Richard Myers

Richard Myers

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Richard Myers

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The caudate nucleus undergoes dramatic and unique transcriptional changes in human prodromal Huntington's disease brain.

BMC Med Genomics 2019 10 16;12(1):137. Epub 2019 Oct 16.

Bioinformatics Nexus, Boston University, Boston, 02118, USA.

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http://dx.doi.org/10.1186/s12920-019-0581-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796419PMC
October 2019

Batf Pioneers the Reorganization of Chromatin in Developing Effector T Cells via Ets1-Dependent Recruitment of Ctcf.

Cell Rep 2019 Oct;29(5):1203-1220.e7

Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.09.064DOI Listing
October 2019

Bi-Directional Learning: Identifying Contaminants on the Yurok Indian Reservation.

Int J Environ Res Public Health 2019 09 20;16(19). Epub 2019 Sep 20.

Yurok Tribe Environmental Program, Klamath, CA 95548, USA.

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http://dx.doi.org/10.3390/ijerph16193513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801823PMC
September 2019

Transmembrane Protein Aptamer Induces Cooperative Signaling by the EPO Receptor and the Cytokine Receptor β-Common Subunit.

iScience 2019 Jul 21;17:167-181. Epub 2019 Jun 21.

Department of Genetics, Yale School of Medicine, P.O. Box 208005, New Haven, CT 06520-8005, USA; Department of Therapeutic Radiology, Yale School of Medicine, P.O. Box 208040, New Haven, CT 06520-8040, USA; Department of Molecular Biophysics & Biochemistry, P.O. Box 208114, Yale University, New Haven, CT 06520-8114, USA; Yale Cancer Center, P.O. Box 208028, New Haven, CT 06520-8028, USA. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2019.06.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614117PMC
July 2019

Genome-wide association study identifies 30 loci associated with bipolar disorder.

