Richard M Weinshilboum

Richard M Weinshilboum

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Richard M Weinshilboum

Richard M Weinshilboum

Publications by authors named "Richard M Weinshilboum"

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Pharmacogenomics-Driven Prediction of Antidepressant Treatment Outcomes: A Machine-Learning Approach With Multi-trial Replication.

Authors:
Arjun P Athreya Drew Neavin Tania Carrillo-Roa Michelle Skime Joanna Biernacka Mark A Frye A John Rush Liewei Wang Elisabeth B Binder Ravishankar K Iyer Richard M Weinshilboum William V Bobo

Clin Pharmacol Ther 2019 Oct 29;106(4):855-865. Epub 2019 Jun 29.

Department of Psychiatry & Psychology, Mayo Clinic, Jacksonville, Florida, USA.

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http://dx.doi.org/10.1002/cpt.1482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739122PMC
October 2019

Deep sequencing across germline genome-wide association study signals relating to breast cancer events in women receiving aromatase inhibitors for adjuvant therapy of early breast cancer.

Authors:
James N Ingle Krishna R Kalari Yukihide Momozawa Michiaki Kubo Yoichi Furukawa Lois E Shepherd Matthew J Ellis Paul E Goss Poulami Barman Erin E Carlson Jason P Sinnwell Xiaojia Tang Matthew P Goetz Bingshu E Chen Junmei Cairns Richard M Weinshilboum Liewei Wang

Pharmacogenet Genomics 2019 Oct;29(8):183-191

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota.

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http://dx.doi.org/10.1097/FPC.0000000000000382DOI Listing
October 2019

Genetic predictors of chemotherapy-related amenorrhea in women with breast cancer.

Authors:
Kathryn J Ruddy Daniel J Schaid Ann H Partridge Nicholas B Larson Anthony Batzler Lothar Häberle Ralf Dittrich Peter Widschwendter Visnja Fink Emanuel Bauer Judith Schwitulla Matthias Rübner Arif B Ekici Viktoria Aivazova-Fuchs Elizabeth A Stewart Matthias W Beckmann Elizabeth Ginsburg Liewei Wang Richard M Weinshilboum Fergus J Couch Wolfgang Janni Brigitte Rack Celine Vachon Peter A Fasching

Fertil Steril 2019 Oct 29;112(4):731-739.e1. Epub 2019 Jul 29.

Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.

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http://dx.doi.org/10.1016/j.fertnstert.2019.05.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765404PMC
October 2019

Dual roles for the TSPYL family in mediating serotonin transport and the metabolism of selective serotonin reuptake inhibitors in MDD patients.

Authors:
Sisi Qin Andy R Eugene Duan Liu Lingxin Zhang Drew Neavin Joanna M Biernacka Jia Yu Richard M Weinshilboum Liewei Wang

Clin Pharmacol Ther 2019 Oct 19. Epub 2019 Oct 19.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cpt.1692
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http://dx.doi.org/10.1002/cpt.1692DOI Listing
October 2019

Single Nucleotide Polymorphisms at a Distance from Aryl Hydrocarbon Receptor (AHR) Binding Sites Influence AHR Ligand-Dependent Gene Expression.

Authors:
Drew R Neavin Jeong-Heon Lee Duan Liu Zhenqing Ye Hu Li Liewei Wang Tamas Ordog Richard M Weinshilboum

Drug Metab Dispos 2019 Sep 10;47(9):983-994. Epub 2019 Jul 10.

Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (D.R.N., D.L., H.L., L.W., R.M.W.), Epigenomics Program, Center for Individualized Medicine (J.-H.L., T.O.), Division of Experimental Pathology and Laboratory Medicine, Department of Laboratory Medicine and Pathology (J.-H.L.), Division of Biomedical Statistics and Informatics (Z.Y.), Department of Physiology and Biomedical Engineering (T.O.), and Division of Gastroenterology and Hepatology, Department of Medicine (T.O.), Mayo Clinic, Rochester, Minnesota

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http://dx.doi.org/10.1124/dmd.119.087312DOI Listing
September 2019

Integration of machine learning and pharmacogenomic biomarkers for predicting response to antidepressant treatment: can computational intelligence be used to augment clinical assessments?

Authors:
Arjun P Athreya Ravishankar Iyer Liewei Wang Richard M Weinshilboum William V Bobo

Pharmacogenomics 2019 Sep;20(14):983-988

Department of Psychiatry & Psychology, Mayo Clinic, Jacksonville, FL 32224, USA.

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http://dx.doi.org/10.2217/pgs-2019-0119DOI Listing
September 2019

Pilot Study of Metabolomic Clusters as State Markers of Major Depression and Outcomes to CBT Treatment.

Authors:
Sudeepa Bhattacharyya Boadie W Dunlop Siamak Mahmoudiandehkordi Ahmed T Ahmed Gregory Louie Mark A Frye Richard M Weinshilboum Ranga R Krishnan A John Rush Helen S Mayberg W Edward Craighead Rima Kaddurah-Daouk

Front Neurosci 2019 12;13:926. Epub 2019 Sep 12.

Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, United States.

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http://dx.doi.org/10.3389/fnins.2019.00926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751322PMC
September 2019

Catechol O-Methyltransferase Pharmacogenomics: Challenges and Opportunities.

Authors:
Ming-Fen Ho Richard M Weinshilboum

Clin Pharmacol Ther 2019 Aug 13;106(2):281-283. Epub 2019 May 13.

1Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1002/cpt.1452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663608PMC
August 2019

Cohort Profile: The Right Drug, Right Dose, Right Time: Using Genomic Data to Individualize Treatment Protocol (RIGHT Protocol).

Authors:
Suzette J Bielinski Jennifer L St Sauver Janet E Olson Nicholas B Larson John L Black Steven E Scherer Matthew E Bernard Eric Boerwinkle Bijan J Borah Pedro J Caraballo Timothy B Curry HarshaVardhan Doddapaneni Christine M Formea Robert R Freimuth Richard A Gibbs Jyothsna Giri Matthew A Hathcock Jianhong Hu Debra J Jacobson Leila A Jones Sara Kalla Tyler H Koep Viktoriya Korchina Christie L Kovar Sandra Lee Hongfang Liu Eric T Matey Michaela E McGree Tammy M McAllister Ann M Moyer Donna M Muzny Wayne T Nicholson Lance J Oyen Xiang Qin Ritika Raj Véronique L Roger Carolyn R Rohrer Vitek Jason L Ross Richard R Sharp Paul Y Takahashi Eric Venner Kimberly Walker Liwei Wang Qiaoyan Wang Jessica A Wright Tsung-Jung Wu Liewei Wang Richard M Weinshilboum

Int J Epidemiol 2019 Aug 4. Epub 2019 Aug 4.

Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1093/ije/dyz123DOI Listing
August 2019

Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome-Wide Association Study: Functional Epistatic Interaction Between SLC38A7 and ALPPL2.

Authors:
Tanda M Dudenkov Duan Liu Junmei Cairns Sandhya Devarajan Yongxian Zhuang James N Ingle Aman U Buzdar Mark E Robson Michiaki Kubo Anthony Batzler Poulami Barman Gregory D Jenkins Erin E Carlson Matthew P Goetz Donald W Northfelt Alvaro Moreno-Aspitia Zeruesenay Desta Joel M Reid Krishna R Kalari Liewei Wang Richard M Weinshilboum

Clin Pharmacol Ther 2019 Jul 18;106(1):219-227. Epub 2019 Mar 18.

Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA.

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http://doi.wiley.com/10.1002/cpt.1359
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http://dx.doi.org/10.1002/cpt.1359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612579PMC
July 2019

Metabolomic signature of exposure and response to citalopram/escitalopram in depressed outpatients.

Authors:
Sudeepa Bhattacharyya Ahmed T Ahmed Matthias Arnold Duan Liu Chunqiao Luo Hongjie Zhu Siamak Mahmoudiandehkordi Drew Neavin Gregory Louie Boadie W Dunlop Mark A Frye Liewei Wang Richard M Weinshilboum Ranga R Krishnan A John Rush Rima Kaddurah-Daouk

Transl Psychiatry 2019 07 4;9(1):173. Epub 2019 Jul 4.

Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, Durham, NC, USA.

