Richard Sherva

Richard Sherva

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Richard Sherva

Richard Sherva

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Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders.

Authors:
Raymond K Walters Renato Polimanti Emma C Johnson Jeanette N McClintick Mark J Adams Amy E Adkins Fazil Aliev Silviu-Alin Bacanu Anthony Batzler Sarah Bertelsen Joanna M Biernacka Tim B Bigdeli Li-Shiun Chen Toni-Kim Clarke Yi-Ling Chou Franziska Degenhardt Anna R Docherty Alexis C Edwards Pierre Fontanillas Jerome C Foo Louis Fox Josef Frank Ina Giegling Scott Gordon Laura M Hack Annette M Hartmann Sarah M Hartz Stefanie Heilmann-Heimbach Stefan Herms Colin Hodgkinson Per Hoffmann Jouke Jan Hottenga Martin A Kennedy Mervi Alanne-Kinnunen Bettina Konte Jari Lahti Marius Lahti-Pulkkinen Dongbing Lai Lannie Ligthart Anu Loukola Brion S Maher Hamdi Mbarek Andrew M McIntosh Matthew B McQueen Jacquelyn L Meyers Yuri Milaneschi Teemu Palviainen John F Pearson Roseann E Peterson Samuli Ripatti Euijung Ryu Nancy L Saccone Jessica E Salvatore Sandra Sanchez-Roige Melanie Schwandt Richard Sherva Fabian Streit Jana Strohmaier Nathaniel Thomas Jen-Chyong Wang Bradley T Webb Robbee Wedow Leah Wetherill Amanda G Wills Jason D Boardman Danfeng Chen Doo-Sup Choi William E Copeland Robert C Culverhouse Norbert Dahmen Louisa Degenhardt Benjamin W Domingue Sarah L Elson Mark A Frye Wolfgang Gäbel Caroline Hayward Marcus Ising Margaret Keyes Falk Kiefer John Kramer Samuel Kuperman Susanne Lucae Michael T Lynskey Wolfgang Maier Karl Mann Satu Männistö Bertram Müller-Myhsok Alison D Murray John I Nurnberger Aarno Palotie Ulrich Preuss Katri Räikkönen Maureen D Reynolds Monika Ridinger Norbert Scherbaum Marc A Schuckit Michael Soyka Jens Treutlein Stephanie Witt Norbert Wodarz Peter Zill Daniel E Adkins Joseph M Boden Dorret I Boomsma Laura J Bierut Sandra A Brown Kathleen K Bucholz Sven Cichon E Jane Costello Harriet de Wit Nancy Diazgranados Danielle M Dick Johan G Eriksson Lindsay A Farrer Tatiana M Foroud Nathan A Gillespie Alison M Goate David Goldman Richard A Grucza Dana B Hancock Kathleen Mullan Harris Andrew C Heath Victor Hesselbrock John K Hewitt Christian J Hopfer John Horwood William Iacono Eric O Johnson Jaakko A Kaprio Victor M Karpyak Kenneth S Kendler Henry R Kranzler Kenneth Krauter Paul Lichtenstein Penelope A Lind Matt McGue James MacKillop Pamela A F Madden Hermine H Maes Patrik Magnusson Nicholas G Martin Sarah E Medland Grant W Montgomery Elliot C Nelson Markus M Nöthen Abraham A Palmer Nancy L Pedersen Brenda W J H Penninx Bernice Porjesz John P Rice Marcella Rietschel Brien P Riley Richard Rose Dan Rujescu Pei-Hong Shen Judy Silberg Michael C Stallings Ralph E Tarter Michael M Vanyukov Scott Vrieze Tamara L Wall John B Whitfield Hongyu Zhao Benjamin M Neale Joel Gelernter Howard J Edenberg Arpana Agrawal

Nat Neurosci 2018 12 26;21(12):1656-1669. Epub 2018 Nov 26.

Washington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA.

