Richard M Siegel

Richard M Siegel

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Richard M Siegel

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Daily variation in macrophage phagocytosis is clock-independent and dispensable for cytokine production.

Immunology 2019 Jun 16;157(2):122-136. Epub 2019 Apr 16.

Immunoregulation Section, Autoimmunity Branch, NIAMS, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1111/imm.13053DOI Listing
June 2019

Insights into rheumatic diseases from next-generation sequencing.

Nat Rev Rheumatol 2019 Jun;15(6):327-339

Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY, USA.

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http://dx.doi.org/10.1038/s41584-019-0217-7DOI Listing
June 2019

Distinct Clinical and Pathological Features of Melorheostosis Associated With Somatic MAP2K1 Mutations.

J Bone Miner Res 2019 Jan 14;34(1):145-156. Epub 2018 Sep 14.

Clinical and Investigative Orthopedics Surgery Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, USA.

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http://doi.wiley.com/10.1002/jbmr.3577
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http://dx.doi.org/10.1002/jbmr.3577DOI Listing
January 2019

Melorheostotic Bone Lesions Caused by Somatic Mutations in MAP2K1 Have Deteriorated Microarchitecture and Periosteal Reaction.

J Bone Miner Res 2019 Jan 22. Epub 2019 Jan 22.

Section on Heritable Disorders of Bone and Extracellular Matrix, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

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http://doi.wiley.com/10.1002/jbmr.3656
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http://dx.doi.org/10.1002/jbmr.3656DOI Listing
January 2019

Reduced monocyte and macrophage TNFSF15/TL1A expression is associated with susceptibility to inflammatory bowel disease.

PLoS Genet 2018 09 10;14(9):e1007458. Epub 2018 Sep 10.

Department of Medicine, University of Cambridge School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.

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https://dx.plos.org/10.1371/journal.pgen.1007458
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http://dx.doi.org/10.1371/journal.pgen.1007458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130856PMC
September 2018

Beyond Cell Death: New Functions for TNF Family Cytokines in Autoimmunity and Tumor Immunotherapy.

Trends Mol Med 2018 07 4;24(7):642-653. Epub 2018 Jun 4.

Immunoregulation Section, Autoimmunity Branch, National Institutes of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2018.05.004DOI Listing
July 2018

Fas Ligand localizes to intraluminal vesicles within NK cell cytolytic granules and is enriched at the immune synapse.

Immun Inflamm Dis 2018 06 11;6(2):312-321. Epub 2018 Apr 11.

Immunoregulation Section, Autoimmunity Branch, National Institutes of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://doi.wiley.com/10.1002/iid3.219
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http://dx.doi.org/10.1002/iid3.219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946154PMC
June 2018

Somatic activating mutations in MAP2K1 cause melorheostosis.

Nat Commun 2018 04 11;9(1):1390. Epub 2018 Apr 11.

Clinical and Investigative Orthopedics Surgery Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1038/s41467-018-03720-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895796PMC
April 2018

Cleavage of TL1A Differentially Regulates Its Effects on Innate and Adaptive Immune Cells.

J Immunol 2018 02 15;200(4):1360-1369. Epub 2018 Jan 15.

Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892;

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http://dx.doi.org/10.4049/jimmunol.1700891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812441PMC
February 2018

Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases.

Nat Rev Rheumatol 2017 Apr 9;13(4):217-233. Epub 2017 Mar 9.

Immunoregulation Section, Autoimmunity Branch, NIAMS, NIH, Bethesda, Maryland, USA.

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http://www.nature.com/articles/nrrheum.2017.22
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http://dx.doi.org/10.1038/nrrheum.2017.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486401PMC
April 2017

TNF superfamily cytokines in the promotion of Th9 differentiation and immunopathology.

Semin Immunopathol 2017 01 28;39(1):21-28. Epub 2016 Nov 28.

Immunoregulation Section, Autoimmunity Branch, NIAMS, National Institutes of Health, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/s00281-016-0612-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461121PMC
January 2017

Breaking the Mold: Partnering with the National Institutes of Health Intramural Research Program to Accelerate PhD Training.

Trends Immunol 2016 12 9;37(12):813-815. Epub 2016 Nov 9.

National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.it.2016.10.005DOI Listing
December 2016

Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction.

Nat Commun 2016 12 23;7:13895. Epub 2016 Dec 23.

Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Intramural Research Program, National Institutes of Health (NIH), Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/ncomms13895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5196435PMC
December 2016

Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex.

Mol Cell 2016 10 13;64(2):236-250. Epub 2016 Oct 13.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765163052
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089849PMC
http://dx.doi.org/10.1016/j.molcel.2016.09.009DOI Listing
October 2016

Critical role of fatty acid metabolism in ILC2-mediated barrier protection during malnutrition and helminth infection.

J Exp Med 2016 07 18;213(8):1409-18. Epub 2016 Jul 18.

Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892

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http://dx.doi.org/10.1084/jem.20151448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986525PMC
July 2016

Targeted genomic analysis reveals widespread autoimmune disease association with regulatory variants in the TNF superfamily cytokine signalling network.

Genome Med 2016 07 19;8(1):76. Epub 2016 Jul 19.

Department of Medicine and Cambridge Institute for Medical Research, The University of Cambridge, Box 139, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, UK.

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http://dx.doi.org/10.1186/s13073-016-0329-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4952362PMC
July 2016

Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4.

Nat Commun 2016 Mar 3;7:10857. Epub 2016 Mar 3.