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http://dx.doi.org/10.1038/s41398-019-0507-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609722PMC
July 2019

4-Hydroxytamoxifen enhances sensitivity of estrogen receptor α-positive breast cancer to docetaxel in an estrogen and ZNF423 SNP-dependent fashion.

Authors:
Gen Wang Sisi Qin Jacqueline Zayas James N Ingle Mohan Liu Richard M Weinshilboum Kunwei Shen Liewei Wang

Breast Cancer Res Treat 2019 Jun 1;175(3):567-578. Epub 2019 Apr 1.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1007/s10549-019-05194-zDOI Listing
June 2019

Spontaneous murine tumors in the development of patient-derived xenografts: a potential pitfall.

Authors:
Ann M Moyer Jia Yu Jason P Sinnwell Travis J Dockter Vera J Suman Richard M Weinshilboum Judy C Boughey Matthew P Goetz Daniel W Visscher Liewei Wang

Oncotarget 2019 Jun 11;10(39):3924-3930. Epub 2019 Jun 11.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.18632/oncotarget.27001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570466PMC
June 2019

Pharmacogenomic Next-Generation DNA Sequencing: Lessons from the Identification and Functional Characterization of Variants of Unknown Significance in and .

Authors:
Sandhya Devarajan Irene Moon Ming-Fen Ho Nicholas B Larson Drew R Neavin Ann M Moyer John L Black Suzette J Bielinski Steven E Scherer Liewei Wang Richard M Weinshilboum Joel M Reid

Drug Metab Dispos 2019 04 11;47(4):425-435. Epub 2019 Feb 11.

Departments of Molecular Pharmacology and Experimental Therapeutics (S.D., I.M., M.-F.H., L.W., R.M.W., J.M.R.) and Health Sciences Research (N.B.L., S.J.B.), Personalized Genomics Laboratory, Department of Laboratory Medicine and Pathology (A.M.M., J.L.B.), and Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Graduate School of Biomedical Sciences (D.R.N.), Mayo Clinic, Rochester, Minnesota; and Human Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas (S.E.S.)

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http://dx.doi.org/10.1124/dmd.118.084269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423619PMC
April 2019

The lncRNA MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1.

Authors:
Junmei Cairns James N Ingle Krishna R Kalari Lois E Shepherd Michiaki Kubo Matthew P Goetz Richard M Weinshilboum Liewei Wang

Breast Cancer Res 2019 04 3;21(1):47. Epub 2019 Apr 3.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, 55905, USA.

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http://dx.doi.org/10.1186/s13058-019-1130-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448248PMC
April 2019

Clopidogrel Pharmacogenetics.

Authors:
Naveen L Pereira Charanjit S Rihal Derek Y F So Yves Rosenberg Ryan J Lennon Verghese Mathew Shaun G Goodman Richard M Weinshilboum Liewei Wang Linnea M Baudhuin Amir Lerman Ahmed Hasan Erin Iturriaga Yi-Ping Fu Nancy Geller Kent Bailey Michael E Farkouh

Circ Cardiovasc Interv 2019 Apr;12(4):e007811

Peter Munk Cardiac Centre, Heart and Stroke Richard Lewar Centre, University of Toronto, Canada (M.E.F.).

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https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.11
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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.119.007811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581205PMC
April 2019

Pharmacokinetic-Pharmacodynamic interaction associated with venlafaxine-XR remission in patients with major depressive disorder with history of citalopram / escitalopram treatment failure.

Authors:
Ahmed T Ahmed Joanna M Biernacka Gregory Jenkins A John Rush Gen Shinozaki Marin Veldic Simon Kung William V Bobo Daniel K Hall-Flavin Richard M Weinshilboum Liewei Wang Mark A Frye

J Affect Disord 2019 03 17;246:62-68. Epub 2018 Dec 17.

Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2018.12.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501809PMC
March 2019

The association of obesity and coronary artery disease genes with response to SSRIs treatment in major depression.

Authors:
Azmeraw T Amare Klaus Oliver Schubert Fasil Tekola-Ayele Yi-Hsiang Hsu Katrin Sangkuhl Gregory Jenkins Ryan M Whaley Poulami Barman Anthony Batzler Russ B Altman Volker Arolt Jürgen Brockmöller Chia-Hui Chen Katharina Domschke Daniel K Hall-Flavin Chen-Jee Hong Ari Illi Yuan Ji Olli Kampman Toshihiko Kinoshita Esa Leinonen Ying-Jay Liou Taisei Mushiroda Shinpei Nonen Michelle K Skime Liewei Wang Masaki Kato Yu-Li Liu Verayuth Praphanphoj Julia C Stingl William V Bobo Shih-Jen Tsai Michiaki Kubo Teri E Klein Richard M Weinshilboum Joanna M Biernacka Bernhard T Baune

J Neural Transm (Vienna) 2019 Jan 4;126(1):35-45. Epub 2019 Jan 4.

Discipline of Psychiatry, School of Medicine, University of Adelaide, North Terrace, Adelaide, SA, 5005, Australia.

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http://dx.doi.org/10.1007/s00702-018-01966-xDOI Listing
January 2019

The Role of the Aryl Hydrocarbon Receptor (AHR) in Immune and Inflammatory Diseases.

Authors:
Drew R Neavin Duan Liu Balmiki Ray Richard M Weinshilboum

Int J Mol Sci 2018 Dec 3;19(12). Epub 2018 Dec 3.

Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55902, USA.

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http://www.mdpi.com/1422-0067/19/12/3851
Publisher Site
http://dx.doi.org/10.3390/ijms19123851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321643PMC
December 2018

PANOPLY: Omics-Guided Drug Prioritization Method Tailored to an Individual Patient.

Authors:
Krishna R Kalari Jason P Sinnwell Kevin J Thompson Xiaojia Tang Erin E Carlson Jia Yu Peter T Vedell James N Ingle Richard M Weinshilboum Judy C Boughey Liewei Wang Matthew P Goetz Vera Suman

JCO Clin Cancer Inform 2018 12;2:1-11

All authors: Mayo Clinic, Rochester, MN.

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http://ascopubs.org/doi/10.1200/CCI.18.00012
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http://dx.doi.org/10.1200/CCI.18.00012DOI Listing
December 2018

Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders.

Authors:
Ahmed T Ahmed Mark A Frye A John Rush Joanna M Biernacka W Edward Craighead William M McDonald William V Bobo Patricio Riva-Posse Susannah J Tye Helen S Mayberg Daniel K Hall-Flavin Michelle K Skime Greg D Jenkins Liewei Wang Ranga Rama Krishnan Richard M Weinshilboum Rima Kaddurah-Daouk Boadie W Dunlop

J Affect Disord 2018 10 26;238:1-7. Epub 2018 May 26.

Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S01650327173266
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http://dx.doi.org/10.1016/j.jad.2018.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374030PMC
October 2018

Single Nucleotide Polymorphisms (SNPs) Distant from Xenobiotic Response Elements Can Modulate Aryl Hydrocarbon Receptor Function: SNP-Dependent CYP1A1 Induction.

Authors:
Duan Liu Sisi Qin Balmiki Ray Krishna R Kalari Liewei Wang Richard M Weinshilboum

Drug Metab Dispos 2018 09 6;46(9):1372-1381. Epub 2018 Jul 6.

Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (D.L., S.Q., B.R., L.W., R.M.W.) and Division of Biomedical Statistics and Informatics, Department of Health Sciences Research (K.R.K.), Mayo Clinic, Rochester, Minnesota

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http://dx.doi.org/10.1124/dmd.118.082164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090174PMC
September 2018

Considerations for automated machine learning in clinical metabolic profiling: Altered homocysteine plasma concentration associated with metformin exposure.

Authors:
Alena Orlenko Jason H Moore Patryk Orzechowski Randal S Olson Junmei Cairns Pedro J Caraballo Richard M Weinshilboum Liewei Wang Matthew K Breitenstein

Pac Symp Biocomput 2018 ;23:460-471

Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882490PMC
August 2018

SLCO1B1 genetic variation and hormone therapy in menopausal women.

