Richard T Pomerantz

Richard T Pomerantz

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Richard T Pomerantz

Richard T Pomerantz

Publications by authors named "Richard T Pomerantz"

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One-step enzymatic modification of RNA 3' termini using polymerase θ.

Nucleic Acids Res 2019 04;47(7):3272-3283

Fels Institute for Cancer Research, Department of Medical Genetics and Molecular Biochemistry, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA.

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http://dx.doi.org/10.1093/nar/gkz029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468238PMC
April 2019

Identification of a Small Interface between the Methyltransferase and RNA Polymerase of NS5 that is Essential for Zika Virus Replication.

Sci Rep 2018 11 26;8(1):17384. Epub 2018 Nov 26.

Fels Institute for Cancer Research, Department of Medical Genetics and Molecular Biochemistry, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/s41598-018-35511-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255901PMC
November 2018

Large deletions induced by Cas9 cleavage.

Nature 2018 08 8;560(7717):E8-E9. Epub 2018 Aug 8.

School of Biological Sciences, University of Adelaide, Adelaide, South Australia, Australia.

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http://www.nature.com/articles/s41586-018-0380-z
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http://dx.doi.org/10.1038/s41586-018-0380-zDOI Listing
August 2018

Polymerase θ-helicase efficiently unwinds DNA and RNA-DNA hybrids.

J Biol Chem 2018 04 14;293(14):5259-5269. Epub 2018 Feb 14.

From the Fels Institute for Cancer Research, Department of Medical Genetics and Molecular Biochemistry, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, 19140

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http://dx.doi.org/10.1074/jbc.RA117.000565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892577PMC
April 2018

How RNA transcripts coordinate DNA recombination and repair.

Nat Commun 2018 03 15;9(1):1091. Epub 2018 Mar 15.

Department of Medical Genetics and Molecular Biochemistry, Fels Institute for Cancer Research, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA.

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http://dx.doi.org/10.1038/s41467-018-03483-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854605PMC
March 2018

The helicase domain of Polθ counteracts RPA to promote alt-NHEJ.

Nat Struct Mol Biol 2017 Dec 23;24(12):1116-1123. Epub 2017 Oct 23.

Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York, USA.

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http://dx.doi.org/10.1038/nsmb.3494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047744PMC
December 2017

PARP1 restricts Epstein Barr Virus lytic reactivation by binding the BZLF1 promoter.

Virology 2017 07 26;507:220-230. Epub 2017 Apr 26.

Fels Institute for Cancer Research & Molecular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2017.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521201PMC
July 2017

Modification of 3' Terminal Ends of DNA and RNA Using DNA Polymerase θ Terminal Transferase Activity.

Bio Protoc 2017 Jun;7(12)

Fels Institute for Cancer Research, Department of Medical Genetics and Molecular Biochemistry, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.21769/BioProtoc.2330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560110PMC
June 2017

DNA polymerase θ specializes in incorporating synthetic expanded-size (xDNA) nucleotides.

Nucleic Acids Res 2016 Nov 2;44(19):9381-9392. Epub 2016 Sep 2.

Fels Institute for Cancer Research, Department of Medical Genetics and Molecular Biochemistry, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19140, USA

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http://dx.doi.org/10.1093/nar/gkw721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100566PMC
November 2016

DNA Polymerase θ: A Unique Multifunctional End-Joining Machine.

Genes (Basel) 2016 Sep 21;7(9). Epub 2016 Sep 21.

Fels Institute for Cancer Research, Department of Medical Genetics and Molecular Biochemistry, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.3390/genes7090067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042397PMC
September 2016

Polymerase θ is a robust terminal transferase that oscillates between three different mechanisms during end-joining.

Elife 2016 06 17;5. Epub 2016 Jun 17.

Fels Institute for Cancer Research, Temple University Lewis Katz School of Medicine, Philadelphia, United States.

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http://dx.doi.org/10.7554/eLife.13740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912351PMC
June 2016

Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers.

