Richard S Hotchkiss

Richard S Hotchkiss

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Richard S Hotchkiss

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Low-dose interleukin-2 reverses behavioral sensitization in multiple mouse models of headache disorders.

Pain 2020 Feb 4. Epub 2020 Feb 4.

Department of Anesthesiology, Washington University Pain Center, Department of Medicine and Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110.

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http://dx.doi.org/10.1097/j.pain.0000000000001818DOI Listing
February 2020

The authors reply.

Crit Care Med 2019 Sep;47(9):e788-e789

Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA Department of Surgery, University of Florida College of Medicine, Gainesville, FL Department of Medicine, The Ohio State University School of Medicine, Columbus, OH Department of Medicine, Emory University School of Medicine, Atlanta, GA Department of Surgery, Emory University School of Medicine, Atlanta, GA University of Florida College of Medicine, Gainesville, FL Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI.

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http://dx.doi.org/10.1097/CCM.0000000000003887DOI Listing
September 2019

What Is the Skinny on Obesity During Sepsis?

Crit Care Med 2019 05;47(5):735-736

Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH Division of Research, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH Department of Anesthesiology, Washington University School of Medicine, St Louis, MO.

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http://dx.doi.org/10.1097/CCM.0000000000003707DOI Listing
May 2019

An Aspirin a Day Keeps the Intensivist Away?

Crit Care Med 2019 04;47(4):603-604

Department of Surgery; and Department of Anesthesia, Washington University School of Medicine, Saint Louis, MO.

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http://Insights.ovid.com/crossref?an=00003246-201904000-0001
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http://dx.doi.org/10.1097/CCM.0000000000003672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424130PMC
April 2019

Immunoadjuvant therapy in sepsis: novel strategies for immunosuppressive sepsis coming down the pike.

Acute Med Surg 2018 Oct 6;5(4):309-315. Epub 2018 Aug 6.

Departments of Anesthesiology, Medicine, and Surgery Washington University School of Medicine St. Louis Missouri.

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http://doi.wiley.com/10.1002/ams2.363
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http://dx.doi.org/10.1002/ams2.363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167396PMC
October 2018

Host-directed therapies for bacterial and viral infections.

Nat Rev Drug Discov 2018 01 22;17(1):35-56. Epub 2017 Sep 22.

Department of Infectious Diseases, Molecular Virology, Heidelberg University, Im Neuenheimer Feld 345, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1038/nrd.2017.162DOI Listing
January 2018

Deep Immune Profiling in Trauma and Sepsis: Flow Is the Way to Go!

Crit Care Med 2017 09;45(9):1577-1578

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University Medical Center, Stanford, CA Department of Anesthesiology, Washington University of St. Louis, St. Louis, MO.

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http://dx.doi.org/10.1097/CCM.0000000000002594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294342PMC
September 2017

A Quasi-Experimental, Before-After Trial Examining the Impact of an Emergency Department Mechanical Ventilator Protocol on Clinical Outcomes and Lung-Protective Ventilation in Acute Respiratory Distress Syndrome.

Crit Care Med 2017 Apr;45(4):645-652

1Departments of Emergency Medicine and Anesthesiology, Division of Critical Care, Washington University School of Medicine in St. Louis, St. Louis, MO.2School of Medicine and Medical Science, University College Dublin, Dublin, Ireland.3Division of Critical Care, Departments of Emergency Medicine and Anesthesiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA.4Division of Critical Care Medicine, Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO.5Washington University School of Medicine, St. Louis, MO.6School of Public Health and Social Justice, Saint Louis University, St. Louis, MO.7Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St. Louis, MO.

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http://Insights.ovid.com/crossref?an=00003246-201704000-0001
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http://dx.doi.org/10.1097/CCM.0000000000002268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350028PMC
April 2017

Widespread Down-Regulation of Cardiac Mitochondrial and Sarcomeric Genes in Patients With Sepsis.

