Publications Authored by Richard Marais

2-Aminomethylene-5-sulfonylthiazole Inhibitors of Lysyl Oxidase (LOX) and LOXL2 Show Significant Efficacy in Delaying Tumor Growth.

Authors:

Deborah A Smithen Leo M H Leung Mairi Challinor Rae Lawrence HaoRan Tang Dan Niculescu-Duvaz Simon P Pearce Robert Mcleary Filipa Lopes Mohammed Aljarah Michael Brown Louise Johnson Graeme Thomson Richard Marais Caroline Springer

J Med Chem 2019 Sep 4. Epub 2019 Sep 4.

Drug Discovery Unit, Cancer Research UK Manchester Institute , University of Manchester , Alderley Park , Macclesfield SK10 4TG , United Kingdom.

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https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b01112	Publisher Site
http://dx.doi.org/10.1021/acs.jmedchem.9b01112	DOI Listing

September 2019

Author Correction: Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface.

Authors:

HaoRan Tang Leo Leung Grazia Saturno Amaya Viros Duncan Smith Gianpiero Di Leva Eamonn Morrison Dan Niculescu-Duvaz Filipa Lopes Louise Johnson Nathalie Dhomen Caroline Springer Richard Marais

Nat Commun 2019 Jul 18;10(1):3151. Epub 2019 Jul 18.

Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, M20 4BX, UK.

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http://dx.doi.org/10.1038/s41467-019-11220-x	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639354	PMC

July 2019

So Close, yet so Far: Discrepancies between Uveal and Other Melanomas. A Position Paper from UM Cure 2020.

Authors:

Manuel Rodrigues Leanne de Koning Sarah E Coupland Aart G Jochemsen Richard Marais Marc-Henri Stern André Valente Raymond Barnhill Nathalie Cassoux Andrew Evans Iain Galloway Martine J Jager Ellen Kapiteijn Bozena Romanowska-Dixon Bettina Ryll Sergio Roman-Roman Sophie Piperno-Neumann

Cancers (Basel) 2019 Jul 22;11(7). Epub 2019 Jul 22.

Department of Medical Oncology and INSERM U830, Institut Curie, PSL Research University, 75005 Paris, France.

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http://dx.doi.org/10.3390/cancers11071032	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678543	PMC

July 2019

Anti-metastatic Inhibitors of Lysyl Oxidase (LOX): Design and Structure-Activity Relationships.

J Med Chem 2019 Jun 23;62(12):5863-5884. Epub 2019 May 23.

Cancer Research UK Centre for Cancer Therapeutics , The Institute of Cancer Research , 15 Cotswold Road , London SM2 5NG , United Kingdom.

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http://dx.doi.org/10.1021/acs.jmedchem.9b00335	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937593	PMC

June 2019

Utility of ctDNA to support patient selection for early phase clinical trials: the TARGET study.

Nat Med 2019 05 22;25(5):738-743. Epub 2019 Apr 22.

Experimental Cancer Medicine Team, The Christie NHS Foundation Trust, Manchester, UK.

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http://dx.doi.org/10.1038/s41591-019-0380-z	DOI Listing

May 2019

A PAX3/BRN2 rheostat controls the dynamics of BRAF mediated MITF regulation in MITF /AXL melanoma.

Authors:

Michael P Smith Sareena Rana Jennifer Ferguson Emily J Rowling Keith T Flaherty Jennifer A Wargo Richard Marais Claudia Wellbrock

Pigment Cell Melanoma Res 2019 03 19;32(2):280-291. Epub 2018 Oct 19.

Manchester Cancer Research Centre, Faculty of Biology, Medicine & Health, Division of Cancer Sciences, The University of Manchester, Manchester, UK.

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http://doi.wiley.com/10.1111/pcmr.12741	Publisher Site
http://dx.doi.org/10.1111/pcmr.12741	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392120	PMC

March 2019

Ultraviolet radiation-induced DNA damage is prognostic for outcome in melanoma.

Authors:

Lucas D Trucco Piyushkumar A Mundra Kate Hogan Pablo Garcia-Martinez Amaya Viros Amit K Mandal Nicolas Macagno Caroline Gaudy-Marqueste Donald Allan Franziska Baenke Martin Cook Clare McManus Berta Sanchez-Laorden Nathalie Dhomen Richard Marais

Nat Med 2019 02 3;25(2):221-224. Epub 2018 Dec 3.

Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1038/s41591-018-0265-6	DOI Listing

February 2019

Publisher Correction: Ultraviolet radiation-induced DNA damage is prognostic for outcome in melanoma.

Authors:

Lucas D Trucco Piyushkumar A Mundra Kate Hogan Pablo Garcia-Martinez Amaya Viros Amit K Mandal Nicolas Macagno Caroline Gaudy-Marqueste Donald Allan Franziska Baenke Martin Cook Clare McManus Berta Sanchez-Laorden Nathalie Dhomen Richard Marais

Nat Med 2019 Feb;25(2):350

Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1038/s41591-018-0325-y	DOI Listing

February 2019

Genomic Evaluation of Multiparametric Magnetic Resonance Imaging-visible and -nonvisible Lesions in Clinically Localised Prostate Cancer.

Eur Urol Oncol 2019 Feb 5;2(1):1-11. Epub 2018 Sep 5.

Belfast-Manchester Movember Centre of Excellence, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park, UK; Prostate Oncobiology, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park, UK. Electronic address:

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http://dx.doi.org/10.1016/j.euo.2018.08.005	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472613	PMC

February 2019

Correction: Biological Characterization of a Novel, Synthetic Diaryl Pyrazole Resorcinol Class of Heat Shock Protein 90 Inhibitors.

Cancer Res 2019 Jan;79(1):287

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http://dx.doi.org/10.1158/0008-5472.CAN-18-3578	DOI Listing

January 2019

Age Correlates with Response to Anti-PD1, Reflecting Age-Related Differences in Intratumoral Effector and Regulatory T-Cell Populations.

Clin Cancer Res 2018 11 13;24(21):5347-5356. Epub 2018 Jun 13.