Authors:
Ann M Moyer Mariza de Andrade Stephanie S Faubion Ekta Kapoor Tanda Dudenkov Richard M Weinshilboum Virginia M Miller

Menopause 2018 08;25(8):877-882

Departments of Surgery and Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1097/GME.0000000000001109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092108PMC
August 2018

BRCA1/2 Mutations and Bevacizumab in the Neoadjuvant Treatment of Breast Cancer: Response and Prognosis Results in Patients With Triple-Negative Breast Cancer From the GeparQuinto Study.

Authors:
Peter A Fasching Sibylle Loibl Chunling Hu Steven N Hart Hermela Shimelis Raymond Moore Christian Schem Hans Tesch Michael Untch Jörn Hilfrich Mahdi Rezai Bernd Gerber Serban Dan Costa Jens-Uwe Blohmer Tanja Fehm Jens Huober Cornelia Liedtke Richard M Weinshilboum Liewei Wang James N Ingle Volkmar Müller Valentina Nekljudova Karsten E Weber Brigitte Rack Matthias Rübner Gunter von Minckwitz Fergus J Couch

J Clin Oncol 2018 08 23;36(22):2281-2287. Epub 2018 May 23.

Peter A. Fasching and Matthias Rübner, Erlangen University Hospital, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen; Sibylle Loibl, Valentina Nekljudova, Karsten E. Weber, and Gunter von Minckwitz, German Breast Group Forschungs, Neu-Isenburg; Christian Schem, University Medical Center Schleswig-Holstein, Kiel; Hans Tesch, Centrum für Hämatologie und Onkologie Bethanien, Frankfurt; Michael Untch, Helios-Klinikum, Berlin-Buch; Jörn Hilfrich, Eilenriede-Klinik, Hannover; Mahdi Rezai, Luisenkrankenhaus; Tanja Fehm, Düsseldorf University Hospital, Heinrich-Heine University of Düsseldorf, Düsseldorf; Bernd Gerber, University of Rostock, Rostock; Serban Dan Costa, Magdeburg University Hospital, Magdeburg; Jens-Uwe Blohmer and Cornelia Liedtke, Charité University Hospital Campus Charité-Mitte, Berlin; Jens Huober, University of Ulm; Brigitte Rack, University Hospital Ulm, Ulm; Volkmar Müller, Hamburg University Hospital, Hamburg, Germany; Chunling Hu, Steven N. Hart, Hermela Shimelis, Raymond Moore, James N. Ingle, and Fergus J. Couch, Mayo Clinic; and Richard M. Weinshilboum and Liewei Wang, Mayo Clinic College of Medicine, Mayo Foundation, Rochester, MN.

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http://ascopubs.org/doi/10.1200/JCO.2017.77.2285
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http://dx.doi.org/10.1200/JCO.2017.77.2285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067803PMC
August 2018

Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: Meta-analysis of data from genome-wide association studies.

Authors:
Chiara Fabbri Katherine E Tansey Roy H Perlis Joanna Hauser Neven Henigsberg Wolfgang Maier Ole Mors Anna Placentino Marcella Rietschel Daniel Souery Gerome Breen Charles Curtis Sang-Hyuk Lee Stephen Newhouse Hamel Patel Michael O'Donovan Glyn Lewis Gregory Jenkins Richard M Weinshilboum Anne Farmer Katherine J Aitchison Ian Craig Peter McGuffin Koen Schruers Joanna M Biernacka Rudolf Uher Cathryn M Lewis

Eur Neuropsychopharmacol 2018 08 28;28(8):945-954. Epub 2018 Jun 28.

Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, PO80, De De Crespigny Park, Denmark Hill United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.euroneuro.2018.05.009DOI Listing
August 2018

TSPYL Family Regulates CYP17A1 and CYP3A4 Expression: Potential Mechanism Contributing to Abiraterone Response in Metastatic Castration-Resistant Prostate Cancer.

Authors:
Sisi Qin Duan Liu Manish Kohli Liguo Wang Peter T Vedell David W Hillman Nifang Niu Jia Yu Richard M Weinshilboum Liewei Wang

Clin Pharmacol Ther 2018 07 22;104(1):201-210. Epub 2017 Nov 22.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1002/cpt.907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899062PMC
July 2018

Machine Learning Helps Identify New Drug Mechanisms in Triple-Negative Breast Cancer.

Authors:
Arjun P Athreya Alan J Gaglio Junmei Cairns Krishna R Kalari Richard M Weinshilboum Liewei Wang Zbigniew T Kalbarczyk Ravishankar K Iyer

IEEE Trans Nanobioscience 2018 07 2;17(3):251-259. Epub 2018 Jul 2.

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http://dx.doi.org/10.1109/TNB.2018.2851997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148350PMC
July 2018

, a Novel Transcription Factor and a Coregulator of Nuclear Factor B p65: Single Nucleotide Polymorphism and Estrogen Dependence.

Authors:
Ming-Fen Ho Edroaldo Lummertz da Rocha Cheng Zhang James N Ingle Paul E Goss Lois E Shepherd Michiaki Kubo Liewei Wang Hu Li Richard M Weinshilboum

J Pharmacol Exp Ther 2018 06 28;365(3):700-710. Epub 2018 Mar 28.

Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (M.H., E.L.d.R., C.Z., L.W., H.L., R.M.W.), and Division of Medical Oncology, Department of Oncology (J.N.I.), Mayo Clinic, Rochester, Minnesota; Division of Hematology/Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, Massachusetts (P.E.G.); Canadian Cancer Trials Group, Kingston, Ontario, Canada (L.E.S.); and RIKEN Center for Integrative Medical Science, Yokohama, Japan (M.K.)

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http://dx.doi.org/10.1124/jpet.118.247718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954488PMC
June 2018

Ketamine and ketamine metabolites as novel estrogen receptor ligands: Induction of cytochrome P450 and AMPA glutamate receptor gene expression.

Authors:
Ming-Fen Ho Cristina Correia James N Ingle Rima Kaddurah-Daouk Liewei Wang Scott H Kaufmann Richard M Weinshilboum

Biochem Pharmacol 2018 06 3;152:279-292. Epub 2018 Apr 3.

Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2018.03.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960634PMC
June 2018

Germline genome-wide association studies in women receiving neoadjuvant chemotherapy with or without bevacizumab.

Authors:
James N Ingle Krishna R Kalari Donald Lawrence Wickerham Gunter von Minckwitz Peter A Fasching Yoichi Furukawa Taisei Mushiroda Matthew P Goetz Poulami Barman Erin E Carlson Priya Rastogi Joseph P Costantino Junmei Cairns Soonmyung Paik Harry D Bear Michiaki Kubo Liewei Wang Norman Wolmark Richard M Weinshilboum

Pharmacogenet Genomics 2018 06;28(6):147-152

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota.

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http://dx.doi.org/10.1097/FPC.0000000000000337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965682PMC
June 2018

Association of the Polygenic Scores for Personality Traits and Response to Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder.

Authors:
Azmeraw T Amare Klaus Oliver Schubert Fasil Tekola-Ayele Yi-Hsiang Hsu Katrin Sangkuhl Gregory Jenkins Ryan M Whaley Poulami Barman Anthony Batzler Russ B Altman Volker Arolt Jürgen Brockmöller Chia-Hui Chen Katharina Domschke Daniel K Hall-Flavin Chen-Jee Hong Ari Illi Yuan Ji Olli Kampman Toshihiko Kinoshita Esa Leinonen Ying-Jay Liou Taisei Mushiroda Shinpei Nonen Michelle K Skime Liewei Wang Masaki Kato Yu-Li Liu Verayuth Praphanphoj Julia C Stingl William V Bobo Shih-Jen Tsai Michiaki Kubo Teri E Klein Richard M Weinshilboum Joanna M Biernacka Bernhard T Baune

Front Psychiatry 2018 6;9:65. Epub 2018 Mar 6.

Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA, Australia.

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http://dx.doi.org/10.3389/fpsyt.2018.00065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845551PMC
March 2018

Pathway-Based Analysis of Genome-Wide Association Data Identified SNPs in as Biomarker for Chemotherapy- Induced Neutropenia in Breast Cancer Patients.

Authors:
Behzad Bidadi Duan Liu Krishna R Kalari Matthias Rubner Alexander Hein Matthias W Beckmann Brigitte Rack Wolfgang Janni Peter A Fasching Richard M Weinshilboum Liewei Wang

Front Pharmacol 2018 13;9:158. Epub 2018 Mar 13.

Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, United States.

