Richard P Hill

Richard P Hill

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Richard P Hill

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Quantifying Reoxygenation in Pancreatic Cancer During Stereotactic Body Radiotherapy.

Sci Rep 2020 Jan 31;10(1):1638. Epub 2020 Jan 31.

Ontario Cancer Institute, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada.

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http://dx.doi.org/10.1038/s41598-019-57364-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994660PMC
January 2020

Intratumoral heterogeneity and hypoxia gene expression signatures: Is a single biopsy adequate?

Clin Transl Radiat Oncol 2019 Nov 3;19:110-115. Epub 2019 Oct 3.

Princess Margaret Cancer Centre, 610 University Ave, Toronto, Ontario M5G 2M9, Canada.

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http://dx.doi.org/10.1016/j.ctro.2019.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804682PMC
November 2019

Peggy Louise Olive.

Radiat Res 2019 04;191(4):380-381

Department of Integrative Oncology, Radiation Biology Unit, British Columbia Cancer Agency Research Centre, Vancouver, BC, Canada.

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April 2019

Letter to the Editor. Multiple sclerosis-related tremor and stereotactic radiosurgery.

J Neurosurg 2018 10;130(1):331-332

2Osage Beach, MO.

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http://dx.doi.org/10.3171/2018.7.JNS182088DOI Listing
October 2018

The Exploitation of Low-Energy Electrons in Cancer Treatment.

Radiat Res 2017 08 30;188(2):123-143. Epub 2017 May 30.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Ontario Cancer Institute and Campbell Family Institute for Cancer Research and Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1667/RR14727.1DOI Listing
August 2017

Cancer Stem Cells.

Recent Results Cancer Res 2016;198:25-44

Princess Margaret Cancer Centre, Ontario Cancer Insitute, Toronto, ON, M5G 2M9, Canada.

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http://dx.doi.org/10.1007/978-3-662-49651-0_2DOI Listing
July 2017

Plerixafor Improves Primary Tumor Response and Reduces Metastases in Cervical Cancer Treated with Radio-Chemotherapy.

Clin Cancer Res 2017 Mar 3;23(5):1242-1249. Epub 2016 Oct 3.

Radiation Medicine Program, University Health Network and Princess Margaret Cancer Centre, Toronto, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-1730DOI Listing
March 2017

The changing paradigm of tumour response to irradiation.

Authors:
Richard P Hill

Br J Radiol 2017 Jan 2;90(1069):20160474. Epub 2016 Aug 2.

1 Ontario Cancer Institute, Princess Margaret Cancer Centre, Toronto, ON, Canada.

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http://dx.doi.org/10.1259/bjr.20160474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605022PMC
January 2017

Hedgehog inhibition enhances efficacy of radiation and cisplatin in orthotopic cervical cancer xenografts.

Br J Cancer 2017 01 22;116(1):50-57. Epub 2016 Nov 22.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario MG5 2M9, Canada.

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http://dx.doi.org/10.1038/bjc.2016.383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220149PMC
January 2017

Targeting hypoxic microenvironment of pancreatic xenografts with the hypoxia-activated prodrug TH-302.

Oncotarget 2016 Jun;7(23):33571-80

Ontario Cancer Institute and Campbell Family Cancer Research Institute, Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.18632/oncotarget.9654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085103PMC
June 2016

Role of Autophagy as a Survival Mechanism for Hypoxic Cells in Tumors.

Neoplasia 2016 06;18(6):347-55

Department of Medical Biophysics, University health Network, University of Toronto, Toronto, ON, Canada; Division of Medical Oncology and Hematology, Princess Margaret Hospital and University Health Network, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2016.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909700PMC
June 2016

Developing a prognostic micro-RNA signature for human cervical carcinoma.

PLoS One 2015 16;10(4):e0123946. Epub 2015 Apr 16.

Ontario Cancer Institute, University Health Network, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Department of Radiation Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123946PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399941PMC
May 2016

Sorafenib Increases Tumor Hypoxia in Cervical Cancer Patients Treated With Radiation Therapy: Results of a Phase 1 Clinical Study.

