Richard P Allen

Richard P Allen

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Richard P Allen

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Resting-state connectivity and the effects of treatment in restless legs syndrome.

Authors:
Yeong Seon Lee Jeonghun Ku Keun Tae Kim HyukWon Chang Christopher J Earley Richard P Allen Yong Won Cho

Sleep Med 2019 Nov 18;67:33-38. Epub 2019 Nov 18.

Department of Neurology Dongsan Medical Center, Keimyung University School of Medicine, Daegu, South Korea. Electronic address:

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http://dx.doi.org/10.1016/j.sleep.2019.10.014DOI Listing
November 2019

Extracellular vesicles reveal abnormalities in neuronal iron metabolism in restless legs syndrome.

Authors:
Sahil Chawla Seema Gulyani Richard P Allen Christopher J Earley Xu Li Peter Van Zijl Dimitrios Kapogiannis

Sleep 2019 Jul;42(7)

Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD.

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http://dx.doi.org/10.1093/sleep/zsz079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612672PMC
July 2019

New Insights into the Neurobiology of Restless Legs Syndrome.

Authors:
Sergi Ferré Diego García-Borreguero Richard P Allen Christopher J Earley

Neuroscientist 2019 04 26;25(2):113-125. Epub 2018 Jul 26.

3 Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.1177/1073858418791763DOI Listing
April 2019

Validation of the self-administered version of the international Restless Legs Syndrome study group severity rating scale - The sIRLS.

Authors:
Denise Sharon Richard P Allen Pablo Martinez-Martin Arthur S Walters Luigi Ferini Strambi Birgit Högl Lynn Marie Trotti Mark Buchfuhrer John Swieca Richard K Bogan Rochelle Zak Jennifer G Hensley Laurel A Schaefer S Marelli Marco Zucconi Ambra Stefani Evi Holzknecht Victoria Olvera Hailey Meaklim Irena Laska Philip M Becker

Sleep Med 2019 02 29;54:94-100. Epub 2018 Oct 29.

The International Restless Legs Syndrome Study Group, Rochester, MN, USA.

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http://dx.doi.org/10.1016/j.sleep.2018.10.014DOI Listing
February 2019

Reply to: Safety of dopamine agonists for treating restless legs syndrome.

Authors:
Aaro V Salminen Richard P Allen Birgit Högl Yuichi Inoue Wolfgang Oertel John W Winkelman Claudia Trenkwalder Cristina Sampaio Juliane Winkelmann

Mov Disord 2019 01;34(1):150-151

Institute of Neurogenomics, Helmholtz Zentrum München, Munich, Germany.

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http://dx.doi.org/10.1002/mds.27571DOI Listing
January 2019

Reply to: A note on rotigotine for restless legs syndrome after renal transplantation.

Authors:
Aaro V Salminen Richard P Allen Birgit Högl Yuichi Inoue Wolfgang Oertel John W Winkelman Claudia Trenkwalder Cristina Sampaio Juliane Winkelmann

Mov Disord 2019 01;34(1):152-153

Institute of Neurogenomics, Helmholtz Zentrum München, Munich, Germany.

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http://dx.doi.org/10.1002/mds.27570DOI Listing
January 2019

Assessment of change in restless legs syndrome symptoms during the acute drug-withdrawal period.

Authors:
Allan Wang Keyana Foster Patrick Skeba Kasidet Hiranniramol Christopher J Earley Richard P Allen

Sleep Med 2018 12 17;52:80-87. Epub 2018 Aug 17.

Department of Neurology, Johns Hopkins University, Johns Hopkins Bayview Medical Center, Asthma & Allergy Bldg 1B76b, 5501 Hopkins Bayview Blvd, Baltimore, MD, 21224, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S13899457183053
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http://dx.doi.org/10.1016/j.sleep.2018.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289284PMC
December 2018

Connecting clinical aspects to corticomotor excitability in restless legs syndrome: a TMS study.

Authors:
Rachel Marie E Salas Aadi Kalloo Christopher J Earley Pablo Celnik Tiana E Cruz Keyana Foster Gabriela Cantarero Richard P Allen

Sleep Med 2018 09 31;49:105-112. Epub 2018 May 31.

Johns Hopkins Medicine, Department of Neurology, USA.

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http://dx.doi.org/10.1016/j.sleep.2018.05.002DOI Listing
September 2018

Treatment of restless legs syndrome: Evidence-based review and implications for clinical practice (Revised 2017).

Authors:
Juliane Winkelmann Richard P Allen Birgit Högl Yuichi Inoue Wolfgang Oertel Aaro V Salminen John W Winkelman Claudia Trenkwalder Cristina Sampaio

Mov Disord 2018 07 14;33(7):1077-1091. Epub 2018 May 14.

CHDI Foundation, Princeton, Princeton, NJ, USA, and the Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal.

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http://dx.doi.org/10.1002/mds.27260DOI Listing
July 2018

A Novel Sleep Stage Scoring System: Combining Expert-Based Rules with a Decision Tree Classifier.

Authors:
Kristin M Gunnarsdottir Charlene E Gamaldo Rachel M E Salas Joshua B Ewen Richard P Allen Sridevi V Sarma

Conf Proc IEEE Eng Med Biol Soc 2018 07;2018:3240-3243

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http://dx.doi.org/10.1109/EMBC.2018.8513039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6496951PMC
July 2018

Restless legs syndrome is associated with major comorbidities in a population of Danish blood donors.

Authors:
Maria Didriksen Richard P Allen Brendan J Burchell Lise W Thørner Andreas S Rigas Emanuele Di Angelantonio Maria H Nielsen Poul J Jennum Thomas Werge Christian Erikstrup Ole B Pedersen Kaspar Nielsen Mie T Bruun Kristoffer S Burgdorf Erik Sørensen Henrik Ullum

Sleep Med 2018 05 8;45:124-131. Epub 2018 Mar 8.

Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.sleep.2018.02.007DOI Listing
May 2018

TOX3 Variants Are Involved in Restless Legs Syndrome and Parkinson's Disease with Opposite Effects.

Authors:
Sadaf Mohtashami Qin He Jennifer A Ruskey Sirui Zhou Patrick A Dion Richard P Allen Christopher J Earley Edward A Fon Lan Xiong Nicolas Dupre Yves Dauvilliers Guy A Rouleau Ziv Gan-Or

J Mol Neurosci 2018 Mar 5;64(3):341-345. Epub 2018 Feb 5.

Montreal Neurological Institute and Hospital, The Department of Human Genetics, McGill University, 1033 Pine Avenue West, Ludmer Pavilion, room 312, Montreal, QC, H3A 1A1, Canada.