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http://dx.doi.org/10.3389/fphar.2018.00158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859084PMC
March 2018

Beta-defensin 1, aryl hydrocarbon receptor and plasma kynurenine in major depressive disorder: metabolomics-informed genomics.

Authors:
Duan Liu Balmiki Ray Drew R Neavin Jiabin Zhang Arjun P Athreya Joanna M Biernacka William V Bobo Daniel K Hall-Flavin Michelle K Skime Hongjie Zhu Gregory D Jenkins Anthony Batzler Krishna R Kalari Felix Boakye-Agyeman Wayne R Matson Swati S Bhasin Taisei Mushiroda Yusuke Nakamura Michiaki Kubo Ravishankar K Iyer Liewei Wang Mark A Frye Rima Kaddurah-Daouk Richard M Weinshilboum

Transl Psychiatry 2018 01 10;8(1):10. Epub 2018 Jan 10.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1038/s41398-017-0056-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802574PMC
January 2018

Pharmacogenomics: Precision Medicine and Drug Response.

Authors:
Richard M Weinshilboum Liewei Wang

Mayo Clin Proc 2017 11 1;92(11):1711-1722. Epub 2017 Nov 1.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1016/j.mayocp.2017.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682947PMC
November 2017

Clinical validation of genetic variants associated with chemotherapy-related lymphoblastoid cell toxicity.

Authors:
Peter A Fasching Lothar Häberle Brigitte Rack Liang Li Alexander Hein Arif B Ekici Andre Reis Michael P Lux Julie M Cunningham Matthias Ruebner Gergory Jenkins Brooke Fridley Andreas Schneeweiss Hans Tesch Werner Lichtenegger Tanja Fehm Georg Heinrich Mahdi Rezai Matthias W Beckmann Wolfgang Janni Richard M Weinshilboum Liewei Wang

Oncotarget 2017 Sep 9;8(44):78133-78143. Epub 2017 May 9.

Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Mayo Medical School-Mayo Foundation, Rochester, MN, USA.

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http://dx.doi.org/10.18632/oncotarget.17726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652844PMC
September 2017

Single-Nucleotide Polymorphisms and Estrogen-Mediated Toll-Like Receptor-MYD88-Dependent Nuclear Factor-B Activation: Single-Nucleotide Polymorphism- and Selective Estrogen Receptor Modulator-Dependent Modification of Inflammation and Immune Response.

Authors:
Ming-Fen Ho James N Ingle Tim Bongartz Krishna R Kalari Paul E Goss Lois E Shepherd Taisei Mushiroda Michiaki Kubo Liewei Wang Richard M Weinshilboum

Mol Pharmacol 2017 08 14;92(2):175-184. Epub 2017 Jun 14.

Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (M.-F.H., L.W., R.M.W.), Division of Medical Oncology, Department of Oncology (J.N.I.), and Division of Biomedical Statistics and Informatics, Department of Health Sciences Research (K.R.K.), Mayo Clinic, Rochester, Minnesota; Department of Emergency Medicine, Vanderbilt Medical Center, Nashville, Tennessee (T.B.); Division of Hematology/Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, Massachusetts (P.E.G.); NCIC Clinical Trials Group, Kingston, Ontario Canada (L.E.S.); and RIKEN Center for Integrative Medical Science, Tsurumi-ku, Yokohama, Japan (T.M., M.K.)

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http://molpharm.aspetjournals.org/lookup/doi/10.1124/mol.117
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http://dx.doi.org/10.1124/mol.117.108340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508195PMC
August 2017

Calmodulin-like protein 3 is an estrogen receptor alpha coregulator for gene expression and drug response in a SNP, estrogen, and SERM-dependent fashion.

Authors:
Sisi Qin James N Ingle Mohan Liu Jia Yu D Lawrence Wickerham Michiaki Kubo Richard M Weinshilboum Liewei Wang

Breast Cancer Res 2017 Aug 18;19(1):95. Epub 2017 Aug 18.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1186/s13058-017-0890-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562991PMC
August 2017

Breast cancer chemoprevention pharmacogenomics: Deep sequencing and functional genomics of the and genes.

Authors:
Duan Liu Ming-Fen Ho Daniel J Schaid Steven E Scherer Krishna Kalari Mohan Liu Joanna Biernacka Vivien Yee Jared Evans Erin Carlson Matthew P Goetz Michiaki Kubo D Lawrence Wickerham Liewei Wang James N Ingle Richard M Weinshilboum

NPJ Breast Cancer 2017 21;3:30. Epub 2017 Aug 21.

Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN USA.

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http://dx.doi.org/10.1038/s41523-017-0036-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566425PMC
August 2017

Immune Mediator Pharmacogenomics: SNPs and Estrogen-Dependent Regulation of Inflammation.

Authors:
Ming-Fen Ho Richard M Weinshilboum

J Nat Sci 2017 Aug;3(8)

Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578609PMC
August 2017

SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+ breast cancer: genome-wide association studies of the estrone pathway.

Authors:
Tanda M Dudenkov James N Ingle Aman U Buzdar Mark E Robson Michiaki Kubo Irada Ibrahim-Zada Anthony Batzler Gregory D Jenkins Tracy L Pietrzak Erin E Carlson Poulami Barman Matthew P Goetz Donald W Northfelt Alvaro Moreno-Aspita Clark V Williard Krishna R Kalari Yusuke Nakamura Liewei Wang Richard M Weinshilboum

Breast Cancer Res Treat 2017 Jul 20;164(1):189-199. Epub 2017 Apr 20.

Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1007/s10549-017-4243-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600471PMC
July 2017

Multidisciplinary model to implement pharmacogenomics at the point of care.

Authors:
Pedro J Caraballo Lucy S Hodge Suzette J Bielinski A Keith Stewart Gianrico Farrugia Cloann G Schultz Carolyn R Rohrer-Vitek Janet E Olson Jennifer L St Sauver Veronique L Roger Mark A Parkulo Iftikhar J Kullo Wayne T Nicholson Michelle A Elliott John L Black Richard M Weinshilboum

Genet Med 2017 04 22;19(4):421-429. Epub 2016 Sep 22.

Department of Molecular Pharmacology and Experimental Therapeutics, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1038/gim.2016.120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362352PMC
April 2017

Genome-wide association studies of drug response and toxicity: an opportunity for genome medicine.

Authors:
Kathleen M Giacomini Sook Wah Yee Taisei Mushiroda Richard M Weinshilboum Mark J Ratain Michiaki Kubo

Nat Rev Drug Discov 2017 Jan 25;16(1). Epub 2016 Nov 25.

RIKEN Center for Integrative Medical Science, Yokohama 230-0045, Japan.

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http://dx.doi.org/10.1038/nrd.2016.234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443656PMC
January 2017

Genetic Polymorphisms in the Long Noncoding RNA MIR2052HG Offer a Pharmacogenomic Basis for the Response of Breast Cancer Patients to Aromatase Inhibitor Therapy.

Authors:
James N Ingle Fang Xie Matthew J Ellis Paul E Goss Lois E Shepherd Judith-Anne W Chapman Bingshu E Chen Michiaki Kubo Yoichi Furukawa Yukihide Momozawa Vered Stearns Kathleen I Pritchard Poulami Barman Erin E Carlson Matthew P Goetz Richard M Weinshilboum Krishna R Kalari Liewei Wang

Cancer Res 2016 12 10;76(23):7012-7023. Epub 2016 Oct 10.

Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-16-1371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135610PMC
December 2016

Using EHR-Linked Biobank Data to Study Metformin Pharmacogenomics.

Authors:
Matthew K Breitenstein Gyorgy Simon Euijung Ryu Sebastian M Armasu Richard M Weinshilboum Liewei Wang Jyotishman Pathak

Stud Health Technol Inform 2015 ;210:914-8

Mayo Clinic, Department of Health of Sciences Research.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5051541PMC
November 2016

Influence of SULT1A1 genetic variation on age at menopause, estrogen levels, and response to hormone therapy in recently postmenopausal white women.

Authors:
Ann M Moyer Mariza de Andrade Richard M Weinshilboum Virginia M Miller

Menopause 2016 08;23(8):863-9

1Department of Laboratory Medicine and Pathology 2Division of Biomedical Statistics and Informatics 3Department of Molecular Pharmacology and Experimental Therapeutics 4Departments of Surgery and Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1097/GME.0000000000000648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961269PMC
August 2016

Combined Effects of Acamprosate and Escitalopram on Ethanol Consumption in Mice.

