Richard O Hynes

Richard O Hynes

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Richard O Hynes

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Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells.

Proc Natl Acad Sci U S A 2019 Sep 4;116(39):19609-19618. Epub 2019 Sep 4.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1908626116DOI Listing
September 2019

Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet.

Cell 2019 Aug;178(5):1115-1131.e15

Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA; Department of Biology, MIT, Cambridge, MA 02139, USA; Department of Pathology, Massachusetts General Hospital Boston and Harvard Medical School, Boston, MA 02114, USA; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.07.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732196PMC
August 2019

Noninvasive imaging of tumor progression, metastasis, and fibrosis using a nanobody targeting the extracellular matrix.

Proc Natl Acad Sci U S A 2019 Jul 8;116(28):14181-14190. Epub 2019 May 8.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1817442116
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http://dx.doi.org/10.1073/pnas.1817442116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628802PMC
July 2019

Antibodies and methods for immunohistochemistry of extracellular matrix proteins.

Matrix Biol 2018 10 3;71-72:10-27. Epub 2018 May 3.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2018.04.011DOI Listing
October 2018

Inflamed neutrophils sequestered at entrapped tumor cells via chemotactic confinement promote tumor cell extravasation.

Proc Natl Acad Sci U S A 2018 07 18;115(27):7022-7027. Epub 2018 Jun 18.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1715932115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142213PMC
July 2018

Endothelium-derived fibronectin regulates neonatal vascular morphogenesis in an autocrine fashion.

Angiogenesis 2017 Nov 30;20(4):519-531. Epub 2017 Jun 30.

Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Ave, 76-361, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1007/s10456-017-9563-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660148PMC
November 2017

Intravital imaging of metastasis in adult Zebrafish.

BMC Cancer 2017 Sep 25;17(1):660. Epub 2017 Sep 25.

Department of Biology, Massachusetts Institute of Technology, 31 Ames Street, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1186/s12885-017-3647-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613480PMC
September 2017

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

J Proteome Res 2017 08 19;16(8):3083-3091. Epub 2017 Jul 19.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/acs.jproteome.7b00191DOI Listing
August 2017

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

Biomaterials 2017 06 7;128:147-159. Epub 2017 Mar 7.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2017.03.008DOI Listing
June 2017

Toward Responsible Human Genome Editing.

JAMA 2017 05;317(18):1829-1830

Pediatrics, Stanford School of Medicine, Stanford, California.

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http://dx.doi.org/10.1001/jama.2017.4548DOI Listing
May 2017

The integrin PSI domain has an endogenous thiol isomerase function and is a novel target for antiplatelet therapy.

Blood 2017 03 25;129(13):1840-1854. Epub 2017 Jan 25.

Toronto Platelet Immunobiology Group and Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1182/blood-2016-07-729400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374287PMC
March 2017

Evolving policy with science.

Science 2017 03;355(6328):889

Richard O. Hynes* is the Daniel K. Ludwig Professor for Cancer Research and Howard Hughes Medical Institute Investigator at the Koch Institute for Integrative Cancer Research, the Massachusetts Institute of Technology, Cambridge, MA.

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http://dx.doi.org/10.1126/science.aan0509DOI Listing
March 2017

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

Sci Rep 2017 01 10;7:40495. Epub 2017 Jan 10.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, U.S.A.

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http://dx.doi.org/10.1038/srep40495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223159PMC
January 2017

PF4 Promotes Platelet Production and Lung Cancer Growth.

Cell Rep 2016 11;17(7):1764-1772

Center for Systems Biology, Massachusetts General Hospital Research Institute, Harvard Medical School, Boston, MA 02114, USA; Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.10.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108525PMC
November 2016

Elucidation of the Roles of Tumor Integrin β1 in the Extravasation Stage of the Metastasis Cascade.

Cancer Res 2016 05 17;76(9):2513-24. Epub 2016 Mar 17.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-1325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873393PMC
May 2016

Tumor angiogenesis in the absence of fibronectin or its cognate integrin receptors.

PLoS One 2015 25;10(3):e0120872. Epub 2015 Mar 25.

Howard Hughes Medical Institute, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0120872PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373772PMC
February 2016

The extracellular matrix: Tools and insights for the "omics" era.