The Wistar Institute, Philadelphia, Philadelphia.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-1116	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324578	PMC

November 2018

Signaling pathway screening platforms are an efficient approach to identify therapeutic targets in cancers that lack known driver mutations: a case report for a cancer of unknown primary origin.

Authors:

Pedro Torres-Ayuso Sudhakar Sahoo Garry Ashton Elvira An Nicole Simms Melanie Galvin Hui Sun Leong Kristopher K Frese Kathryn Simpson Natalie Cook Andrew Hughes Crispin J Miller Richard Marais Caroline Dive Matthew G Krebs John Brognard

NPJ Genom Med 2018 20;3:15. Epub 2018 Jun 20.

1Signalling Networks in Cancer Group, Cancer Research UK, Manchester Institute, University of Manchester, Manchester, M20 4BX UK.

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http://dx.doi.org/10.1038/s41525-018-0055-6	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010465	PMC

June 2018

Nodular Melanoma: A Histopathologic Entity?

Authors:

Adèle C Green Amaya Viros Maria Celia B Hughes Caroline Gaudy-Marqueste Victoria Akhras Martin G Cook Richard Marais

Acta Derm Venereol 2018 Apr;98(4):460-462

Cancer and Population Studies Group, QIMR Berghofer Medical Research Institute, Locked Bag 2000 Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia.

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http://dx.doi.org/10.2340/00015555-2855	DOI Listing

April 2018

New insights into naevoid melanomas: a clinicopathological reassessment.

Authors:

Martin G Cook Daniela Massi Willeke A M Blokx Joost Van den Oord Senada Koljenović Vincenzo De Giorgi Eleanor Kissin Megan Grant Amit Mandal Gabriela Gremel Caroline Gaudy Amaya Viros Nathalie Dhomen Kiarash Khosrotehrani Richard Marais Adele C Green Martin C Mihm

Histopathology 2017 Dec 2;71(6):943-950. Epub 2017 Oct 2.

Members of EORTC Melanoma Group Pathology Working Group, Florence, Italy.

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http://dx.doi.org/10.1111/his.13317	DOI Listing

December 2017

Molecular analysis of single circulating tumour cells following long-term storage of clinical samples.

Authors:

Barbara Mesquita Dominic G Rothwell Deborah J Burt Francesca Chemi Fabiola Fernandez-Gutierrez Daniel Slane-Tan Jenny Antonello Mathew Carter Louise Carter Marina Parry Lynsey Franklin Richard Marais Fiona Blackhall Caroline Dive Ged Brady

Mol Oncol 2017 12 24;11(12):1687-1697. Epub 2017 Oct 24.

Clinical & Experimental Pharmacology Group, CRUK Manchester Institute, University of Manchester, UK.

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http://dx.doi.org/10.1002/1878-0261.12113	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709616	PMC

December 2017

Cancer: Tumours addicted to drugs are vulnerable.

Authors:

Rebecca J Lee Richard Marais

Nature 2017 10 4;550(7675):192-193. Epub 2017 Oct 4.

Molecular Oncology Group, Cancer Research UK Manchester Institute, Manchester M20 4BX, UK. R.M. is also in the Faculty of Biology, Medicine and Health, The University of Manchester.

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http://dx.doi.org/10.1038/nature24148	DOI Listing

October 2017

Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models.

Authors:

Garima Khandelwal María Romina Girotti Christopher Smowton Sam Taylor Christopher Wirth Marek Dynowski Kristopher K Frese Ged Brady Caroline Dive Richard Marais Crispin Miller

Mol Cancer Res 2017 08 25;15(8):1012-1016. Epub 2017 Apr 25.

RNA Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1158/1541-7786.MCR-16-0431	DOI Listing

August 2017

A Braf kinase-inactive mutant induces lung adenocarcinoma.

Authors:

Patricia Nieto Chiara Ambrogio Laura Esteban-Burgos Gonzalo Gómez-López María Teresa Blasco Zhan Yao Richard Marais Neal Rosen Roberto Chiarle David G Pisano Mariano Barbacid David Santamaría

Nature 2017 08 2;548(7666):239-243. Epub 2017 Aug 2.

Experimental Oncology, Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), 28029 Madrid, Spain.

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http://dx.doi.org/10.1038/nature23297	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648056	PMC

August 2017

Safeguarding the future of independent, academic clinical cancer research in Europe for the benefit of patients.

Authors:

Anastassia Negrouk Denis Lacombe Fatima Cardoso Franck Morin Eva Carrasco Joan Maurel Rudolf Maibach Enrique Aranda Richard Marais Rolf A Stahel

ESMO Open 2017 3;2(3):e000187. Epub 2017 Aug 3.

European Society for Medical Oncology (ESMO), Clinic of Oncology,University Hospital, Zürich, Zurich, Switzerland.

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http://dx.doi.org/10.1136/esmoopen-2017-000187	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634488	PMC

August 2017

MAPK pathway control of stem cell proliferation and differentiation in the embryonic pituitary provides insights into the pathogenesis of papillary craniopharyngioma.

Authors:

Scott Haston Sara Pozzi Gabriela Carreno Saba Manshaei Leonidas Panousopoulos Jose Mario Gonzalez-Meljem John R Apps Alex Virasami Selvam Thavaraj Alice Gutteridge Tim Forshew Richard Marais Sebastian Brandner Thomas S Jacques Cynthia L Andoniadou Juan Pedro Martinez-Barbera

Development 2017 06 15;144(12):2141-2152. Epub 2017 May 15.

Developmental Biology and Cancer Programme, Birth Defects Research Centre, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK

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http://dx.doi.org/10.1242/dev.150490	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482995	PMC

June 2017

Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface.

Authors:

HaoRan Tang Leo Leung Grazia Saturno Amaya Viros Duncan Smith Gianpiero Di Leva Eamonn Morrison Dan Niculescu-Duvaz Filipa Lopes Louise Johnson Nathalie Dhomen Caroline Springer Richard Marais

Nat Commun 2017 04 18;8:14909. Epub 2017 Apr 18.

Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester M20 4BX, UK.

