Richard N Fedorak

Richard N Fedorak

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Richard N Fedorak

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Early Initiation of Tumor Necrosis Factor Antagonist-Based Therapy for Patients With Crohn's Disease Reduces Costs Compared With Late Initiation.

Clin Gastroenterol Hepatol 2019 Jul 26;17(8):1515-1524.e4. Epub 2018 Jul 26.

Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2018.07.032DOI Listing
July 2019

IBDoc Canadian User Performance Evaluation.

Inflamm Bowel Dis 2019 May;25(6):1107-1114

Department of Gastroenterology, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1093/ibd/izy357DOI Listing
May 2019

The Costs of Industry-Sponsored Medical Device Clinical Trials in Alberta.

Pharmacoecon Open 2019 Apr 29. Epub 2019 Apr 29.

Department of Medicine, University of Alberta, Edmonton, AB, Canada.

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http://dx.doi.org/10.1007/s41669-019-0137-0DOI Listing
April 2019

Heterogeneity in Definitions of Efficacy and Safety Endpoints for Clinical Trials of Crohn's Disease: A Systematic Review.

Clin Gastroenterol Hepatol 2018 Sep 27;16(9):1407-1419.e22. Epub 2018 Mar 27.

Robarts Clinical Trials, Western University, London, Ontario, Canada; Department of Medicine, Western University, London, Ontario, Canada; Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2018.02.051DOI Listing
September 2018

Heterogeneity in Definitions of Endpoints for Clinical Trials of Ulcerative Colitis: A Systematic Review for Development of a Core Outcome Set.

Clin Gastroenterol Hepatol 2018 05 24;16(5):637-647.e13. Epub 2017 Aug 24.

Robarts Clinical Trials, Western University, London, Ontario, Canada; Department of Medicine, Western University, London, Ontario, Canada; Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2017.08.025DOI Listing
May 2018

A BACH2 Gene Variant Is Associated with Postoperative Recurrence of Crohn's Disease.

J Am Coll Surg 2018 05 13;226(5):902-908. Epub 2018 Feb 13.

Department of Medicine, University of Alberta, Edmonton, Alberta, Canada; The Centre of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jamcollsurg.2018.01.052DOI Listing
May 2018

Noninvasive Fecal Immunochemical Testing and Fecal Calprotectin Predict Mucosal Healing in Inflammatory Bowel Disease: A Prospective Cohort Study.

Inflamm Bowel Dis 2017 09;23(9):1643-1649

*Division of Gastroenterology, University of Calgary, Calgary, Alberta, Canada; †Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada; and ‡Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1097/MIB.0000000000001173DOI Listing
September 2017

Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study.

World J Gastroenterol 2017 Jun;23(21):3890-3899

Ammar Hassanzadeh Keshteli, Floris F van den Brand, Karen L Madsen, Rosica Valcheva, Karen I Kroeker, Thomas Hoevers, Richard N Fedorak, Levinus A Dieleman, Department of Medicine, Division of Gastroenterology and CEGIIR, University of Alberta, Edmonton, AB T6G 2X8, Canada.

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http://dx.doi.org/10.3748/wjg.v23.i21.3890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467075PMC
June 2017

Long-term Maintenance of Clinical, Endoscopic, and Radiographic Response to Ustekinumab in Moderate-to-Severe Crohn's Disease: Real-world Experience from a Multicenter Cohort Study.

Inflamm Bowel Dis 2017 05;23(5):833-839

*Department of Medicine, Division of Gastroenterology, University of Calgary, Calgary, Alberta, Canada;†Department of Medicine, Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada;‡Department of Medicine, Division of Gastroenterology, University of British Columbia, Vancouver, British Columbia, Canada; and§Institute of Translational Medicine, University of Birmingham, Birmingham, United Kingdom.

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http://dx.doi.org/10.1097/MIB.0000000000001074DOI Listing
May 2017

Practical Considerations and the Intestinal Microbiome in Disease: Antibiotics for IBD Therapy.

Dig Dis 2016 16;34(1-2):112-21. Epub 2016 Mar 16.

Division of Gastroenterology, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alta., Canada.

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https://www.karger.com/Article/FullText/443014
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http://dx.doi.org/10.1159/000443014DOI Listing
December 2016

Role of Vitamin D in Infliximab-induced Remission in Adult Patients with Crohn's Disease.

Inflamm Bowel Dis 2016 Jan;22(1):92-9

Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1097/MIB.0000000000000588DOI Listing
January 2016

Recurrent Fevers After Infliximab Therapy for Ulcerative Colitis.

