Publications by authors named "Richard Marais"

100Publications

Ultraviolet radiation drives mutations in a subset of mucosal melanomas.

Nat Commun 2021 01 11;12(1):259. Epub 2021 Jan 11.

Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park, SK10 4TG, UK.

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January 2021

Map3k1 Loss Cooperates with Braf to Drive Melanomagenesis.

J Invest Dermatol 2021 Jan 22;141(1):221-225.e6. Epub 2020 May 22.

Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, United Kingdom. Electronic address:

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January 2021

Genomic Evaluation of Multiparametric Magnetic Resonance Imaging-visible and -nonvisible Lesions in Clinically Localised Prostate Cancer.

Eur Urol Oncol 2019 02 5;2(1):1-11. Epub 2018 Sep 5.

Belfast-Manchester Movember Centre of Excellence, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park, UK; Prostate Oncobiology, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park, UK. Electronic address:

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February 2019

A PAX3/BRN2 rheostat controls the dynamics of BRAF mediated MITF regulation in MITF /AXL melanoma.

Pigment Cell Melanoma Res 2019 03 19;32(2):280-291. Epub 2018 Oct 19.

Manchester Cancer Research Centre, Faculty of Biology, Medicine & Health, Division of Cancer Sciences, The University of Manchester, Manchester, UK.

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March 2019

Nodular Melanoma: A Histopathologic Entity?

Acta Derm Venereol 2018 Apr;98(4):460-462

Cancer and Population Studies Group, QIMR Berghofer Medical Research Institute, Locked Bag 2000 Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia.

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April 2018

Safeguarding the future of independent, academic clinical cancer research in Europe for the benefit of patients.

ESMO Open 2017 3;2(3):e000187. Epub 2017 Aug 3.

European Society for Medical Oncology (ESMO), Clinic of Oncology,University Hospital, Zürich, Zurich, Switzerland.

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August 2017

Cancer: Tumours addicted to drugs are vulnerable.

Nature 2017 10 4;550(7675):192-193. Epub 2017 Oct 4.

Molecular Oncology Group, Cancer Research UK Manchester Institute, Manchester M20 4BX, UK. R.M. is also in the Faculty of Biology, Medicine and Health, The University of Manchester.

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October 2017

A Braf kinase-inactive mutant induces lung adenocarcinoma.

Nature 2017 08 2;548(7666):239-243. Epub 2017 Aug 2.

Experimental Oncology, Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), 28029 Madrid, Spain.

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August 2017

Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models.

Mol Cancer Res 2017 08 25;15(8):1012-1016. Epub 2017 Apr 25.

RNA Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, United Kingdom.

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August 2017

So You Can Teach Old Fibroblasts New Tricks.

Cancer Discov 2016 06;6(6):581-3

Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, United Kingdom.

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June 2016

Inhibiting Drivers of Non-mutational Drug Tolerance Is a Salvage Strategy for Targeted Melanoma Therapy.

Cancer Cell 2016 Mar;29(3):270-284

Manchester Cancer Research Centre, Wellcome Trust Centre for Cell-Matrix Research, The University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK. Electronic address:

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March 2016

RETROSPECTIVE. Christopher Marshall (1949-2015).

Authors:
Richard Marais

Science 2015 Nov;350(6264):1040

CRUK Manchester Institute, University of Manchester, Manchester M20 4BX, UK,.

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November 2015

Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells.

Mol Oncol 2016 Jan 20;10(1):73-84. Epub 2015 Aug 20.

Molecular Oncology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester, Wilmslow Road, Manchester M20 4BX, UK. Electronic address:

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January 2016

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity.

Cell 2015 Sep 3;162(6):1257-70. Epub 2015 Sep 3.

Immunobiology Laboratory, The Francis Crick Institute, Lincoln's Inn Fields Laboratory, 44 Lincoln's Inn Fields, London WC2A 3LY, UK. Electronic address:

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September 2015

Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGFR.

Nat Med 2015 Jul 1;21(7):741-50. Epub 2015 Jun 1.

1] Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, L'Hospitalet, Barcelona, Catalonia, Spain. [2] Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain. [3] Institucio Catalana de Recerca i Estudis Avançats, Barcelona, Catalonia, Spain.

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July 2015

Onco-STS: a web-based laboratory information management system for sample and analysis tracking in oncogenomic experiments.

Source Code Biol Med 2014 5;9(1):25. Epub 2014 Dec 5.

Molecular Oncology Group, University of Manchester, Wilmslow Road, Manchester, M20 4BX UK.

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January 2015

The immune microenvironment confers resistance to MAPK pathway inhibitors through macrophage-derived TNFα.