Int J Radiat Oncol Biol Phys 2016 Jan 18;94(1):111-117. Epub 2015 Sep 18.

Department of Medical Oncology, Princess Margaret Cancer Center, University Health Network, Toronto, Canada; Department of Medicine, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.ijrobp.2015.09.009DOI Listing
January 2016

Hypoxia and Predicting Radiation Response.

Semin Radiat Oncol 2015 Oct 15;25(4):260-72. Epub 2015 May 15.

Ontario Cancer Institute and Campbell Family Institute for Cancer Research, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.semradonc.2015.05.004DOI Listing
October 2015

Cyclic hypoxia does not alter RAD51 expression or PARP inhibitor cell kill in tumor cells.

Radiother Oncol 2015 Sep 2;116(3):388-91. Epub 2015 Apr 2.

Ontario Cancer Institute, Princess Margaret Cancer Centre (University Health Network), Canada; Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2015.03.027DOI Listing
September 2015

Establishment of orthotopic primary cervix cancer xenografts.

Methods Mol Biol 2015 ;1249:381-91

Ontario Cancer Institute and Campbell Family Institute for Cancer Research, Princess Margaret Cancer Centre and University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/978-1-4939-2013-6_28DOI Listing
June 2015

Single-cell measurement of the uptake, intratumoral distribution and cell cycle effects of cisplatin using mass cytometry.

Int J Cancer 2015 Mar 16;136(5):1202-9. Epub 2014 Jul 16.

Ontario Cancer Institute/Princess Margaret Hospital, University of Toronto, Canada.

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http://dx.doi.org/10.1002/ijc.29074DOI Listing
March 2015

Proteolysis during tumor cell extravasation in vitro: metalloproteinase involvement across tumor cell types.

PLoS One 2013 23;8(10):e78413. Epub 2013 Oct 23.

Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Ontario, Canada ; Department of Biology, Dominican College, Orangeburg, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078413PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806793PMC
February 2015

The microRNA-218~Survivin axis regulates migration, invasion, and lymph node metastasis in cervical cancer.

Oncotarget 2015 Jan;6(2):1090-100

Ontario Cancer Institute, University Health Network (UHN), Toronto, Ontario, Canada.Department of Medical Biophysics, University of Toronto, Toronto, Canada.Department of Radiation Oncology, University of Toronto, Toronto, Canada.Department of Radiation Oncology, Princess Margaret Cancer Centre, UHN, Toronto, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359219PMC
http://dx.doi.org/10.18632/oncotarget.2836DOI Listing
January 2015

High tumor interstitial fluid pressure identifies cervical cancer patients with improved survival from radiotherapy plus cisplatin versus radiotherapy alone.

Int J Cancer 2014 Oct 25;135(7):1692-9. Epub 2014 Apr 25.

Radiation Medicine Program, Princess Margaret Cancer Center, University Health Network, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1002/ijc.28403DOI Listing
October 2014

Hypoxia as a biomarker for radioresistant cancer stem cells.

Int J Radiat Biol 2014 Aug 25;90(8):636-52. Epub 2014 Jun 25.

OncoRay - National Center for Radiation Research in Oncology at the Medical Faculty Carl Gustav Carus, Technische Universität Dresden and Helmholtz Zentrum Dresden Rossendorf , Germany.

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http://dx.doi.org/10.3109/09553002.2014.916841DOI Listing
August 2014

VEGF regulates region-specific localization of perivascular bone marrow-derived cells in glioblastoma.

Cancer Res 2014 Jul 12;74(14):3727-39. Epub 2014 May 12.

Authors' Affiliations: Department of Cell Biology, The Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children; Division of Neurosurgery, Toronto Western Hospital, Toronto, Ontario, Canada

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http://dx.doi.org/10.1158/0008-5472.CAN-13-3119DOI Listing
July 2014

Targeting the Renin-angiotensin system combined with an antioxidant is highly effective in mitigating radiation-induced lung damage.

Int J Radiat Oncol Biol Phys 2014 Jul 24;89(4):722-8. Epub 2014 May 24.