Gastroenterology 2016 Jan 25;150(1):e1-2. Epub 2015 Nov 25.

Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1053/j.gastro.2015.04.048DOI Listing
January 2016

Lymphoproliferative disorders in inflammatory bowel disease patients on immunosuppression: Lessons from other inflammatory disorders.

World J Gastrointest Pathophysiol 2015 Nov;6(4):181-92

Grace Y Lam, Department of Medicine, Division of Internal Medicine, University of Alberta, 8440 112 St NW Edmonton, Alberta, Canada.

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http://dx.doi.org/10.4291/wjgp.v6.i4.181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644882PMC
November 2015

TP53 codon 72 Arg/Arg polymorphism is associated with a higher risk for inflammatory bowel disease development.

World J Gastroenterol 2015 Sep;21(36):10358-66

Natalia Volodko, Hien Q Huynh, Shairaz Baksh, Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2E1, Canada.

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http://dx.doi.org/10.3748/wjg.v21.i36.10358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579882PMC
September 2015

Patients with Active Luminal Crohn's Disease Have Evidence of Significant Functional and Clinical Pulmonary Involvement.

Inflamm Bowel Dis 2015 Aug;21(8):1817-24

*Department of Medicine, Division of Gastroenterology, University of Alberta, Edmonton, AB, Canada; and †Department of Medicine, Division of Pulmonary Medicine, University of Alberta, Edmonton, AB, Canada.

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http://dx.doi.org/10.1097/MIB.0000000000000442DOI Listing
August 2015

Fecal Microbial Transplant After Ileocolic Resection Reduces Ileitis but Restores Colitis in IL-10-/- Mice.

Inflamm Bowel Dis 2015 Jul;21(7):1479-90

Departments of *Surgery, †Medicine and ‡Biological Sciences, University of Alberta, Edmonton, AB, Canada; §BGI-Shenzhen, Shenzhen, China; and ‖Department of Laboratory Medicine, University of Alberta, Edmonton, AB, Canada.

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http://dx.doi.org/10.1097/MIB.0000000000000383DOI Listing
July 2015

Knowledge of Fecal Calprotectin and Infliximab Trough Levels Alters Clinical Decision-making for IBD Outpatients on Maintenance Infliximab Therapy.

Inflamm Bowel Dis 2015 Jun;21(6):1359-67

*Department of Medicine, Division of Gastroenterology, University of Alberta, Edmonton, AB, Canada; †Department of Laboratory Medicine and Pathology, Division of Medical Laboratory Science, University of Alberta, Edmonton, AB, Canada; and ‡Department of Surgery, Division of Surgery, University of Alberta, Edmonton, AB, Canada.

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http://dx.doi.org/10.1097/MIB.0000000000000376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450916PMC
June 2015

Molecular patterns in human ulcerative colitis and correlation with response to infliximab.

Inflamm Bowel Dis 2014 Dec;20(12):2353-63

*Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, AB, Canada; †F. Widjaja Foundation, Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California; ‡Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada; §Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; and ‖Division of Nephrology and Transplant Immunology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.

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http://pdfs.journals.lww.com/ibdjournal/2014/12000/Molecular
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1097/MIB.0000000000000239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985265PMC
December 2014

Real-life treatment paradigms show infliximab is cost-effective for management of ulcerative colitis.

Clin Gastroenterol Hepatol 2014 Nov 24;12(11):1871-8.e8. Epub 2014 Mar 24.

Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2014.03.012DOI Listing
November 2014

Crohn's disease outpatients treated with adalimumab have an earlier secondary loss of response and requirement for dose escalation compared to infliximab: a real life cohort study.

J Crohns Colitis 2014 Nov 16;8(11):1454-63. Epub 2014 Jun 16.

Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.crohns.2014.05.007DOI Listing
November 2014

A machine-learned predictor of colonic polyps based on urinary metabolomics.

Biomed Res Int 2013 7;2013:303982. Epub 2013 Nov 7.

Department of Computing Science, University of Alberta, Edmonton, AB, Canada T6G 2E8.

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http://dx.doi.org/10.1155/2013/303982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838851PMC
June 2014

Vitamin D improves inflammatory bowel disease outcomes: basic science and clinical review.

World J Gastroenterol 2014 May;20(17):4934-47

Krista M Reich, Richard N Fedorak, Karen Madsen, Karen I Kroeker, Division of Gastroenterology, University of Alberta, Edmonton, Alberta T6G 2X8, Canada.

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http://dx.doi.org/10.3748/wjg.v20.i17.4934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009525PMC
May 2014

Phenotypic features of Crohn's disease associated with failure of medical treatment.