Cancer Discov 2014 Oct;4(10):1214-1229

Manchester Cancer Research Centre, Wellcome Trust Center for Cell Matrix Research, Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK.

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October 2014

No longer an untreatable disease: how targeted and immunotherapies have changed the management of melanoma patients.

Mol Oncol 2014 Sep 15;8(6):1140-58. Epub 2014 Aug 15.

Molecular Oncology Group, Cancer Research UK Manchester Institute, Manchester, UK. Electronic address:

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September 2014

Hooked on UVR.

Pigment Cell Melanoma Res 2014 Nov 6;27(6):1009-10. Epub 2014 Oct 6.

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November 2014

(G12D) NRAS and kinase-dead BRAF cooperate to drive naevogenesis and melanomagenesis.

Pigment Cell Melanoma Res 2014 Nov 12;27(6):1162-6. Epub 2014 Aug 12.

Targeted Therapy Team, The Institute of Cancer Research, London, UK.

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November 2014

Diverse matrix metalloproteinase functions regulate cancer amoeboid migration.

Nat Commun 2014 Jun 25;5:4255. Epub 2014 Jun 25.

Tumour Plasticity Team, Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL, UK.

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June 2014

Ultraviolet radiation accelerates BRAF-driven melanomagenesis by targeting TP53.

Nature 2014 Jul 11;511(7510):478-482. Epub 2014 Jun 11.

Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester, Wilmslow Road, Manchester, M20 4BX, UK.

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July 2014

The mutational burden of acral melanoma revealed by whole-genome sequencing and comparative analysis.

Pigment Cell Melanoma Res 2014 Sep 30;27(5):835-8. Epub 2014 Jun 30.

Molecular Oncology Group, Cancer Research UK Manchester Institute, Manchester, UK.

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September 2014

COX-2 inhibition prevents the appearance of cutaneous squamous cell carcinomas accelerated by BRAF inhibitors.

Mol Oncol 2014 Mar 1;8(2):250-60. Epub 2013 Dec 1.

Department of Medicine (Division of Hematology-Oncology), David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USA; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USA; Department of Surgery (Division of Surgical-Oncology), David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA. Electronic address:

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March 2014

Braking BRAF: AMPK leaves ERK stranded in the desert.

Mol Cell 2013 Oct;52(2):155-6

The CRUK Manchester Institute, University of Manchester, Manchester M20 4BX, UK.

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October 2013

Transonic, thermodilution, or ionic dialysance to manage vascular access: which method is best?

Hemodial Int 2014 Jan 9;18(1):127-35. Epub 2013 Sep 9.

Department of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, Toulouse, France.

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January 2014

Mind the IQGAP.

Cancer Cell 2013 Jun;23(6):715-7

Molecular Oncology Group, The Paterson Institute for Cancer Research, Manchester M20 4, UK.

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June 2013

Deja Vu: EGF receptors drive resistance to BRAF inhibitors.

Cancer Discov 2013 May;3(5):487-90

The University of Manchester, Manchester, UK.

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May 2013

MEK1/2 inhibition decreases lactate in BRAF-driven human cancer cells.

Cancer Res 2013 Jul 2;73(13):4039-49. Epub 2013 May 2.

Cancer Research UK and EPSRC Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research, Sutton, Surrey, United Kingdom.

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July 2013

Potent BRAF kinase inhibitors based on 2,4,5-trisubstituted imidazole with naphthyl and benzothiophene 4-substituents.

Bioorg Med Chem 2013 Mar 3;21(5):1284-304. Epub 2013 Jan 3.

The Institute of Cancer Research, Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, 15 Cotswold Road, Sutton, Surrey SM2 5NG, United Kingdom.

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March 2013

BRAF as a therapeutic target: a patent review (2006 - 2012).

Expert Opin Ther Pat 2013 Feb 7;23(2):155-64. Epub 2013 Jan 7.

The Institute of Cancer Research, Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK.

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February 2013

Effect of SMURF2 targeting on susceptibility to MEK inhibitors in melanoma.

J Natl Cancer Inst 2013 Jan 17;105(1):33-46. Epub 2012 Dec 17.

Molecular Cancer Studies, Wellcome Trust Centre for Cell Matrix Research, University of Manchester, Oxford Rd, Manchester, UK.

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January 2013

Twenty-fourth annual Pezcoller symposium: Molecular basis for resistance to targeted agents.

Cancer Res 2013 Feb 7;73(3):1046-9. Epub 2012 Dec 7.

The Paterson Institute for Cancer Research, Manchester, United Kingdom.

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February 2013

Elucidating distinct roles for NF1 in melanomagenesis.