Crit Care Med 2017 03;45(3):407-414

1Center for Pharmacogenomics, John T. Milliken Department of Medicine, Washington University School of Medicine, St. Louis, MO. 2Center for Cardiovascular Research, Cardiovascular Division, John T. Milliken Department of Medicine, Washington University School of Medicine, St. Louis, MO. 3Division of Cardiovascular Medicine, Sulpizio Cardiovascular Center, University of California, San Diego, CA. 4Department of Biomedical Engineering, George Washington University, Washington, DC. 5Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO.

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http://dx.doi.org/10.1097/CCM.0000000000002207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315660PMC
March 2017

Interleukin 7 immunotherapy improves host immunity and survival in a two-hit model of Pseudomonas aeruginosa pneumonia.

J Leukoc Biol 2017 02 14;101(2):543-554. Epub 2016 Sep 14.

Anesthesiology, Medicine, Surgery, and Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1189/jlb.4A1215-581RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5235902PMC
February 2017

Anti-PD-L1 peptide improves survival in sepsis.

J Surg Res 2017 02 8;208:33-39. Epub 2016 Sep 8.

Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri; Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; Department of Surgery, Washington University School of Medicine, St. Louis, Missouri; Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, Missouri. Electronic address:

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http://dx.doi.org/10.1016/j.jss.2016.08.099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535083PMC
February 2017

Sepsis: Preventing organ failure in sepsis - the search continues.

Nat Rev Nephrol 2017 01 21;13(1):5-6. Epub 2016 Nov 21.

Departments of Anesthesiology, Medicine, and Surgery, Washington University School of Medicine, Campus Box 8054, 660 South Euclid, St. Louis, Missouri 63110, USA.

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http://www.nature.com/articles/nrneph.2016.171
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http://dx.doi.org/10.1038/nrneph.2016.171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523107PMC
January 2017

Desperate Times Call for Desperate Measures: Self-Cannibalism Is Protective During Sepsis.

Crit Care Med 2017 01;45(1):145-147

Division of Pulmonary Critical Care and Sleep Medicine The Ohio State University Wexner Medical Center Columbus, OH Department of Anesthesiology Washington University in St Louis St Louis, MO.

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http://dx.doi.org/10.1097/CCM.0000000000002106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538254PMC
January 2017

Nivolumab plus interferon-γ in the treatment of intractable mucormycosis.

Lancet Infect Dis 2017 01;17(1):18

Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(16)30541-2DOI Listing
January 2017

Chemical chaperone TUDCA prevents apoptosis and improves survival during polymicrobial sepsis in mice.

Sci Rep 2016 10 3;6:34702. Epub 2016 Oct 3.

Department of Biochemistry and Genetics, La Trobe Institute of Molecular Science, La Trobe University, Kingsbury Dr. Victoria 3086, Australia.

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http://dx.doi.org/10.1038/srep34702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046154PMC
October 2016

Is this critically ill patient immunocompromised?

Intensive Care Med 2016 Jun 2;42(6):1051-4. Epub 2015 Dec 2.

Departments of Anesthesiology, Medicine, and Surgery, Washington University School of Medicine, 660 South Euclid, St Louis, MO, 63110, USA.

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http://dx.doi.org/10.1007/s00134-015-4161-yDOI Listing
June 2016

Erratum to: Is this critically ill patient immunocompromised?

Intensive Care Med 2016 Jun;42(6):1106

Departments of Anesthesiology, Medicine, and Surgery, Washington University School of Medicine, 660 South Euclid, St Louis, MO, 63110, USA.

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http://dx.doi.org/10.1007/s00134-016-4232-8DOI Listing
June 2016

Sepsis and septic shock.

Nat Rev Dis Primers 2016 Jun 30;2:16045. Epub 2016 Jun 30.

Department of Intensive Care, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium.

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http://dx.doi.org/10.1038/nrdp.2016.45DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538252PMC
June 2016

Tolerance and Cross-Tolerance following Toll-Like Receptor (TLR)-4 and -9 Activation Are Mediated by IRAK-M and Modulated by IL-7 in Murine Splenocytes.