Authors:
Eli A Stahl Gerome Breen Andreas J Forstner Andrew McQuillin Stephan Ripke Vassily Trubetskoy Manuel Mattheisen Yunpeng Wang Jonathan R I Coleman Héléna A Gaspar Christiaan A de Leeuw Stacy Steinberg Jennifer M Whitehead Pavlides Maciej Trzaskowski Enda M Byrne Tune H Pers Peter A Holmans Alexander L Richards Liam Abbott Esben Agerbo Huda Akil Diego Albani Ney Alliey-Rodriguez Thomas D Als Adebayo Anjorin Verneri Antilla Swapnil Awasthi Judith A Badner Marie Bækvad-Hansen Jack D Barchas Nicholas Bass Michael Bauer Richard Belliveau Sarah E Bergen Carsten Bøcker Pedersen Erlend Bøen Marco P Boks James Boocock Monika Budde William Bunney Margit Burmeister Jonas Bybjerg-Grauholm William Byerley Miquel Casas Felecia Cerrato Pablo Cervantes Kimberly Chambert Alexander W Charney Danfeng Chen Claire Churchhouse Toni-Kim Clarke William Coryell David W Craig Cristiana Cruceanu David Curtis Piotr M Czerski Anders M Dale Simone de Jong Franziska Degenhardt Jurgen Del-Favero J Raymond DePaulo Srdjan Djurovic Amanda L Dobbyn Ashley Dumont Torbjørn Elvsåshagen Valentina Escott-Price Chun Chieh Fan Sascha B Fischer Matthew Flickinger Tatiana M Foroud Liz Forty Josef Frank Christine Fraser Nelson B Freimer Louise Frisén Katrin Gade Diane Gage Julie Garnham Claudia Giambartolomei Marianne Giørtz Pedersen Jaqueline Goldstein Scott D Gordon Katherine Gordon-Smith Elaine K Green Melissa J Green Tiffany A Greenwood Jakob Grove Weihua Guan José Guzman-Parra Marian L Hamshere Martin Hautzinger Urs Heilbronner Stefan Herms Maria Hipolito Per Hoffmann Dominic Holland Laura Huckins Stéphane Jamain Jessica S Johnson Anders Juréus Radhika Kandaswamy Robert Karlsson James L Kennedy Sarah Kittel-Schneider James A Knowles Manolis Kogevinas Anna C Koller Ralph Kupka Catharina Lavebratt Jacob Lawrence William B Lawson Markus Leber Phil H Lee Shawn E Levy Jun Z Li Chunyu Liu Susanne Lucae Anna Maaser Donald J MacIntyre Pamela B Mahon Wolfgang Maier Lina Martinsson Steve McCarroll Peter McGuffin Melvin G McInnis James D McKay Helena Medeiros Sarah E Medland Fan Meng Lili Milani Grant W Montgomery Derek W Morris Thomas W Mühleisen Niamh Mullins Hoang Nguyen Caroline M Nievergelt Annelie Nordin Adolfsson Evaristus A Nwulia Claire O'Donovan Loes M Olde Loohuis Anil P S Ori Lilijana Oruc Urban Ösby Roy H Perlis Amy Perry Andrea Pfennig James B Potash Shaun M Purcell Eline J Regeer Andreas Reif Céline S Reinbold John P Rice Fabio Rivas Margarita Rivera Panos Roussos Douglas M Ruderfer Euijung Ryu Cristina Sánchez-Mora Alan F Schatzberg William A Scheftner Nicholas J Schork Cynthia Shannon Weickert Tatyana Shehktman Paul D Shilling Engilbert Sigurdsson Claire Slaney Olav B Smeland Janet L Sobell Christine Søholm Hansen Anne T Spijker David St Clair Michael Steffens John S Strauss Fabian Streit Jana Strohmaier Szabolcs Szelinger Robert C Thompson Thorgeir E Thorgeirsson Jens Treutlein Helmut Vedder Weiqing Wang Stanley J Watson Thomas W Weickert Stephanie H Witt Simon Xi Wei Xu Allan H Young Peter Zandi Peng Zhang Sebastian Zöllner Rolf Adolfsson Ingrid Agartz Martin Alda Lena Backlund Bernhard T Baune Frank Bellivier Wade H Berrettini Joanna M Biernacka Douglas H R Blackwood Michael Boehnke Anders D Børglum Aiden Corvin Nicholas Craddock Mark J Daly Udo Dannlowski Tõnu Esko Bruno Etain Mark Frye Janice M Fullerton Elliot S Gershon Michael Gill Fernando Goes Maria Grigoroiu-Serbanescu Joanna Hauser David M Hougaard Christina M Hultman Ian Jones Lisa A Jones René S Kahn George Kirov Mikael Landén Marion Leboyer Cathryn M Lewis Qingqin S Li Jolanta Lissowska Nicholas G Martin Fermin Mayoral Susan L McElroy Andrew M McIntosh Francis J McMahon Ingrid Melle Andres Metspalu Philip B Mitchell Gunnar Morken Ole Mors Preben Bo Mortensen Bertram Müller-Myhsok Richard M Myers Benjamin M Neale Vishwajit Nimgaonkar Merete Nordentoft Markus M Nöthen Michael C O'Donovan Ketil J Oedegaard Michael J Owen Sara A Paciga Carlos Pato Michele T Pato Danielle Posthuma Josep Antoni Ramos-Quiroga Marta Ribasés Marcella Rietschel Guy A Rouleau Martin Schalling Peter R Schofield Thomas G Schulze Alessandro Serretti Jordan W Smoller Hreinn Stefansson Kari Stefansson Eystein Stordal Patrick F Sullivan Gustavo Turecki Arne E Vaaler Eduard Vieta John B Vincent Thomas Werge John I Nurnberger Naomi R Wray Arianna Di Florio Howard J Edenberg Sven Cichon Roel A Ophoff Laura J Scott Ole A Andreassen John Kelsoe Pamela Sklar

Nat Genet 2019 05 1;51(5):793-803. Epub 2019 May 1.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://www.nature.com/articles/s41588-019-0397-8
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http://dx.doi.org/10.1038/s41588-019-0397-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956732PMC
May 2019

Genetic variation at the glycosaminoglycan metabolism pathway contributes to the risk of psoriatic arthritis but not psoriasis.

Ann Rheum Dis 2019 03 14;78(3). Epub 2018 Dec 14.

Rheumatology Research Group, Vall d'Hebron Research Institute, Barcelona, Spain

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http://dx.doi.org/10.1136/annrheumdis-2018-214158DOI Listing
March 2019

Herpes ICP8 protein stimulates homologous recombination in human cells.

PLoS One 2018 15;13(8):e0200955. Epub 2018 Aug 15.

Department of Orthopaedics, University of Miami Miller School of Medicine, Miami, Florida, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200955PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093641PMC
January 2019

powerTCR: A model-based approach to comparative analysis of the clone size distribution of the T cell receptor repertoire.

PLoS Comput Biol 2018 11 28;14(11):e1006571. Epub 2018 Nov 28.