Ontario Cancer Institute and the Campbell Family Institute for Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Departments of Medical Biophysics and Radiation Oncology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03603016140041
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http://dx.doi.org/10.1016/j.ijrobp.2014.03.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146496PMC
July 2014

Hypoxic activation of the PERK/eIF2α arm of the unfolded protein response promotes metastasis through induction of LAMP3.

Clin Cancer Res 2013 Nov 17;19(22):6126-37. Epub 2013 Sep 17.

Authors' Affiliations: Ontario Cancer Institute and Campbell Family Institute for Cancer Research, Princess Margaret Cancer Centre, University Health Network; Departments of Laboratory Medicine and Pathobiology, Radiation Oncology, and Medical Biophysics; Radiation Medicine Program, Department of Biostatistics, Princess Margaret Cancer Centre, Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Maastricht Radiation Oncology (MaastRO) Lab, GROW - School for Oncology and Developmental Biology, Maastricht University, Maastricht; and Departments of Radiation Oncology and Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0526DOI Listing
November 2013

Hypoxia and metastasis in an orthotopic cervix cancer xenograft model.

Radiother Oncol 2013 Sep 12;108(3):506-10. Epub 2013 Jul 12.

Ontario Cancer Institute/Princess Margaret Cancer Centre and The Campbell Family Institute for Cancer Research, Toronto, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S01678140130029
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http://dx.doi.org/10.1016/j.radonc.2013.06.019DOI Listing
September 2013

Investigations of antioxidant-mediated protection and mitigation of radiation-induced DNA damage and lipid peroxidation in murine skin.

Int J Radiat Biol 2013 Aug 23;89(8):618-27. Epub 2013 Apr 23.

Ontario Cancer Institute, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.3109/09553002.2013.782450DOI Listing
August 2013

Tumor-stroma interaction in orthotopic primary pancreatic cancer xenografts during hedgehog pathway inhibition.

Int J Cancer 2013 Jul 5;133(1):225-34. Epub 2013 Feb 5.

Ontario Cancer Institute/Princess Margaret Hospital, ON, Canada.

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http://dx.doi.org/10.1002/ijc.28006DOI Listing
July 2013

Effects of lipopolysaccharide on the response of C57BL/6J mice to whole thorax irradiation.

Radiother Oncol 2012 Dec 14;105(3):341-9. Epub 2012 Sep 14.

Ontario Cancer Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.radonc.2012.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632095PMC
December 2012

High-resolution in-vivo analysis of normal brain response to cranial irradiation.

PLoS One 2012 4;7(6):e38366. Epub 2012 Jun 4.

Brain Tumor Research Centre, SickKids Research Institute, Toronto, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0038366PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366930PMC
October 2012

Characterization of the Tumor-Microenvironment in Patient-Derived Cervix Xenografts (OCICx).

Cancers (Basel) 2012 Aug 29;4(3):821-45. Epub 2012 Aug 29.

Ontario Cancer Institute/Princess Margaret Cancer Centre and Campbell Family Institute for Cancer Research, University Health Network, Toronto, Ontario M5G 2M9, Canada.

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http://dx.doi.org/10.3390/cancers4030821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712708PMC
August 2012

Hedgehog pathway signaling in cervical carcinoma and outcome after chemoradiation.

Cancer 2012 Jun 25;118(12):3105-15. Epub 2011 Oct 25.

Ontario Cancer Institute/Princess Margaret Hospital and The Campbell Family Institute for Cancer Research, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cncr.26635DOI Listing
June 2012

Tumor hypoxia predicts biochemical failure following radiotherapy for clinically localized prostate cancer.

Clin Cancer Res 2012 Apr 31;18(7):2108-14. Epub 2012 Mar 31.

Radiation Medicine Program, Princess Margaret Hospital and Ontario Cancer Institute, University Health Network, 610 University Avenue, Toronto, ON, Canada M5G 2M9.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-2711DOI Listing
April 2012

Radiation Resistance in Cancer Therapy: meeting summary and research opportunities. Report of an NCI Workshop held September 1-3, 2010.

Radiat Res 2011 Sep 8;176(3):e0016-21. Epub 2011 Jul 8.

Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA.