Matrix Biol 2016 Jan 8;49:10-24. Epub 2015 Jul 8.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0945053X150012
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http://dx.doi.org/10.1016/j.matbio.2015.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013529PMC
January 2016

Deformability of Tumor Cells versus Blood Cells.

Sci Rep 2015 Dec 18;5:18542. Epub 2015 Dec 18.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA.

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http://dx.doi.org/10.1038/srep18542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683468PMC
December 2015

Enrichment of Extracellular Matrix Proteins from Tissues and Digestion into Peptides for Mass Spectrometry Analysis.

J Vis Exp 2015 Jul 23(101):e53057. Epub 2015 Jul 23.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology.

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http://dx.doi.org/10.3791/53057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545199PMC
July 2015

α5 and αv integrins cooperate to regulate vascular smooth muscle and neural crest functions in vivo.

Development 2015 Feb;142(4):797-808

Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

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http://dx.doi.org/10.1242/dev.117572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514387PMC
February 2015

Stretching the boundaries of extracellular matrix research.

Authors:
Richard O Hynes

Nat Rev Mol Cell Biol 2014 12;15(12):761-3

Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://search.proquest.com/openview/0d5d34676f842805d4e46792
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http://dx.doi.org/10.1038/nrm3908DOI Listing
December 2014

Alternative splicing of endothelial fibronectin is induced by disturbed hemodynamics and protects against hemorrhage of the vessel wall.

Arterioscler Thromb Vasc Biol 2014 Sep 5;34(9):2042-50. Epub 2014 Jun 5.

From the Howard Hughes Medical Institute, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA.

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http://dx.doi.org/10.1161/ATVBAHA.114.303879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140979PMC
September 2014

Integrin-α5β1 is not required for mural cell functions during development of blood vessels but is required for lymphatic-blood vessel separation and lymphovenous valve formation.

Dev Biol 2014 Aug 21;392(2):381-92. Epub 2014 May 21.

Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2014.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113717PMC
August 2014

Platelets guide the formation of early metastatic niches.

Proc Natl Acad Sci U S A 2014 Jul 14;111(30):E3053-61. Epub 2014 Jul 14.

Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139; and

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http://dx.doi.org/10.1073/pnas.1411082111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121772PMC
July 2014

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

BMC Cancer 2014 Jul 18;14:518. Epub 2014 Jul 18.

David H, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://bmccancer.biomedcentral.com/articles/10.1186/1471-240
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http://dx.doi.org/10.1186/1471-2407-14-518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223627PMC
July 2014

Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters.

Elife 2014 Mar 11;3:e01308. Epub 2014 Mar 11.

David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944437PMC
http://dx.doi.org/10.7554/eLife.01308DOI Listing
March 2014

Determination of 35 cell surface antigen levels in malignant pleural effusions identifies CD24 as a marker of disseminated tumor cells.

Int J Cancer 2013 Dec 13;133(12):2925-33. Epub 2013 Jul 13.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA.

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http://dx.doi.org/10.1002/ijc.28312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107365PMC
December 2013

The initial hours of metastasis: the importance of cooperative host-tumor cell interactions during hematogenous dissemination.

Cancer Discov 2012 Dec 19;2(12):1091-9. Epub 2012 Nov 19.

Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://cancerdiscovery.aacrjournals.org/cgi/doi/10.1158/2159
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http://dx.doi.org/10.1158/2159-8290.CD-12-0329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540992PMC
December 2012

An angiogenic role for the α5β1 integrin in promoting endothelial cell proliferation during cerebral hypoxia.

Exp Neurol 2012 Sep 18;237(1):46-54. Epub 2012 Jun 18.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.expneurol.2012.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748139PMC
September 2012

The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain.

Proc Natl Acad Sci U S A 2012 Sep 13;109(37):E2441-50. Epub 2012 Aug 13.

Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.1212021109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443162PMC
September 2012

Mena binds α5 integrin directly and modulates α5β1 function.

J Cell Biol 2012 Aug;198(4):657-76

The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1083/jcb.201202079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514034PMC
August 2012

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.

Mol Cell Proteomics 2012 Apr 9;11(4):M111.014647. Epub 2011 Dec 9.

Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1074/mcp.M111.014647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322572PMC
April 2012

The evolution of metazoan extracellular matrix.

Authors:
Richard O Hynes

J Cell Biol 2012 Mar;196(6):671-9

Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1083/jcb.201109041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308698PMC
March 2012

Extracellular matrix proteins in hemostasis and thrombosis.