Cancer Discov 2013 Mar 21;3(3):338-49. Epub 2012 Nov 21.

Genetics Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02115, USA.

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March 2013

Topical 5-fluorouracil elicits regressions of BRAF inhibitor-induced cutaneous squamous cell carcinoma.

J Invest Dermatol 2013 Jan 16;133(1):274-6. Epub 2012 Aug 16.

Seccio Dermatologia, Departament de Medicina, Hospital Universitari Vall d’Hebron, Universitat Autonomade Barcelona, Spain.

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January 2013

Metformin accelerates the growth of BRAF V600E-driven melanoma by upregulating VEGF-A.

Cancer Discov 2012 Apr 31;2(4):344-55. Epub 2012 Mar 31.

Division of Tumour Biology, The Institute of Cancer Research, London, United Kingdom.

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April 2012

Metformin: a diabetes drug for cancer, or a cancer drug for diabetics?

J Clin Oncol 2012 Jul 7;30(21):2698-700. Epub 2012 May 7.

The Paterson Institute for Cancer Research, Wilmslow Rd, Manchester, UK.

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July 2012

Raf inhibitors target ras spatiotemporal dynamics.

Curr Biol 2012 Jun 3;22(11):945-55. Epub 2012 May 3.

Department of Integrative Biology and Pharmacology, The University of Texas Medical School-Houston, 6431 Fannin Street, Houston, TX 77030, USA.

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June 2012

New insight puts CRAF in sight as a therapeutic target.

Cancer Discov 2011 Jul;1(2):98-9

Signal Transduction Team, Division of Tumour Biology, The Institute of Cancer Research, London, United Kingdom.

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July 2011

Small molecule inhibitors of BRAF in clinical trials.

Bioorg Med Chem Lett 2012 Jan 3;22(2):789-92. Epub 2011 Dec 3.

The Institute of Cancer Research, Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, 15 Cotswold Road, Sutton, Surrey SM2 5NG, United Kingdom.

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January 2012

[Murine cutaneous melanoma models. Importance of the genetic background].

Ann Pathol 2011 Nov 5;31(5 Suppl):S70-3. Epub 2011 Oct 5.

Developmental Genetics of Melanocytes, centre de recherche, institut Curie, bâtiment 110, 91405 Orsay, France.

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November 2011

ROCK and JAK1 signaling cooperate to control actomyosin contractility in tumor cells and stroma.

Cancer Cell 2011 Aug;20(2):229-45

Oncogene Team, Institute of Cancer Research, Section of Cell and Molecular Biology, Cancer Research UK Tumour Cell Signalling Unit, 237 Fulham Road, London SW3 6JB, UK.

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August 2011

Unswitch-ABL drugs overcome resistance in chronic myeloid leukemia.

Cancer Cell 2011 Apr;19(4):435-7

Division of Tumour Biology, The Institute of Cancer Research, London, UK.

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April 2011

Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMP-specific phosphodiesterase PDE5A.

Cancer Cell 2011 Jan 6;19(1):45-57. Epub 2011 Jan 6.

The Institute of Cancer Research, Signal Transduction Team, Section of Cell and Molecular Biology, 237 Fulham Road, London SW3 6JB, UK.

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January 2011

BRAF inactivation drives aneuploidy by deregulating CRAF.

Cancer Res 2010 Nov 26;70(21):8475-86. Epub 2010 Oct 26.

Department of Biochemistry, University of Leicester, Leicester, United Kingdom.

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November 2010

Activation of forkhead box O transcription factors by oncogenic BRAF promotes p21cip1-dependent senescence.

Cancer Res 2010 Nov 19;70(21):8526-36. Epub 2010 Oct 19.

Department of Physiological Chemistry and Center for Biomedical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands.

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November 2010

A novel, selective, and efficacious nanomolar pyridopyrazinone inhibitor of V600EBRAF.

Cancer Res 2010 Oct 31;70(20):8036-44. Epub 2010 Aug 31.

Signal Transduction Team, Section of Cell and Molecular Biology, Molecular Pathology Team, The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom.

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October 2010

Combined zebrafish-yeast chemical-genetic screens reveal gene-copper-nutrition interactions that modulate melanocyte pigmentation.

Dis Model Mech 2010 Sep-Oct;3(9-10):639-51. Epub 2010 Aug 16.

Institute of Genetics and Molecular Medicine, MRC Human Genetics Unit and The University of Edinburgh, Western General Hospital, Edinburgh, UK.

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December 2010

All roads lead to the ribosome.

Cancer Cell 2010 Jul;18(1):5-6

Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.

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July 2010