Publications by authors named "Richard Moriggl"

100Publications

TYK2 licenses non-canonical inflammasome activation during endotoxemia.

Cell Death Differ 2020 Sep 14. Epub 2020 Sep 14.

Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.

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http://dx.doi.org/10.1038/s41418-020-00621-xDOI Listing
September 2020

Targeting STAT3 and STAT5 in Cancer.

Cancers (Basel) 2020 Jul 22;12(8). Epub 2020 Jul 22.

Institute of Animal Breeding and Genetics, University of Veterinary Medicine, A-1210 Vienna, Austria.

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http://dx.doi.org/10.3390/cancers12082002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465272PMC
July 2020

STAT5 is required for lipid breakdown and beta-adrenergic responsiveness of brown adipose tissue.

Mol Metab 2020 Oct 28;40:101026. Epub 2020 May 28.

Institute of Animal Breeding and Genetics, University of Veterinary Medicine, 1210, Vienna, Austria; Ludwig Boltzmann Institute for Cancer Research, 1090, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2020.101026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322099PMC
October 2020

Advances in covalent kinase inhibitors.

Chem Soc Rev 2020 May 30;49(9):2617-2687. Epub 2020 Mar 30.

Department of Chemical & Physical Sciences, University of Toronto, 3359 Mississauga Road, Mississauga, ON L5L 1C6, Canada.

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http://dx.doi.org/10.1039/c9cs00720bDOI Listing
May 2020

Direct Targeting Options for STAT3 and STAT5 in Cancer.

Cancers (Basel) 2019 Dec 3;11(12). Epub 2019 Dec 3.

Institute of Animal Breeding and Genetics, University of Veterinary Medicine, 1210 Vienna, Austria.

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http://dx.doi.org/10.3390/cancers11121930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966570PMC
December 2019

Structural Implications of STAT3 and STAT5 SH2 Domain Mutations.

Cancers (Basel) 2019 Nov 8;11(11). Epub 2019 Nov 8.

Centre for Medicinal Chemistry, University of Toronto at Mississauga, Mississauga, ON L5L 1C6, Canada.

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http://dx.doi.org/10.3390/cancers11111757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895964PMC
November 2019

The stromal microenvironment provides an escape route from FLT3 inhibitors through the GAS6-AXL-STAT5 axis.

Haematologica 2019 10;104(10):1907-1909

Institute of Animal Breeding and Genetics, University of Veterinary Medicine.

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http://dx.doi.org/10.3324/haematol.2019.225862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886418PMC
October 2019

JAK-STAT inhibition impairs K-RAS-driven lung adenocarcinoma progression.

Int J Cancer 2019 12 10;145(12):3376-3388. Epub 2019 Sep 10.

Department of Physiology, Center of Physiology and Pharmacology & Comprehensive Cancer Center (CCC), Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1002/ijc.32624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856680PMC
December 2019

Editorial: Cytokines in liver diseases.

Cytokine 2019 12 16;124:154608. Epub 2018 Dec 16.

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10434666183046
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http://dx.doi.org/10.1016/j.cyto.2018.12.001DOI Listing
December 2019

Crosstalk between inflammatory mediators and endoplasmic reticulum stress in liver diseases.

Cytokine 2019 12 14;124:154577. Epub 2018 Nov 14.

Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria; Laboratory of Navigational Redox Lipidomics and Department of Human Pathology, IM Sechenov Moscow State Medical University, Russian Federation. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10434666183040
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http://dx.doi.org/10.1016/j.cyto.2018.10.018DOI Listing
December 2019

Pharmacologic IL-6Rα inhibition in cholangiocarcinoma promotes cancer cell growth and survival.

Biochim Biophys Acta Mol Basis Dis 2019 02 9;1865(2):308-321. Epub 2018 Nov 9.

Diagnostic & Research Center for Molecular BioMedicine, Institute of Pathology, Medical University of Graz, Austria; Center for Biomarker Research in Medicine, Graz, Austria; Department of Pathology, Medical Faculty, Otto von Guericke University Magdeburg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09254439183045
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http://dx.doi.org/10.1016/j.bbadis.2018.11.006DOI Listing
February 2019

Hepatic growth hormone - JAK2 - STAT5 signalling: Metabolic function, non-alcoholic fatty liver disease and hepatocellular carcinoma progression.