Authors:
Ada Man-Choi Ho Yanyan Qiu Yun-Fang Jia Felipe S Aguiar David J Hinton Victor M Karpyak Richard M Weinshilboum Doo-Sup Choi

Alcohol Clin Exp Res 2016 07 17;40(7):1531-9. Epub 2016 May 17.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, College of Medicine, Rochester, Minnesota.

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http://dx.doi.org/10.1111/acer.13099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020905PMC
July 2016

Preemptive Pharmacogenomic Testing for Precision Medicine: A Comprehensive Analysis of Five Actionable Pharmacogenomic Genes Using Next-Generation DNA Sequencing and a Customized CYP2D6 Genotyping Cascade.

Authors:
Yuan Ji Jennifer M Skierka Joseph H Blommel Brenda E Moore Douglas L VanCuyk Jamie K Bruflat Lisa M Peterson Tamra L Veldhuizen Numrah Fadra Sandra E Peterson Susan A Lagerstedt Laura J Train Linnea M Baudhuin Eric W Klee Matthew J Ferber Suzette J Bielinski Pedro J Caraballo Richard M Weinshilboum John L Black

J Mol Diagn 2016 05 3;18(3):438-445. Epub 2016 Mar 3.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15251578160004
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http://dx.doi.org/10.1016/j.jmoldx.2016.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851731PMC
May 2016

Estrogen, SNP-Dependent Chemokine Expression and Selective Estrogen Receptor Modulator Regulation.

Authors:
Ming-Fen Ho Tim Bongartz Mohan Liu Krishna R Kalari Paul E Goss Lois E Shepherd Matthew P Goetz Michiaki Kubo James N Ingle Liewei Wang Richard M Weinshilboum

Mol Endocrinol 2016 Mar 11;30(3):382-98. Epub 2016 Feb 11.

Division of Clinical Pharmacology (M.-F.H., M.L., L.W., R.M.W.), Department of Molecular Pharmacology and Experimental Therapeutics, Division of Rheumatology (M.-F.H., T.B.), Department of Medicine, Division of Biomedical Statistics and Informatics (K.R.K.), Department of Health Sciences Research, and Division of Medical Oncology (M.P.G., J.N.I.), Department of Oncology, Mayo Clinic, Rochester, Minnesota 55905; Division of Hematology/Oncology (P.E.G.), Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard University, Boston, Massachusetts 02114; National Cancer Institute of Canada Clinical Trials Group (L.E.S.), Kingston, Ontario, Canada K7L 3N6; and RIKEN Center for Integrative Medical Science (M.K.), Yokohama 230-0045, Japan.

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http://dx.doi.org/10.1210/me.2015-1267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771694PMC
March 2016

Genetic variants in VEGF pathway genes in neoadjuvant breast cancer patients receiving bevacizumab: Results from the randomized phase III GeparQuinto study.

Authors:
Alexander Hein Diether Lambrechts Gunter von Minckwitz Lothar Häberle Holger Eidtmann Hans Tesch Michael Untch Jörn Hilfrich Christian Schem Mahdi Rezai Bernd Gerber Serban Dan Costa Jens-Uwe Blohmer Kathrin Schwedler Kornelia Kittel Tanja Fehm Georg Kunz Matthias W Beckmann Arif B Ekici Claus Hanusch Jens Huober Cornelia Liedtke Christine Mau Matthieu Moisse Volkmar Müller Valentina Nekljudova Gilian Peuteman Brigitte Rack Matthias Rübner Thomas Van Brussel Liewei Wang Richard M Weinshilboum Sibylle Loibl Peter A Fasching

Int J Cancer 2015 Dec 6;137(12):2981-8. Epub 2015 Jul 6.

Department of Gynecology and Obstetrics, University Breast Center for Franconia, Erlangen University Hospital, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen-EMN Comprehensive Cancer Center, Erlangen, Germany.

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http://dx.doi.org/10.1002/ijc.29656DOI Listing
December 2015

Leveraging an Electronic Health Record-Linked Biorepository to Generate a Metformin Pharmacogenomics Hypothesis.

Authors:
Matthew K Breitenstein Liewei Wang Gyorgy Simon Euijung Ryu Sebastian M Armasu Balmiki Ray Richard M Weinshilboum Jyotishman Pathak

AMIA Jt Summits Transl Sci Proc 2015 23;2015:26-30. Epub 2015 Mar 23.

Mayo Clinic, Rochester, MN.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525256PMC
August 2015

Estrogens and their precursors in postmenopausal women with early breast cancer receiving anastrozole.

Authors:
James N Ingle Krishna R Kalari Aman U Buzdar Mark E Robson Matthew P Goetz Zeruesenay Desta Poulami Barman Tanda T Dudenkov Donald W Northfelt Edith A Perez David A Flockhart Clark V Williard Liewei Wang Richard M Weinshilboum

Steroids 2015 Jul 24;99(Pt A):32-8. Epub 2014 Aug 24.

Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, United States.

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http://dx.doi.org/10.1016/j.steroids.2014.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339673PMC
July 2015

Accuracy of Electronic Medical Record Medication Reconciliation in Emergency Department Patients.

Authors:
Andrew A Monte Peter Anderson Jason A Hoppe Richard M Weinshilboum Vasilis Vasiliou Kennon J Heard

J Emerg Med 2015 Jul 19;49(1):78-84. Epub 2015 Mar 19.

Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, Colorado; Rocky Mountain Poison & Drug Center, Denver, Colorado.

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http://dx.doi.org/10.1016/j.jemermed.2014.12.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476907PMC
July 2015

Detecting Associations between Major Depressive Disorder Treatment and Essential Hypertension using Electronic Health Records.

Authors:
Jyotishman Pathak Gyorgy Simon Dingcheng Li Joanna M Biernacka Gregory J Jenkins Christopher G Chute Daniel K Hall-Flavin Richard M Weinshilboum

AMIA Jt Summits Transl Sci Proc 2014 7;2014:91-6. Epub 2014 Apr 7.

Mayo Clinic, Rochester, MN.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419773PMC
May 2015

Circulating atrial natriuretic peptide genetic association study identifies a novel gene cluster associated with stroke in whites.

Authors:
Naveen L Pereira Nirubol Tosakulwong Christopher G Scott Gregory D Jenkins Naresh Prodduturi Yubo Chai Timothy M Olson Richard J Rodeheffer Margaret M Redfield Richard M Weinshilboum John C Burnett

Circ Cardiovasc Genet 2015 Feb 1;8(1):141-9. Epub 2014 Dec 1.

From the Division of Cardiovascular Diseases, Department of Internal Medicine (N.L.P., T.M.O., R.J.R., M.M.R., J.C.B.), Department of Biomedical Statistics and Informatics (N.T., C.G.S, G.D.J., N.P.), and Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (N.L.P., R.M.W.), Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1161/CIRCGENETICS.114.000624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387792PMC
February 2015

Myelotoxicity after high-dose methotrexate in childhood acute leukemia is influenced by 6-mercaptopurine dosing but not by intermediate thiopurine methyltransferase activity.

Authors:
Mette Levinsen Susanne Rosthøj Ulrikka Nygaard Jesper Heldrup Arja Harila-Saari Olafur G Jonsson Anne Grete Bechensteen Jonas Abrahamsson Birgitte Lausen Thomas L Frandsen Richard M Weinshilboum Kjeld Schmiegelow

Cancer Chemother Pharmacol 2015 Jan 28;75(1):59-66. Epub 2014 Oct 28.

Department of Paediatrics and Adolescent Medicine, The University Hospital Rigshospitalet, Copenhagen, Denmark.

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http://link.springer.com/10.1007/s00280-014-2613-7
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http://dx.doi.org/10.1007/s00280-014-2613-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446052PMC
January 2015

Electrophysiological Neuroimaging using sLORETA Comparing 22 Age Matched Male and Female Schizophrenia Patients.