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http://dx.doi.org/10.1038/s41593-018-0275-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430207PMC
December 2018

Genome-wide Association Study Identifies a Regulatory Variant of RGMA Associated With Opioid Dependence in European Americans.

Biol Psychiatry 2018 11 11;84(10):762-770. Epub 2018 Jan 11.

Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, Massachusetts; Departments of Genetics and Neuroscience, Yale University School of Medicine, New Haven, Massachusetts; VA Connecticut Healthcare Center, West Haven, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2017.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041180PMC
November 2018

Genome-wide association study of Alzheimer's disease endophenotypes at prediagnosis stages.

Alzheimers Dement 2018 05 20;14(5):623-633. Epub 2017 Dec 20.

Department of Medicine (Biomedical Genetics), Boston University, Boston, MA, USA; Neurogenetics and Integrated Genomics, Andover Innovative Medicines (AiM) Institute, Eisai Inc, Andover, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2017.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938137PMC
May 2018

Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression.

JAMA Psychiatry 2017 12;74(12):1234-1241

Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1001/jamapsychiatry.2017.3275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331050PMC
December 2017

Oxytocin receptor gene polymorphisms, attachment, and PTSD: Results from the National Health and Resilience in Veterans Study.

J Psychiatr Res 2017 11 8;94:139-147. Epub 2017 Jul 8.

U.S. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1016/j.jpsychires.2017.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605420PMC
November 2017

Transethnic genome-wide scan identifies novel Alzheimer's disease loci.

Alzheimers Dement 2017 Jul 7;13(7):727-738. Epub 2017 Feb 7.

Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine, Boston, MA, USA; Department of Neurology, Boston University Schools of Medicine, Boston, MA, USA; Department of Biostatistics, Boston University Schools of Public Health, Boston, MA, USA; Department of Ophthalmology, Boston University Schools of Medicine, Boston, MA, USA; Department of Epidemiology, Boston University Schools of Public Health, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2016.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496797PMC
July 2017

identified in a genome-wide gene × cannabis dependence interaction analysis of risky sexual behaviours.

J Psychiatry Neurosci 2017 06;42(4):252-261

From the Department of Psychiatry, Yale University School of Medicine and VA CT Healthcare Center, West Haven, Conn., USA (Polimanti, Pearlson, Gelernter); Olin Research Center, Institute of Living/Hartford Hospital, Hartford, Conn., USA (Meda, Pearlson); the Department of Neuroscience, Yale University School of Medicine, New Haven, Conn., USA (Pearlson, Gelernter); the Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Mass., USA (Sherva, Farrer); the Department of Biostatistics, Yale University School of Public Health, New Haven, Conn., USA (Zhao); the Department of Genetics, Yale University School of Medicine, New Haven, Conn., USA (Zhao, Gelernter); the Departments of Neurology, Ophthalmology, Biostatistics, and Epidemiology, Boston University Schools of Medicine and Public Health, Boston, Mass., USA (Farrer); and the Department of Psychiatry, University of Pennsylvania School of Medicine and VISN 4 MIRECC, Crescenz VAMC, Philadelphia, Pa., USA (Kranzler).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487272PMC
June 2017

Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans.

Alzheimers Dement 2017 02 20;13(2):119-129. Epub 2016 Oct 20.

Department of Neurology, Boston University School of Medicine, Boston, MA, USA; Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, MA, USA; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA; Department of Ophthalmology, Boston University School of Medicine, Boston, MA, USA; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.jalz.2016.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318231PMC
February 2017

Association of maternal and infant variants in PNOC and COMT genes with neonatal abstinence syndrome severity.

Am J Addict 2017 Jan 16;26(1):42-49. Epub 2016 Dec 16.

Department of Biomedical Genetics, Boston University School of Medicine, Boston, Massachusetts.

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http://dx.doi.org/10.1111/ajad.12483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206487PMC
January 2017

Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks.