Department of Statistics, Pennsylvania State University, University Park, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1006571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287877PMC
November 2018

Connective Tissue Growth Factor Is a Novel Prodepressant.

Biol Psychiatry 2018 10 3;84(8):555-562. Epub 2018 May 3.

Molecular & Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan; Department of Psychiatry, University of Michigan, Ann Arbor, Michigan.

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https://linkinghub.elsevier.com/retrieve/pii/S00063223183146
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http://dx.doi.org/10.1016/j.biopsych.2018.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249676PMC
October 2018

SnapperDB: a database solution for routine sequencing analysis of bacterial isolates.

Bioinformatics 2018 09;34(17):3028-3029

Gastrointestinal Bacteria Reference Unit, National Infections Service, Public Health England, London, UK.

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http://dx.doi.org/10.1093/bioinformatics/bty212DOI Listing
September 2018

Stage-specific epigenetic regulation of CD4 expression by coordinated enhancer elements during T cell development.

Nat Commun 2018 09 5;9(1):3594. Epub 2018 Sep 5.

The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY, 10016, USA.

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http://www.nature.com/articles/s41467-018-05834-w
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http://dx.doi.org/10.1038/s41467-018-05834-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125341PMC
September 2018

Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function.

Authors:
Annah B Wyss Tamar Sofer Mi Kyeong Lee Natalie Terzikhan Jennifer N Nguyen Lies Lahousse Jeanne C Latourelle Albert Vernon Smith Traci M Bartz Mary F Feitosa Wei Gao Tarunveer S Ahluwalia Wenbo Tang Christopher Oldmeadow Qing Duan Kim de Jong Mary K Wojczynski Xin-Qun Wang Raymond Noordam Fernando Pires Hartwig Victoria E Jackson Tianyuan Wang Ma'en Obeidat Brian D Hobbs Tianxiao Huan Hongsheng Gui Margaret M Parker Donglei Hu Lauren S Mogil Gleb Kichaev Jianping Jin Mariaelisa Graff Tamara B Harris Ravi Kalhan Susan R Heckbert Lavinia Paternoster Kristin M Burkart Yongmei Liu Elizabeth G Holliday James G Wilson Judith M Vonk Jason L Sanders R Graham Barr Renée de Mutsert Ana Maria Baptista Menezes Hieab H H Adams Maarten van den Berge Roby Joehanes Albert M Levin Jennifer Liberto Lenore J Launer Alanna C Morrison Colleen M Sitlani Juan C Celedón Stephen B Kritchevsky Rodney J Scott Kaare Christensen Jerome I Rotter Tobias N Bonten Fernando César Wehrmeister Yohan Bossé Shujie Xiao Sam Oh Nora Franceschini Jennifer A Brody Robert C Kaplan Kurt Lohman Mark McEvoy Michael A Province Frits R Rosendaal Kent D Taylor David C Nickle L Keoki Williams Esteban G Burchard Heather E Wheeler Don D Sin Vilmundur Gudnason Kari E North Myriam Fornage Bruce M Psaty Richard H Myers George O'Connor Torben Hansen Cathy C Laurie Patricia A Cassano Joohon Sung Woo Jin Kim John R Attia Leslie Lange H Marike Boezen Bharat Thyagarajan Stephen S Rich Dennis O Mook-Kanamori Bernardo Lessa Horta André G Uitterlinden Hae Kyung Im Michael H Cho Guy G Brusselle Sina A Gharib Josée Dupuis Ani Manichaikul Stephanie J London

Nat Commun 2018 07 30;9(1):2976. Epub 2018 Jul 30.

Epidemiology Branch National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC, 27709, USA.

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http://dx.doi.org/10.1038/s41467-018-05369-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065313PMC
July 2018