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http://dx.doi.org/10.1038/ncomms14909	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399287	PMC

April 2017

Paradox-Breaking RAF Inhibitors that Also Target SRC Are Effective in Drug-Resistant BRAF Mutant Melanoma.

Cancer Cell 2017 03;31(3):466

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http://dx.doi.org/10.1016/j.ccell.2017.02.007	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848950	PMC

March 2017

The BRAF Inhibitor Vemurafenib Activates Mitochondrial Metabolism and Inhibits Hyperpolarized Pyruvate-Lactate Exchange in BRAF-Mutant Human Melanoma Cells.

Authors:

Teresa Delgado-Goni Maria Falck Miniotis Slawomir Wantuch Harold G Parkes Richard Marais Paul Workman Martin O Leach Mounia Beloueche-Babari

Mol Cancer Ther 2016 12 7;15(12):2987-2999. Epub 2016 Oct 7.

Cancer Research UK Cancer Imaging Centre, The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1158/1535-7163.MCT-16-0068	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136471	PMC

December 2016

Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells.

Authors:

Lindsay C Spender G John Ferguson Sijia Liu Chao Cui Maria Romina Girotti Gary Sibbet Ellen B Higgs Morven K Shuttleworth Tom Hamilton Paul Lorigan Michael Weller David F Vincent Owen J Sansom Margaret Frame Peter Ten Dijke Richard Marais Gareth J Inman

Oncotarget 2016 Dec;7(50):81995-82012

Growth Factor Signalling Laboratory, The Beatson Institute for Cancer Research, Bearsden, Glasgow, United Kingdom.

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http://dx.doi.org/10.18632/oncotarget.13226	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347669	PMC

December 2016

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma.

Nat Commun 2016 08 25;7:12493. Epub 2016 Aug 25.

Division of Cancer Research, School of Medicine, University of Dundee, Dundee DD1 9SY, UK.

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http://dx.doi.org/10.1038/ncomms12493	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007296	PMC

August 2016

So You Can Teach Old Fibroblasts New Tricks.

Authors:

Amaya Virós Maria Romina Girotti Richard Marais

Cancer Discov 2016 06;6(6):581-3

Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0503	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321576	PMC

June 2016

Application of Sequencing, Liquid Biopsies, and Patient-Derived Xenografts for Personalized Medicine in Melanoma.

Cancer Discov 2016 Mar 29;6(3):286-99. Epub 2015 Dec 29.

Molecular Oncology Group, Cancer Research UK Manchester Institute, Manchester, United Kingdom.

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http://dx.doi.org/10.1158/2159-8290.CD-15-1336	DOI Listing

March 2016

Inhibiting Drivers of Non-mutational Drug Tolerance Is a Salvage Strategy for Targeted Melanoma Therapy.

Authors:

Michael P Smith Holly Brunton Emily J Rowling Jennifer Ferguson Imanol Arozarena Zsofia Miskolczi Jessica L Lee Maria R Girotti Richard Marais Mitchell P Levesque Reinhard Dummer Dennie T Frederick Keith T Flaherty Zachary A Cooper Jennifer A Wargo Claudia Wellbrock

Cancer Cell 2016 Mar;29(3):270-284

Manchester Cancer Research Centre, Wellcome Trust Centre for Cell-Matrix Research, The University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.02.003	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796027	PMC

March 2016

Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells.

Authors:

Franziska Baenke Barbara Chaneton Matthew Smith Niels Van Den Broek Kate Hogan Haoran Tang Amaya Viros Matthew Martin Laura Galbraith Maria R Girotti Nathalie Dhomen Eyal Gottlieb Richard Marais

Mol Oncol 2016 Jan 20;10(1):73-84. Epub 2015 Aug 20.

Molecular Oncology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester, Wilmslow Road, Manchester M20 4BX, UK. Electronic address:

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http://doi.wiley.com/10.1016/j.molonc.2015.08.003	Publisher Site
http://dx.doi.org/10.1016/j.molonc.2015.08.003	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717845	PMC

January 2016

RETROSPECTIVE. Christopher Marshall (1949-2015).

Authors:

Richard Marais

Science 2015 Nov;350(6264):1040

CRUK Manchester Institute, University of Manchester, Manchester M20 4BX, UK,.

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http://dx.doi.org/10.1126/science.aad8404	DOI Listing

November 2015

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity.

Authors:

Santiago Zelenay Annemarthe G van der Veen Jan P Böttcher Kathryn J Snelgrove Neil Rogers Sophie E Acton Probir Chakravarty Maria Romina Girotti Richard Marais Sergio A Quezada Erik Sahai Caetano Reis e Sousa

Cell 2015 Sep 3;162(6):1257-70. Epub 2015 Sep 3.

Immunobiology Laboratory, The Francis Crick Institute, Lincoln's Inn Fields Laboratory, 44 Lincoln's Inn Fields, London WC2A 3LY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.08.015	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4597191	PMC

September 2015

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy.

EMBO Mol Med 2015 Aug;7(8):1063-76

Cancer Research UK Beatson Institute Garscube Estate, Glasgow, UK

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http://dx.doi.org/10.15252/emmm.201404827	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551344	PMC

August 2015

A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity.

Authors:

Alejandro Conde-Perez Gwendoline Gros Christine Longvert Malin Pedersen Valérie Petit Zackie Aktary Amaya Viros Franck Gesbert Véronique Delmas Florian Rambow Boris C Bastian Andrew D Campbell Sophie Colombo Isabel Puig Alfonso Bellacosa Owen Sansom Richard Marais Leon C L T Van Kempen Lionel Larue

Nat Commun 2015 Aug 26;6:8093. Epub 2015 Aug 26.

Normal and Pathological Development of Melanocytes, Institut Curie, Orsay 91405, France.

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http://dx.doi.org/10.1038/ncomms9093	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560817	PMC

August 2015

Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGFR.

Nat Med 2015 Jul 1;21(7):741-50. Epub 2015 Jun 1.

1] Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, L'Hospitalet, Barcelona, Catalonia, Spain. [2] Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain. [3] Institucio Catalana de Recerca i Estudis Avançats, Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1038/nm.3863	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968631	PMC

July 2015

BRAF- and MEK-Targeted Small Molecule Inhibitors Exert Enhanced Antimelanoma Effects in Combination With Oncolytic Reovirus Through ER Stress.