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http://dx.doi.org/10.1007/s12031-018-1031-4DOI Listing
March 2018

Efficacy of ferric carboxymaltose (FCM) 500 mg dose for the treatment of Restless Legs Syndrome.

Authors:
Yong Won Cho Richard P Allen Christopher J Earley

Sleep Med 2018 02 6;42:7-12. Epub 2017 Dec 6.

Department of Neurology, Johns Hopkins University, Hopkins Bayview Medical Center, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.sleep.2017.11.1134DOI Listing
February 2018

Comparison of Subjective Sleep Quality of Long-Term Residents at Low and High Altitudes: SARAHA Study.

Authors:
Ravi Gupta Jan Ulfberg Richard P Allen Deepak Goel

J Clin Sleep Med 2018 01 15;14(1):15-21. Epub 2018 Jan 15.

Sleep Clinic, Himalayan Institute of Medical Sciences, Swami Ram Nagar, Jolly Grant, Dehradun, India.

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http://dx.doi.org/10.5664/jcsm.6870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734886PMC
January 2018

Pivotal Role of Adenosine Neurotransmission in Restless Legs Syndrome.

Authors:
Sergi Ferré César Quiroz Xavier Guitart William Rea Arta Seyedian Estefanía Moreno Verònica Casadó-Anguera Manuel Díaz-Ríos Vicent Casadó Stefan Clemens Richard P Allen Christopher J Earley Diego García-Borreguero

Front Neurosci 2017 8;11:722. Epub 2018 Jan 8.

Sleep Research Institute, Madrid, Spain.

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http://dx.doi.org/10.3389/fnins.2017.00722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766678PMC
January 2018

Diurnal variation of default mode network in patients with restless legs syndrome.

Authors:
Jeonghun Ku Yeong Seon Lee Hyuk Won Chang Christopher J Earley Richard P Allen Yong Won Cho

Sleep Med 2018 01 25;41:1-8. Epub 2017 Oct 25.

Department of Neurology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, South Korea. Electronic address:

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http://dx.doi.org/10.1016/j.sleep.2017.09.031DOI Listing
January 2018

Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an IRLSSG task force report.

Authors:
Richard P Allen Daniel L Picchietti Michael Auerbach Yong Won Cho James R Connor Christopher J Earley Diego Garcia-Borreguero Suresh Kotagal Mauro Manconi William Ondo Jan Ulfberg John W Winkelman

Sleep Med 2018 01 24;41:27-44. Epub 2017 Nov 24.

Departments of Psychiatry and Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.sleep.2017.11.1126DOI Listing
January 2018

Targeting hypersensitive corticostriatal terminals in restless legs syndrome.

Authors:
Gabriel Yepes Xavier Guitart William Rea Amy H Newman Richard P Allen Christopher J Earley César Quiroz Sergi Ferré

Ann Neurol 2017 Dec 7;82(6):951-960. Epub 2017 Dec 7.

Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD.

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http://dx.doi.org/10.1002/ana.25104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739944PMC
December 2017

Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis.

Authors:
Barbara Schormair Chen Zhao Steven Bell Erik Tilch Aaro V Salminen Benno Pütz Yves Dauvilliers Ambra Stefani Birgit Högl Werner Poewe David Kemlink Karel Sonka Cornelius G Bachmann Walter Paulus Claudia Trenkwalder Wolfgang H Oertel Magdolna Hornyak Maris Teder-Laving Andres Metspalu Georgios M Hadjigeorgiou Olli Polo Ingo Fietze Owen A Ross Zbigniew Wszolek Adam S Butterworth Nicole Soranzo Willem H Ouwehand David J Roberts John Danesh Richard P Allen Christopher J Earley William G Ondo Lan Xiong Jacques Montplaisir Ziv Gan-Or Markus Perola Pavel Vodicka Christian Dina Andre Franke Lukas Tittmann Alexandre F R Stewart Svati H Shah Christian Gieger Annette Peters Guy A Rouleau Klaus Berger Konrad Oexle Emanuele Di Angelantonio David A Hinds Bertram Müller-Myhsok Juliane Winkelmann

Lancet Neurol 2017 11;16(11):898-907

Institute of Neurogenomics, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; Institute of Human Genetics, Technische Universität München, Munich, Germany; Neurologische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(17)30327-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755468PMC
November 2017

Prevalence of restless legs syndrome and associated factors in an otherwise healthy population: results from the Danish Blood Donor Study.

Authors:
Maria Didriksen Andreas S Rigas Richard P Allen Brendan J Burchell Emanuele Di Angelantonio Maria H Nielsen Poul Jennum Thomas Werge Christian Erikstrup Ole B Pedersen Mie T Bruun Kristoffer S Burgdorf Erik Sørensen Henrik Ullum

Sleep Med 2017 Aug 26;36:55-61. Epub 2017 May 26.

Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.sleep.2017.04.014DOI Listing
August 2017

High prevalence of restless legs syndrome/Willis Ekbom Disease (RLS/WED) among people living at high altitude in the Indian Himalaya.

Authors:
Ravi Gupta Jan Ulfberg Richard P Allen Deepak Goel

Sleep Med 2017 Jul 20;35:7-11. Epub 2017 Apr 20.

Department of Neurology, Himalayan Institute of Medical Sciences, Swami Ram Nagar, Jolly Grant, Dehradun 248016, India; Sleep Clinic, Himalayan Institute of Medical Sciences, Swami Ram Nagar, Jolly Grant, Dehradun 248016, India.

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https://linkinghub.elsevier.com/retrieve/pii/S13899457173017
Publisher Site
http://dx.doi.org/10.1016/j.sleep.2017.02.031DOI Listing
July 2017

Author response: Practice guideline summary: Treatment of restless legs syndrome in adults: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology.

Authors:
Richard P Allen Melissa J Armstrong Claudia Trenkwalder Phyllis C Zee John W Winkelman

Neurology 2017 06;88(24):2337-2338

Boston.

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http://dx.doi.org/10.1212/WNL.0000000000004047DOI Listing
June 2017

Animal models of RLS phenotypes.

Authors:
Richard P Allen Nathan C Donelson Byron C Jones Yuqing Li Mauro Manconi David B Rye Subhabrata Sanyal Juliane Winkelmann

Sleep Med 2017 03 2;31:23-28. Epub 2016 Sep 2.

Institute of Neurogenomics, Helmholtz Zentrum München, Munich, Germany.