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Authors:
Aude Nicolas Kevin P Kenna Alan E Renton Nicola Ticozzi Faraz Faghri Ruth Chia Janice A Dominov Brendan J Kenna Mike A Nalls Pamela Keagle Alberto M Rivera Wouter van Rheenen Natalie A Murphy Joke J F A van Vugt Joshua T Geiger Rick A Van der Spek Hannah A Pliner Shankaracharya Bradley N Smith Giuseppe Marangi Simon D Topp Yevgeniya Abramzon Athina Soragia Gkazi John D Eicher Aoife Kenna Gabriele Mora Andrea Calvo Letizia Mazzini Nilo Riva Jessica Mandrioli Claudia Caponnetto Stefania Battistini Paolo Volanti Vincenzo La Bella Francesca L Conforti Giuseppe Borghero Sonia Messina Isabella L Simone Francesca Trojsi Fabrizio Salvi Francesco O Logullo Sandra D'Alfonso Lucia Corrado Margherita Capasso Luigi Ferrucci Cristiane de Araujo Martins Moreno Sitharthan Kamalakaran David B Goldstein Aaron D Gitler Tim Harris Richard M Myers Hemali Phatnani Rajeeva Lochan Musunuri Uday Shankar Evani Avinash Abhyankar Michael C Zody Julia Kaye Steven Finkbeiner Stacia K Wyman Alex LeNail Leandro Lima Ernest Fraenkel Clive N Svendsen Leslie M Thompson Jennifer E Van Eyk James D Berry Timothy M Miller Stephen J Kolb Merit Cudkowicz Emily Baxi Michael Benatar J Paul Taylor Evadnie Rampersaud Gang Wu Joanne Wuu Giuseppe Lauria Federico Verde Isabella Fogh Cinzia Tiloca Giacomo P Comi Gianni Sorarù Cristina Cereda Philippe Corcia Hannu Laaksovirta Liisa Myllykangas Lilja Jansson Miko Valori John Ealing Hisham Hamdalla Sara Rollinson Stuart Pickering-Brown Richard W Orrell Katie C Sidle Andrea Malaspina John Hardy Andrew B Singleton Janel O Johnson Sampath Arepalli Peter C Sapp Diane McKenna-Yasek Meraida Polak Seneshaw Asress Safa Al-Sarraj Andrew King Claire Troakes Caroline Vance Jacqueline de Belleroche Frank Baas Anneloor L M A Ten Asbroek José Luis Muñoz-Blanco Dena G Hernandez Jinhui Ding J Raphael Gibbs Sonja W Scholz Mary Kay Floeter Roy H Campbell Francesco Landi Robert Bowser Stefan M Pulst John M Ravits Daniel J L MacGowan Janine Kirby Erik P Pioro Roger Pamphlett James Broach Glenn Gerhard Travis L Dunckley Christopher B Brady Neil W Kowall Juan C Troncoso Isabelle Le Ber Kevin Mouzat Serge Lumbroso Terry D Heiman-Patterson Freya Kamel Ludo Van Den Bosch Robert H Baloh Tim M Strom Thomas Meitinger Aleksey Shatunov Kristel R Van Eijk Mamede de Carvalho Maarten Kooyman Bas Middelkoop Matthieu Moisse Russell L McLaughlin Michael A Van Es Markus Weber Kevin B Boylan Marka Van Blitterswijk Rosa Rademakers Karen E Morrison A Nazli Basak Jesús S Mora Vivian E Drory Pamela J Shaw Martin R Turner Kevin Talbot Orla Hardiman Kelly L Williams Jennifer A Fifita Garth A Nicholson Ian P Blair Guy A Rouleau Jesús Esteban-Pérez Alberto García-Redondo Ammar Al-Chalabi Ekaterina Rogaeva Lorne Zinman Lyle W Ostrow Nicholas J Maragakis Jeffrey D Rothstein Zachary Simmons Johnathan Cooper-Knock Alexis Brice Stephen A Goutman Eva L Feldman Summer B Gibson Franco Taroni Antonia Ratti Cinzia Gellera Philip Van Damme Wim Robberecht Pietro Fratta Mario Sabatelli Christian Lunetta Albert C Ludolph Peter M Andersen Jochen H Weishaupt William Camu John Q Trojanowski Vivianna M Van Deerlin Robert H Brown Leonard H van den Berg Jan H Veldink Matthew B Harms Jonathan D Glass David J Stone Pentti Tienari Vincenzo Silani Adriano Chiò Christopher E Shaw Bryan J Traynor John E Landers

Neuron 2018 03;97(6):1268-1283.e6

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867896PMC
March 2018

MicroRNAs in CSF as prodromal biomarkers for Huntington disease in the PREDICT-HD study.

Neurology 2018 01 27;90(4):e264-e272. Epub 2017 Dec 27.

From the Bioinformatics Program (E.R.R., R.H.M.), Boston University; Department of Neurology (J.C.L., J.B., R.H.M.), Boston University School of Medicine, MA; and Departments of Neurology and Psychiatry (J.H.B., J.S.P.) and Internal Medicine (J.S.), Carver College of Medicine, University of Iowa, Iowa City.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000004844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798654PMC
January 2018

Evidence for a Pan-Neurodegenerative Disease Response in Huntington's and Parkinson's Disease Expression Profiles.

