI, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.1165/rcmb.2003-0188OCDOI Listing
March 2004

Eosinophil-induced release of acetylcholine from differentiated cholinergic nerve cells.

Am J Physiol Lung Cell Mol Physiol 2003 Dec 29;285(6):L1296-304. Epub 2003 Aug 29.

Department of Pharmacology and Therapeutics, University of Liverpool L69 3GE, United Kingdom.

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http://dx.doi.org/10.1152/ajplung.00107.2003DOI Listing
December 2003

Effects of eosinophils on nerve cell morphology and development: the role of reactive oxygen species and p38 MAP kinase.

Am J Physiol Lung Cell Mol Physiol 2003 Oct 6;285(4):L915-24. Epub 2003 Jun 6.

Dept. of Pharmacology and Therapeutics, Univ. of Liverpool, The Sherrington Bldgs., Ashton St., Liverpool L69 3GE, UK.

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http://dx.doi.org/10.1152/ajplung.00094.2003DOI Listing
October 2003

Eosinophil and airway nerve interactions.

Pulm Pharmacol Ther 2003 ;16(1):9-13

Department of Pharmacology, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1016/S1094-5539(02)00093-7DOI Listing
July 2003

A pilot study examining the relationship between stress and serum cortisol concentrations in women with asthma.

Respir Med 2002 Oct;96(10):823-8

Johns Hopkins University Medical Institutions, Baltimore, MD 21287-2533, USA.

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http://dx.doi.org/10.1053/rmed.2002.1366DOI Listing
October 2002

Adhesion-dependent interactions between eosinophils and cholinergic nerves.

Am J Physiol Lung Cell Mol Physiol 2002 Jun;282(6):L1229-38

Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool L69 3GE, United Kingdom.

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http://dx.doi.org/10.1152/ajplung.00278.2001DOI Listing
June 2002

Eosinophil adhesion to cholinergic nerves via ICAM-1 and VCAM-1 and associated eosinophil degranulation.

Am J Physiol Lung Cell Mol Physiol 2002 Jun;282(6):L1279-88

Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool L69 3GE, United Kingdom.

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http://dx.doi.org/10.1152/ajplung.00279.2001DOI Listing
June 2002

Interactions between inflammatory cells and nerves.

Curr Opin Pharmacol 2002 Jun;2(3):243-8

Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.1016/s1471-4892(02)00155-8DOI Listing
June 2002