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September 2011

Mitigation of radiation-induced lung injury by genistein and EUK-207.

Int J Radiat Biol 2011 Aug 15;87(8):889-901. Epub 2011 Jun 15.

Ontario Cancer Institute/Princess Margaret Hospital, University Health Network, and the Campbell Family Institute for Cancer Research, Toronto, Ontario, Canada.

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http://dx.doi.org/10.3109/09553002.2011.583315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155801PMC
August 2011

Biodosimetry using radiation-induced micronuclei in skin fibroblasts.

Int J Radiat Biol 2011 Aug;87(8):824-38

Ontario Cancer Institute/Princess Margaret Hospital, University Health Network and Campbell Family Institute for Cancer Research, Toronto, Ontario, Canada.

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http://dx.doi.org/10.3109/09553002.2011.582927DOI Listing
August 2011

Orthotopic xenograft model of cervical cancer for studying microenvironmental effects on metastasis formation and response to drug treatment.

Curr Protoc Pharmacol 2011 Jun;Chapter 14:Unit 14.19

Ontario Cancer Institute/Princess Margaret Hospital, Campbell Family Institute for Cancer Research and University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/0471141755.ph1419s53DOI Listing
June 2011

Gold nanoparticles as radiation sensitizers in cancer therapy.

Radiat Res 2010 Jun;173(6):719-28

STTARR Innovation Centre, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1667/RR1984.1DOI Listing
June 2010

Genistein can mitigate the effect of radiation on rat lung tissue.

Radiat Res 2010 May;173(5):602-11

Ontario Cancer Institute/Princess Margaret Hospital, University Health Network, Toronto, Ontario, M5G 2M9, Canada.

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http://dx.doi.org/10.1667/RR1896.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139496PMC
May 2010

Dynamics of micronuclei in mouse skin fibroblasts after gamma irradiation.

Health Phys 2010 Feb;98(2):228-33

Applied Molecular Oncology, Ontario Cancer Institute/Princess Margaret Hospital, 610, University Ave, Toronto, Ontario, Canada, M5G2M9.

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http://dx.doi.org/10.1097/HP.0b013e3181b02f90DOI Listing
February 2010

Late residual gamma-H2AX foci in murine skin are dose responsive and predict radiosensitivity in vivo.

Radiat Res 2010 Jan;173(1):1-9

Applied Molecular Oncology and Radiation Medicine Program, Ontario Cancer Institute/Princess Margaret Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1667/RR1851.1DOI Listing
January 2010

Progression and metastasis in a transgenic mouse breast cancer model: effects of exposure to in vivo hypoxia.

Cancer Lett 2009 Sep 7;282(1):98-108. Epub 2009 Apr 7.

Applied Molecular Oncology Division, Ontario Cancer Institute/Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.canlet.2009.03.009DOI Listing
September 2009

Effects of genistein following fractionated lung irradiation in mice.

Radiother Oncol 2009 Sep 9;92(3):500-10. Epub 2009 May 9.

Ontario Cancer Institute/Princess Margaret Hospital, University Health Network, Toronto, Ont., Canada.

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http://dx.doi.org/10.1016/j.radonc.2009.04.005DOI Listing
September 2009

Increased expression of metastasis-related genes in hypoxic cells sorted from cervical and lymph nodal xenograft tumors.

Lab Invest 2009 May 23;89(5):587-96. Epub 2009 Mar 23.

Division of Applied Molecular Oncology, Ontario Cancer Institute/Princess Margaret Hospital, Toronto, ON, Canada.

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http://www.nature.com/articles/labinvest200916
Publisher Site
http://dx.doi.org/10.1038/labinvest.2009.16DOI Listing
May 2009

Seminars in radiation oncology. Introduction.

Authors:
Richard P Hill

Semin Radiat Oncol 2009 Apr;19(2):69-70

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http://dx.doi.org/10.1016/j.semradonc.2008.12.001DOI Listing
April 2009

Cancer stem cells, hypoxia and metastasis.

Semin Radiat Oncol 2009 Apr;19(2):106-11

Division of Applied Molecular Oncology, Ontario Cancer Institute/Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.semradonc.2008.12.002DOI Listing
April 2009

Heterogeneity and power in clinical biomarker studies.