Cytokine 2019 12 30;124:154569. Epub 2018 Oct 30.

Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria; Medical University of Vienna, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2018.10.010DOI Listing
December 2019

STAT5 deficiency in hepatocytes reduces diethylnitrosamine-induced liver tumorigenesis in mice.

Cytokine 2019 12 28;124:154573. Epub 2018 Oct 28.

Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria; Medical University of Vienna, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2018.10.014DOI Listing
December 2019

A haunted beast: Targeting STAT5B in T-Cell Neoplasia.

Mol Cell Oncol 2018 28;5(3):e1435181. Epub 2018 Mar 28.

Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.

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http://dx.doi.org/10.1080/23723556.2018.1435181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964446PMC
March 2018

Tumor target amplification: Implications for nano drug delivery systems.

J Control Release 2018 04 16;275:142-161. Epub 2018 Feb 16.

Institute for Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210 Vienna, Austria; Ludwig Boltzmann Institute for Cancer Research, 1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2018.02.020DOI Listing
April 2018

AKT3 drives adenoid cystic carcinoma development in salivary glands.

Cancer Med 2018 02 28;7(2):445-453. Epub 2017 Dec 28.

Department of Physiology, Center of Physiology and Pharmacology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1002/cam4.1293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806106PMC
February 2018

Emerging therapeutic targets in myeloproliferative neoplasms and peripheral T-cell leukemia and lymphomas.

Expert Opin Ther Targets 2018 01 24;22(1):45-57. Epub 2017 Nov 24.

a Institute of Animal Breeding and Genetics , University of Veterinary Medicine Vienna , Vienna , Austria.

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http://dx.doi.org/10.1080/14728222.2018.1406924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743003PMC
January 2018

Human stem cells alter the invasive properties of somatic cells via paracrine activation of mTORC1.

Nat Commun 2017 09 19;8(1):595. Epub 2017 Sep 19.

Institute of Medical Genetics, Center of Pathobiochemistry and Genetics, Medical University of Vienna, 1090, Vienna, Austria.

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http://dx.doi.org/10.1038/s41467-017-00661-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605703PMC
September 2017

When the guardian sleeps: Reactivation of the p53 pathway in cancer.

Mutat Res 2017 07 17;773:1-13. Epub 2017 Feb 17.

Department of Clinical Pathology, Medical University Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria; Ludwig Boltzmann Institute for Cancer Research, Waehringerstrasse 13a, 1090 Vienna, Austria; Institute of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, Veterinaerplatz 1, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.mrrev.2017.02.003DOI Listing
July 2017

Expansion of BCR/ABL1 cells requires PAK2 but not PAK1.

Br J Haematol 2017 10 14;179(2):229-241. Epub 2017 Jul 14.

Institute of Pharmacology and Toxicology, Department of Biomedical Sciences, University of Veterinary Medicine Vienna, Vienna, Austria.

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http://dx.doi.org/10.1111/bjh.14833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655792PMC
October 2017

A rare castration-resistant progenitor cell population is highly enriched in Pten-null prostate tumours.

J Pathol 2017 09 28;243(1):51-64. Epub 2017 Jul 28.

Institut Necker Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Paris, France.

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http://dx.doi.org/10.1002/path.4924DOI Listing
September 2017

The JAK2/STAT5 signaling pathway as a potential therapeutic target in canine mastocytoma.

Vet Comp Oncol 2018 Mar 11;16(1):55-68. Epub 2017 Apr 11.

Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1111/vco.12311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824979PMC
March 2018

Steering of carcinoma progression by the YIN/YANG interaction of STAT1/STAT3.

Biosci Trends 2017 Mar 2;11(1):1-8. Epub 2017 Feb 2.

Institute of Biochemistry II, University Hospital Jena.