JAMA Psychiatry 2016 May;73(5):472-80

VA Cooperative Studies Program Coordinating Center, West Haven, Connecticut8Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut13Department of Psychiatry, VA Connecticut Healthcare Center, Yale University School of Medicine, West Hav.

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http://dx.doi.org/10.1001/jamapsychiatry.2016.0036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974817PMC
May 2016

The genetics of alcohol dependence: Twin and SNP-based heritability, and genome-wide association study based on AUDIT scores.

Am J Med Genet B Neuropsychiatr Genet 2015 Dec 14;168(8):739-48. Epub 2015 Sep 14.

Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/ajmg.b.32379DOI Listing
December 2015

Variations in opioid receptor genes in neonatal abstinence syndrome.

Drug Alcohol Depend 2015 Oct 8;155:253-9. Epub 2015 Jul 8.

Psychology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, United States. Electronic address:

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http://dx.doi.org/10.1016/j.drugalcdep.2015.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581974PMC
October 2015

Genomewide Association Study for Maximum Number of Alcoholic Drinks in European Americans and African Americans.

Alcohol Clin Exp Res 2015 Jul 3;39(7):1137-47. Epub 2015 Jun 3.

Department of Psychiatry, Yale School of Medicine, and VA CT Healthcare Center, West Haven, Connecticut.

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http://dx.doi.org/10.1111/acer.12751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706077PMC
July 2015

Genome-wide association study of nicotine dependence in American populations: identification of novel risk loci in both African-Americans and European-Americans.

Biol Psychiatry 2015 Mar 16;77(5):493-503. Epub 2014 Sep 16.

Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts; Departments of Neurology, Ophthalmology, Genetics and Genomics, and Epidemiology and Biostatistics, Boston University Schools of Medicine and Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.biopsych.2014.08.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386684PMC
March 2015

Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways.

Biol Psychiatry 2014 Jul 19;76(1):66-74. Epub 2013 Oct 19.

Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts; Departments of Neurology, Ophthalmology, Genetics and Genomics, Epidemiology and Biostatistics, Boston University Schools of Medicine and Public Health, Boston, Massachusetts.

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https://linkinghub.elsevier.com/retrieve/pii/S00063223130082
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http://dx.doi.org/10.1016/j.biopsych.2013.08.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992201PMC
July 2014

Reply: To PMID 23740775.

Arthritis Rheumatol 2014 May;66(5):1401

Boston University School of Medicine, Boston, MA.

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http://dx.doi.org/10.1002/art.38366DOI Listing
May 2014

Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.

Alzheimers Dement 2014 Jan 25;10(1):45-52. Epub 2013 Mar 25.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.jalz.2013.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760995PMC
January 2014

Power and pitfalls of the genome-wide association study approach to identify genes for Alzheimer's disease.

Curr Psychiatry Rep 2011 Apr;13(2):138-46

Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA 02118, USA.

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http://dx.doi.org/10.1007/s11920-011-0184-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154249PMC
April 2011

Common CD36 SNPs reduce protein expression and may contribute to a protective atherogenic profile.

Hum Mol Genet 2011 Jan 8;20(1):193-201. Epub 2010 Oct 8.

Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1093/hmg/ddq449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000679PMC
January 2011

Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes.

Neuropsychopharmacology 2010 Aug 19;35(9):1921-31. Epub 2010 May 19.

Department of Medicine (Genetics Program), Boston University School of Medicine, Boston, MA, USA.

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http://dx.doi.org/10.1038/npp.2010.64DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055642PMC
August 2010

No evidence for multiple loci affecting rheumatoid arthritis risk on chromosome 6p21.

BMC Proc 2007 18;1 Suppl 1:S42. Epub 2007 Dec 18.

Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, Missouri 63104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367585PMC
http://dx.doi.org/10.1186/1753-6561-1-s1-s42DOI Listing
December 2009

Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol.

Hum Mol Genet 2008 Jun 27;17(11):1695-704. Epub 2008 Feb 27.

Department of Medicine, Center for Human Nutrition, Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1093/hmg/ddn060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655228PMC
June 2008