J Clin Oncol 2009 Mar 9;27(9):1517-21. Epub 2009 Feb 9.

Department of Biostatistics, Radiation Medicine Program, and the Division of Applied Molecular Oncology, Ontario Cancer Institute/Princess Margaret Hospital, University Health Network, Canada.

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http://dx.doi.org/10.1200/JCO.2008.18.7393DOI Listing
March 2009

The tumor microenvironment and metastatic disease.

Clin Exp Metastasis 2009 10;26(1):19-34. Epub 2008 Jun 10.

Applied Molecular Oncology, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, OCI/PMH, Toronto, ON, Canada.

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http://link.springer.com/10.1007/s10585-008-9182-2
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http://dx.doi.org/10.1007/s10585-008-9182-2DOI Listing
February 2009

Activation of Src and Src-associated signaling pathways in relation to hypoxia in human cancer xenograft models.

Int J Cancer 2009 Jan;124(2):280-6

Ontario Cancer Institute, Princess Margaret Hospital, and Department of Laboratory Medicine and Pathology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/ijc.23912DOI Listing
January 2009

Beta-catenin is a mediator of the response of fibroblasts to irradiation.

Am J Pathol 2009 Jan 26;174(1):248-55. Epub 2008 Nov 26.

Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S000294401061283
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http://dx.doi.org/10.2353/ajpath.2009.080576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631337PMC
January 2009

Interstitial fluid pressure in tumors: therapeutic barrier and biomarker of angiogenesis.

Future Oncol 2008 Dec;4(6):793-802

Division of Applied Molecular Oncology, Princess Margaret Hospital/Ontario Cancer Institute, University Health Network, Department of Medical Biophysics, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.2217/14796694.4.6.793DOI Listing
December 2008

Graded hypoxia modulates the invasive potential of HT1080 fibrosarcoma and MDA MB231 carcinoma cells.

Clin Exp Metastasis 2008 10;25(3):253-64. Epub 2008 Jan 10.

Applied Molecular Oncology Division, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s10585-007-9139-xDOI Listing
July 2008

Can sparsely and heterogeneously expressed proteins be detected using tissue microarrays? A simulation study of the hypoxia marker carbonic anhydrase IX (CA IX) in human soft tissue sarcoma.

Pathol Res Pract 2008 3;204(3):175-83. Epub 2008 Jan 3.

Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, 610 University Avenue, Toronto, ON, Canada M5G 2M9.

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http://dx.doi.org/10.1016/j.prp.2007.10.009DOI Listing
May 2008

Low-dose radiation effects on human health with implications to radioprotection and cancer radiotherapy.

Int J Radiat Biol 2008 May;84(5):441-4

United Research Institute for Science and Technology (URIST), Naini, Allahabad, Uttar Pradesh, India and United Institute of Technology, Naini.

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http://dx.doi.org/10.1080/09553000802061293DOI Listing
May 2008

Analysis of the effects of exposure to acute hypoxia on oxidative lesions and tumour progression in a transgenic mouse breast cancer model.

BMC Cancer 2008 May 28;8:151. Epub 2008 May 28.

Applied Molecular Oncology Division, Ontario Cancer Institute/Princess Margaret Hospital, Canada.

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http://dx.doi.org/10.1186/1471-2407-8-151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427038PMC
May 2008

Interstitial permeability and elasticity in human cervix cancer.

Microvasc Res 2008 Apr 3;75(3):381-90. Epub 2007 Dec 3.

Radiation Medicine Program, Princess Margaret Hospital/Ontario Cancer Institute, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1016/j.mvr.2007.11.003DOI Listing
April 2008

Nutlin-3 radiosensitizes hypoxic prostate cancer cells independent of p53.

Mol Cancer Ther 2008 Apr;7(4):993-9

Princess Margaret Hospital (University Health Network), Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9.

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http://dx.doi.org/10.1158/1535-7163.MCT-07-0442DOI Listing
April 2008

PRIMA-1(met) radiosensitizes prostate cancer cells independent of their MTp53-status.