Chem Biol 2015 Nov 5;22(11):1491-1504. Epub 2015 Nov 5.

Department of Medical Genetics and Molecular Biochemistry, Fels Institute for Cancer Research, Temple University School of Medicine, Philadelphia, PA 19140, USA. Electronic address:

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http://www.cell.com/cms/attachment/2039928857/2053490077/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S107455211500379
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http://dx.doi.org/10.1016/j.chembiol.2015.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701204PMC
November 2015

Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ.

Nat Struct Mol Biol 2015 Mar 2;22(3):230-7. Epub 2015 Feb 2.

1] Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA. [2] Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.

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http://www.nature.com/articles/nsmb.2961
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http://dx.doi.org/10.1038/nsmb.2961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351179PMC
March 2015

DNA polymerases are error-prone at RecA-mediated recombination intermediates.

Cell Cycle 2013 Aug 29;12(16):2558-63. Epub 2013 Jul 29.

Fels Institute for Cancer Research, Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.4161/cc.25691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865045PMC
August 2013

Preferential D-loop extension by a translesion DNA polymerase underlies error-prone recombination.

Nat Struct Mol Biol 2013 Jun 19;20(6):748-55. Epub 2013 May 19.

The Rockefeller University, Howard Hughes Medical Institute, New York, New York, USA.

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http://dx.doi.org/10.1038/nsmb.2573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685420PMC
June 2013

Polymerase trafficking: A role for transcription factors in preventing replication fork arrest.

Transcription 2010 Nov 30;1(3):136-139. Epub 2010 Aug 30.

The Rockefeller University; Howard Hughes Medical Institute; New York, NY USA.

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http://dx.doi.org/10.4161/trns.1.3.13488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023573PMC
November 2010

What happens when replication and transcription complexes collide?

Cell Cycle 2010 Jul;9(13):2537-43

The Rockefeller University, Howard Hughes Medical Institute, New York, NY, USA.

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http://dx.doi.org/10.4161/cc.9.13.12122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918965PMC
July 2010

Direct restart of a replication fork stalled by a head-on RNA polymerase.

J Vis Exp 2010 Apr 29(38). Epub 2010 Apr 29.

Howard Hughes Medical Institute, The Rockefeller University, USA.

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http://dx.doi.org/10.3791/1919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146238PMC
April 2010

Direct restart of a replication fork stalled by a head-on RNA polymerase.

Science 2010 Jan;327(5965):590-2

The Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1126/science.1179595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861996PMC
January 2010

The replisome uses mRNA as a primer after colliding with RNA polymerase.

Nature 2008 Dec 19;456(7223):762-6. Epub 2008 Nov 19.

The Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/nature07527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605185PMC
December 2008

Replisome mechanics: insights into a twin DNA polymerase machine.

Trends Microbiol 2007 Apr 9;15(4):156-64. Epub 2007 Mar 9.

Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.tim.2007.02.007DOI Listing
April 2007

A mechanism of nucleotide misincorporation during transcription due to template-strand misalignment.

Mol Cell 2006 Oct;24(2):245-55

Department of Microbiology and Immunology, The State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, New York 11203, USA.

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http://dx.doi.org/10.1016/j.molcel.2006.08.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810628PMC
October 2006

Template misalignment in multisubunit RNA polymerases and transcription fidelity.

Mol Cell 2006 Oct;24(2):257-66

Department of Cell Biology, School of Osteopathic Medicine, University of Medicine and Dentistry of New Jersey, 42 East Laurel Road, Stratford, New Jersey 08084, USA.

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http://dx.doi.org/10.1016/j.molcel.2006.10.001DOI Listing
October 2006

A tightly regulated molecular motor based upon T7 RNA polymerase.

Nano Lett 2005 Sep;5(9):1698-703

Department of Microbiology and Immunology and Graduate Program in Molecular and Cellular Biology, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, New York 11203-2098, USA.

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http://dx.doi.org/10.1021/nl0509125DOI Listing
September 2005