Cold Spring Harb Perspect Biol 2012 Feb 1;4(2). Epub 2012 Feb 1.

Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599-7035, USA.

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http://dx.doi.org/10.1101/cshperspect.a005132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281566PMC
February 2012

Overview of the matrisome--an inventory of extracellular matrix constituents and functions.

Cold Spring Harb Perspect Biol 2012 Jan 1;4(1):a004903. Epub 2012 Jan 1.

Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1101/cshperspect.a004903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249625PMC
January 2012

Metastatic cells will take any help they can get.

Authors:
Richard O Hynes

Cancer Cell 2011 Dec;20(6):689-90

Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.ccr.2011.11.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462586PMC
December 2011

Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis.

Cancer Cell 2011 Nov;20(5):576-90

Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15356108110035
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http://dx.doi.org/10.1016/j.ccr.2011.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487108PMC
November 2011

GPR56 Regulates VEGF production and angiogenesis during melanoma progression.

Cancer Res 2011 Aug 1;71(16):5558-68. Epub 2011 Jul 1.

Departments of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York 14612, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-4543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156271PMC
August 2011

Essential roles of fibronectin in the development of the left-right embryonic body plan.

Dev Biol 2011 Jun 3;354(2):208-20. Epub 2011 Apr 3.

Weill Cornell Medical College, Department of Medicine, Division of Cardiology, New York, NY, USA.

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http://dx.doi.org/10.1016/j.ydbio.2011.03.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225965PMC
June 2011

Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner.

Proc Natl Acad Sci U S A 2011 Jun 27;108(24):9939-44. Epub 2011 May 27.

Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1073/pnas.1105041108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116421PMC
June 2011

CUB-domain-containing protein 1 (CDCP1) activates Src to promote melanoma metastasis.

Proc Natl Acad Sci U S A 2011 Jan 10;108(4):1379-84. Epub 2011 Jan 10.

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.1017228108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3029734PMC
January 2011

αv Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice.

J Clin Invest 2010 Dec 22;120(12):4445-52. Epub 2010 Nov 22.

1Program of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://www.jci.org/articles/view/43796
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http://dx.doi.org/10.1172/JCI43796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993596PMC
December 2010

Endothelial alpha5 and alphav integrins cooperate in remodeling of the vasculature during development.

Development 2010 Jul;137(14):2439-49

Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1242/dev.049551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889609PMC
July 2010

GPR56 plays varying roles in endogenous cancer progression.

Clin Exp Metastasis 2010 Apr 24;27(4):241-9. Epub 2010 Mar 24.

Howard Hughes Medical Institute and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1007/s10585-010-9322-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065979PMC
April 2010

Integrin alpha5beta1 is necessary for regulation of radial migration of cortical neurons during mouse brain development.

Eur J Neurosci 2010 Feb 25;31(3):399-409. Epub 2010 Jan 25.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Department of Cell Biology and Development, CNRS UMR7104, Inserm U964, Université de Strasbourg, 67404 Illkirch, France.

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http://dx.doi.org/10.1111/j.1460-9568.2009.07072.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460545PMC
February 2010

Engulfing tumors with synthetic extracellular matrices for cancer immunotherapy.

Biomaterials 2009 Dec 19;30(35):6757-67. Epub 2009 Sep 19.

Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S014296120900899
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http://dx.doi.org/10.1016/j.biomaterials.2009.08.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788234PMC
December 2009

The extracellular matrix: not just pretty fibrils.

Authors:
Richard O Hynes

Science 2009 Nov;326(5957):1216-9

Howard Hughes Medical Institute, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/science.1176009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536535PMC
November 2009

Fibronectins in vascular morphogenesis.

Angiogenesis 2009 14;12(2):165-75. Epub 2009 Feb 14.

Greenberg Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10065, USA.

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http://dx.doi.org/10.1007/s10456-009-9136-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716138PMC
August 2009

Natural killer cells require selectins for suppression of subcutaneous tumors.

Cancer Res 2009 Mar 3;69(6):2531-9. Epub 2009 Mar 3.

Howard Hughes Medical Institute, David H. Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-3126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694740PMC
March 2009

US policies on human embryonic stem cells.