Radiother Oncol 2008 Mar 30;86(3):407-11. Epub 2008 Jan 30.

Princess Margaret Hospital (University Health Network), Toronto, Canada.

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http://dx.doi.org/10.1016/j.radonc.2008.01.001DOI Listing
March 2008

No apoptotic endothelial cells in irradiated intestine: regarding Schuller et al. (Int J Radiat Oncol Biol Phys 2007;68:205-210).

Int J Radiat Oncol Biol Phys 2008 Mar;70(3):801-2; author reply 803

Adlington, Macclesfield, Cheshire, United Kingdom.

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http://dx.doi.org/10.1016/j.ijrobp.2007.07.2395DOI Listing
March 2008

Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability.

Nat Rev Cancer 2008 Mar;8(3):180-92

Departments of Medical Biophysics and Radiation Oncology, University of Toronto and Ontario Cancer Institute and Princess Margaret Hospital (University Health Network), 610 University Avenue, Toronto, Ontario, M5G2M9, Canada.

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http://dx.doi.org/10.1038/nrc2344DOI Listing
March 2008

Cervical cancer regression measured using weekly magnetic resonance imaging during fractionated radiotherapy: radiobiologic modeling and correlation with tumor hypoxia.

Int J Radiat Oncol Biol Phys 2008 Jan 4;70(1):126-33. Epub 2007 Sep 4.

Radiation Medicine Program, Princess Margaret Hospital/Ontario Cancer Institute, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.ijrobp.2007.06.033DOI Listing
January 2008

Interstitial fluid pressure, vascularity and metastasis in ectopic, orthotopic and spontaneous tumours.

BMC Cancer 2008 Jan 7;8. Epub 2008 Jan 7.

Ontario Cancer Institute, Princess Margaret Hospital, University of Toronto, 610 University Ave, Toronto, Ontario, M5G 2M9, Canada.

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http://dx.doi.org/10.1186/1471-2407-8-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2245966PMC
January 2008

Nuclear E-cadherin and VHL immunoreactivity are prognostic indicators of clear-cell renal cell carcinoma.

Lab Invest 2007 Dec 1;87(12):1252-64. Epub 2007 Oct 1.

Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/labinvest.3700684DOI Listing
December 2007

Effect of distributional heterogeneity on the analysis of tumor hypoxia based on carbonic anhydrase IX.

Lab Invest 2007 Dec 1;87(12):1206-17. Epub 2007 Oct 1.

Ontario Cancer Institute, Princess Margaret Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/labinvest.3700680DOI Listing
December 2007

"Destemming" cancer stem cells.

J Natl Cancer Inst 2007 Oct 25;99(19):1435-40. Epub 2007 Sep 25.

Ontario Cancer Institute/Princess Margaret Hospital, University Health Network, and Department of Medical Biophysics, University of Toronto, 610 University Ave, Toronto, Canada M5G2M9.

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http://dx.doi.org/10.1093/jnci/djm136DOI Listing
October 2007

Hypoxia enhances metastatic efficiency in HT1080 fibrosarcoma cells by increasing cell survival in lungs, not cell adhesion and invasion.

Cancer Res 2007 Aug;67(16):7789-97

Research Division, Ontario Cancer Institute/Princess Margaret Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-4221DOI Listing
August 2007

Hypoxia and metastasis in breast cancer.

Breast Dis 2006-2007;26:55-64

Applied Molecular Oncology, Ontario Cancer Institute/Princess Margaret Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.3233/bd-2007-26105DOI Listing
July 2007

Hypoxia-regulated p53 and its effect on radiosensitivity in cancer cells.

Int J Radiat Biol 2007 Jul;83(7):443-56

Research Division, Ontario Cancer Institute/Princess Margaret Hospital, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1080/09553000701373708DOI Listing
July 2007

Studies of the in vivo radiosensitivity of human skin fibroblasts.

Radiother Oncol 2007 Jul 27;84(1):75-83. Epub 2007 Jun 27.

Division of Applied Molecular Oncology, Ontario Cancer Institute/Princess Margaret Hospital, University Ave., Toronto, Ont., Canada M5G 2M9.