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http://dx.doi.org/10.1016/j.sleep.2016.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349858PMC
March 2017

Introduction: Towards a better understanding of the science of RLS/WED.

Authors:
Diego Garcia Borreguero Juliane Winkelmann Richard P Allen

Sleep Med 2017 03 28;31:1-2. Epub 2016 Oct 28.

Johns Hopkins Univ., Dept of Neurology, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.sleep.2016.10.007DOI Listing
March 2017

Iron and restless legs syndrome: treatment, genetics and pathophysiology.

Authors:
James R Connor Stephanie M Patton Konrad Oexle Richard P Allen

Sleep Med 2017 03 10;31:61-70. Epub 2016 Nov 10.

The Johns Hopkins University, Dep of neuroloy, Baltimore, MD USA.

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http://dx.doi.org/10.1016/j.sleep.2016.07.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334282PMC
March 2017

Intervening Leg Movements Disrupt PLMS Sequences.

Authors:
Kasidet Hiranniramol Stephany Fulda Patrick Skeba Christopher J Earley Richard P Allen

Sleep 2017 Jan;40(1)

Center for Restless Legs Study, Department of Neurology, Johns Hopkins University, Baltimore, MD.

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http://dx.doi.org/10.1093/sleep/zsw023DOI Listing
January 2017

Adenosine receptors as markers of brain iron deficiency: Implications for Restless Legs Syndrome.

Authors:
César Quiroz Seema Gulyani Wan Ruiqian Jordi Bonaventura Roy Cutler Virginia Pearson Richard P Allen Christopher J Earley Mark P Mattson Sergi Ferré

Neuropharmacology 2016 12 4;111:160-168. Epub 2016 Sep 4.

Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056844PMC
http://dx.doi.org/10.1016/j.neuropharm.2016.09.002DOI Listing
December 2016

Defining morphology of periodic leg movements in sleep: an evidence-based definition of a minimum window of sustained activity.

Authors:
Patrick Skeba Stephany Fulda Kasidet Hiranniramol Christopher J Earley Richard P Allen

Sleep Breath 2016 Dec 21;20(4):1293-1299. Epub 2016 Sep 21.

Center for Restless Legs Study, Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.1007/s11325-016-1404-2DOI Listing
December 2016

Depth and Distribution of Symptoms in Restless Legs Syndrome/ Willis-Ekbom Disease.

Authors:
Paul Yeh William G Ondo Daniel L Picchietti J Steven Poceta Richard P Allen Charles R Davies Lily Wang Yaping Shi Kanika Bagai Arthur S Walters

J Clin Sleep Med 2016 12 15;12(12):1669-1680. Epub 2016 Dec 15.

Department of Neurology, Vanderbilt University Medical Center, Nashville, TN.

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http://dx.doi.org/10.5664/jcsm.6356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155205PMC
December 2016

Practice guideline summary: Treatment of restless legs syndrome in adults: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology.

Authors:
John W Winkelman Melissa J Armstrong Richard P Allen K Ray Chaudhuri William Ondo Claudia Trenkwalder Phyllis C Zee Gary S Gronseth David Gloss Theresa Zesiewicz

Neurology 2016 Dec 16;87(24):2585-2593. Epub 2016 Nov 16.

From Harvard Medical School and Massachusetts General Hospital (J.W.W.), Boston; Department of Neurology (M.J.A.), University of Florida College of Medicine, Gainesville; Department of Neurology (R.P.A.), Johns Hopkins University, Baltimore, MD; King's College and King's College Hospital (K.R.C.), London; Methodist Neurological Institute (W.O.), Houston, TX; Department of Neurology (C.T.), University Medical Center, Göttingen, Germany; Northwestern University Feinberg School of Medicine (P.C.Z.), Chicago, IL; University of Kansas Medical Center (G.S.G.), Kansas City; CAMC Neurology Section (D.G.), Charleston, WV; and Department of Neurology (T.Z.), University of South Florida, James A Haley Veterans Administration Hospital, Tampa.

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http://dx.doi.org/10.1212/WNL.0000000000003388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206998PMC
December 2016

Clinical efficacy of ferric carboxymaltose treatment in patients with restless legs syndrome.

Authors:
Yong Won Cho Richard P Allen Christopher J Earley

Sleep Med 2016 09 22;25:16-23. Epub 2016 Aug 22.

Department of Neurology, Johns Hopkins University, Hopkins Bayview Medical Center, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.sleep.2016.06.021DOI Listing
September 2016

Default mode network disturbances in restless legs syndrome/Willis-Ekbom disease.

Authors:
Jeonghun Ku Yeong Seon Lee HyukWon Chang Christopher J Earley Richard P Allen Yong Won Cho

Sleep Med 2016 07 6;23:6-11. Epub 2016 Jul 6.

Department of Neurology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, South Korea. Electronic address:

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http://dx.doi.org/10.1016/j.sleep.2016.05.007DOI Listing
July 2016

Brain iron deficiency in idiopathic restless legs syndrome measured by quantitative magnetic susceptibility at 7 tesla.

Authors:
Xu Li Richard P Allen Christopher J Earley Hongjun Liu Tiana E Cruz Richard A E Edden Peter B Barker Peter C M van Zijl

Sleep Med 2016 06 21;22:75-82. Epub 2016 Jun 21.

F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA; Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.sleep.2016.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992945PMC
June 2016

Guidelines for the first-line treatment of restless legs syndrome/Willis-Ekbom disease, prevention and treatment of dopaminergic augmentation: a combined task force of the IRLSSG, EURLSSG, and the RLS-foundation.

Authors:
Diego Garcia-Borreguero Michael H Silber John W Winkelman Birgit Högl Jacquelyn Bainbridge Mark Buchfuhrer Georgios Hadjigeorgiou Yuichi Inoue Mauro Manconi Wolfgang Oertel William Ondo Juliane Winkelmann Richard P Allen

Sleep Med 2016 05 23;21:1-11. Epub 2016 Feb 23.

Sleep Disorders Center, Johns Hopkins Bayview Medical Center, Baltimore, MD, USA; Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.sleep.2016.01.017DOI Listing
May 2016

Case-Control and Family-Based Association Study of Specific Variants in Restless Legs Syndrome.

Authors:
Ziv Gan-Or Sirui Zhou Amelie Johnson Jacques Y Montplaisir Richard P Allen Christopher J Earley Alex Desautels Patrick A Dion Lan Xiong Guy A Rouleau

Mov Disord Clin Pract 2016 Sep-Oct;3(5):460-464. Epub 2016 Jan 9.

Montreal Neurological Institute and McGill University Montréal Québec Canada.