PLoS One 2015 28;10(7):e0132921. Epub 2015 Jul 28.

Dorothy M. Davis Heart and Lung Research Institute, Division of Pulmonary Allergy, Critical Care, and Sleep Medicine, Wexner Medical Center, Columbus, OH, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132921PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517781PMC
April 2016

Understanding why clinicians should care about danger-associated molecular patterns.

Intensive Care Med 2016 Apr 24;42(4):611-614. Epub 2016 Feb 24.

Immunology Department, Hôpital Edouard Herriot , Hospices Civils de Lyon, 69003, Lyon, France.

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http://dx.doi.org/10.1007/s00134-015-4198-yDOI Listing
April 2016

Lung-protective ventilation initiated in the emergency department (LOV-ED): a study protocol for a quasi-experimental, before-after trial aimed at reducing pulmonary complications.

BMJ Open 2016 Apr 11;6(4):e010991. Epub 2016 Apr 11.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1136/bmjopen-2015-010991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838728PMC
April 2016

Epidemiology of Bloodstream Infections in a Multicenter Retrospective Cohort of Liver Transplant Recipients.

Transplant Direct 2016 Mar 22;2(3):e67. Epub 2016 Feb 22.

Section of Infectious Diseases, Department of Internal Medicine, Rush University Medical Center, Chicago, IL.; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO.

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http://dx.doi.org/10.1097/TXD.0000000000000573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946508PMC
March 2016

T cells from patients with Candida sepsis display a suppressive immunophenotype.

Crit Care 2016 Jan 20;20:15. Epub 2016 Jan 20.

Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1186/s13054-016-1182-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719210PMC
January 2016

Imaging Apoptosis in Sepsis--A Technology We Would Die for!

Crit Care Med 2015 Nov;43(11):2506-8

Departments of Anesthesiology, Medicine, and Surgery, Washington University School of Medicine, St Louis, MO Department of Medicine, Ohio State University Medical College, Columbus, OH.

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http://dx.doi.org/10.1097/CCM.0000000000001289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837329PMC
November 2015

The authors reply.

Crit Care Med 2015 Nov;43(11):e529-30

Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, and Department of Emergency Medicine, Washington University School of Medicine, St. Louis, MO Department of Pharmacy, Barnes-Jewish Hospital, St. Louis, MO Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, and Department of Surgery, Washington University School of Medicine, St. Louis, MO.

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http://dx.doi.org/10.1097/CCM.0000000000001235DOI Listing
November 2015

The presence of hypothermia within 24 hours of sepsis diagnosis predicts persistent lymphopenia.

Crit Care Med 2015 Jun;43(6):1165-9

1Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO. 2Department of Emergency Medicine, Washington University School of Medicine, St. Louis, MO. 3Department of Pharmacy, Barnes-Jewish Hospital, St. Louis, MO. 4Department of Surgery, Washington University School of Medicine, St. Louis, MO.

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http://dx.doi.org/10.1097/CCM.0000000000000940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700928PMC
June 2015

Sepsis: Revising definitions of sepsis.

Nat Rev Nephrol 2015 Jun 28;11(6):326-8. Epub 2015 Apr 28.

Department of Anaesthesiology, Department of Surgery, Washington University School of Medicine, 660 South Euclid, Saint Louis, MO 63110, USA.

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http://dx.doi.org/10.1038/nrneph.2015.66DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673399PMC
June 2015

Interleukin-7 and anti-programmed cell death 1 antibody have differing effects to reverse sepsis-induced immunosuppression.

Shock 2015 Apr;43(4):334-43

*Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; †Institute for Advanced Research, Nagoya University, Nagoya, Japan; ‡Departments of Anesthesiology, §Pathology and Immunology and Pediatrics, and ∥Anesthesiology, Medicine, and Surgery, Washington University School of Medicine, St. Louis, Missouri.

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http://dx.doi.org/10.1097/SHK.0000000000000317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359667PMC
April 2015

Immunology. Getting sepsis therapy right.