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http://dx.doi.org/10.1016/j.radonc.2007.05.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034367PMC
July 2007

Hypoxia and metastasis.

Clin Cancer Res 2007 Apr;13(7):1947-9

Applied Molecular Oncology, Ontario Cancer Institute/Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-2971DOI Listing
April 2007

Long-term performance of interstial fluid pressure and hypoxia as prognostic factors in cervix cancer.

Radiother Oncol 2006 Aug 21;80(2):132-7. Epub 2006 Aug 21.

Department of Radiation Oncology, Princess Margaret Hospital/Ontario Cancer Institute, Canada.

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http://dx.doi.org/10.1016/j.radonc.2006.07.014DOI Listing
August 2006

Partial volume rat lung irradiation: the protective/mitigating effects of Eukarion-189, a superoxide dismutase-catalase mimetic.

Radiother Oncol 2006 May 3;79(2):231-8. Epub 2006 May 3.

Research Division, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ont., Canada.

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http://dx.doi.org/10.1016/j.radonc.2006.03.017DOI Listing
May 2006

Identifying cancer stem cells in solid tumors: case not proven.

Authors:
Richard P Hill

Cancer Res 2006 Feb;66(4):1891-5; discussion 1890

Ontario Cancer Institute, Princess Margaret Hospital, University Health Network and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-3450DOI Listing
February 2006

Partial volume rat lung irradiation: temporal fluctuations of in-field and out-of-field DNA damage and inflammatory cytokines following irradiation.

Int J Radiat Biol 2005 Dec;81(12):887-99

Research Division, Ontario Cancer Institute/Princess Margaret Hospital, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1080/09553000600568002DOI Listing
December 2005

Targeted treatment: insights from studies of osteopontin and hypoxia.

Authors:
Richard P Hill

Lancet Oncol 2005 Oct;6(10):733-4

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http://dx.doi.org/10.1016/S1470-2045(05)70363-6DOI Listing
October 2005

Tumor suppression by the von Hippel-Lindau protein requires phosphorylation of the acidic domain.

J Biol Chem 2005 Jun 11;280(23):22205-11. Epub 2005 Apr 11.

Department of Medical Oncology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M503220200DOI Listing
June 2005

A fluorescent orthotopic model of metastatic cervical carcinoma.

Clin Exp Metastasis 2004 ;21(3):275-81

Experimental Therapeutics Division, Ontario Cancer Institute/Princess Margaret Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1023/b:clin.0000037729.75981.9eDOI Listing
November 2004

Evaluation of clinical utility of BTC-2000 for measuring soft tissue fibrosis.

Int J Radiat Oncol Biol Phys 2004 Sep;60(1):286-94

Research Toronto Rehabilitation Institute, 550 University Avenue, Toronto, Ontario M5G 2A2, Canada.

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http://dx.doi.org/10.1016/j.ijrobp.2004.02.042DOI Listing
September 2004

Clonogenic survival and cytokinesis-blocked binucleation of skin fibroblasts and normal tissue complications in soft tissue sarcoma patients treated with preoperative radiotherapy.

Radiother Oncol 2004 Jul;72(1):103-12

Division of Experimental Therapeutics, Ontario Cancer Institute/Princess Margaret Hospital and Department of Medical Biophysics, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.radonc.2004.03.010DOI Listing
July 2004

Carbonic anhydrase IX as a marker for poor prognosis in soft tissue sarcoma.

Clin Cancer Res 2004 Jul;10(13):4464-71

Ontario Cancer Institute/Princess Margaret Hospital, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-03-0541DOI Listing
July 2004

Hypoxia enhances metastatic efficiency by up-regulating Mdm2 in KHT cells and increasing resistance to apoptosis.

Cancer Res 2004 Jun;64(12):4180-9

Research Division, Ontario Cancer Institute/Princess Margaret Hospital, and Department of Medical Biophysics, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-03-3038DOI Listing
June 2004

pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development.

Mol Cell Biol 2004 Apr;24(8):3251-61

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC381603PMC
http://dx.doi.org/10.1128/mcb.24.8.3251-3261.2004DOI Listing
April 2004