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http://doi.wiley.com/10.1002/mdc3.12306
Publisher Site
http://dx.doi.org/10.1002/mdc3.12306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178739PMC
January 2016

Inter-movement interval as a primary stable measure of periodic limb movements of sleep.

Authors:
Patrick Skeba Kasidet Hiranniramol Christopher J Earley Richard P Allen

Sleep Med 2016 Jan 11;17:138-43. Epub 2015 Nov 11.

Center for Restless Legs Study, Department of Neurology, Johns Hopkins University, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.sleep.2015.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744335PMC
January 2016

MATPLM1, A MATLAB script for scoring of periodic limb movements: preliminary validation with visual scoring.

Authors:
Andy S Huang Patrick Skeba Myung S Yang Francis P Sgambati Christopher J Earley Richard P Allen

Sleep Med 2015 Dec 24;16(12):1541-9. Epub 2015 Apr 24.

Department of Neurology, Johns Hopkins Bayview Medical Center, Johns Hopkins University, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.sleep.2015.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619191PMC
December 2015

Response to the letter "Characterization of the painful restless legs syndrome".

Authors:
Yong Won Cho Mei Ling Song Christopher J Earley Richard P Allen

Sleep Med 2015 Nov 7;16(11):1448. Epub 2015 Sep 7.

Department of Neurology, Hopkins Bayview Medical Center, Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.sleep.2015.08.018DOI Listing
November 2015

Analysis of functional GLO1 variants in the BTBD9 locus and restless legs syndrome.

Authors:
Ziv Gan-Or Sirui Zhou Amirthagowri Ambalavanan Claire S Leblond Pingxing Xie Amelie Johnson Dan Spiegelman Richard P Allen Christopher J Earley Alex Desautels Jacques Y Montplaisir Patrick A Dion Lan Xiong Guy A Rouleau

Sleep Med 2015 Sep 17;16(9):1151-5. Epub 2015 Jun 17.

Montreal Neurological Institute and McGill University, Montréal, QC, Canada; Department of Human Genetics, McGill University, Montréal, QC, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.sleep.2015.06.002DOI Listing
September 2015

Restless Leg Syndrome/Willis-Ekbom Disease Pathophysiology.

Authors:
Richard P Allen

Sleep Med Clin 2015 Sep 15;10(3):207-14, xi. Epub 2015 Jul 15.

Department of Neurology, Johns Hopkins University, Asthma & Allergy Building, 1B76b, 5501 Hopkins Bayview Boulevard, Baltimore, MD 21224, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jsmc.2015.05.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559751PMC
September 2015

A comparison of MRI tissue relaxometry and ROI methods used to determine regional brain iron concentrations in restless legs syndrome.

Authors:
Hye-Jin Moon Yongmin Chang Yeong Seon Lee Huijin Song Hyuk Won Chang Jeonghun Ku Richard P Allen Christopher J Earley Yong Won Cho

Med Devices (Auckl) 2015 30;8:341-50. Epub 2015 Jul 30.

Department of Neurology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Republic of Korea.

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http://www.dovepress.com/a-comparison-of-mri-tissue-relaxome
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http://dx.doi.org/10.2147/MDER.S83629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525804PMC
August 2015

Response to "Characterization of the painful restless legs syndrome".

Authors:
Yong Won Cho Mei Ling Song Christopher J Earley Richard P Allen

Sleep Med 2015 Jul 30;16(7):898. Epub 2015 Apr 30.

Department of Neurology, Hopkins Bayview Medical Center, Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.sleep.2015.04.007DOI Listing
July 2015

Gray matter alteration in patients with restless legs syndrome: a voxel-based morphometry study.

Authors:
Yongmin Chang Hyuk Won Chang Huijin Song Jeonghun Ku Christopher J Earley Richard P Allen Yong Won Cho

Clin Imaging 2015 Jan-Feb;39(1):20-5. Epub 2014 Aug 2.

Department of Neurology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.clinimag.2014.07.010DOI Listing
June 2015

Prevalence and clinical characteristics of patients with restless legs syndrome with painful symptoms.

Authors:
Yong Won Cho Mei Ling Song Christopher J Earley Richard P Allen

Sleep Med 2015 Jun 18;16(6):775-8. Epub 2015 Mar 18.

Department of Neurology, Johns Hopkins University, Hopkins Bayview Medical Center, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.sleep.2014.12.024DOI Listing
June 2015

Diagnostic accuracy of behavioral, activity, ferritin, and clinical indicators of restless legs syndrome.

Authors:
Kathy C Richards James E Bost Valerie E Rogers Lisa C Hutchison Cornelia K Beck Donald L Bliwise Christine R Kovach Norma Cuellar Richard P Allen

Sleep 2015 Mar 1;38(3):371-80. Epub 2015 Mar 1.

Johns Hopkins University, Baltimore, MD.

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https://academic.oup.com/sleep/article-lookup/doi/10.5665/sl
Publisher Site
http://dx.doi.org/10.5665/sleep.4492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335520PMC
March 2015

Co-registration of magnetic resonance spectroscopy and transcranial magnetic stimulation.

Authors:
Antoine Hone-Blanchet Rachel E Salas Pablo Celnik Aadi Kalloo Michael Schar Nicolaas A J Puts Ashley D Harris Peter B Barker Shirley Fecteau Christopher J Earley Richard P Allen Richard A Edden

J Neurosci Methods 2015 Mar 3;242:52-7. Epub 2015 Jan 3.

FM Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA; Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407646PMC
March 2015

Response to intravenous iron in patients with iron deficiency anemia (IDA) and restless leg syndrome (Willis-Ekbom disease).

Authors:
Tahir Mehmood Michael Auerbach Christopher J Earley Richard P Allen

Sleep Med 2014 Dec 10;15(12):1473-6. Epub 2014 Sep 10.

Department of Neurology, Johns Hopkins University, Baltimore, MD, USA. Electronic address:

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December 2014

Low brain iron effects and reversibility on striatal dopamine dynamics.

Authors:
Erica L Unger Laura E Bianco Byron C Jones Richard P Allen Christopher J Earley

Exp Neurol 2014 Nov 3;261:462-8. Epub 2014 Jul 3.

Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2014.06.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318655PMC
November 2014

Altered white matter integrity in primary restless legs syndrome patients: diffusion tensor imaging study.

Authors:
Yongmin Chang Jong Soo Paik Hui Joong Lee Hyuk Won Chang Hye-Jin Moon Richard P Allen Christopher J Earley Yong Won Cho

Neurol Res 2014 Aug 11;36(8):769-74. Epub 2014 Feb 11.