Science 2015 Mar;347(6227):1201-2

Department of Anesthesiology and Pathology, Microbiology and Immunology. Vanderbilt University School of Medicine, Nashville, TN, USA.

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http://dx.doi.org/10.1126/science.aaa8334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398343PMC
March 2015

Persistent lymphopenia after diagnosis of sepsis predicts mortality.

Shock 2014 Nov;42(5):383-91

Departments of *Anesthesiology and †Surgery, Washington University School of Medicine; ‡Department of Pharmacy, Barnes-Jewish Hospital; and §Department of Emergency Medicine, Washington University School of Medicine, St Louis, Missouri.

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http://dx.doi.org/10.1097/SHK.0000000000000234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362626PMC
November 2014

Probiotics for preventing ventilator-associated pneumonia.

Cochrane Database Syst Rev 2014 Oct 25(10):CD009066. Epub 2014 Oct 25.

Department of Anaesthesiology and Intensive Care Medicine, Changhai Hospital, Second Military Medical University, 14th Floor, 168 Changhai Rd, Shanghai, China, 200433.

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http://dx.doi.org/10.1002/14651858.CD009066.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283465PMC
October 2014

Parallels between cancer and infectious disease.

N Engl J Med 2014 Jul;371(4):380-3

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http://dx.doi.org/10.1056/NEJMcibr1404664DOI Listing
July 2014

Abandon the mouse research ship? Not just yet!

Shock 2014 Jun;41(6):463-75

*Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the AUVA Research Center, Vienna, Austria; †Boston University School of Medicine and ‡Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; §Pennsylvania State College of Medicine, Hershey, Pennsylvania; ∥Oslo University Hospital, Oslo, Norway; ¶Ehime University, Matsuyama, Japan; **Research and Education Institute, Hospital Sirio-Libanes, São Paulo, Brazil; ††Institute of Surgical Research, University of Szeged, Szeged, Hungary; ‡‡State University of New York Upstate Medical University, Syracuse, New York; §§Department of Biological and Environmental Sciences, University of Messina, Messina, Italy; ∥∥Southern Medical University Guangzhou, Guangzhou, China; ¶¶Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts; ***Chiba University Graduate School of Medicine, Chiba, Japan; †††Washington University School of Medicine, St Louis, Missouri; ‡‡‡University of Kentucky College of Medicine, Lexington, Kentucky; §§§Ulm Medical University Clinic, Ulm, Germany; ∥∥∥Division of Infectious Diseases, Department of Medicine, Hospital São Paulo-Escola Paulista de Medicina, Federal University of São Paulo, Sao Paulo, Brazil; ¶¶¶University of Indonesia, Jakarta, Indonesia;****The William Harvey Research Institute, Queen Mary University of London, London, United Kingdom; ††††University of Brussels, Erasme University Hospital, Brussels, Belgium; ‡‡‡‡The University of Michigan Medical School, Ann Arbor, Michigan; §§§§Burns Institute, First Hospital Affiliated to the Chinese PLA General Hospital, Beijing, China; ∥∥∥∥Chang Gung Memorial Hospital, Taipei, Taiwan; ¶¶¶¶Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; and *****University of Alabama at Birmingham, Birmingham, Alabama.

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http://dx.doi.org/10.1097/SHK.0000000000000153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139038PMC
June 2014

Reducing the burden of acute respiratory distress syndrome: the case for early intervention and the potential role of the emergency department.

Shock 2014 May;41(5):378-87

*Divisions of Critical Care and Emergency Medicine, Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri; †Departments of Emergency Medicine and Anesthesiology, Division of Critical Care Roy J. and Lucille A. Carver College of Medicine, University of Iowa; ‡Division of Critical Care, Department of Anesthesiology, and §Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St Louis, Missouri.

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http://dx.doi.org/10.1097/SHK.0000000000000142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108587PMC
May 2014

The new normal: immunomodulatory agents against sepsis immune suppression.

Trends Mol Med 2014 Apr 30;20(4):224-33. Epub 2014 Jan 30.

