Publications by authors named "Richard S Smith"

100Publications

A digital 3D reference atlas reveals cellular growth patterns shaping the ovule.

Elife 2021 Jan 6;10. Epub 2021 Jan 6.

Plant Developmental Biology, School of Life Sciences, Technical University of Munich, Freising, Germany.

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January 2021

Robust organ size requires robust timing of initiation orchestrated by focused auxin and cytokinin signalling.

Nat Plants 2020 06 25;6(6):686-698. Epub 2020 May 25.

Weill Institute for Cell and Molecular Biology and School of Integrative Plant Science, Section of Plant Biology, Cornell University, Ithaca, NY, USA.

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June 2020

Ion Channel Functions in Early Brain Development.

Trends Neurosci 2020 02 17;43(2):103-114. Epub 2020 Jan 17.

Division of Genetics and Genomics, Manton Center for Orphan Disease Research, and Howard Hughes Medical Institute, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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February 2020

Osmotic Treatment for Quantifying Cell Wall Elasticity in the Sepal of Arabidopsis thaliana.

Methods Mol Biol 2020 ;2094:101-112

John Innes Centre, Computational and Systems Biology, Norwich Research Park, Norwich, UK.

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January 2020

Phyllotaxis: is the golden angle optimal for light capture?

New Phytol 2020 01 2;225(1):499-510. Epub 2019 Aug 2.

Department of Comparative Development and Genetics, Max Planck Institute for Plant Breeding Research, Cologne, 50829, Germany.

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January 2020

Quantifying Plant Growth and Cell Proliferation with MorphoGraphX.

Methods Mol Biol 2019 ;1992:269-290

Max Planck Institute for Plant Breeding Research, Cologne, Germany.

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February 2020

Cellular Force Microscopy to Measure Mechanical Forces in Plant Cells.

Methods Mol Biol 2019 ;1992:215-230

Max Planck Institute for Plant Breeding Research, Cologne, Germany.

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February 2020

A Growth-Based Framework for Leaf Shape Development and Diversity.

Cell 2019 05 23;177(6):1405-1418.e17. Epub 2019 May 23.

Department of Comparative Development and Genetics, Max Planck Institute for Plant Breeding Research, Carl-von-Linné-Weg 10, 50829, Cologne, Germany. Electronic address:

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May 2019

3DCellAtlas Meristem: a tool for the global cellular annotation of shoot apical meristems.

Plant Methods 2019 4;15:33. Epub 2019 Apr 4.

3School of Biosciences, College of Life and Environmental and Life Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT UK.

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April 2019

The role of in petal number robustness.

Elife 2018 10 18;7. Epub 2018 Oct 18.

Max Planck Institute for Plant Breeding Research, Cologne, Germany.

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October 2018

Mechanics, geometry and genetics of epidermal cell shape regulation: different pieces of the same puzzle.

Curr Opin Plant Biol 2019 02 28;47:1-8. Epub 2018 Aug 28.

Department of Comparative Development and Genetics, Max Planck Institute for Plant Breeding Research, Carl-von-Linne-Weg 10, 50829 Cologne, Germany. Electronic address:

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February 2019

Mechanical Shielding of Rapidly Growing Cells Buffers Growth Heterogeneity and Contributes to Organ Shape Reproducibility.

Curr Biol 2017 Nov 9;27(22):3468-3479.e4. Epub 2017 Nov 9.

Laboratoire de Reproduction et Développement des Plantes, Université de Lyon, UCB Lyon 1, ENS de Lyon, INRA, CNRS, 46 Allée d'Italie, 69364 Lyon Cedex 07, France. Electronic address:

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November 2017

Seasonal Regulation of Petal Number.

Plant Physiol 2017 Oct 31;175(2):886-903. Epub 2017 Aug 31.

Max Planck Institute for Plant Breeding Research, 50829 Köln, Germany

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October 2017

Cell-size dependent progression of the cell cycle creates homeostasis and flexibility of plant cell size.

Nat Commun 2017 04 27;8:15060. Epub 2017 Apr 27.

Division of Molecular Biosciences, Cardiff School of Biosciences, Cardiff University, Cardiff, Wales CF10 3AX, UK.

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April 2017

On the micro-indentation of plant cells in a tissue context.

Phys Biol 2017 02 9;14(1):015003. Epub 2017 Feb 9.

Department of Comparative Development and Genetics, Max Planck Institute for Plant Breeding Research, Cologne, Germany. Institute of Plant Sciences, University of Bern, Bern, Switzerland.

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February 2017

Left-right leaf asymmetry in decussate and distichous phyllotactic systems.