Authors:
Andy R Eugene Jolanta Masiak Jacek Kapica Marek Masiak Richard M Weinshilboum

Hosp Chron 2015;10(2):91-98

Department of Molecular Pharmacology and Experimental Therapeutics, Division of Clinical Pharmacology, Gonda 19, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662405PMC
January 2015

The eSNV-detect: a computational system to identify expressed single nucleotide variants from transcriptome sequencing data.

Authors:
Xiaojia Tang Saurabh Baheti Khader Shameer Kevin J Thompson Quin Wills Nifang Niu Ilona N Holcomb Stephane C Boutet Ramesh Ramakrishnan Jennifer M Kachergus Jean-Pierre A Kocher Richard M Weinshilboum Liewei Wang E Aubrey Thompson Krishna R Kalari

Nucleic Acids Res 2014 Dec 28;42(22):e172. Epub 2014 Oct 28.

Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN 55905, USA

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http://dx.doi.org/10.1093/nar/gku1005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267611PMC
December 2014

Aromatase inhibitor-associated bone fractures: a case-cohort GWAS and functional genomics.

Authors:
Mohan Liu Paul E Goss James N Ingle Michiaki Kubo Yoichi Furukawa Anthony Batzler Gregory D Jenkins Erin E Carlson Yusuke Nakamura Daniel J Schaid Judy-Anne W Chapman Lois E Shepherd Matthew J Ellis Sundeep Khosla Liewei Wang Richard M Weinshilboum

Mol Endocrinol 2014 Oct 22;28(10):1740-51. Epub 2014 Aug 22.

Division of Clinical Pharmacology (M.L., L.W., R.M.W.), Department of Molecular Pharmacology and Experimental Therapeutics; Departments of Oncology (J.N.I.) and Health Sciences Research (A.B., G.D.J., E.E.C., D.J.S.); and Division of Endocrinology (S.K.), Mayo Clinic, Rochester, Minnesota 55905; Massachusetts General Hospital (P.E.G.), Harvard University, Boston, Massachusetts 02114; Rikagaku Kenkyūsho Center for Integrative Medical Science (M.K., Y.F.), Yokohama, Japan 230-0045; School of Medicine (Y.N.), Chicago University, Chicago, Illinois 60637; National Cancer Institute of Canada Clinical Trials Group (J.-A.W.C., L.E.S.), Kingston, Ontario, Canada K7L 3N6; and Division of Oncology (M.J.E.), Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110.

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http://dx.doi.org/10.1210/me.2014-1147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179631PMC
October 2014

Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations.

Authors:
Yuan Ji Daniel J Schaid Zeruesenay Desta Michiaki Kubo Anthony J Batzler Karen Snyder Taisei Mushiroda Naoyuki Kamatani Evan Ogburn Daniel Hall-Flavin David Flockhart Yusuke Nakamura David A Mrazek Richard M Weinshilboum

Br J Clin Pharmacol 2014 Aug;78(2):373-83

Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1111/bcp.12348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137829PMC
August 2014

The effect of CYP2D6 drug-drug interactions on hydrocodone effectiveness.

Authors:
Andrew A Monte Kennon J Heard Jenny Campbell D Hamamura Richard M Weinshilboum Vasilis Vasiliou

Acad Emerg Med 2014 Aug 24;21(8):879-85. Epub 2014 Aug 24.

Department of Emergency Medicine, University of Colorado, Aurora, CO; Skaggs School of Pharmacy and Pharmaceutical Sciences, San Diego, CA; Rocky Mountain Poison & Drug Center, Denver, CO.

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http://dx.doi.org/10.1111/acem.12431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150819PMC
August 2014

Genotype-guided dosing of vitamin K antagonists.

Authors:
Naveen L Pereira Charanjit S Rihal Richard M Weinshilboum

N Engl J Med 2014 05;370(18):1762

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http://dx.doi.org/10.1056/NEJMc1402521DOI Listing
May 2014

Preemptive genotyping for personalized medicine: design of the right drug, right dose, right time-using genomic data to individualize treatment protocol.

Authors:
Suzette J Bielinski Janet E Olson Jyotishman Pathak Richard M Weinshilboum Liewei Wang Kelly J Lyke Euijung Ryu Paul V Targonski Michael D Van Norstrand Matthew A Hathcock Paul Y Takahashi Jennifer B McCormick Kiley J Johnson Karen J Maschke Carolyn R Rohrer Vitek Marissa S Ellingson Eric D Wieben Gianrico Farrugia Jody A Morrisette Keri J Kruckeberg Jamie K Bruflat Lisa M Peterson Joseph H Blommel Jennifer M Skierka Matthew J Ferber John L Black Linnea M Baudhuin Eric W Klee Jason L Ross Tamra L Veldhuizen Cloann G Schultz Pedro J Caraballo Robert R Freimuth Christopher G Chute Iftikhar J Kullo

Mayo Clin Proc 2014 Jan;89(1):25-33

Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1016/j.mayocp.2013.10.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932754PMC
January 2014

TPMT genetic variants are associated with increased rejection with azathioprine use in heart transplantation.

Authors:
Jackson J Liang Jennifer R Geske Barry A Boilson Robert P Frantz Brooks S Edwards Sudhir S Kushwaha Walter K Kremers Richard M Weinshilboum Naveen L Pereira

Pharmacogenet Genomics 2013 Dec;23(12):658-65

Department of aInternal Medicine bBiostatistics cMedicine, Division of Cardiovascular Diseases dDepartment of Molecular Pharmacology and Experimental Therapeutics, Division of Clinical Pharmacology, Mayo Clinic, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1097/FPC.0000000000000005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894785PMC
December 2013

Preclinical discovery of candidate genes to guide pharmacogenetics during phase I development: the example of the novel anticancer agent ABT-751.

Authors:
Federico Innocenti Jacqueline Ramírez Jennifer Obel Julia Xiong Snezana Mirkov Yi-Lin Chiu David A Katz Robert A Carr Wei Zhang Soma Das Araba Adjei Ann M Moyer Pei Xian Chen Andrew Krivoshik Diane Medina Gary B Gordon Mark J Ratain Leonardo Sahelijo Richard M Weinshilboum Gini F Fleming Anahita Bhathena

Pharmacogenet Genomics 2013 Jul;23(7):374-81

Eshelman School of Pharmacy, Lineberger Comprehensive Cancer Center, Institute for Pharmacogenomics and Individualized Therapy, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1097/FPC.0b013e3283623e81DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858967PMC
July 2013

Selective estrogen receptor modulators and pharmacogenomic variation in ZNF423 regulation of BRCA1 expression: individualized breast cancer prevention.

Authors:
James N Ingle Mohan Liu D Lawrence Wickerham Daniel J Schaid Liewei Wang Taisei Mushiroda Michiaki Kubo Joseph P Costantino Victor G Vogel Soonmyung Paik Matthew P Goetz Matthew M Ames Gregory D Jenkins Anthony Batzler Erin E Carlson David A Flockhart Norman Wolmark Yusuke Nakamura Richard M Weinshilboum

Cancer Discov 2013 Jul 13;3(7):812-25. Epub 2013 Jun 13.

Division of Medical Oncology, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710533PMC
July 2013

Two-phase designs to follow-up genome-wide association signals with DNA resequencing studies.

Authors:
Daniel J Schaid Gregory D Jenkins James N Ingle Richard M Weinshilboum

Genet Epidemiol 2013 Apr 24;37(3):229-38. Epub 2013 Jan 24.

Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1002/gepi.21708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740575PMC
April 2013

Mammographic breast density response to aromatase inhibition.

Authors:
Celine M Vachon Vera J Suman Kathleen R Brandt Matthew L Kosel Aman U Buzdar Janet E Olson Fang-Fang Wu Lynn M Flickinger Giske Ursin Catherine R Elliott Lois Shepherd Richard M Weinshilboum Paul E Goss James N Ingle

Clin Cancer Res 2013 Apr 6;19(8):2144-53. Epub 2013 Mar 6.

Department of Health Sciences, Mayo Clinic College of Medicine, Rochester, Minnesota, 55905, USA.

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http://clincancerres.aacrjournals.org/content/early/2013/03/
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April 2013

Natriuretic peptide receptor-3 gene (NPR3): nonsynonymous polymorphism results in significant reduction in protein expression because of accelerated degradation.