Division of Surgical Research, Rhode Island Hospital, Providence, RI 02903, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2014.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976785PMC
April 2014

The changing immune system in sepsis: is individualized immuno-modulatory therapy the answer?

Virulence 2014 Jan 25;5(1):45-56. Epub 2013 Sep 25.

Department of Anesthesiology, Medicine, and Surgery; Washington University School of Medicine; St. Louis, MO USA.

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http://dx.doi.org/10.4161/viru.26516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916383PMC
January 2014

Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy.

Nat Rev Immunol 2013 Dec 15;13(12):862-74. Epub 2013 Nov 15.

Department of Anesthesiology, Medicine, and Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA.

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http://www.nature.com/articles/nri3552
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http://dx.doi.org/10.1038/nri3552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077177PMC
December 2013

Sepsis-induced disseminated intravascular coagulation, symmetrical peripheral gangrene, and amputations.

Crit Care Med 2013 Oct;41(10):e290-1

Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO Department of Anesthesiology, Duke University Medical Center, Durham, NC Department of Medicine, University of Amsterdam, Academic Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1097/CCM.0b013e31828cef48DOI Listing
October 2013

Rebuttal From Drs Drewry and Hotchkiss.

Chest 2013 Oct 12;144(4):1102-1103. Epub 2013 Oct 12.

Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO; Department of Surgery, Washington University School of Medicine, St. Louis, MO; Department of Medicine, Washington University School of Medicine, St. Louis, MO.

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http://dx.doi.org/10.1378/chest.13-0919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787913PMC
October 2013

Counterpoint: Should antipyretic therapy be given routinely to febrile patients in septic shock? No.

Chest 2013 Oct;144(4):1098-1101

Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO; Department of Surgery, Washington University School of Medicine, St. Louis, MO; Department of Medicine, Washington University School of Medicine, St. Louis, MO.

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http://dx.doi.org/10.1378/chest.13-0918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787912PMC
October 2013

Reply: The role of arrhythmias in defining cardiac dysfunction during sepsis.

Am J Respir Crit Care Med 2013 Sep;188(6):751

1 Washington University School of Medicine St. Louis, Missouri.

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http://dx.doi.org/10.1164/rccm.201303-0548LEDOI Listing
September 2013

TLR3 agonist improves survival to secondary pneumonia in a double injury model.

J Surg Res 2013 Jun 11;182(2):270-6. Epub 2012 Oct 11.

Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1016/j.jss.2012.09.039DOI Listing
June 2013

Mechanisms of cardiac and renal dysfunction in patients dying of sepsis.

Am J Respir Crit Care Med 2013 Mar 24;187(5):509-17. Epub 2013 Jan 24.

Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1164/rccm.201211-1983OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733408PMC
March 2013

Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach.

Lancet Infect Dis 2013 Mar;13(3):260-8

Department of Anesthesiology, Medicine, and Surgery; Washington University School of Medicine, St Louis, MO, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S14733099137000
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http://dx.doi.org/10.1016/S1473-3099(13)70001-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798159PMC
March 2013

Development of a new humanized mouse model to study acute inflammatory arthritis.

J Transl Med 2012 Sep 13;10:190. Epub 2012 Sep 13.

Department of Medicine/Rheumatology, Northwestern University, Feinberg School of Medicine, 240 East Huron Street, Room Chicago, IL 60611, USA.

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http://dx.doi.org/10.1186/1479-5876-10-190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480927PMC
September 2012

Interleukin-7 ameliorates immune dysfunction and improves survival in a 2-hit model of fungal sepsis.

J Infect Dis 2012 Aug 12;206(4):606-16. Epub 2012 Jun 12.

Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1093/infdis/jis383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491749PMC
August 2012

The first step in utilizing immune-modulating therapies: immune status determination.

Crit Care 2011 24;15(1):108. Epub 2011 Jan 24.

Division of Research, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0558, USA.