Front Mol Neurosci 2017 11;10:430. Epub 2018 Jan 11.

Bioinformatics Program, Boston University, Boston, MA, United States.

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http://dx.doi.org/10.3389/fnmol.2017.00430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768647PMC
January 2018

Haplotype-based stratification of Huntington's disease.

Eur J Hum Genet 2017 11 23;25(11):1202-1209. Epub 2017 Aug 23.

Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1038/ejhg.2017.125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643960PMC
November 2017

Stress amplifies sex differences in primate prefrontal profiles of gene expression.

Biol Sex Differ 2017 11 2;8(1):36. Epub 2017 Nov 2.

Department of Psychiatry and Behavioral Sciences, Stanford University, 1201 Welch Rd MSLS Room P104, Stanford, CA, 94305-5485, USA.

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http://dx.doi.org/10.1186/s13293-017-0157-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667444PMC
November 2017

A modifier of Huntington's disease onset at the MLH1 locus.

Hum Mol Genet 2017 10;26(19):3859-3867

Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1093/hmg/ddx286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455020PMC
October 2017

Bio-Progressive Therapy.

Authors:
Richard B Myers

J Clin Orthod 2017 Sep;51(9):524-527

Orthodontic Graduate Program, Eastman Institute for Oral Health, University of Rochester; Department of Orthodontics, State University of New York at Buffalo.

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September 2017

When Should We Change Drill Bits? A Mechanical Comparison of New, Reprocessed, and Damaged Bits.

J Orthop Trauma 2017 May;31(5):281-286

*R Adams Cowley Shock Trauma Center, Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD; and †Fischell Department of Bioengineering, Orthopaedic Mechanobiology Laboratory, University of Maryland, College Park, MD.

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http://dx.doi.org/10.1097/BOT.0000000000000812DOI Listing
May 2017

The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington's disease patients.

Sci Rep 2017 05 2;7(1):1307. Epub 2017 May 2.

UCL Huntington's Disease Centre, Sobell Department of Motor Neuroscience, UCL Institute of Neurology, University College London, London, United Kingdom.

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http://dx.doi.org/10.1038/s41598-017-01510-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431000PMC
May 2017

Evaluation of logistic regression models and effect of covariates for case-control study in RNA-Seq analysis.

BMC Bioinformatics 2017 Feb 6;18(1):91. Epub 2017 Feb 6.

Department of Biostatistics, Boston University, 801 Massachusetts Avenue, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1186/s12859-017-1498-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294900PMC
February 2017

Enhanced surveillance of HIV-1 drug resistance in recently infected MSM in the UK.

J Antimicrob Chemother 2017 01 14;72(1):227-234. Epub 2016 Oct 14.

Virus Reference Department, National Infection Service, Public Health England, London, UK

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http://dx.doi.org/10.1093/jac/dkw404DOI Listing
January 2017

The microRNA network is altered in anterior cingulate cortex of patients with unipolar and bipolar depression.

J Psychiatr Res 2016 11 18;82:58-67. Epub 2016 Jul 18.

Molecular and Behavioral Neuroscience Institute, University of Michigan, 205 Zina Pitcher Pl, Ann Arbor, MI, 48109, USA; Neuroscience Graduate Program, University of Michigan, 4137 Undergraduate Science Building (USB), 204 Washtenaw Avenue, Ann Arbor, MI, 48109, USA; Pritzker Neuropsychiatric Disorders Research Consortium, USA; Department of Psychiatry, University of Michigan, 530 Church St, Ann Arbor, MI, 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jpsychires.2016.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026930PMC
November 2016

A reference panel of 64,976 haplotypes for genotype imputation.