Clin Gastroenterol Hepatol 2014 Mar 24;12(3):434-42.e1. Epub 2013 Aug 24.

Inflammatory Bowel Disease Clinic, University of Calgary, Alberta, Canada; Division of Gastroenterology, University of Calgary, Alberta, Canada; Department of Medicine, University of Calgary, Alberta, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2013.08.026DOI Listing
March 2014

Development and validation of a highly sensitive urine-based test to identify patients with colonic adenomatous polyps.

Clin Transl Gastroenterol 2014 Mar 20;5:e54. Epub 2014 Mar 20.

Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1038/ctg.2014.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940838PMC
March 2014

Metabolomic profiles are gender, disease and time specific in the interleukin-10 gene-deficient mouse model of inflammatory bowel disease.

PLoS One 2013 9;8(7):e67654. Epub 2013 Jul 9.

Centre of Excellence for Gastrointestinal Inflammation and Immunity Research, Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0067654PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706546PMC
February 2014

Distance management of inflammatory bowel disease: systematic review and meta-analysis.

World J Gastroenterol 2014 Jan;20(3):829-42

Vivian W Huang, Krista M Reich, Richard N Fedorak, Division of Gastroenterology, University of Alberta, Edmonton, Alberta T6G 2X8, Canada.

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http://dx.doi.org/10.3748/wjg.v20.i3.829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921492PMC
January 2014

Varicella zoster meningitis complicating combined anti-tumor necrosis factor and corticosteroid therapy in Crohn's disease.

World J Gastroenterol 2013 Jun;19(21):3347-51

Division of Gastroenterology, University of Alberta, Edmonton, AL T6G 2X8, Canada.

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http://dx.doi.org/10.3748/wjg.v19.i21.3347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671088PMC
June 2013

Breaks in the wall: increased gaps in the intestinal epithelium of irritable bowel syndrome patients identified by confocal laser endomicroscopy (with videos).

Gastrointest Endosc 2013 Apr 26;77(4):624-30. Epub 2013 Jan 26.

Division of Gastroenterology, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1016/j.gie.2012.11.006DOI Listing
April 2013

Adalimumab for orbital myositis in a patient with Crohn's disease who discontinued infliximab: a case report and review of the literature.

BMC Gastroenterol 2013 Apr 4;13:59. Epub 2013 Apr 4.

Division of Gastroenterology, University of Alberta, Zeidler Ledcor Center, Edmonton, Alberta, Canada T6G 2X8.

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http://dx.doi.org/10.1186/1471-230X-13-59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621100PMC
April 2013

Urinary NMR metabolomic profiles discriminate inflammatory bowel disease from healthy.

J Crohns Colitis 2013 Mar 22;7(2):e42-8. Epub 2012 May 22.

Department of Food Science & Technology, University of California, Davis, Davis, CA 95616, USA.

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http://dx.doi.org/10.1016/j.crohns.2012.04.019DOI Listing
March 2013

The sensitivity and specificity of guaiac and immunochemical fecal occult blood tests for the detection of advanced colonic adenomas and cancer.

Int J Colorectal Dis 2012 Dec 14;27(12):1657-64. Epub 2012 Jun 14.

Division of Gastroenterology, Royal Alexandra Hospital, 10240 Kingsway Ave, Edmonton, AB, T5H 3V9, Canada.

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http://dx.doi.org/10.1007/s00384-012-1518-3DOI Listing
December 2012

Small bowel fibrosis and systemic inflammatory response after ileocolonic anastomosis in IL-10 null mice.

J Surg Res 2012 Nov 31;178(1):147-54. Epub 2012 Mar 31.

Department of Surgery, University of Alberta, 2-14A Zeidler Building, Edmonton, T6G 2X8 Alberta, Canada.

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http://dx.doi.org/10.1016/j.jss.2012.01.048DOI Listing
November 2012

Development and validation of an administrative case definition for inflammatory bowel diseases.

Can J Gastroenterol 2012 Oct;26(10):711-7

Department of Medicine, University of Calgary, Calgary, Edmonton, Alberta.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472911PMC
http://dx.doi.org/10.1155/2012/278495DOI Listing
October 2012

Risedronate improves bone mineral density in Crohn's disease: a two year randomized controlled clinical trial.

J Crohns Colitis 2012 Aug 10;6(7):777-86. Epub 2012 Feb 10.

Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1016/j.crohns.2012.01.004DOI Listing
August 2012

Iron replacement therapy in inflammatory bowel disease patients with iron deficiency anemia: a systematic review and meta-analysis.