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http://dx.doi.org/10.1179/1743132814Y.0000000336DOI Listing
August 2014

Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria--history, rationale, description, and significance.

Authors:
Richard P Allen Daniel L Picchietti Diego Garcia-Borreguero William G Ondo Arthur S Walters John W Winkelman Marco Zucconi Raffaele Ferri Claudia Trenkwalder Hochang B Lee

Sleep Med 2014 Aug 17;15(8):860-73. Epub 2014 May 17.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

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August 2014

In memoriam Ralf Kohnen, PhD, professor of clinical psychology.

Authors:
Claudia Trenkwalder Heike Benes Richard P Allen

Sleep Med 2014 Jun;15(6):603-4

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June 2014

Pregabalin versus pramipexole for restless legs syndrome.

Authors:
Richard P Allen

N Engl J Med 2014 05;370(21):2050-1

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May 2014

Restless legs syndrome/Willis Ekbom disease: evaluation and treatment.

Authors:
Richard P Allen

Int Rev Psychiatry 2014 Apr;26(2):248-62

Department of Nerology, Johns Hopkins University , Baltimore, Maryland , USA.

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http://dx.doi.org/10.3109/09540261.2014.904279DOI Listing
April 2014

Pregabalin versus pramipexole: effects on sleep disturbance in restless legs syndrome.

Authors:
Diego Garcia-Borreguero Jeffrey Patrick Sarah DuBrava Philip M Becker Alan Lankford Crystal Chen Jeffrey Miceli Lloyd Knapp Richard P Allen

Sleep 2014 Apr 1;37(4):635-43. Epub 2014 Apr 1.

Johns Hopkins University, Department of Neurology, Baltimore, MD.

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http://dx.doi.org/10.5665/sleep.3558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4044751PMC
April 2014

Functional connectivity alternation of the thalamus in restless legs syndrome patients during the asymptomatic period: a resting-state connectivity study using functional magnetic resonance imaging.

Authors:
Jeonghun Ku Yong Won Cho Yeong Seon Lee Hye-Jin Moon Hyukwon Chang Christopher J Earley Richard P Allen

Sleep Med 2014 Mar 30;15(3):289-94. Epub 2014 Jan 30.

Department of Neurology, Johns Hopkins University, Hopkins Bayview Medical Center, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.sleep.2013.09.030DOI Listing
March 2014

Increased use-dependent plasticity in chronic insomnia.

Authors:
Rachel E Salas Joseph M Galea Alyssa A Gamaldo Charlene E Gamaldo Richard P Allen Michael T Smith Gabriela Cantarero Barbara D Lam Pablo A Celnik

Sleep 2014 Mar 1;37(3):535-44. Epub 2014 Mar 1.

Department of Neurology, Johns Hopkins Medical Institution, Baltimore, MD ; Department of Physical Medicine and Rehabilitation, Johns Hopkins Medical Institution, Baltimore, MD.

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http://dx.doi.org/10.5665/sleep.3492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920319PMC
March 2014

Comparison of pregabalin with pramipexole for restless legs syndrome.

Authors:
Richard P Allen Crystal Chen Diego Garcia-Borreguero Olli Polo Sarah DuBrava Jeffrey Miceli Lloyd Knapp John W Winkelman

N Engl J Med 2014 Feb;370(7):621-31

From the Department of Neurology, Johns Hopkins University, Baltimore (R.P.A.); Pfizer Global Research and Development, Groton, CT (C.C., S.D., J.M., L.K.); Sleep Research Institute, Madrid (D.G.-B.); the Department of Pulmonary Medicine, Tampere University Hospital, Tampere, Finland (O.P.); and Massachusetts General Hospital, Boston (J.W.W.).

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February 2014

Valid measures of periodic leg movements (PLMs) during a suggested immobilization test using the PAM-RL leg activity monitors require adjusting detection parameters for noise and signal in each recording.

Authors:
Myung Sung Yang Jacques Montplaisir Alex Desautels John W Winkelman Michel A Cramer Bornemann Christopher J Earley Richard P Allen

Sleep Med 2014 Jan 16;15(1):132-7. Epub 2013 Oct 16.

Johns Hopkins University, 5501 Hopkins Bayview Circle, 1B.70, Baltimore, MD 21224, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921115PMC
January 2014

Prolonged release oxycodone-naloxone for treatment of severe restless legs syndrome after failure of previous treatment: a double-blind, randomised, placebo-controlled trial with an open-label extension.

Authors:
Claudia Trenkwalder Heike Beneš Ludger Grote Diego García-Borreguero Birgit Högl Michael Hopp Björn Bosse Alexander Oksche Karen Reimer Juliane Winkelmann Richard P Allen Ralf Kohnen

Lancet Neurol 2013 Dec 18;12(12):1141-50. Epub 2013 Oct 18.

Paracelsus-Elena Hospital, Kassel, Germany; Department of Neurosurgery, University of Göttingen, Göttingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(13)70239-4DOI Listing
December 2013

Prevalence and clinical characteristics of restless legs syndrome in diabetic peripheral neuropathy: comparison with chronic osteoarthritis.

Authors:
Yong Won Cho Geon Youb Na Jeong Geun Lim Sang-Hyon Kim Hye Soon Kim Christopher J Earley Richard P Allen

Sleep Med 2013 Dec 16;14(12):1387-92. Epub 2013 Oct 16.

Department of Neurology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, South Korea. Electronic address:

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http://dx.doi.org/10.1016/j.sleep.2013.09.013DOI Listing
December 2013

Association of restless legs syndrome variants in Korean patients with restless legs syndrome.

Authors:
Myeong-Kyu Kim Yong Won Cho Won Chul Shin Jae Wook Cho Young Min Shon Jee Hyun Kim Kwang Ik Yang Christopher J Earley Richard P Allen

Sleep 2013 Dec 1;36(12):1787-91. Epub 2013 Dec 1.

Department of Neurology, The Brain Korea 21 Project, Chonnam National University Medical School, Gwangju, Korea.

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http://dx.doi.org/10.5665/sleep.3200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825427PMC
December 2013

Minimal clinically significant change for the International Restless Legs Syndrome Study Group rating scale in clinical trials is a score of 3.

Authors:
Richard P Allen

Sleep Med 2013 Nov 14;14(11):1229. Epub 2013 Aug 14.

Dept. of Neurology, Johns Hopkins Univ., Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.sleep.2013.08.001DOI Listing
November 2013

The long-term treatment of restless legs syndrome/Willis-Ekbom disease: evidence-based guidelines and clinical consensus best practice guidance: a report from the International Restless Legs Syndrome Study Group.