Philos Trans R Soc Lond B Biol Sci 2016 12;371(1710)

Department of Plant Biology, University of California, Davis, CA 95616, USA

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December 2016

YBR/EiJ mice: a new model of glaucoma caused by genes on chromosomes 4 and 17.

Dis Model Mech 2016 08 9;9(8):863-71. Epub 2016 Jun 9.

The Jackson Laboratory, Bar Harbor, ME, USA Howard Hughes Medical Institute, The Jackson Laboratory, Bar Harbor, ME, USA Department of Ophthalmology, Tufts University School of Medicine, Boston, MA, USA

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August 2016

Variable Cell Growth Yields Reproducible OrganDevelopment through Spatiotemporal Averaging.

Dev Cell 2016 07;38(1):15-32

Weill Institute for Cell and Molecular Biology and Section of Plant Biology, School of Integrative Plant Sciences, Cornell University, Ithaca, NY 14853, USA. Electronic address:

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July 2016

A Mechanical Feedback Restricts Sepal Growth and Shape in Arabidopsis.

Curr Biol 2016 Apr 12. Epub 2016 Apr 12.

Plant Reproduction and Development Laboratory, Université de Lyon, ENS Lyon, UCB Lyon 1, INRA, CNRS, 46 Allée d'Italie, 69007 Lyon, France. Electronic address:

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April 2016

Extracting Subcellular Fibrillar Alignment with Error Estimation: Application to Microtubules.

Biophys J 2016 04;110(8):1836-1844

Research Institute for Electronic Science, Hokkaido University, Sapporo 001-0020 Japan. Electronic address:

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April 2016

Rules and Self-Organizing Properties of Post-embryonic Plant Organ Cell Division Patterns.

Curr Biol 2016 Feb 28;26(4):439-49. Epub 2016 Jan 28.

Center for Organismal Studies, Heidelberg University, 69120 Heidelberg, Germany. Electronic address:

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February 2016

Quantifying morphogenesis in plants in 4D.

Curr Opin Plant Biol 2016 Feb 1;29:87-94. Epub 2016 Jan 1.

Department of Comparative Development and Genetics, Max Planck Institute for Plant Breeding Research, Carl-von-Linné-Weg 10, 50829 Cologne, Germany. Electronic address:

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February 2016

Actin-dependent vacuolar occupancy of the cell determines auxin-induced growth repression.

Proc Natl Acad Sci U S A 2016 Jan 29;113(2):452-7. Epub 2015 Dec 29.

Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, 1190 Vienna, Austria;

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January 2016

Strain-Dependent Anterior Segment Dysgenesis and Progression to Glaucoma in Col4a1 Mutant Mice.

Invest Ophthalmol Vis Sci 2015 Oct;56(11):6823-31

Departments of Ophthalmology and Anatomy Institute for Human Genetics, UCSF School of Medicine, San Francisco, California, United States.

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October 2015

Variability and Constancy in Cellular Growth of Arabidopsis Sepals.

Plant Physiol 2015 Dec 2;169(4):2342-58. Epub 2015 Oct 2.

Computational Science and Engineering Laboratory, ETH Zürich, 8092 Zurich, Switzerland (G.T., P.K.);Weill Institute for Cell and Molecular Biology (H.M.M., A.H.K.R.), Genetics, Genomics, and Development Program (H.M.M., A.H.K.R), and School of Integrative Plant Sciences, Section of Plant Biology (A.H.K.R), Cornell University, Ithaca, New York 14853; andDepartment of Comparative Development and Genetics, Max Planck Institute for Plant Breeding Research, 50829 Cologne, Germany (R.S.S.)

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December 2015

Differential Muscarinic Modulation in the Olfactory Bulb.

J Neurosci 2015 Jul;35(30):10773-85

Department of Biology, University of Maryland, College Park, Maryland 20742

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July 2015

Movement of magnetic nanoparticles in brain tissue: mechanisms and impact on normal neuronal function.

Nanomedicine 2015 Oct 24;11(7):1821-9. Epub 2015 Jun 24.

Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA; The Institute for Systems Research (ISR), University of Maryland, College Park, MD, USA.

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October 2015

Digital Single-Cell Analysis of Plant Organ Development Using 3DCellAtlas.

Plant Cell 2015 Apr 21;27(4):1018-33. Epub 2015 Apr 21.

School of Biosciences, University of Birmingham, Birmingham B15 2TT, United Kingdom

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April 2015

Measuring the mechanical properties of plant cells by combining micro-indentation with osmotic treatments.

J Exp Bot 2015 Jun 7;66(11):3229-41. Epub 2015 Apr 7.

Institute of Plant Sciences, University of Bern, Altenbergrain 21, CH-3013 Bern, Switzerland Max Planck Institute for Plant Breeding Research, Carl-von-Linné-Weg 1050829 Köln, Cologne, Germany

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June 2015

Improved PeT molecules for optically sensing voltage in neurons.