J Crohns Colitis 2012 Apr 26;6(3):267-75. Epub 2011 Oct 26.

Division of Gastroenterology, Center of Excellence for Gastrointestinal Inflammation and Immunity Research (CEGIIR), University of Alberta, Alberta, Canada.

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http://dx.doi.org/10.1016/j.crohns.2011.09.010DOI Listing
April 2012

Validation of a point-of-care desk top device to quantitate fecal calprotectin and distinguish inflammatory bowel disease from irritable bowel syndrome.

J Crohns Colitis 2012 Mar 7;6(2):207-14. Epub 2011 Sep 7.

Center of Excellence for Gastrointestinal Inflammation and Immunity Research, Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1016/j.crohns.2011.08.008DOI Listing
March 2012

Intravenous injection of endogenous microbial components abrogates DSS-induced colitis.

Dig Dis Sci 2012 Feb 1;57(2):345-54. Epub 2011 Sep 1.

Division of Gastroenterology, Department of Medicine, Center of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, AB, T6G 2E1, Canada.

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http://dx.doi.org/10.1007/s10620-011-1878-5DOI Listing
February 2012

Inadequate knowledge of immunization guidelines: a missed opportunity for preventing infection in immunocompromised IBD patients.

Inflamm Bowel Dis 2012 Jan 18;18(1):34-40. Epub 2011 Feb 18.

Division of Gastroenterology, University of Alberta, Edmonton, Canada.

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http://dx.doi.org/10.1002/ibd.21668DOI Listing
January 2012

Health care resource use and costs in Crohn's disease before and after infliximab therapy.

Can J Gastroenterol 2011 Sep;25(9):497-502

Division of GAstroenterology, University of Alberta, Edmonton, Alberta.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202357PMC
http://dx.doi.org/10.1155/2011/157604DOI Listing
September 2011

Increased epithelial gaps in the small intestines of patients with inflammatory bowel disease: density matters.

Gastrointest Endosc 2011 Jun 11;73(6):1174-80. Epub 2011 Mar 11.

Department of Medicine, Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1016/j.gie.2011.01.018DOI Listing
June 2011

Neonatal exposure to fecal antigens reduces intestinal inflammation.

Inflamm Bowel Dis 2011 Apr 7;17(4):899-906. Epub 2010 Sep 7.

Division of Gastroenterology, Department of Medicine, University of Alberta, Center of Excellence for Gastrointestinal Inflammation and Immunity Research, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1002/ibd.21453DOI Listing
April 2011

Mind the gaps: confocal endomicroscopy showed increased density of small bowel epithelial gaps in inflammatory bowel disease.

J Clin Gastroenterol 2011 Mar;45(3):240-5

Department of Medicine, Division of Gastroenterology, University of Alberta, Edmonton, Canada.

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http://dx.doi.org/10.1097/MCG.0b013e3181fbdb8aDOI Listing
March 2011

Predicting, treating and preventing postoperative recurrence of Crohn's disease: the state of the field.

Can J Gastroenterol 2011 Mar;25(3):140-6

Division of General Surgery, Department of Surgery, University of Alberta, Edmonton, Alberta.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076032PMC
http://dx.doi.org/10.1155/2011/591347DOI Listing
March 2011

Patients with IBD are exposed to high levels of ionizing radiation through CT scan diagnostic imaging: a five-year study.

J Clin Gastroenterol 2011 Jan;45(1):34-9

Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1097/MCG.0b013e3181e5d1c5DOI Listing
January 2011

Probiotics in the management of ulcerative colitis.

Gastroenterol Hepatol (N Y) 2010 Nov;6(11):688-90

Associate Vice President of Research University of Alberta Edmonton, Alberta.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033537PMC
November 2010

Metabolomics and detection of colorectal cancer in humans: a systematic review.

Future Oncol 2010 Sep;6(9):1395-406

University of Alberta, 130 University Campus, 112th St & 85th Avenue, Edmonton, AB, Canada.

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http://dx.doi.org/10.2217/fon.10.107DOI Listing
September 2010

Tumor necrosis factor-α monoclonal antibodies in the treatment of inflammatory bowel disease: clinical practice pharmacology.

Gastroenterol Clin North Am 2010 Sep;39(3):543-57

Division of Gastroenterology, University of Alberta, 2-14A Zeidler Building, Edmonton, AB T6G 2X8, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S08898553100006
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http://dx.doi.org/10.1016/j.gtc.2010.08.018DOI Listing
September 2010