Authors:
Diego Garcia-Borreguero Ralf Kohnen Michael H Silber John W Winkelman Christopher J Earley Birgit Högl Mauro Manconi Jacques Montplaisir Yuichi Inoue Richard P Allen

Sleep Med 2013 Jul;14(7):675-84

Sleep Research Institute, Madrid, Spain.

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July 2013

Proteomic analysis of the cerebrospinal fluid of patients with restless legs syndrome/Willis-Ekbom disease.

Authors:
Stephanie M Patton Yong Won Cho Thomas W Clardy Richard P Allen Christopher J Earley James R Connor

Fluids Barriers CNS 2013 Jun 7;10(1):20. Epub 2013 Jun 7.

Department of Neurosurgery, Penn State University, Milton S, Hershey Medical Center, 500 University Drive, Hershey, Pennsylvania PA 17033, USA.

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http://dx.doi.org/10.1186/2045-8118-10-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680184PMC
June 2013

Thalamic glutamate/glutamine in restless legs syndrome: increased and related to disturbed sleep.

Authors:
Richard P Allen Peter B Barker Alena Horská Christopher J Earley

Neurology 2013 May 26;80(22):2028-34. Epub 2013 Apr 26.

Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.1212/WNL.0b013e318294b3f6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716406PMC
May 2013

The prevalence and impact of restless legs syndrome on patients with iron deficiency anemia.

Authors:
Richard P Allen Sarah Auerbach Huzefa Bahrain Michael Auerbach Christopher J Earley

Am J Hematol 2013 Apr 12;88(4):261-4. Epub 2013 Mar 12.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1002/ajh.23397DOI Listing
April 2013

Lower molecular weight intravenous iron dextran for restless legs syndrome.

Authors:
Yong Won Cho Richard P Allen Christopher J Earley

Sleep Med 2013 Mar 18;14(3):274-7. Epub 2013 Jan 18.

Department of Neurology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, South Korea.

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http://dx.doi.org/10.1016/j.sleep.2012.11.001DOI Listing
March 2013

Increased synaptic dopamine in the putamen in restless legs syndrome.

Authors:
Christopher J Earley Hiroto Kuwabara Dean F Wong Charlene Gamaldo Rachel E Salas James R Brašić Hayden T Ravert Robert F Dannals Richard P Allen

Sleep 2013 Jan 1;36(1):51-7. Epub 2013 Jan 1.

Departments of Neurology, Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.5665/sleep.2300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524542PMC
January 2013

Assessing health-related quality of life in patients with restless legs syndrome in Korea: comparison with other chronic medical diseases.

Authors:
Yong Won Cho Do Hyung Kim Richard P Allen Christopher J Earley

Sleep Med 2012 Oct 30;13(9):1158-63. Epub 2012 Aug 30.

Department of Neurology, Dongsan Medical Center, Keimyung University, School of Medicine, Daegu, South Korea.

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http://dx.doi.org/10.1016/j.sleep.2012.05.005DOI Listing
October 2012

When gender matters: restless legs syndrome. Report of the "RLS and woman" workshop endorsed by the European RLS Study Group.

Authors:
Mauro Manconi Jan Ulfberg Klaus Berger Imad Ghorayeb Jan Wesström Stephany Fulda Richard P Allen Thomas Pollmächer

Sleep Med Rev 2012 Aug 9;16(4):297-307. Epub 2011 Nov 9.

Sleep and Epilepsy Center, Neurocenter (EOC) of Southern Switzerland, Civic Hospital, Lugano, Via Tesserete 46, 6900 Lugano, Switzerland.

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http://dx.doi.org/10.1016/j.smrv.2011.08.006DOI Listing
August 2012

Systems genetic analysis of multivariate response to iron deficiency in mice.

Authors:
Lina Yin Erica L Unger Leslie C Jellen Christopher J Earley Richard P Allen Ann Tomaszewicz James C Fleet Byron C Jones

Am J Physiol Regul Integr Comp Physiol 2012 Jun 28;302(11):R1282-96. Epub 2012 Mar 28.

Graduate Program in Neuroscience,The Pennsylvania State University, PA 16802, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378346PMC
June 2012

Systems genetic analysis of the effects of iron deficiency in mouse brain.

Authors:
Leslie C Jellen Erica L Unger Lu Lu Robert W Williams Sarah Rousseau Xusheng Wang Christopher J Earley Richard P Allen Michael F Miles Byron C Jones

Neurogenetics 2012 May 29;13(2):147-57. Epub 2012 Mar 29.

Intercollege Graduate Degree Program in Neuroscience, The Pennsylvania State University, University Park, PA 16802, USA.

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http://dx.doi.org/10.1007/s10048-012-0321-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427775PMC
May 2012

Dissociative changes in the Bmax and KD of dopamine D2/D3 receptors with aging observed in functional subdivisions of the striatum: a revisit with an improved data analysis method.

Authors:
Hiroto Kuwabara Mary E McCaul Gary S Wand Christopher J Earley Richard P Allen Elise M Weerts Robert F Dannals Dean F Wong

J Nucl Med 2012 May 9;53(5):805-12. Epub 2012 Apr 9.

Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.2967/jnumed.111.098186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533866PMC
May 2012

Incidence of restless legs syndrome and its correlates.

Authors:
Pooja Budhiraja Rohit Budhiraja James L Goodwin Richard P Allen Anne B Newman Brian B Koo Stuart F Quan

J Clin Sleep Med 2012 Apr 15;8(2):119-24. Epub 2012 Apr 15.

Southern Arizona VA HealthCare System, 3601 S 6th Ave, Tucson, Arizona 85723, USA.

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http://dx.doi.org/10.5664/jcsm.1756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311406PMC
April 2012

Pediatric restless legs syndrome: analysis of symptom descriptions and drawings.

Authors:
Daniel L Picchietti Robert A Arbuckle Linda Abetz Jeffrey S Durmer Anna Ivanenko Judith A Owens Jens Croenlein Richard P Allen Arthur S Walters

J Child Neurol 2011 Nov 2;26(11):1365-76. Epub 2011 Jun 2.

University of Illinois School of Medicine and Carle Foundation Hospital, Urbana, Illinois 61801, USA.

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http://dx.doi.org/10.1177/0883073811405852DOI Listing
November 2011

Genetic analysis of iron-deficiency effects on the mouse spleen.