Authors:
Naveen L Pereira Dong Lin Linda Pelleymounter Irene Moon Gail Stilling Bruce W Eckloff Eric D Wieben Margaret M Redfield John C Burnett Vivien C Yee Richard M Weinshilboum

Circ Cardiovasc Genet 2013 Apr 14;6(2):201-10. Epub 2013 Mar 14.

Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.

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April 2013

TSPYL5 SNPs: association with plasma estradiol concentrations and aromatase expression.

Authors:
Mohan Liu James N Ingle Brooke L Fridley Aman U Buzdar Mark E Robson Michiaki Kubo Liewei Wang Anthony Batzler Gregory D Jenkins Tracy L Pietrzak Erin E Carlson Matthew P Goetz Donald W Northfelt Edith A Perez Clark V Williard Daniel J Schaid Yusuke Nakamura Richard M Weinshilboum

Mol Endocrinol 2013 Apr 21;27(4):657-70. Epub 2013 Mar 21.

Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1210/me.2012-1397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607698PMC
April 2013

FKBP5 genetic variation: association with selective serotonin reuptake inhibitor treatment outcomes in major depressive disorder.

Authors:
Katarzyna A Ellsworth Irene Moon Bruce W Eckloff Brooke L Fridley Gregory D Jenkins Anthony Batzler Joanna M Biernacka Ryan Abo Abra Brisbin Yuan Ji Scott Hebbring Eric D Wieben David A Mrazek Richard M Weinshilboum Liewei Wang

Pharmacogenet Genomics 2013 Mar;23(3):156-66

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1097/FPC.0b013e32835dc133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784025PMC
March 2013

Interview: Richard M Weinshilboum talks to Hannah Branch, Assistant Commissioning Editor.

Authors:
Richard M Weinshilboum

Biomark Med 2013 Feb;7(1):5-10

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http://dx.doi.org/10.2217/bmm.12.106DOI Listing
February 2013

CYP2D6 metabolism and patient outcome in the Austrian Breast and Colorectal Cancer Study Group trial (ABCSG) 8.

Authors:
Matthew P Goetz Vera J Suman Tanya L Hoskin Michael Gnant Martin Filipits Stephanie L Safgren Mary Kuffel Raimund Jakesz Margaretha Rudas Richard Greil Otto Dietze Alois Lang Felix Offner Carol A Reynolds Richard M Weinshilboum Matthew M Ames James N Ingle

Clin Cancer Res 2013 Jan 4;19(2):500-7. Epub 2012 Dec 4.

Department of Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548984PMC
January 2013

Human liver methionine cycle: MAT1A and GNMT gene resequencing, functional genomics, and hepatic genotype-phenotype correlation.

Authors:
Yuan Ji Kendra K S Nordgren Yubo Chai Scott J Hebbring Gregory D Jenkins Ryan P Abo Yi Peng Linda L Pelleymounter Irene Moon Bruce W Eckloff Xiaoshan Chai Jianping Zhang Brooke L Fridley Vivien C Yee Eric D Wieben Richard M Weinshilboum

Drug Metab Dispos 2012 Oct 17;40(10):1984-92. Epub 2012 Jul 17.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1124/dmd.112.046953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463826PMC
October 2012

Pharmacogenomics and patient care: one size does not fit all.

Authors:
Kathleen M Giacomini Sook Wah Yee Mark J Ratain Richard M Weinshilboum Naoyuki Kamatani Yusuke Nakamura

Sci Transl Med 2012 Sep;4(153):153ps18

Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1126/scitranslmed.3003471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963516PMC
September 2012

PharmGKB summary: very important pharmacogene information for GSTT1.

Authors:
Caroline F Thorn Yuan Ji Richard M Weinshilboum Russ B Altman Teri E Klein

Pharmacogenet Genomics 2012 Aug;22(8):646-51

Department of Genetics, Stanford University Medical Center, Stanford, California, USA.

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http://dx.doi.org/10.1097/FPC.0b013e3283527c02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395771PMC
August 2012

Automated discovery of drug treatment patterns for endocrine therapy of breast cancer within an electronic medical record.

Authors:
Guergana K Savova Janet E Olson Sean P Murphy Victoria L Cafourek Fergus J Couch Matthew P Goetz James N Ingle Vera J Suman Christopher G Chute Richard M Weinshilboum

J Am Med Inform Assoc 2012 Jun 1;19(e1):e83-9. Epub 2011 Dec 1.

Mayo Clinic, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1136/amiajnl-2011-000295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392847PMC
June 2012

Merging pharmacometabolomics with pharmacogenomics using '1000 Genomes' single-nucleotide polymorphism imputation: selective serotonin reuptake inhibitor response pharmacogenomics.

Authors:
Ryan Abo Scott Hebbring Yuan Ji Hongjie Zhu Zhao-Bang Zeng Anthony Batzler Gregory D Jenkins Joanna Biernacka Karen Snyder Maureen Drews Oliver Fiehn Brooke Fridley Daniel Schaid Naoyuki Kamatani Yusuke Nakamura Michiaki Kubo Taisei Mushiroda Rima Kaddurah-Daouk David A Mrazek Richard M Weinshilboum

Pharmacogenet Genomics 2012 Apr;22(4):247-53

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303952PMC
April 2012

An interview with Pharmacogenomics for the breast cancer special focus issue.

Authors:
Richard M Weinshilboum

Pharmacogenomics 2012 Apr;13(6):655-8

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http://dx.doi.org/10.2217/pgs.12.33DOI Listing
April 2012

Serine hydroxymethyltransferase 1 and 2: gene sequence variation and functional genomic characterization.

Authors:
Scott J Hebbring Yubo Chai Yuan Ji Ryan P Abo Gregory D Jenkins Brooke Fridley Jianping Zhang Bruce W Eckloff Eric D Wieben Richard M Weinshilboum

J Neurochem 2012 Mar 6;120(6):881-90. Epub 2012 Feb 6.

Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2012.07646.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296836PMC
March 2012

Aromatase inhibitors, estrogens and musculoskeletal pain: estrogen-dependent T-cell leukemia 1A (TCL1A) gene-mediated regulation of cytokine expression.

Authors:
Mohan Liu Liewei Wang Tim Bongartz John R Hawse Svetomir N Markovic Daniel J Schaid Taisei Mushiroda Michiaki Kubo Yusuke Nakamura Naoyuki Kamatani Paul E Goss James N Ingle Richard M Weinshilboum

Breast Cancer Res 2012 Mar 9;14(2):R41. Epub 2012 Mar 9.

Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1186/bcr3137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446375PMC
March 2012

Using the gene ontology to scan multilevel gene sets for associations in genome wide association studies.

Authors:
Daniel J Schaid Jason P Sinnwell Gregory D Jenkins Shannon K McDonnell James N Ingle Michiaki Kubo Paul E Goss Joseph P Costantino D Lawrence Wickerham Richard M Weinshilboum

Genet Epidemiol 2012 Jan 7;36(1):3-16. Epub 2011 Dec 7.

Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://doi.wiley.com/10.1002/gepi.20632
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310255PMC
January 2012

Methionine adenosyltransferase 2A/2B and methylation: gene sequence variation and functional genomics.

Authors:
Kendra K S Nordgren Yi Peng Linda L Pelleymounter Irene Moon Ryan Abo Qiping Feng Bruce Eckloff Vivien C Yee Eric Wieben Richard M Weinshilboum

Drug Metab Dispos 2011 Nov 3;39(11):2135-47. Epub 2011 Aug 3.

Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1124/dmd.111.040857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198898PMC
November 2011

Gene set analysis of purine and pyrimidine antimetabolites cancer therapies.

Authors:
Brooke L Fridley Anthony Batzler Liang Li Fang Li Alice Matimba Gregory D Jenkins Yuan Ji Liewei Wang Richard M Weinshilboum

Pharmacogenet Genomics 2011 Nov;21(11):701-12

Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1097/FPC.0b013e32834a48a9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192305PMC
November 2011

Evaluation of CYP2D6 and efficacy of tamoxifen and raloxifene in women treated for breast cancer chemoprevention: results from the NSABP P1 and P2 clinical trials.

Authors:
Matthew P Goetz Daniel J Schaid D Lawrence Wickerham Stephanie Safgren Taisei Mushiroda Michiaki Kubo Anthony Batzler Joseph P Costantino Victor G Vogel Soonmyung Paik Erin E Carlson David A Flockhart Norman Wolmark Yusuke Nakamura Richard M Weinshilboum James N Ingle Matthew M Ames

Clin Cancer Res 2011 Nov 31;17(21):6944-51. Epub 2011 Aug 31.