Authors:
Shane McCarthy Sayantan Das Warren Kretzschmar Olivier Delaneau Andrew R Wood Alexander Teumer Hyun Min Kang Christian Fuchsberger Petr Danecek Kevin Sharp Yang Luo Carlo Sidore Alan Kwong Nicholas Timpson Seppo Koskinen Scott Vrieze Laura J Scott He Zhang Anubha Mahajan Jan Veldink Ulrike Peters Carlos Pato Cornelia M van Duijn Christopher E Gillies Ilaria Gandin Massimo Mezzavilla Arthur Gilly Massimiliano Cocca Michela Traglia Andrea Angius Jeffrey C Barrett Dorrett Boomsma Kari Branham Gerome Breen Chad M Brummett Fabio Busonero Harry Campbell Andrew Chan Sai Chen Emily Chew Francis S Collins Laura J Corbin George Davey Smith George Dedoussis Marcus Dorr Aliki-Eleni Farmaki Luigi Ferrucci Lukas Forer Ross M Fraser Stacey Gabriel Shawn Levy Leif Groop Tabitha Harrison Andrew Hattersley Oddgeir L Holmen Kristian Hveem Matthias Kretzler James C Lee Matt McGue Thomas Meitinger David Melzer Josine L Min Karen L Mohlke John B Vincent Matthias Nauck Deborah Nickerson Aarno Palotie Michele Pato Nicola Pirastu Melvin McInnis J Brent Richards Cinzia Sala Veikko Salomaa David Schlessinger Sebastian Schoenherr P Eline Slagboom Kerrin Small Timothy Spector Dwight Stambolian Marcus Tuke Jaakko Tuomilehto Leonard H Van den Berg Wouter Van Rheenen Uwe Volker Cisca Wijmenga Daniela Toniolo Eleftheria Zeggini Paolo Gasparini Matthew G Sampson James F Wilson Timothy Frayling Paul I W de Bakker Morris A Swertz Steven McCarroll Charles Kooperberg Annelot Dekker David Altshuler Cristen Willer William Iacono Samuli Ripatti Nicole Soranzo Klaudia Walter Anand Swaroop Francesco Cucca Carl A Anderson Richard M Myers Michael Boehnke Mark I McCarthy Richard Durbin

Nat Genet 2016 10 22;48(10):1279-83. Epub 2016 Aug 22.

Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.

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http://dx.doi.org/10.1038/ng.3643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388176PMC
October 2016

Novel microRNA discovery using small RNA sequencing in post-mortem human brain.

BMC Genomics 2016 10 4;17(1):776. Epub 2016 Oct 4.

Department of Neurology, Boston University School of Medicine, Boston, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050850PMC
http://dx.doi.org/10.1186/s12864-016-3114-3DOI Listing
October 2016

Decoding transcriptional enhancers: Evolving from annotation to functional interpretation.

Semin Cell Dev Biol 2016 09 22;57:40-50. Epub 2016 May 22.

HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, United States. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2016.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018832PMC
September 2016

De Novo Mutations in SON Disrupt RNA Splicing of Genes Essential for Brain Development and Metabolism, Causing an Intellectual-Disability Syndrome.

Am J Hum Genet 2016 09 18;99(3):711-719. Epub 2016 Aug 18.

Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA; Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA. Electronic address:

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http://www.cell.com/ajhg/pdf/S0002-9297(16)30267-1.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S000292971630267
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http://dx.doi.org/10.1016/j.ajhg.2016.06.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011044PMC
September 2016

Advancements in Next-Generation Sequencing.

Annu Rev Genomics Hum Genet 2016 08 9;17:95-115. Epub 2016 Jun 9.

HudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806; email: ,

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http://dx.doi.org/10.1146/annurev-genom-083115-022413DOI Listing
August 2016

Evidence of Extensive Alternative Splicing in Post Mortem Human Brain HTT Transcription by mRNA Sequencing.

PLoS One 2015 23;10(10):e0141298. Epub 2015 Oct 23.

Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America; Bioinformatics Program, Boston University, Boston, Massachusetts, United States of America; Genome Science Institute, Boston University School of Medicine, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141298PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619731PMC
June 2016

The Role of H3K4me3 in Transcriptional Regulation Is Altered in Huntington's Disease.

PLoS One 2015 4;10(12):e0144398. Epub 2015 Dec 4.

Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0144398PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670094PMC
June 2016

Molecular Mechanisms and New Treatment Paradigm for Atrial Fibrillation.

Circ Arrhythm Electrophysiol 2016 May;9(5)

From the Division of Cardiovascular Medicine (P.S., N.L., V.T., X.-D.Z., S.M.M., D.S., V.C.L., R.E.M., D.K.L., J.E.L., N.C.), Department of Pharmacology (L.W., C.M.R.), Department of Entomology and Nematology, Comprehensive Cancer Center (J.Y., K.S.S.L., B.D.H.), Department of Nutrition (A.B., F.H.), and Department of Cardiothoracic Surgery (J.N.Y.), University of California, Davis; Department of Physiology and Cell Biology, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (N.C.).

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http://dx.doi.org/10.1161/CIRCEP.115.003721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869994PMC
May 2016

microRNA Profiles in Parkinson's Disease Prefrontal Cortex.