Authors:

Victoria Roulstone Malin Pedersen Joan Kyula David Mansfield Aadil A Khan Grainne McEntee Michelle Wilkinson Eleni Karapanagiotou Matt Coffey Richard Marais Adel Jebar Fiona Errington-Mais Alan Melcher Richard Vile Hardev Pandha Martin McLaughlin Kevin J Harrington

Mol Ther 2015 May 26;23(5):931-942. Epub 2015 Jan 26.

Targeted Therapy Team, The Institute of Cancer Research, London, UK. Electronic address:

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http://dx.doi.org/10.1038/mt.2015.15	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427871	PMC

May 2015

Intravital imaging reveals how BRAF inhibition generates drug-tolerant microenvironments with high integrin β1/FAK signaling.

Authors:

Eishu Hirata Maria Romina Girotti Amaya Viros Steven Hooper Bradley Spencer-Dene Michiyuki Matsuda James Larkin Richard Marais Erik Sahai

Cancer Cell 2015 Apr;27(4):574-88

Tumor Cell Biology Laboratory, Cancer Research UK London Research Institute, London WC2A 3LY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.03.008	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402404	PMC

April 2015

Paradox-breaking RAF inhibitors that also target SRC are effective in drug-resistant BRAF mutant melanoma.

Cancer Cell 2015 Jan 11;27(1):85-96. Epub 2014 Dec 11.

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2014.11.006	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297292	PMC

January 2015

Onco-STS: a web-based laboratory information management system for sample and analysis tracking in oncogenomic experiments.

Authors:

Mike Gavrielides Simon J Furney Tim Yates Crispin J Miller Richard Marais

Source Code Biol Med 2014 5;9(1):25. Epub 2014 Dec 5.

Molecular Oncology Group, University of Manchester, Wilmslow Road, Manchester, M20 4BX UK.

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http://dx.doi.org/10.1186/s13029-014-0025-z	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288629	PMC

January 2015

(G12D) NRAS and kinase-dead BRAF cooperate to drive naevogenesis and melanomagenesis.

Authors:

Malin Pedersen Amaya Viros Martin Cook Richard Marais

Pigment Cell Melanoma Res 2014 Nov 12;27(6):1162-6. Epub 2014 Aug 12.

Targeted Therapy Team, The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1111/pcmr.12293	DOI Listing

November 2014

Hooked on UVR.

Authors:

Amaya Viros Richard Marais

Pigment Cell Melanoma Res 2014 Nov 6;27(6):1009-10. Epub 2014 Oct 6.

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http://dx.doi.org/10.1111/pcmr.12305	DOI Listing

November 2014

The immune microenvironment confers resistance to MAPK pathway inhibitors through macrophage-derived TNFα.

Authors:

Michael P Smith Berta Sanchez-Laorden Kate O'Brien Holly Brunton Jennifer Ferguson Helen Young Nathalie Dhomen Keith T Flaherty Dennie T Frederick Zachary A Cooper Jennifer A Wargo Richard Marais Claudia Wellbrock

Cancer Discov 2014 Oct;4(10):1214-1229

Manchester Cancer Research Centre, Wellcome Trust Center for Cell Matrix Research, Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK.

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http://dx.doi.org/10.1158/2159-8290.CD-13-1007	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184867	PMC

October 2014

Future perspectives in melanoma research: meeting report from the "Melanoma Bridge", Napoli, December 5th-8th 2013.

J Transl Med 2014 Oct 28;12:277. Epub 2014 Oct 28.

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http://dx.doi.org/10.1186/s12967-014-0277-z	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232645	PMC

October 2014

The mutational burden of acral melanoma revealed by whole-genome sequencing and comparative analysis.

Authors:

Simon J Furney Samra Turajlic Gordon Stamp J Meirion Thomas Andrew Hayes Dirk Strauss Mike Gavrielides Wei Xing Martin Gore James Larkin Richard Marais

Pigment Cell Melanoma Res 2014 Sep 30;27(5):835-8. Epub 2014 Jun 30.

Molecular Oncology Group, Cancer Research UK Manchester Institute, Manchester, UK.

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http://dx.doi.org/10.1111/pcmr.12279	DOI Listing

September 2014

No longer an untreatable disease: how targeted and immunotherapies have changed the management of melanoma patients.

Authors:

Maria Romina Girotti Grazia Saturno Paul Lorigan Richard Marais

Mol Oncol 2014 Sep 15;8(6):1140-58. Epub 2014 Aug 15.

Molecular Oncology Group, Cancer Research UK Manchester Institute, Manchester, UK. Electronic address:

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http://doi.wiley.com/10.1016/j.molonc.2014.07.027	Publisher Site
http://dx.doi.org/10.1016/j.molonc.2014.07.027	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528622	PMC

September 2014

Ultraviolet radiation accelerates BRAF-driven melanomagenesis by targeting TP53.

Authors:

Amaya Viros Berta Sanchez-Laorden Malin Pedersen Simon J Furney Joel Rae Kate Hogan Sarah Ejiama Maria Romina Girotti Martin Cook Nathalie Dhomen Richard Marais

Nature 2014 Jul 11;511(7510):478-482. Epub 2014 Jun 11.

Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester, Wilmslow Road, Manchester, M20 4BX, UK.

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http://dx.doi.org/10.1038/nature13298	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112218	PMC

July 2014

Diverse matrix metalloproteinase functions regulate cancer amoeboid migration.

Authors:

Jose L Orgaz Pahini Pandya Rimple Dalmeida Panagiotis Karagiannis Berta Sanchez-Laorden Amaya Viros Jean Albrengues Frank O Nestle Anne J Ridley Cedric Gaggioli Richard Marais Sophia N Karagiannis Victoria Sanz-Moreno

Nat Commun 2014 Jun 25;5:4255. Epub 2014 Jun 25.

Tumour Plasticity Team, Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL, UK.

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http://dx.doi.org/10.1038/ncomms5255	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118761	PMC

June 2014

Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors.