Authors:
Jennifer N Gibson Leslie C Jellen Erica L Unger Grant Morahan Munish Mehta Christopher J Earley Richard P Allen Lu Lu Byron C Jones

Mamm Genome 2011 Oct 6;22(9-10):556-62. Epub 2011 Jul 6.

Department of Biobehavioral Health, The Pennsylvania State University, 315 E. Health and Human Development Building, University Park, PA 16802, USA.

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http://dx.doi.org/10.1007/s00335-011-9344-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179527PMC
October 2011

Clinical efficacy and safety of IV ferric carboxymaltose (FCM) treatment of RLS: a multi-centred, placebo-controlled preliminary clinical trial.

Authors:
Richard P Allen Charles H Adler Wei Du Angelia Butcher David B Bregman Christopher J Earley

Sleep Med 2011 Oct 5;12(9):906-13. Epub 2011 Oct 5.

Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.sleep.2011.06.009DOI Listing
October 2011

Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1.

Authors:
Juliane Winkelmann Darina Czamara Barbara Schormair Franziska Knauf Eva C Schulte Claudia Trenkwalder Yves Dauvilliers Olli Polo Birgit Högl Klaus Berger Andrea Fuhs Nadine Gross Karin Stiasny-Kolster Wolfgang Oertel Cornelius G Bachmann Walter Paulus Lan Xiong Jacques Montplaisir Guy A Rouleau Ingo Fietze Jana Vávrová David Kemlink Karel Sonka Sona Nevsimalova Siong-Chi Lin Zbigniew Wszolek Carles Vilariño-Güell Matthew J Farrer Viola Gschliesser Birgit Frauscher Tina Falkenstetter Werner Poewe Richard P Allen Christopher J Earley William G Ondo Wei-Dong Le Derek Spieler Maria Kaffe Alexander Zimprich Johannes Kettunen Markus Perola Kaisa Silander Isabelle Cournu-Rebeix Marcella Francavilla Claire Fontenille Bertrand Fontaine Pavel Vodicka Holger Prokisch Peter Lichtner Paul Peppard Juliette Faraco Emmanuel Mignot Christian Gieger Thomas Illig H-Erich Wichmann Bertram Müller-Myhsok Thomas Meitinger

PLoS Genet 2011 Jul 14;7(7):e1002171. Epub 2011 Jul 14.

Institute of Human Genetics, Technische Universität München, Munich, Germany.

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http://dx.doi.org/10.1371/journal.pgen.1002171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136436PMC
July 2011

Postmortem and imaging based analyses reveal CNS decreased myelination in restless legs syndrome.

Authors:
James R Connor Padmavathi Ponnuru Byeong-Yeul Lee Gerald D Podskalny Shoaib Alam Richard P Allen Christopher J Earley Qing X Yang

Sleep Med 2011 Jun 12;12(6):614-9. Epub 2011 May 12.

Department of Neurosurgery, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, PA 17033-0850, USA.

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http://dx.doi.org/10.1016/j.sleep.2010.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110510PMC
June 2011

Alterations in pain responses in treated and untreated patients with restless legs syndrome: associations with sleep disruption.

Authors:
Robert R Edwards Phillip J Quartana Richard P Allen Seth Greenbaum Christopher J Earley Michael T Smith

Sleep Med 2011 Jun 12;12(6):603-9. Epub 2011 May 12.

Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Medical School, Brigham & Women's Hospital, Chesnut Hill, MA 02467, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433041PMC
June 2011

A 10-year, longitudinal assessment of dopamine agonists and methadone in the treatment of restless legs syndrome.

Authors:
Nathan Silver Richard P Allen Julia Senerth Christopher J Earley

Sleep Med 2011 May 15;12(5):440-4. Epub 2011 Jan 15.

Dept of Psychology and Brain Sciences, Johns Hopkins University, 3400 N Charles St, Baltimore, MD 21216, USA.

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http://dx.doi.org/10.1016/j.sleep.2010.11.002DOI Listing
May 2011

Restless legs syndrome (RLS) augmentation associated with dopamine agonist and levodopa usage in a community sample.

Authors:
Richard P Allen William G Ondo Eric Ball Michael O Calloway Ranjani Manjunath Rachel L Higbie Mechele R Lee Paul A Nisbet

Sleep Med 2011 May 13;12(5):431-9. Epub 2011 Apr 13.

Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.sleep.2011.03.003DOI Listing
May 2011

Efficacy and augmentation during 6 months of double-blind pramipexole for restless legs syndrome.

Authors:
Birgit Högl Diego Garcia-Borreguero Claudia Trenkwalder Luigi Ferini-Strambi Wayne Hening Werner Poewe Stefanie S Brenner Mandy Fraessdorf Michael Busse Stefan Albrecht Richard P Allen

Sleep Med 2011 Apr 26;12(4):351-60. Epub 2011 Feb 26.

Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria.

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http://dx.doi.org/10.1016/j.sleep.2010.12.007DOI Listing
April 2011

Profile of altered brain iron acquisition in restless legs syndrome.

Authors:
James R Connor Padmavathi Ponnuru Xin-Sheng Wang Stephanie M Patton Richard P Allen Christopher J Earley

Brain 2011 Apr 11;134(Pt 4):959-68. Epub 2011 Mar 11.

Department of Neurosurgery (H110), G.M. Leader Family Laboratory for Alzheimer's Disease Research, Penn State College of Medicine, 500 University Dr., Hershey, PA 17033, USA.

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http://dx.doi.org/10.1093/brain/awr012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069701PMC
April 2011

The dopamine transporter is decreased in the striatum of subjects with restless legs syndrome.

Authors:
Christopher J Earley Hiroto Kuwabara Dean F Wong Charlene Gamaldo Rachel Salas James Brasic Hayden T Ravert Robert F Dannals Richard P Allen

Sleep 2011 Mar 1;34(3):341-7. Epub 2011 Mar 1.

Department of Neurology, Division of Nuclear Medicine, Johns Hopkins University, Baltimore, MD, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041710PMC
http://dx.doi.org/10.1093/sleep/34.3.341DOI Listing
March 2011

Restless legs syndrome and periodic leg movements in sleep.

Authors:
Christopher J Earley Richard P Allen Wayne Hening

Handb Clin Neurol 2011 ;99:913-48

Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/B978-0-444-52007-4.00015-1DOI Listing
February 2011

Prevalence and disease burden of primary restless legs syndrome: results of a general population survey in the United States.

Authors:
Richard P Allen Murtuza Bharmal Michael Calloway

Mov Disord 2011 Jan 10;26(1):114-20. Epub 2010 Nov 10.