J Am Chem Soc 2015 Feb 29;137(5):1817-24. Epub 2015 Jan 29.

Departments of Chemistry and Biochemistry, ‡Pharmacology, §Neurosciences Graduate Group, ∥Division of Biological Sciences, ⊥Biomedical Sciences, and #Howard Hughes Medical Institute, University of California, San Diego , La Jolla, California 92093, United States.

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February 2015

Time for a new vision of doctoring.

Med J Aust 2014 Jul;201(1):63-4

Patients Know Best, London, UK.

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July 2014

Mechanical constraints imposed by 3D cellular geometry and arrangement modulate growth patterns in the Arabidopsis embryo.

Proc Natl Acad Sci U S A 2014 Jun 27;111(23):8685-90. Epub 2014 May 27.

Institute of Plant Sciences, University of Bern, CH-3013 Bern, Switzerland;Max Planck Institute for Plant Breeding Research, 50829 Cologne, Germany

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June 2014

Genetic control of plant development by overriding a geometric division rule.

Dev Cell 2014 Apr 27;29(1):75-87. Epub 2014 Mar 27.

Laboratory of Biochemistry, Wageningen University, Dreijenlaan 3, 6703HA Wageningen, the Netherlands. Electronic address:

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April 2014

Determining immune components necessary for progression of pigment dispersing disease to glaucoma in DBA/2J mice.

BMC Genet 2014 Mar 28;15:42. Epub 2014 Mar 28.

Howard Hughes Medical Institute, The Jackson Laboratory, Bar Harbor, ME, USA.

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March 2014

Phospholipid flippase ATP8A2 is required for normal visual and auditory function and photoreceptor and spiral ganglion cell survival.

J Cell Sci 2014 Mar 10;127(Pt 5):1138-49. Epub 2014 Jan 10.

Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.

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March 2014

Modeling framework for the establishment of the apical-basal embryonic axis in plants.

Curr Biol 2013 Dec 27;23(24):2513-8. Epub 2013 Nov 27.

Department of Plant Systems Biology, Flanders Institute for Biotechnology (VIB) and Department of Plant Biotechnology and Genetics, Ghent University, Technologiepark 927, 9052 Gent, Belgium; Mendel Centre for Genomics and Proteomics of Plants Systems, Central European Institute of Technology (CEITEC), Masaryk University, 625 00 Brno, Czech Republic; Institute of Science and Technology Austria, 3400 Klosterneuburg, Austria. Electronic address:

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December 2013

Mechanical measurements on living plant cells by micro-indentation with cellular force microscopy.

Methods Mol Biol 2014 ;1080:135-46

Department of Comparative Development and Genetics, Max Planck Institute for Plant Breeding Research, Köln, Germany.

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May 2014

Quantifying cell shape and gene expression in the shoot apical meristem using MorphoGraphX.

Methods Mol Biol 2014 ;1080:121-34

Department of Comparative Development and Genetics, Max Planck Institute for Plant Breeding Research, Köln, Germany.

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May 2014

Disruption of centrifugal inhibition to olfactory bulb granule cells impairs olfactory discrimination.

Proc Natl Acad Sci U S A 2013 Sep 19;110(36):14777-82. Epub 2013 Aug 19.

Department of Biology, University of Maryland, College Park, MD 20742, USA.

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September 2013

Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice.

J Neuroinflammation 2013 Jun 27;10:76. Epub 2013 Jun 27.

The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine, USA.

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June 2013

Pharmacology of mammalian olfactory receptors.

Methods Mol Biol 2013 ;1003:203-9

Department of Biology, University of Maryland, College Park, MD, USA.

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September 2013

A bHLH complex controls embryonic vascular tissue establishment and indeterminate growth in Arabidopsis.

Dev Cell 2013 Feb 14;24(4):426-37. Epub 2013 Feb 14.

Laboratory of Biochemistry, Wageningen University, Dreijenlaan 3, 6703HA Wageningen, The Netherlands.

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February 2013

α(1A)-Adrenergic regulation of inhibition in the olfactory bulb.

J Physiol 2013 Apr 24;591(7):1631-43. Epub 2012 Dec 24.

Department of Biology, University of Maryland, College Park, MD 20742, USA.

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April 2013

Measuring the mechanics of morphogenesis.

Curr Opin Plant Biol 2013 Feb 4;16(1):25-32. Epub 2012 Dec 4.

Institute of Plant Sciences, University of Bern, Switzerland.

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February 2013

The pollen tube: a soft shell with a hard core.