Authors:

Anna A Marusiak Zoe C Edwards Willy Hugo Eleanor W Trotter Maria R Girotti Natalie L Stephenson Xiangju Kong Michael G Gartside Shameem Fawdar Andrew Hudson Wolfgang Breitwieser Nicholas K Hayward Richard Marais Roger S Lo John Brognard

Nat Commun 2014 May 22;5:3901. Epub 2014 May 22.

Signalling Networks in Cancer Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK.

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http://dx.doi.org/10.1038/ncomms4901	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046110	PMC

May 2014

COX-2 inhibition prevents the appearance of cutaneous squamous cell carcinomas accelerated by BRAF inhibitors.

Authors:

Helena Escuin-Ordinas Mohammad Atefi Yong Fu Ashley Cass Charles Ng Rong Rong Huang Sharona Yashar Begonya Comin-Anduix Earl Avramis Alistair J Cochran Richard Marais Roger S Lo Thomas G Graeber Harvey R Herschman Antoni Ribas

Mol Oncol 2014 Mar 1;8(2):250-60. Epub 2013 Dec 1.

Department of Medicine (Division of Hematology-Oncology), David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USA; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USA; Department of Surgery (Division of Surgical-Oncology), David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2013.11.005	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943738	PMC

March 2014

BRAF inhibitors induce metastasis in RAS mutant or inhibitor-resistant melanoma cells by reactivating MEK and ERK signaling.

Authors:

Berta Sanchez-Laorden Amaya Viros Maria Romina Girotti Malin Pedersen Grazia Saturno Alfonso Zambon Dan Niculescu-Duvaz Samra Turajlic Andrew Hayes Martin Gore James Larkin Paul Lorigan Martin Cook Caroline Springer Richard Marais

Sci Signal 2014 Mar 25;7(318):ra30. Epub 2014 Mar 25.

1Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK.

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http://dx.doi.org/10.1126/scisignal.2004815	DOI Listing

March 2014

Transonic, thermodilution, or ionic dialysance to manage vascular access: which method is best?

Authors:

Bouchra Badr Pierre Bories Richard Marais Béatrice Frat Bruno Seigneuric Nathalie Longlune Nassim Kamar Sébastien Maggioni Lionel Rostaing

Hemodial Int 2014 Jan 9;18(1):127-35. Epub 2013 Sep 9.

Department of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, Toulouse, France.

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http://dx.doi.org/10.1111/hdi.12092	DOI Listing

January 2014

SF3B1 mutations are associated with alternative splicing in uveal melanoma.

Authors:

Simon J Furney Malin Pedersen David Gentien Amaury G Dumont Audrey Rapinat Laurence Desjardins Samra Turajlic Sophie Piperno-Neumann Pierre de la Grange Sergio Roman-Roman Marc-Henri Stern Richard Marais

Cancer Discov 2013 Oct 16;3(10):1122-1129. Epub 2013 Jul 16.

The Cancer Research UK Manchester Institute, Wilmslow Road, Manchester M20 4BX, UK.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0330	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321577	PMC

October 2013

Braking BRAF: AMPK leaves ERK stranded in the desert.

Authors:

Matthew Martin Richard Marais

Mol Cell 2013 Oct;52(2):155-6

The CRUK Manchester Institute, University of Manchester, Manchester M20 4BX, UK.

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http://dx.doi.org/10.1016/j.molcel.2013.10.011	DOI Listing

October 2013

Genome sequencing of mucosal melanomas reveals that they are driven by distinct mechanisms from cutaneous melanoma.

Authors:

Simon J Furney Samra Turajlic Gordon Stamp Mahrokh Nohadani Anna Carlisle J Meirion Thomas Andrew Hayes Dirk Strauss Martin Gore Joost van den Oord James Larkin Richard Marais

J Pathol 2013 Jul;230(3):261-9

Molecular Oncology Group, Cancer Research UK Manchester Institute, Wilmslow Road, Manchester, M20 4BX, UK.

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http://dx.doi.org/10.1002/path.4204	DOI Listing

July 2013

MEK1/2 inhibition decreases lactate in BRAF-driven human cancer cells.

Authors:

Maria Falck Miniotis Vaitha Arunan Thomas R Eykyn Richard Marais Paul Workman Martin O Leach Mounia Beloueche-Babari

Cancer Res 2013 Jul 2;73(13):4039-49. Epub 2013 May 2.

Cancer Research UK and EPSRC Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research, Sutton, Surrey, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-1969	DOI Listing

July 2013

Mind the IQGAP.

Authors:

Berta Sanchez-Laorden Amaya Viros Richard Marais

Cancer Cell 2013 Jun;23(6):715-7

Molecular Oncology Group, The Paterson Institute for Cancer Research, Manchester M20 4, UK.

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http://dx.doi.org/10.1016/j.ccr.2013.05.017	DOI Listing

June 2013

Deja Vu: EGF receptors drive resistance to BRAF inhibitors.

Authors:

Maria Romina Girotti Richard Marais

Cancer Discov 2013 May;3(5):487-90

The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0131	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736320	PMC

May 2013

Primary melanoma of the CNS in children is driven by congenital expression of oncogenic NRAS in melanocytes.

Authors:

Malin Pedersen Heidi V N Küsters-Vandevelde Amaya Viros Patricia J T A Groenen Berta Sanchez-Laorden Jacobus H Gilhuis Ilse A van Engen-van Grunsven Willy Renier Jolanda Schieving Ion Niculescu-Duvaz Caroline J Springer Benno Küsters Pieter Wesseling Willeke A M Blokx Richard Marais

Cancer Discov 2013 Apr 9;3(4):458-469. Epub 2013 Jan 9.

Signal Transduction Team, The Institute of Cancer Research, London, SW3 6JB, UK.

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http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2	Publisher Site
http://dx.doi.org/10.1158/2159-8290.CD-12-0464	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999382	PMC

April 2013

Elucidating distinct roles for NF1 in melanomagenesis.