Front Aging Neurosci 2016 1;8:36. Epub 2016 Mar 1.

Department of Neurology, Boston University School of MedicineBoston, MA, USA; Graduate Program in Genetics and Genomics, Boston University School of MedicineBoston, MA, USA; Bioinformatics Program, Boston UniversityBoston, MA, USA; Genome Science Institute, Boston University School of MedicineBoston, MA, USA.

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http://dx.doi.org/10.3389/fnagi.2016.00036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772525PMC
March 2016

SON and Its Alternatively Spliced Isoforms Control MLL Complex-Mediated H3K4me3 and Transcription of Leukemia-Associated Genes.

Mol Cell 2016 Mar;61(6):859-73

Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA; Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.02.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799497PMC
March 2016

Quantitative Trait Locus and Brain Expression of HLA-DPA1 Offers Evidence of Shared Immune Alterations in Psychiatric Disorders.

Microarrays (Basel) 2016 Mar 7;5(1). Epub 2016 Mar 7.

Functional Genomics Laboratory, Department of Psychiatry & Human Behavior, University of California, Irvine, CA 92697; Department of Psychiatry & Human Behavior, University of California, Irvine, CA 92697, USA.

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http://dx.doi.org/10.3390/microarrays5010006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795482PMC
March 2016

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.

Authors:
Tuomas O Kilpeläinen Jayne F Martin Carli Alicja A Skowronski Qi Sun Jennifer Kriebel Mary F Feitosa Åsa K Hedman Alexander W Drong James E Hayes Jinghua Zhao Tune H Pers Ursula Schick Niels Grarup Zoltán Kutalik Stella Trompet Massimo Mangino Kati Kristiansson Marian Beekman Leo-Pekka Lyytikäinen Joel Eriksson Peter Henneman Jari Lahti Toshiko Tanaka Jian'an Luan Fabiola Del Greco M Dorota Pasko Frida Renström Sara M Willems Anubha Mahajan Lynda M Rose Xiuqing Guo Yongmei Liu Marcus E Kleber Louis Pérusse Tom Gaunt Tarunveer S Ahluwalia Yun Ju Sung Yolande F Ramos Najaf Amin Antoinette Amuzu Inês Barroso Claire Bellis John Blangero Brendan M Buckley Stefan Böhringer Yii-Der I Chen Anton J N de Craen David R Crosslin Caroline E Dale Zari Dastani Felix R Day Joris Deelen Graciela E Delgado Ayse Demirkan Francis M Finucane Ian Ford Melissa E Garcia Christian Gieger Stefan Gustafsson Göran Hallmans Susan E Hankinson Aki S Havulinna Christian Herder Dena Hernandez Andrew A Hicks David J Hunter Thomas Illig Erik Ingelsson Andreea Ioan-Facsinay John-Olov Jansson Nancy S Jenny Marit E Jørgensen Torben Jørgensen Magnus Karlsson Wolfgang Koenig Peter Kraft Joanneke Kwekkeboom Tiina Laatikainen Karl-Heinz Ladwig Charles A LeDuc Gordon Lowe Yingchang Lu Pedro Marques-Vidal Christa Meisinger Cristina Menni Andrew P Morris Richard H Myers Satu Männistö Mike A Nalls Lavinia Paternoster Annette Peters Aruna D Pradhan Tuomo Rankinen Laura J Rasmussen-Torvik Wolfgang Rathmann Treva K Rice J Brent Richards Paul M Ridker Naveed Sattar David B Savage Stefan Söderberg Nicholas J Timpson Liesbeth Vandenput Diana van Heemst Hae-Won Uh Marie-Claude Vohl Mark Walker Heinz-Erich Wichmann Elisabeth Widén Andrew R Wood Jie Yao Tanja Zeller Yiying Zhang Ingrid Meulenbelt Margreet Kloppenburg Arne Astrup Thorkild I A Sørensen Mark A Sarzynski D C Rao Pekka Jousilahti Erkki Vartiainen Albert Hofman Fernando Rivadeneira André G Uitterlinden Eero Kajantie Clive Osmond Aarno Palotie Johan G Eriksson Markku Heliövaara Paul B Knekt Seppo Koskinen Antti Jula Markus Perola Risto K Huupponen Jorma S Viikari Mika Kähönen Terho Lehtimäki Olli T Raitakari Dan Mellström Mattias Lorentzon Juan P Casas Stefanie Bandinelli Winfried März Aaron Isaacs Ko W van Dijk Cornelia M van Duijn Tamara B Harris Claude Bouchard Matthew A Allison Daniel I Chasman Claes Ohlsson Lars Lind Robert A Scott Claudia Langenberg Nicholas J Wareham Luigi Ferrucci Timothy M Frayling Peter P Pramstaller Ingrid B Borecki Dawn M Waterworth Sven Bergmann Gérard Waeber Peter Vollenweider Henrik Vestergaard Torben Hansen Oluf Pedersen Frank B Hu P Eline Slagboom Harald Grallert Tim D Spector J W Jukema Robert J Klein Erik E Schadt Paul W Franks Cecilia M Lindgren Rudolph L Leibel Ruth J F Loos