Department of Neurology, Johns Hopkins Bayview Medical Center, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1002/mds.23430DOI Listing
January 2011

Polysomnogram changes in marijuana users who report sleep disturbances during prior abstinence.

Authors:
Karen I Bolla Suzanne R Lesage Charlene E Gamaldo David N Neubauer Nae-Yuh Wang Frank R Funderburk Richard P Allen Paula M David Jean Lud Cadet

Sleep Med 2010 Oct 3;11(9):882-9. Epub 2010 Aug 3.

Department of Neurology, Johns Hopkins Medical Institutions, Bayview Medical Center, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1016/j.sleep.2010.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938870PMC
October 2010

Development of the Pediatric Restless Legs Syndrome Severity Scale (P-RLS-SS): a patient-reported outcome measure of pediatric RLS symptoms and impact.

Authors:
Robert Arbuckle Linda Abetz Jeffrey S Durmer Anna Ivanenko Judith A Owens Jens Croenlein Kate Bolton Adam Moore Richard P Allen Arthur S Walters Daniel L Picchietti

Sleep Med 2010 Oct;11(9):897-906

Mapi Values Ltd., Cheshire, United Kingdom.

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http://dx.doi.org/10.1016/j.sleep.2010.03.016DOI Listing
October 2010

Update in restless legs syndrome.

Authors:
Rachel E Salas Charlene E Gamaldo Richard P Allen

Curr Opin Neurol 2010 Aug;23(4):401-6

Department of Neurology, Division of Pulmonary/Critical Care, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA.

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http://dx.doi.org/10.1097/WCO.0b013e32833bcdd8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964787PMC
August 2010

Rotigotine improves restless legs syndrome: a 6-month randomized, double-blind, placebo-controlled trial in the United States.

Authors:
Wayne A Hening Richard P Allen William G Ondo Arthur S Walters John W Winkelman Philip Becker Richard Bogan June M Fry David B Kudrow Kurt W Lesh Andreas Fichtner Erwin Schollmayer

Mov Disord 2010 Aug;25(11):1675-83

Department of Neurology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.

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http://dx.doi.org/10.1002/mds.23157DOI Listing
August 2010

Pregnancy accounts for most of the gender difference in prevalence of familial RLS.

Authors:
Nicholas P Pantaleo Wayne A Hening Richard P Allen Christopher J Earley

Sleep Med 2010 Mar 9;11(3):310-3. Epub 2009 Jul 9.

Dept. of Psychology and Brain Science, Johns Hopkins Univ., Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.sleep.2009.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830334PMC
March 2010

Progressive development of augmentation during long-term treatment with levodopa in restless legs syndrome: results of a prospective multi-center study.

Authors:
Birgit Högl Diego García-Borreguero Ralf Kohnen Luigi Ferini-Strambi Georgios Hadjigeorgiou Magdolna Hornyak Al de Weerd Svenja Happe Karin Stiasny-Kolster Viola Gschliesser Renata Egatz Birgit Frauscher Heike Benes Claudia Trenkwalder Wayne A Hening Richard P Allen

J Neurol 2010 Feb 11;257(2):230-7. Epub 2009 Sep 11.

Department of Neurology, Innsbruck Medical University, Anichstr. 35, 6020, Innsbruck, Austria.

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http://dx.doi.org/10.1007/s00415-009-5299-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085743PMC
February 2010

Physician-diagnosed restless legs syndrome in a large sample of primary medical care patients in western Europe: Prevalence and characteristics.

Authors:
Richard P Allen Paul Stillman Andrew J Myers

Sleep Med 2010 Jan 22;11(1):31-7. Epub 2009 May 22.

Department of Neurology, Johns Hopkins University, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1016/j.sleep.2009.03.007DOI Listing
January 2010

Validation of the self-completed Cambridge-Hopkins questionnaire (CH-RLSq) for ascertainment of restless legs syndrome (RLS) in a population survey.

Authors:
Richard P Allen Brendan J Burchell Ben MacDonald Wayne A Hening Christopher J Earley

Sleep Med 2009 Dec 4;10(10):1097-100. Epub 2009 Feb 4.

Department of Neurology, Johns Hopkins University, Baltimore, MD 21224, USA.

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https://www.repository.cam.ac.uk/bitstream/handle/1810/24216
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http://linkinghub.elsevier.com/retrieve/pii/S138994570800353
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http://dx.doi.org/10.1016/j.sleep.2008.10.007DOI Listing
December 2009

The dopaminergic neurons of the A11 system in RLS autopsy brains appear normal.

Authors:
Christopher J Earley Richard P Allen James R Connor Luigi Ferrucci Juan Troncoso

Sleep Med 2009 Dec 23;10(10):1155-7. Epub 2009 Mar 23.

Department of Neurology, Johns Hopkins University, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1016/j.sleep.2009.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783651PMC
December 2009

Mitochondrial ferritin in the substantia nigra in restless legs syndrome.

Authors:
Amanda M Snyder XinSheng Wang Stephanie M Patton Paolo Arosio Sonia Levi Christopher J Earley Richard P Allen James R Connor

J Neuropathol Exp Neurol 2009 Nov;68(11):1193-9

Department of Neurosurgery, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA.

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http://dx.doi.org/10.1097/NEN.0b013e3181bdc44fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024883PMC
November 2009

The four diagnostic criteria for Restless Legs Syndrome are unable to exclude confounding conditions ("mimics").

Authors:
Wayne A Hening Richard P Allen Mystinna Washburn Suzanne R Lesage Christopher J Earley

Sleep Med 2009 Oct 29;10(9):976-81. Epub 2009 Jan 29.

UMDNJ-RW Johnson Medical Center, New Brunswick, NJ, USA.

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http://dx.doi.org/10.1016/j.sleep.2008.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769267PMC
October 2009

Altered dopaminergic profile in the putamen and substantia nigra in restless leg syndrome.

Authors:
James R Connor Xin-Sheng Wang Richard P Allen John L Beard Jason A Wiesinger Barbara T Felt Christopher J Earley

Brain 2009 Sep 25;132(Pt 9):2403-12. Epub 2009 May 25.

Department of Neurosurgery, Penn State College of Medicine, Hershey, PA 17033-0850, USA.

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http://dx.doi.org/10.1093/brain/awp125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732265PMC
September 2009

A case of compulsive behaviors observed in a restless legs syndrome patient treated with a dopamine agonist.

Authors:
Rachel E Salas Richard P Allen Christopher J Earley Charlene E Gamaldo

Sleep 2009 May;32(5):587-8

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675892PMC
http://dx.doi.org/10.1093/sleep/32.5.587DOI Listing
May 2009