Authors:

Ophélia Maertens Bryan Johnson Pablo Hollstein Dennie T Frederick Zachary A Cooper Ludwine Messiaen Roderick T Bronson Martin McMahon Scott Granter Keith Flaherty Jennifer A Wargo Richard Marais Karen Cichowski

Cancer Discov 2013 Mar 21;3(3):338-49. Epub 2012 Nov 21.

Genetics Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1158/2159-8290.CD-12-0313	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595355	PMC

March 2013

Potent BRAF kinase inhibitors based on 2,4,5-trisubstituted imidazole with naphthyl and benzothiophene 4-substituents.

Authors:

Dan Niculescu-Duvaz Ion Niculescu-Duvaz Bart M J M Suijkerbuijk Delphine Ménard Alfonso Zambon Lawrence Davies Jean-Francois Pons Steven Whittaker Richard Marais Caroline J Springer

Bioorg Med Chem 2013 Mar 3;21(5):1284-304. Epub 2013 Jan 3.

The Institute of Cancer Research, Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, 15 Cotswold Road, Sutton, Surrey SM2 5NG, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S09680896120100	Publisher Site
http://dx.doi.org/10.1016/j.bmc.2012.12.035	DOI Listing

March 2013

Twenty-fourth annual Pezcoller symposium: Molecular basis for resistance to targeted agents.

Authors:

Richard Marais William Sellers David Livingston Enrico Mihich

Cancer Res 2013 Feb 7;73(3):1046-9. Epub 2012 Dec 7.

The Paterson Institute for Cancer Research, Manchester, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-3236	DOI Listing

February 2013

Inhibiting EGF receptor or SRC family kinase signaling overcomes BRAF inhibitor resistance in melanoma.

Authors:

Maria R Girotti Malin Pedersen Berta Sanchez-Laorden Amaya Viros Samra Turajlic Dan Niculescu-Duvaz Alfonso Zambon John Sinclair Andrew Hayes Martin Gore Paul Lorigan Caroline Springer James Larkin Claus Jorgensen Richard Marais

Cancer Discov 2013 Feb 14;3(2):158-67. Epub 2012 Dec 14.

Signal Transduction Team, The Institute of Cancer Research, Royal Marsden Hospital, London, UK.

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http://dx.doi.org/10.1158/2159-8290.CD-12-0386	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321574	PMC

February 2013

BRAF as a therapeutic target: a patent review (2006 - 2012).

Authors:

Alfonso Zambon Dan Niculescu-Duvaz Ion Niculescu-Duvaz Richard Marais Caroline J Springer

Expert Opin Ther Pat 2013 Feb 7;23(2):155-64. Epub 2013 Jan 7.

The Institute of Cancer Research, Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK.

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http://dx.doi.org/10.1517/13543776.2013.741593	DOI Listing

February 2013

Topical 5-fluorouracil elicits regressions of BRAF inhibitor-induced cutaneous squamous cell carcinoma.

Authors:

Amaya Viros Robert Hayward Matthew Martin Sharona Yashar Clarissa C Yu Berta Sanchez-Laorden Alfonso Zambon Dan Niculescu-Duvaz Caroline Springer Roger S Lo Richard Marais

J Invest Dermatol 2013 Jan 16;133(1):274-6. Epub 2012 Aug 16.

Seccio Dermatologia, Departament de Medicina, Hospital Universitari Vall d’Hebron, Universitat Autonomade Barcelona, Spain.

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http://dx.doi.org/10.1038/jid.2012.268	DOI Listing

January 2013

Effect of SMURF2 targeting on susceptibility to MEK inhibitors in melanoma.

Authors:

Michael P Smith Jennifer Ferguson Imanol Arozarena Robert Hayward Richard Marais Anna Chapman Adam Hurlstone Claudia Wellbrock

J Natl Cancer Inst 2013 Jan 17;105(1):33-46. Epub 2012 Dec 17.

Molecular Cancer Studies, Wellcome Trust Centre for Cell Matrix Research, University of Manchester, Oxford Rd, Manchester, UK.

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http://dx.doi.org/10.1093/jnci/djs471	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536641	PMC

January 2013

The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway.

Authors:

Catherine Andreadi Lai-Kay Cheung Susan Giblett Bipin Patel Hong Jin Kathryn Mercer Tamihiro Kamata Pearl Lee Alexander Williams Martin McMahon Richard Marais Catrin Pritchard

Genes Dev 2012 Sep 14;26(17):1945-58. Epub 2012 Aug 14.

Department of Biochemistry, University of Leicester, Leicester LE1 9HN, United Kingdom.

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http://genesdev.cshlp.org/cgi/doi/10.1101/gad.193458.112	Publisher Site
http://dx.doi.org/10.1101/gad.193458.112	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435497	PMC

September 2012

Future perspectives in melanoma research. Meeting report from the "Melanoma research: a bridge from Naples to the World. Napoli, December 5th-6th 2011".

J Transl Med 2012 Jul 4;10:83. Epub 2012 Jul 4.

Department of Melanoma, Sarcoma, and Head and Neck Disease, Istituto Nazionale Tumori Fondazione Pascale, Naples, Italy.

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http://dx.doi.org/10.1186/1479-5876-10-83	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390271	PMC

July 2012

Metformin: a diabetes drug for cancer, or a cancer drug for diabetics?

Authors:

Matthew Martin Richard Marais

J Clin Oncol 2012 Jul 7;30(21):2698-700. Epub 2012 May 7.

The Paterson Institute for Cancer Research, Wilmslow Rd, Manchester, UK.

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http://dx.doi.org/10.1200/JCO.2012.42.1677	DOI Listing

July 2012

Genomic characterisation of acral melanoma cell lines.

Authors:

Simon J Furney Samra Turajlic Kerry Fenwick Maryou B Lambros Alan MacKay Gerda Ricken Costas Mitsopoulos Iwanka Kozarewa Jarle Hakas Marketa Zvelebil Christopher J Lord Alan Ashworth Jorge S Reis-Filho Meenhard Herlyn Hiroshi Murata Richard Marais

Pigment Cell Melanoma Res 2012 Jul;25(4):488-92

Signal Transduction Team, Division of Cancer Biology, Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1111/j.1755-148X.2012.01016.x	DOI Listing

July 2012

Raf inhibitors target ras spatiotemporal dynamics.