Plant J 2013 Feb 10;73(4):617-27. Epub 2012 Dec 10.

Institute of Plant Biology and Zürich-Basel Plant Science Center, University of Zürich, Zollikerstrasse 107, CH 8008, Zürich, Switzerland.

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February 2013

Fascination and isolation: a grounded theory exploration of unusual sensory experiences in adults with Asperger syndrome.

J Autism Dev Disord 2013 Apr;43(4):891-910

Sheffield Health and Social Care NHS Foundation Trust, St Georges Community Hospital, Winter Street, Sheffield, South Yorkshire, S3 7ND, UK.

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April 2013

Mutations in a P-type ATPase gene cause axonal degeneration.

PLoS Genet 2012 9;8(8):e1002853. Epub 2012 Aug 9.

The Jackson Laboratory, Bar Harbor, Maine, United States of America.

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December 2012

Mechanical regulation of auxin-mediated growth.

Curr Biol 2012 Aug 19;22(16):1468-76. Epub 2012 Jul 19.

Institute of Plant Sciences, University of Bern, Altenbergrain 21, CH-3013 Bern, Switzerland.

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August 2012

Pin1-independent leaf initiation in Arabidopsis.

Plant Physiol 2012 Aug 21;159(4):1501-10. Epub 2012 Jun 21.

Institute of Plant Sciences, University of Bern, CH-3013 Bern, Switzerland.

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August 2012

Evolutionary genetics of the human Rh blood group system.

Hum Genet 2012 Jul 25;131(7):1205-16. Epub 2012 Feb 25.

Department of Anthropology, Pennsylvania State University, University Park, PA 16801, USA.

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July 2012

Cellular force microscopy for in vivo measurements of plant tissue mechanics.

Plant Physiol 2012 Apr 21;158(4):1514-22. Epub 2012 Feb 21.

Institute of Plant Sciences, University of Bern, CH-3013 Bern, Switzerland.

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April 2012

Mutations in zebrafish lrp2 result in adult-onset ocular pathogenesis that models myopia and other risk factors for glaucoma.

PLoS Genet 2011 Feb 17;7(2):e1001310. Epub 2011 Feb 17.

Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America.

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February 2011

Cholinergic modulation of neuronal excitability in the accessory olfactory bulb.

J Neurophysiol 2010 Dec 22;104(6):2963-74. Epub 2010 Sep 22.

Dept. of Biology, Bioscience Research Bldg. R-1239, University of Maryland, College Park, MD 20742, USA.

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December 2010

Auxin influx inhibitors 1-NOA, 2-NOA, and CHPAA interfere with membrane dynamics in tobacco cells.

J Exp Bot 2010 Aug 1;61(13):3589-98. Epub 2010 Jul 1.

Institute of Experimental Botany, Academy of Sciences of the Czech Republic, Rozvojová 263, CZ-165 02 Prague 6, Czech Republic.

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August 2010

Control of bud activation by an auxin transport switch.

Proc Natl Acad Sci U S A 2009 Oct 24;106(41):17431-6. Epub 2009 Sep 24.

Department of Computer Science, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada T2N 1N4.

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October 2009

Excitatory actions of noradrenaline and metabotropic glutamate receptor activation in granule cells of the accessory olfactory bulb.

J Neurophysiol 2009 Aug 27;102(2):1103-14. Epub 2009 May 27.

Department of Biology, University of Maryland, College Park, Maryland 20742, USA.

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August 2009

Auxin transport-feedback models of patterning in plants.

Plant Cell Environ 2009 Sep 15;32(9):1258-71. Epub 2009 May 15.

Institute of Plant Sciences, University of Bern, Altenbergrain 21, Bern CH-3013, Switzerland.

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September 2009

The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids.

J Allergy Clin Immunol 2009 Jun 28;123(6):1376-83.e7. Epub 2009 Feb 28.

Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

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June 2009

The aqueous humor outflow pathway of zebrafish.

Invest Ophthalmol Vis Sci 2009 Apr 5;50(4):1515-21. Epub 2008 Dec 5.

Department of Cell Biology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.

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April 2009

Cataracts in transgenic mice caused by a human papillomavirus type 18 E7 oncogene driven by KRT1-14.

Exp Mol Pathol 2008 Oct 6;85(2):77-82. Epub 2008 Aug 6.

John Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA.

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October 2008

Defects in actin dynamics lead to an autoinflammatory condition through the upregulation of CXCL5.

PLoS One 2008 Jul 16;3(7):e2701. Epub 2008 Jul 16.

Department of Medical Genetics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.

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July 2008

Sequence analysis of HSPA1A and HSPA1B in a multi-ethnic study population.

DNA Seq 2007 Feb;18(1):47-53

Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA.

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February 2007