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http://ccforum.biomedcentral.com/articles/10.1186/cc9397
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http://dx.doi.org/10.1186/cc9397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222027PMC
May 2012

Radiolabeled isatin binding to caspase-3 activation induced by anti-Fas antibody.

Nucl Med Biol 2012 Jan 26;39(1):137-44. Epub 2011 Oct 26.

Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.nucmedbio.2011.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253226PMC
January 2012

Advances in the management of sepsis and the understanding of key immunologic defects.

Anesthesiology 2011 Dec;115(6):1349-62

Barnes Jewish Hospital, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1097/ALN.0b013e31823422e8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433833PMC
December 2011

Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site.

Nat Commun 2011 Jul 5;2:380. Epub 2011 Jul 5.

Division of Radiological Sciences, Department of Radiology, Mail Box 8225, Washington University School of Medicine, 510 S. Kingshighway Boulevard, St Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1038/ncomms1386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624020PMC
July 2011

CD4+ lymphocyte adenosine triphosphate determination in sepsis: a cohort study.

Crit Care 2010 11;14(3):R110. Epub 2010 Jun 11.

Department of Medicine, Washington University in St, Louis School of Medicine, 660 South Euclid, Campus Box 8052, St Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1186/cc9059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911756PMC
January 2011

Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis.

J Leukoc Biol 2010 Aug 18;88(2):233-40. Epub 2010 May 18.

Department of Surgery, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, USA.

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http://doi.wiley.com/10.1189/jlb.0110037
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607999PMC
August 2010

A genetically encoded multifunctional TRAIL trimer facilitates cell-specific targeting and tumor cell killing.

Mol Cancer Ther 2010 Jul 22;9(7):2142-51. Epub 2010 Jun 22.

Department of Surgery, Washington University School of Medicine, and Siteman Cancer Center, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-10-0225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947203PMC
July 2010

Immunotherapy for sepsis--a new approach against an ancient foe.

N Engl J Med 2010 Jul;363(1):87-9

Department of Anesthesiology, Washington University School of Medicine, St. Louis, USA.

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http://dx.doi.org/10.1056/NEJMcibr1004371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136660PMC
July 2010

Characterization and modulation of the immunosuppressive phase of sepsis.

Infect Immun 2010 Apr 25;78(4):1582-92. Epub 2010 Jan 25.

Department of Pediatrics, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA.

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http://iai.asm.org/cgi/doi/10.1128/IAI.01213-09
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849407PMC
April 2010

Mechanisms and consequences of ebolavirus-induced lymphocyte apoptosis.

J Immunol 2010 Jan;184(1):327-35

United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.0901231
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January 2010

Cell death.

N Engl J Med 2009 Oct;361(16):1570-83

Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1056/NEJMra0901217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760419PMC
October 2009

Leukocyte phenotyping to stratify septic shock patients.

Crit Care 2009 3;13(2):127. Epub 2009 Apr 3.

Department of Anesthesiology, Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, MI 63110, USA.

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http://dx.doi.org/10.1186/cc7748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689472PMC
September 2009

Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice.

J Leukoc Biol 2009 Aug 15;86(2):219-27. Epub 2009 Apr 15.

Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1189/jlb.1008615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726769PMC
August 2009

The sepsis seesaw: tilting toward immunosuppression.

Nat Med 2009 May;15(5):496-7

Departments of Anesthesiology, Medicine and Surgery, St. Louis, Missouri 63110, USA.

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http://www.nature.com/articles/nm0509-496
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786779PMC
May 2009

Differential lymphopenia-induced homeostatic proliferation for CD4+ and CD8+ T cells following septic injury.

J Leukoc Biol 2009 Mar 30;85(3):382-90. Epub 2008 Dec 30.

Washington University School of Medicine, 660 S. Euclid, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1189/jlb.0808491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653946PMC
March 2009

Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma.

J Transl Med 2009 Mar 26;7:24. Epub 2009 Mar 26.

Department of Surgery, Washington University School of Medicine, 660 S, Euclid Avenue, Campus Box 8109, St, Louis, MO 63110, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669042PMC
March 2009