Authors:

Kwang-jin Cho Rinshi S Kasai Jin-Hee Park Sravanthi Chigurupati Sonja J Heidorn Dharini van der Hoeven Sarah J Plowman Akihiro Kusumi Richard Marais John F Hancock

Curr Biol 2012 Jun 3;22(11):945-55. Epub 2012 May 3.

Department of Integrative Biology and Pharmacology, The University of Texas Medical School-Houston, 6431 Fannin Street, Houston, TX 77030, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S096098221200400	Publisher Site
http://dx.doi.org/10.1016/j.cub.2012.03.067	DOI Listing

June 2012

A whole-genome massively parallel sequencing analysis of BRCA1 mutant oestrogen receptor-negative and -positive breast cancers.

J Pathol 2012 May 23;227(1):29-41. Epub 2012 Feb 23.

The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.

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http://dx.doi.org/10.1002/path.4003	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976800	PMC

May 2012

Metformin accelerates the growth of BRAF V600E-driven melanoma by upregulating VEGF-A.

Authors:

Matthew J Martin Robert Hayward Amaya Viros Richard Marais

Cancer Discov 2012 Apr 31;2(4):344-55. Epub 2012 Mar 31.

Division of Tumour Biology, The Institute of Cancer Research, London, United Kingdom.

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http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2	Publisher Site
http://dx.doi.org/10.1158/2159-8290.CD-11-0280	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364710	PMC

April 2012

(V600E)Braf::Tyr-CreERT2::K14-Kitl mice do not develop superficial spreading-like melanoma: keratinocyte Kit ligand is insufficient to "translocate" (V600E)Braf-driven melanoma to the epidermis.

Authors:

Joel Rae Amaya Viros Robert Hayward Dorothy C Bennett Nathalie Dhomen B Jack Longley Jorge S Reis-Filho Richard Marais

J Invest Dermatol 2012 Feb 24;132(2):488-91. Epub 2011 Nov 24.

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http://linkinghub.elsevier.com/retrieve/pii/S0022202X1535565	Publisher Site
http://dx.doi.org/10.1038/jid.2011.341	DOI Listing

February 2012

KIT and BRAF mutational status in a patient with a synchronous lentigo maligna melanoma and a gastrointestinal stromal tumor.

Authors:

Rubeta N Matin David Gonzalez Lisa Thompson Sally R Lambert Farrah Bakr Nathalie Dhomen Richard Marais Jane M McGregor Peter Szlosarek Rino Cerio Catherine A Harwood

Am J Clin Dermatol 2012 Feb;13(1):64-5

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http://dx.doi.org/10.2165/11593910-000000000-00000	DOI Listing

February 2012

Whole genome sequencing of matched primary and metastatic acral melanomas.

Authors:

Samra Turajlic Simon J Furney Maryou B Lambros Costas Mitsopoulos Iwanka Kozarewa Felipe C Geyer Alan Mackay Jarle Hakas Marketa Zvelebil Christopher J Lord Alan Ashworth Meirion Thomas Gordon Stamp James Larkin Jorge S Reis-Filho Richard Marais

Genome Res 2012 Feb 19;22(2):196-207. Epub 2011 Dec 19.

Signal Transduction Team, Division of Cancer Biology, Institute of Cancer Research, London SW3 6JB, United Kingdom.

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http://dx.doi.org/10.1101/gr.125591.111	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266028	PMC

February 2012

Small molecule inhibitors of BRAF in clinical trials.

Authors:

Alfonso Zambon Ion Niculescu-Duvaz Dan Niculescu-Duvaz Richard Marais Caroline J Springer

Bioorg Med Chem Lett 2012 Jan 3;22(2):789-92. Epub 2011 Dec 3.

The Institute of Cancer Research, Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, 15 Cotswold Road, Sutton, Surrey SM2 5NG, United Kingdom.

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http://dx.doi.org/10.1016/j.bmcl.2011.11.060	DOI Listing

January 2012

RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors.

N Engl J Med 2012 Jan;366(3):207-15

Hoffmann-La Roche, Nutley, NJ, USA.

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http://dx.doi.org/10.1056/NEJMoa1105358	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724537	PMC

January 2012

Nilotinib and MEK inhibitors induce synthetic lethality through paradoxical activation of RAF in drug-resistant chronic myeloid leukemia.

Authors:

Leisl M Packer Sareena Rana Robert Hayward Thomas O'Hare Christopher A Eide Ana Rebocho Sonja Heidorn Matthew S Zabriskie Ion Niculescu-Duvaz Brian J Druker Caroline Springer Richard Marais

Cancer Cell 2011 Dec;20(6):715-27

Division of Cancer Biology, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.

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http://dx.doi.org/10.1016/j.ccr.2011.11.004	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951999	PMC

December 2011

[Murine cutaneous melanoma models. Importance of the genetic background].

Authors:

Christine Longvert Gwendoline Gros Friedrich Beermann Richard Marais Véronique Delmas Lionel Larue

Ann Pathol 2011 Nov 5;31(5 Suppl):S70-3. Epub 2011 Oct 5.

Developmental Genetics of Melanocytes, centre de recherche, institut Curie, bâtiment 110, 91405 Orsay, France.

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http://dx.doi.org/10.1016/j.annpat.2011.09.002	DOI Listing

November 2011

Analysis of the efficacy and toxicity of sorafenib in thyroid cancer: a phase II study in a UK based population.

Authors:

Merina Ahmed Yolanda Barbachano Angela Riddell Jen Hickey Katie L Newbold Amaya Viros Kevin J Harrington Richard Marais Christopher M Nutting

Eur J Endocrinol 2011 Aug 12;165(2):315-22. Epub 2011 May 12.

Head and Neck Unit, The Royal Marsden NHS Foundation Trust, Fulham Road, London SW3 6JJ, UK.