Department of Oncology, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-0860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207003PMC
November 2011

SULT1A1, CYP2C19 and disease-free survival in early breast cancer patients receiving tamoxifen.

Authors:
Ann M Moyer Vera J Suman Richard M Weinshilboum Rajeswari Avula John L Black Stephanie L Safgren Mary J Kuffel Matthew M Ames James N Ingle Matthew P Goetz

Pharmacogenomics 2011 Nov 3;12(11):1535-43. Epub 2011 Oct 3.

Mayo Clinic, Rochester, MN 55905, USA.

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https://www.futuremedicine.com/doi/10.2217/pgs.11.97
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http://dx.doi.org/10.2217/pgs.11.97DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235041PMC
November 2011

Mycophenolic acid response biomarkers: a cell line model system-based genome-wide screen.

Authors:
Tse-Yu Wu Brooke L Fridley Gregory D Jenkins Anthony Batzler Liewei Wang Richard M Weinshilboum

Int Immunopharmacol 2011 Aug 23;11(8):1057-64. Epub 2011 Mar 23.

Division of Clinical Pharmacology, Department of Pharmacology and Experimental Therapeutics, Rochester, MN 55905, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S156757691100119
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http://dx.doi.org/10.1016/j.intimp.2011.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138818PMC
August 2011

Acetaminophen-NAPQI hepatotoxicity: a cell line model system genome-wide association study.

Authors:
Ann M Moyer Brooke L Fridley Gregory D Jenkins Anthony J Batzler Linda L Pelleymounter Krishna R Kalari Yuan Ji Yubo Chai Kendra K S Nordgren Richard M Weinshilboum

Toxicol Sci 2011 Mar 22;120(1):33-41. Epub 2010 Dec 22.

Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1093/toxsci/kfq375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044203PMC
March 2011

Genomics and drug response.

Authors:
Liewei Wang Howard L McLeod Richard M Weinshilboum

N Engl J Med 2011 Mar;364(12):1144-53

Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Medical School, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1056/NEJMra1010600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184612PMC
March 2011

Betaine-homocysteine methyltransferase: human liver genotype-phenotype correlation.

Authors:
Qiping Feng Krishna Kalari Brooke L Fridley Gregory Jenkins Yuan Ji Ryan Abo Scott Hebbring Jianping Zhang Monica D Nye J Steven Leeder Richard M Weinshilboum

Mol Genet Metab 2011 Feb 21;102(2):126-33. Epub 2010 Oct 21.

Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/j.ymgme.2010.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053054PMC
February 2011

CYP2C19 variation and citalopram response.

Authors:
David A Mrazek Joanna M Biernacka Dennis J O'Kane John L Black Julie M Cunningham Maureen S Drews Karen A Snyder Susanna R Stevens Augustus John Rush Richard M Weinshilboum

Pharmacogenet Genomics 2011 Jan;21(1):1-9

Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090085PMC
http://dx.doi.org/10.1097/fpc.0b013e328340bc5aDOI Listing
January 2011

Ecto-5'-nucleotidase and thiopurine cellular circulation: association with cytotoxicity.

Authors:
Fang Li Brooke L Fridley Alice Matimba Krishna R Kalari Linda Pelleymounter Irene Moon Yuan Ji Gregory D Jenkins Anthony Batzler Liewei Wang Richard M Weinshilboum

Drug Metab Dispos 2010 Dec 20;38(12):2329-38. Epub 2010 Sep 20.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1124/dmd.110.035220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993460PMC
December 2010

Natriuretic peptide pharmacogenetics: membrane metallo-endopeptidase (MME): common gene sequence variation, functional characterization and degradation.

Authors:
Naveen L Pereira Pinar Aksoy Irene Moon Yi Peng Margaret M Redfield John C Burnett Eric D Wieben Vivien C Yee Richard M Weinshilboum

J Mol Cell Cardiol 2010 Nov 6;49(5):864-74. Epub 2010 Aug 6.

Division of Cardiovascular Diseases and Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2010.07.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092155PMC
November 2010

Genome-wide associations and functional genomic studies of musculoskeletal adverse events in women receiving aromatase inhibitors.

Authors:
James N Ingle Daniel J Schaid Paul E Goss Mohan Liu Taisei Mushiroda Judy-Anne W Chapman Michiaki Kubo Gregory D Jenkins Anthony Batzler Lois Shepherd Joseph Pater Liewei Wang Matthew J Ellis Vered Stearns Daniel C Rohrer Matthew P Goetz Kathleen I Pritchard David A Flockhart Yusuke Nakamura Richard M Weinshilboum

J Clin Oncol 2010 Nov 27;28(31):4674-82. Epub 2010 Sep 27.

Mayo Clinic, Rochester, MN 55905, USA.

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http://ascopubs.org/doi/10.1200/JCO.2010.28.5064
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http://dx.doi.org/10.1200/JCO.2010.28.5064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020700PMC
November 2010

Cancer pharmacogenomics and pharmacoepidemiology: setting a research agenda to accelerate translation.

Authors:
Andrew N Freedman Leah B Sansbury William D Figg Arnold L Potosky Sheila R Weiss Smith Muin J Khoury Stefanie A Nelson Richard M Weinshilboum Mark J Ratain Howard L McLeod Robert S Epstein Geoffrey S Ginsburg Richard L Schilsky Geoffrey Liu David A Flockhart Cornelia M Ulrich Robert L Davis Lawrence J Lesko Issam Zineh Gurvaneet Randhawa Christine B Ambrosone Mary V Relling Nat Rothman Heng Xie Margaret R Spitz Rachel Ballard-Barbash James H Doroshow Lori M Minasian

J Natl Cancer Inst 2010 Nov 13;102(22):1698-705. Epub 2010 Oct 13.

National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-7393, USA.

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http://dx.doi.org/10.1093/jnci/djq390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982809PMC
November 2010

CD38 expression, function, and gene resequencing in a human lymphoblastoid cell line-based model system.

Authors:
William R Hartman Linda L Pelleymounter Irene Moon Krishna Kalari Mohan Liu Tse-Yu Wu Carlos Escande Veronica Nin Eduardo N Chini Richard M Weinshilboum

Leuk Lymphoma 2010 Jul;51(7):1315-25

Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.3109/10428194.2010.483299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892000PMC
July 2010

Coprescription of tamoxifen and medications that inhibit CYP2D6.

Authors:
Kostandinos Sideras James N Ingle Matthew M Ames Charles L Loprinzi David P Mrazek John L Black Richard M Weinshilboum John R Hawse Thomas C Spelsberg Matthew P Goetz

J Clin Oncol 2010 Jun 3;28(16):2768-76. Epub 2010 May 3.

Department of Oncology, Mayo Clinic, 200 1st Street Southwest, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1200/JCO.2009.23.8931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881853PMC
June 2010

Copy number variation and cytidine analogue cytotoxicity: a genome-wide association approach.

Authors:
Krishna R Kalari Scott J Hebbring High Seng Chai Liang Li Jean-Pierre A Kocher Liewei Wang Richard M Weinshilboum

BMC Genomics 2010 Jun 4;11:357. Epub 2010 Jun 4.

Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1186/1471-2164-11-357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894803PMC
June 2010

Variation in anastrozole metabolism and pharmacodynamics in women with early breast cancer.

Authors:
James N Ingle Aman U Buzdar Daniel J Schaid Matthew P Goetz Anthony Batzler Mark E Robson Donald W Northfelt Janet E Olson Edith A Perez Zeruesenay Desta Randy A Weintraub Clark V Williard David A Flockhart Richard M Weinshilboum

Cancer Res 2010 Apr 30;70(8):3278-86. Epub 2010 Mar 30.

Division of Medical Oncology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-09-3024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855746PMC
April 2010

Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.

Authors:
Ann M Moyer Zhifu Sun Anthony J Batzler Liang Li Daniel J Schaid Ping Yang Richard M Weinshilboum

Cancer Epidemiol Biomarkers Prev 2010 Mar 3;19(3):811-21. Epub 2010 Mar 3.

Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-09-0871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837367PMC
March 2010