Authors:
Richard O Hynes

Nat Rev Mol Cell Biol 2008 12 9;9(12):993-7. Epub 2008 Oct 9.

Howard Hughes Medical Institute, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139-4307, USA.

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http://dx.doi.org/10.1038/nrm2528DOI Listing
December 2008

A system for Cre-regulated RNA interference in vivo.

Proc Natl Acad Sci U S A 2008 Sep 8;105(37):13895-900. Epub 2008 Sep 8.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1073/pnas.0806907105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2532697PMC
September 2008

Analyses of the role of endogenous SPARC in mouse models of prostate and breast cancer.

Clin Exp Metastasis 2008 5;25(2):109-18. Epub 2007 Dec 5.

Howard Hughes Medical Institute, Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1007/s10585-007-9126-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252392PMC
June 2008

Genetic ablation of alphav integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma.

Am J Pathol 2008 Jun 8;172(6):1740-7. Epub 2008 May 8.

Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.2353/ajpath.2008.070700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408432PMC
June 2008

GPR56 regulates pial basement membrane integrity and cortical lamination.

J Neurosci 2008 May;28(22):5817-26

Division of Newborn Medicine, Department of Medicine, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.0853-08.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504715PMC
May 2008

Identification of the peptide sequences within the EIIIA (EDA) segment of fibronectin that mediate integrin alpha9beta1-dependent cellular activities.

J Biol Chem 2008 Feb 29;283(5):2858-70. Epub 2007 Oct 29.

Center for Cell Biology and Cancer Research, Albany Medical College, Albany, NY 12208, USA.

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http://dx.doi.org/10.1074/jbc.M708306200DOI Listing
February 2008

Multiple cardiovascular defects caused by the absence of alternatively spliced segments of fibronectin.

Dev Biol 2007 Nov 12;311(1):11-24. Epub 2007 Jul 12.

Howard Hughes Medical Institute, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1016/j.ydbio.2007.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080666PMC
November 2007

Importance of donor- and recipient-derived selectins in cardiac allograft rejection.

J Am Soc Nephrol 2007 Nov 10;18(11):2929-36. Epub 2007 Oct 10.

Transplantation Research Center, Brigham & Women's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1681/ASN.2006111261DOI Listing
November 2007

Ulcerative colitis and autoimmunity induced by loss of myeloid alphav integrins.

Proc Natl Acad Sci U S A 2007 Oct 25;104(40):15823-8. Epub 2007 Sep 25.

Medical Research Council/University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0707421104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994135PMC
October 2007

Heart development in fibronectin-null mice is governed by a genetic modifier on chromosome four.

Mech Dev 2007 Aug 2;124(7-8):551-8. Epub 2007 Jun 2.

Howard Hughes Medical Institute, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.mod.2007.05.004DOI Listing
August 2007

Tumor-lymphatic interactions in an activated stromal microenvironment.

J Cell Biochem 2007 Jul;101(4):840-50

Howard Hughes Medical Institute, Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1002/jcb.21146DOI Listing
July 2007

Protein 4.1B suppresses prostate cancer progression and metastasis.

Proc Natl Acad Sci U S A 2007 Jul 18;104(31):12784-9. Epub 2007 Jul 18.

Howard Hughes Medical Institute, Massachusetts Institute of Technology Center for Cancer Research, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.0705499104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1924789PMC
July 2007

Structure-function analysis reveals discrete beta3 integrin inside-out and outside-in signaling pathways in platelets.

Blood 2007 Apr 14;109(8):3284-90. Epub 2006 Dec 14.

Division of Cardiology and Department of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2006-10-05
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http://dx.doi.org/10.1182/blood-2006-10-051664DOI Listing
April 2007

GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment.

Cell Cycle 2007 Jan 28;6(2):160-5. Epub 2007 Jan 28.

Howard Hughes Medical Institute, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.4161/cc.6.2.3760DOI Listing
January 2007

The echinoderm adhesome.

Dev Biol 2006 Dec 7;300(1):252-66. Epub 2006 Aug 7.

Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.ydbio.2006.07.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565218PMC
December 2006

The genome of the sea urchin Strongylocentrotus purpuratus.