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http://dx.doi.org/10.5582/bst.2016.01250DOI Listing
March 2017

STAT5 drives abnormal proliferation in autosomal dominant polycystic kidney disease.

Kidney Int 2017 03 16;91(3):575-586. Epub 2017 Jan 16.

Academic Nephrology Unit, Department of Infection, Immunity and Cardiovascular Disease, The Medical School, University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.1016/j.kint.2016.10.039DOI Listing
March 2017

JAK-STAT signaling in cancer: From cytokines to non-coding genome.

Cytokine 2016 11 24;87:26-36. Epub 2016 Jun 24.

Clinical Institute of Pathology, Medical University of Vienna, 1090 Vienna, Austria; Ludwig Boltzmann Institute for Cancer Research, Medical University of Vienna, 1090 Vienna, Austria; Department for Pathology of Laboratory Animals, University of Veterinary Medicine Vienna, 1210 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2016.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059362PMC
November 2016

Epigenetic program and transcription factor circuitry of dendritic cell development.

Nucleic Acids Res 2015 Nov 17;43(20):9680-93. Epub 2015 Oct 17.

Institute for Biomedical Engineering, Department of Cell Biology, RWTH Aachen University Medical School, 52074 Aachen, Germany Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, 52074 Aachen, Germany

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http://dx.doi.org/10.1093/nar/gkv1056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787753PMC
November 2015

Natural compound methyl protodioscin protects against intestinal inflammation through modulation of intestinal immune responses.

Pharmacol Res Perspect 2015 Mar 10;3(2):e00118. Epub 2015 Feb 10.

Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center (CCHMC) Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1002/prp2.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448980PMC
March 2015

Stat5 Exerts Distinct, Vital Functions in the Cytoplasm and Nucleus of Bcr-Abl+ K562 and Jak2(V617F)+ HEL Leukemia Cells.

Cancers (Basel) 2015 Mar 19;7(1):503-37. Epub 2015 Mar 19.

Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main 60596, Germany.

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http://dx.doi.org/10.3390/cancers7010503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381271PMC
March 2015

Inhibition of STAT5: a therapeutic option in BCR-ABL1-driven leukemia.

Oncotarget 2014 Oct;5(20):9564-76

Ludwig-Boltzmann Institute for Cancer Research, University of Veterinary Medicine, Medical University Vienna, Austria.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259420PMC
http://dx.doi.org/10.18632/oncotarget.2465DOI Listing
October 2014

Reliable quantification of protein expression and cellular localization in histological sections.

PLoS One 2014 11;9(7):e100822. Epub 2014 Jul 11.

Ludwig Boltzmann Institute for Cancer Research (LBI-CR), Vienna, Austria; Institute of Clinical Pathology, Medical University of Vienna, Vienna, Austria; Unit of Pathology of Laboratory Animals, University of Veterinary Medicine Vienna (Vetmeduni Vienna), Vienna, Austria.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0100822PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094387PMC
March 2015

Recovery from chemotherapy depends on STAT1 for replenishment of B lymphopoiesis.

J Leukoc Biol 2014 Jun;95(6):849-51

Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Austria; and Ludwig Boltzmann Institute for Cancer Research and Medical University of Vienna, Austria

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http://dx.doi.org/10.1189/jlb.0114051DOI Listing
June 2014

A novel germline JAK2 mutation in familial myeloproliferative neoplasms.

Am J Hematol 2014 Jan;89(1):117-8

Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.

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http://dx.doi.org/10.1002/ajh.23614DOI Listing
January 2014

Reply: To PMID 21725989.

Hepatology 2013 Dec 7;58(6):2210. Epub 2013 Oct 7.

Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.

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http://dx.doi.org/10.1002/hep.26545DOI Listing
December 2013

Acetylation and sumoylation control STAT5 activation antagonistically.

JAKSTAT 2012 Jul;1(3):203-7

Center for Molecular Biomedicine; Institute for Biochemistry and Biophysics; Department of Biochemistry; Friedrich Schiller University of Jena; Jena, Germany.

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http://dx.doi.org/10.4161/jkst.21232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670247PMC
July 2012