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http://www.eje-online.org/content/165/2/315.full.pdf	Web Search
http://www.eje-online.org/cgi/doi/10.1530/EJE-11-0129	Publisher Site
http://dx.doi.org/10.1530/EJE-11-0129	DOI Listing

August 2011

ROCK and JAK1 signaling cooperate to control actomyosin contractility in tumor cells and stroma.

Authors:

Victoria Sanz-Moreno Cedric Gaggioli Maggie Yeo Jean Albrengues Fredrik Wallberg Amaya Viros Steven Hooper Richard Mitter Chloé C Féral Martin Cook James Larkin Richard Marais Guerrino Meneguzzi Erik Sahai Chris J Marshall

Cancer Cell 2011 Aug;20(2):229-45

Oncogene Team, Institute of Cancer Research, Section of Cell and Molecular Biology, Cancer Research UK Tumour Cell Signalling Unit, 237 Fulham Road, London SW3 6JB, UK.

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http://dx.doi.org/10.1016/j.ccr.2011.06.018	DOI Listing

August 2011

New insight puts CRAF in sight as a therapeutic target.

Authors:

Ana Paula Rebocho Richard Marais

Cancer Discov 2011 Jul;1(2):98-9

Signal Transduction Team, Division of Tumour Biology, The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1158/2159-8290.CD-11-0118	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272431	PMC

July 2011

Malignancy without immortality? Cellular immortalization as a possible late event in melanoma progression.

Authors:

Julia K Soo Alastair D Mackenzie Ross David M Kallenberg Carla Milagre W Heung Chong Jade Chow Lucy Hill Stacey Hoare Rebecca S Collinson Mehnaz Hossain W Nicol Keith Richard Marais Dorothy C Bennett

Pigment Cell Melanoma Res 2011 Jun 20;24(3):490-503. Epub 2011 Apr 20.

Division of Biomedical Sciences, St. George's, University of London, UK.

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http://dx.doi.org/10.1111/j.1755-148X.2011.00850.x	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123747	PMC

June 2011

Unswitch-ABL drugs overcome resistance in chronic myeloid leukemia.

Authors:

Leisl Packer Richard Marais

Cancer Cell 2011 Apr;19(4):435-7

Division of Tumour Biology, The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1016/j.ccr.2011.03.019	DOI Listing

April 2011

Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMP-specific phosphodiesterase PDE5A.

Authors:

Imanol Arozarena Berta Sanchez-Laorden Leisl Packer Cristina Hidalgo-Carcedo Robert Hayward Amaya Viros Erik Sahai Richard Marais

Cancer Cell 2011 Jan 6;19(1):45-57. Epub 2011 Jan 6.

The Institute of Cancer Research, Signal Transduction Team, Section of Cell and Molecular Biology, 237 Fulham Road, London SW3 6JB, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S153561081000431	Publisher Site
http://dx.doi.org/10.1016/j.ccr.2010.10.029	DOI Listing

January 2011

Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice.

Authors:

Aime T Franco Roberta Malaguarnera Samuel Refetoff Xiao-Hui Liao Emma Lundsmith Shioko Kimura Catrin Pritchard Richard Marais Terry F Davies Lee S Weinstein Min Chen Neal Rosen Ronald Ghossein Jeffrey A Knauf James A Fagin

Proc Natl Acad Sci U S A 2011 Jan 10;108(4):1615-20. Epub 2011 Jan 10.

Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1073/pnas.1015557108	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3029699	PMC

January 2011

Combined zebrafish-yeast chemical-genetic screens reveal gene-copper-nutrition interactions that modulate melanocyte pigmentation.

Authors:

Hironori Ishizaki Michaela Spitzer Jan Wildenhain Corina Anastasaki Zhiqiang Zeng Sonam Dolma Michael Shaw Erik Madsen Jonathan Gitlin Richard Marais Mike Tyers E Elizabeth Patton

Dis Model Mech 2010 Sep-Oct;3(9-10):639-51. Epub 2010 Aug 16.

Institute of Genetics and Molecular Medicine, MRC Human Genetics Unit and The University of Edinburgh, Western General Hospital, Edinburgh, UK.

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http://dx.doi.org/10.1242/dmm.005769	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938393	PMC

December 2010

V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16INK4a.

Authors:

Linda A S Carragher Kimberley R Snell Susan M Giblett Victoria S S Aldridge Bipin Patel Simon J Cook Doug J Winton Richard Marais Catrin A Pritchard

EMBO Mol Med 2010 Nov;2(11):458-71

Department of Biochemistry, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1002/emmm.201000099	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394506	PMC

November 2010

Activation of forkhead box O transcription factors by oncogenic BRAF promotes p21cip1-dependent senescence.

Authors:

Peter L J de Keizer Leisl M Packer Anna A Szypowska Paulien E Riedl-Polderman Niels J F van den Broek Alain de Bruin Tobias B Dansen Richard Marais Arjan B Brenkman Boudewijn M T Burgering

Cancer Res 2010 Nov 19;70(21):8526-36. Epub 2010 Oct 19.

Department of Physiological Chemistry and Center for Biomedical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-1563	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989643	PMC

November 2010

BRAF inactivation drives aneuploidy by deregulating CRAF.

Authors:

Tamihiro Kamata Jahan Hussain Susan Giblett Robert Hayward Richard Marais Catrin Pritchard

Cancer Res 2010 Nov 26;70(21):8475-86. Epub 2010 Oct 26.

Department of Biochemistry, University of Leicester, Leicester, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-0603	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975377	PMC

November 2010

A novel, selective, and efficacious nanomolar pyridopyrazinone inhibitor of V600EBRAF.

Authors:

Steven Whittaker Delphine Ménard Ruth Kirk Lesley Ogilvie Douglas Hedley Alfonso Zambon Filipa Lopes Natasha Preece Helen Manne Sareena Rana Maryou Lambros Jorge S Reis-Filho Richard Marais Caroline J Springer

Cancer Res 2010 Oct 31;70(20):8036-44. Epub 2010 Aug 31.

Signal Transduction Team, Section of Cell and Molecular Biology, Molecular Pathology Team, The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom.

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http://cancerres.aacrjournals.org/content/70/20/8036.full.pd	Web Search
http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.	Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-10-1366	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001191	PMC