Authors:
Erica Sodergren George M Weinstock Eric H Davidson R Andrew Cameron Richard A Gibbs Robert C Angerer Lynne M Angerer Maria Ina Arnone David R Burgess Robert D Burke James A Coffman Michael Dean Maurice R Elphick Charles A Ettensohn Kathy R Foltz Amro Hamdoun Richard O Hynes William H Klein William Marzluff David R McClay Robert L Morris Arcady Mushegian Jonathan P Rast L Courtney Smith Michael C Thorndyke Victor D Vacquier Gary M Wessel Greg Wray Lan Zhang Christine G Elsik Olga Ermolaeva Wratko Hlavina Gretchen Hofmann Paul Kitts Melissa J Landrum Aaron J Mackey Donna Maglott Georgia Panopoulou Albert J Poustka Kim Pruitt Victor Sapojnikov Xingzhi Song Alexandre Souvorov Victor Solovyev Zheng Wei Charles A Whittaker Kim Worley K James Durbin Yufeng Shen Olivier Fedrigo David Garfield Ralph Haygood Alexander Primus Rahul Satija Tonya Severson Manuel L Gonzalez-Garay Andrew R Jackson Aleksandar Milosavljevic Mark Tong Christopher E Killian Brian T Livingston Fred H Wilt Nikki Adams Robert Bellé Seth Carbonneau Rocky Cheung Patrick Cormier Bertrand Cosson Jenifer Croce Antonio Fernandez-Guerra Anne-Marie Genevière Manisha Goel Hemant Kelkar Julia Morales Odile Mulner-Lorillon Anthony J Robertson Jared V Goldstone Bryan Cole David Epel Bert Gold Mark E Hahn Meredith Howard-Ashby Mark Scally John J Stegeman Erin L Allgood Jonah Cool Kyle M Judkins Shawn S McCafferty Ashlan M Musante Robert A Obar Amanda P Rawson Blair J Rossetti Ian R Gibbons Matthew P Hoffman Andrew Leone Sorin Istrail Stefan C Materna Manoj P Samanta Viktor Stolc Waraporn Tongprasit Qiang Tu Karl-Frederik Bergeron Bruce P Brandhorst James Whittle Kevin Berney David J Bottjer Cristina Calestani Kevin Peterson Elly Chow Qiu Autumn Yuan Eran Elhaik Dan Graur Justin T Reese Ian Bosdet Shin Heesun Marco A Marra Jacqueline Schein Michele K Anderson Virginia Brockton Katherine M Buckley Avis H Cohen Sebastian D Fugmann Taku Hibino Mariano Loza-Coll Audrey J Majeske Cynthia Messier Sham V Nair Zeev Pancer David P Terwilliger Cavit Agca Enrique Arboleda Nansheng Chen Allison M Churcher F Hallböök Glen W Humphrey Mohammed M Idris Takae Kiyama Shuguang Liang Dan Mellott Xiuqian Mu Greg Murray Robert P Olinski Florian Raible Matthew Rowe John S Taylor Kristin Tessmar-Raible D Wang Karen H Wilson Shunsuke Yaguchi Terry Gaasterland Blanca E Galindo Herath J Gunaratne Celina Juliano Masashi Kinukawa Gary W Moy Anna T Neill Mamoru Nomura Michael Raisch Anna Reade Michelle M Roux Jia L Song Yi-Hsien Su Ian K Townley Ekaterina Voronina Julian L Wong Gabriele Amore Margherita Branno Euan R Brown Vincenzo Cavalieri Véronique Duboc Louise Duloquin Constantin Flytzanis Christian Gache François Lapraz Thierry Lepage Annamaria Locascio Pedro Martinez Giorgio Matassi Valeria Matranga Ryan Range Francesca Rizzo Eric Röttinger Wendy Beane Cynthia Bradham Christine Byrum Tom Glenn Sofia Hussain Gerard Manning Esther Miranda Rebecca Thomason Katherine Walton Athula Wikramanayke Shu-Yu Wu Ronghui Xu C Titus Brown Lili Chen Rachel F Gray Pei Yun Lee Jongmin Nam Paola Oliveri Joel Smith Donna Muzny Stephanie Bell Joseph Chacko Andrew Cree Stacey Curry Clay Davis Huyen Dinh Shannon Dugan-Rocha Jerry Fowler Rachel Gill Cerrissa Hamilton Judith Hernandez Sandra Hines Jennifer Hume Laronda Jackson Angela Jolivet Christie Kovar Sandra Lee Lora Lewis George Miner Margaret Morgan Lynne V Nazareth Geoffrey Okwuonu David Parker Ling-Ling Pu Rachel Thorn Rita Wright

Science 2006 Nov;314(5801):941-52

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http://dx.doi.org/10.1126/science.1133609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159423PMC
November 2006

Decreased plasma fibronectin leads to delayed thrombus growth in injured arterioles.