Nat Commun 2016 Feb 1;7:10494. Epub 2016 Feb 1.

MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.

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http://dx.doi.org/10.1038/ncomms10494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740377PMC
February 2016

Evidence for alterations of the glial syncytial function in major depressive disorder.

J Psychiatr Res 2016 Jan 23;72:15-21. Epub 2015 Oct 23.

Molecular & Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1016/j.jpsychires.2015.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813495PMC
January 2016

Clinical-Genetic Associations in the Prospective Huntington at Risk Observational Study (PHAROS): Implications for Clinical Trials.

Authors:
Kevin Michael Biglan Ira Shoulson Karl Kieburtz David Oakes Elise Kayson M Aileen Shinaman Hongwei Zhao Megan Romer Anne Young Steven Hersch Jack Penney Karen Marder Jane Paulsen Kimberly Quaid Eric Siemers Caroline Tanner William Mallonee Greg Suter Richard Dubinsky Carolyn Gray Martha Nance Scott Bundlie Dawn Radtke Sandra Kostyk Corrine Baic James Caress Francis Walker Victoria Hunt Christine O'Neill Sylvain Chouinard Stewart Factor Timothy Greenamyre Cathy Wood-Siverio Jody Corey-Bloom David Song Guerry Peavy Carol Moskowitz Melissa Wesson Ali Samii Thomas Bird Hillary Lipe Karen Blindauer Frederick Marshall Carol Zimmerman Jody Goldstein Diana Rosas Peter Novak John Caviness Charles Adler Amy Duffy Vicki Wheelock Teresa Tempkin David Richman Lauren Seeberger Roger Albin Kelvin L Chou Brad Racette Joel S Perlmutter Susan Perlman Yvette Bordelon Wayne Martin Marguerite Wieler Blair Leavitt Lynn Raymond Joji Decolongon Lorne Clarke Joseph Jankovic Christine Hunter Robert A Hauser Juan Sanchez-Ramos Sarah Furtado Oksana Suchowersky Mary Lou Klimek Mark Guttman Rustom Sethna Andrew Feigin Marie Cox Barbara Shannon Alan Percy Leon Dure Madaline Harrison William Johnson Donald Higgins Eric Molho Constance Nickerson Sharon Evans Douglas Hobson Carlos Singer Nestor Galvez-Jimenez Kathleen Shannon Cynthia Comella Christopher Ross Marie H Saint-Hilaire Claudia Testa Adam Rosenblatt Penelope Hogarth William Weiner Peter Como Rajeev Kumar Candace Cotto Julie Stout Alicia Brocht Arthur Watts Shirley Eberly Christine Weaver Tatiana Foroud James Gusella Marcy MacDonald Richard Myers Stanley Fahn Clifford Shults

JAMA Neurol 2016 Jan;73(1):102-10

Department of Neuroscience, University of California, San Diego, La Jolla.

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http://dx.doi.org/10.1001/jamaneurol.2015.2736DOI Listing
January 2016

Evolving New Skeletal Traits by cis-Regulatory Changes in Bone Morphogenetic Proteins.

Cell 2016 Jan 7;164(1-2):45-56. Epub 2016 Jan 7.

Howard Hughes Medical Institute; Stanford University School of Medicine, Department of Developmental Biology, 279 Campus Drive, Beckman Center B300, Stanford, CA 94305, USA. Electronic address:

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http://www.cell.com/cell/pdf/S0092-8674(15)01631-1.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S009286741501631
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http://dx.doi.org/10.1016/j.cell.2015.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759241PMC
January 2016

Study of plasma-derived miRNAs mimic differences in Huntington's disease brain.

Mov Disord 2015 Dec 17;30(14):1961-4. Epub 2015 Nov 17.

Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/mds.26457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715548PMC
December 2015