Arterioscler Thromb Vasc Biol 2006 Jun 9;26(6):1391-6. Epub 2006 Mar 9.

CBR Institute for Biomedical Research, Harvard Medical School, Boston, USA.

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http://dx.doi.org/10.1161/01.ATV.0000216282.58291.c6DOI Listing
June 2006

GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis.

Proc Natl Acad Sci U S A 2006 Jun 6;103(24):9023-8. Epub 2006 Jun 6.

Howard Hughes Medical Institute, Center For Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0602681103
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http://dx.doi.org/10.1073/pnas.0602681103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474142PMC
June 2006

A novel murine model of fetal and neonatal alloimmune thrombocytopenia: response to intravenous IgG therapy.

Blood 2006 Apr 29;107(7):2976-83. Epub 2005 Nov 29.

Canadian Blood Services and Dept of Laboratory Medicine and Pathobiology, St Michael's Hospital, University of Toronto, 30 Bond St Rm 2-006, Bond Wing, Toronto, ON, Canada M5B 1W8.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2005-06-25
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http://dx.doi.org/10.1182/blood-2005-06-2562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895387PMC
April 2006

Lymphatic or hematogenous dissemination: how does a metastatic tumor cell decide?

Cell Cycle 2006 Apr 17;5(8):812-7. Epub 2006 Apr 17.

Howard Hughes Medical Institute, Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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https://www.tandfonline.com/doi/full/10.4161/cc.5.8.2646
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459485PMC
http://dx.doi.org/10.4161/cc.5.8.2646DOI Listing
April 2006

A direct test of potential roles for beta3 and beta5 integrins in growth and metastasis of murine mammary carcinomas.

Cancer Res 2005 Nov;65(22):10324-9

Howard Hughes Medical Institute, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-4098DOI Listing
November 2005

Therapeutic expression of the platelet-specific integrin, alphaIIbbeta3, in a murine model for Glanzmann thrombasthenia.

Blood 2005 Oct 21;106(8):2671-9. Epub 2005 Jun 21.

Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA.

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http://dx.doi.org/10.1182/blood-2004-12-4619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895311PMC
October 2005

An interaction between {alpha}v{beta}8 integrin and Band 4.1B via a highly conserved region of the Band 4.1 C-terminal domain.

Proc Natl Acad Sci U S A 2005 Sep 12;102(38):13479-83. Epub 2005 Sep 12.

Howard Hughes Medical Institute and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.0506068102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1224645PMC
September 2005

Layilin, a cell surface hyaluronan receptor, interacts with merlin and radixin.

Exp Cell Res 2005 Aug;308(1):177-87

Howard Hughes Medical Institute, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.yexcr.2005.04.017DOI Listing
August 2005

Complete replication of hepatitis C virus in cell culture.

Science 2005 Jul 9;309(5734):623-6. Epub 2005 Jun 9.

Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1114016
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July 2005

Guidelines for human embryonic stem cell research.

Nat Biotechnol 2005 Jul;23(7):793-4

Center for Biomedical Ethics, University of Virginia, USA.

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http://dx.doi.org/10.1038/nbt0705-793DOI Listing
July 2005

Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death.

Development 2005 Jan 2;132(1):165-76. Epub 2004 Dec 2.

Center for Cancer Research, Massachusetts Institute of Technology, 40 Ames Street, E17-227, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1242/dev.01551DOI Listing
January 2005

Activation of Latent TGF-β1 by Thrombospondin-1 is a Major Component of Wound Repair.

Oral Biosci Med 2005 ;2(2):153-161

Angiogenesis Research Laboratory; Department of Cariology, Restorative Sciences, and Endodontics, University of Michigan School of Dentistry, Ann Arbor, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150167PMC
January 2005

The emergence of integrins: a personal and historical perspective.

Authors:
Richard O Hynes

Matrix Biol 2004 Oct;23(6):333-40

Howard Hughes Medical Institute, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.matbio.2004.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493146PMC
October 2004