National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/ncomms10857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782063PMC
March 2016

Recruitment of A20 by the C-terminal domain of NEMO suppresses NF-κB activation and autoinflammatory disease.

Proc Natl Acad Sci U S A 2016 Feb 22;113(6):1612-7. Epub 2016 Jan 22.

Immunodeficiency and Inflammation Unit, Autoimmunity Branch, National Institute of Arthritis, Musculoskeletal and Skin Disease, National Institutes of Health, Bethesda, MD 20892;

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http://dx.doi.org/10.1073/pnas.1518163113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760784PMC
February 2016

Structural Basis and Functional Role of Intramembrane Trimerization of the Fas/CD95 Death Receptor.

Mol Cell 2016 Feb 4;61(4):602-613. Epub 2016 Feb 4.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761300PMC
February 2016

Chrono-immunology: progress and challenges in understanding links between the circadian and immune systems.

Immunology 2015 Nov 28;146(3):349-58. Epub 2015 Sep 28.

Immunoregulation Section, Autoimmunity Branch, NIAMS, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1111/imm.12525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610624PMC
November 2015

The TNF-family cytokine TL1A: from lymphocyte costimulator to disease co-conspirator.

J Leukoc Biol 2015 Sep 17;98(3):333-45. Epub 2015 Jul 17.

*Immunoregulation Section, Autoimmunity Branch, NIAMS, National Institutes of Health, Bethesda, Maryland, USA; Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge, Cambridge, United Kingdom; Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom

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http://dx.doi.org/10.1189/jlb.3RI0315-095RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763597PMC
September 2015

Protein misfolding and dysregulated protein homeostasis in autoinflammatory diseases and beyond.

Semin Immunopathol 2015 Jul 21;37(4):335-47. Epub 2015 May 21.

Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/s00281-015-0496-2DOI Listing
July 2015

Extracellular flux analysis to monitor glycolytic rates and mitochondrial oxygen consumption.

Methods Enzymol 2014 ;542:125-49

Autoimmunity Branch, Immunoregulation Section, National Institutes of Arthritis, Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, Maryland, USA. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-416618-9.00007-8DOI Listing
May 2015

Comparison of gene expression microarray data with count-based RNA measurements informs microarray interpretation.

BMC Genomics 2014 Aug 4;15:649. Epub 2014 Aug 4.

Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1186/1471-2164-15-649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143561PMC
August 2014

Outflanking RANK with a designer antagonist cytokine.

Sci Signal 2014 Aug 19;7(339):pe20. Epub 2014 Aug 19.

Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1126/scisignal.2005674DOI Listing
August 2014

Inhibition of caspase-8 activity promotes protective Th1- and Th2-mediated immunity to Leishmania major infection.

J Leukoc Biol 2014 Feb 26;95(2):347-55. Epub 2013 Sep 26.

5.Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho 373, Ilha do Fundão, Rio de Janeiro, RJ, 21941-902, Brazil.

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http://dx.doi.org/10.1189/jlb.0912463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896658PMC
February 2014

A rapid ex vivo clinical diagnostic assay for fas receptor-induced T lymphocyte apoptosis.

J Clin Immunol 2013 Feb 11;33(2):479-88. Epub 2012 Oct 11.

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1007/s10875-012-9811-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567298PMC
February 2013

Mitochondrial ROS fire up T cell activation.

Immunity 2013 Feb;38(2):201-2

MRC Mitochondrial Biology Unit, MRC/Wellcome Trust Building, Hills Road, Cambridge CB2 0XY, UK.

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http://dx.doi.org/10.1016/j.immuni.2013.02.005DOI Listing
February 2013

Autoimmunity: twenty years in the Fas lane.

J Immunol 2012 Dec;189(11):5097-100

Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.4049/jimmunol.1202833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580219PMC
December 2012

New tricks from an old dog: mitochondrial redox signaling in cellular inflammation.

Semin Immunol 2012 Dec 4;24(6):384-92. Epub 2013 Feb 4.

Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, United States.

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http://dx.doi.org/10.1016/j.smim.2013.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650900PMC
December 2012

Lighting the fires within: the cell biology of autoinflammatory diseases.

Nat Rev Immunol 2012 Jul 25;12(8):570-80. Epub 2012 Jul 25.

Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/nri3261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165575PMC
July 2012

Inflammation-inducing Th1 and Th17 cells differ in their expression patterns of apoptosis-related molecules.

Cell Immunol 2011 17;271(2):210-3. Epub 2011 Aug 17.

Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892-1857, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000887491100207
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http://dx.doi.org/10.1016/j.cellimm.2011.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249224PMC
December 2011

Wiskott-Aldrich Syndrome at the nexus of autoimmune and primary immunodeficiency diseases.

FEBS Lett 2011 Dec 25;585(23):3710-4. Epub 2011 Oct 25.

Immunoregulation Section, Autoimmunity Branch National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://doi.wiley.com/10.1016/j.febslet.2011.10.031
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http://dx.doi.org/10.1016/j.febslet.2011.10.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580218PMC
December 2011

TL1A and DR3, a TNF family ligand-receptor pair that promotes lymphocyte costimulation, mucosal hyperplasia, and autoimmune inflammation.

Immunol Rev 2011 Nov;244(1):188-96

Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1111/j.1600-065X.2011.01068.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882070PMC
November 2011

Medicine. Progranulin resolves inflammation.

Science 2011 Apr;332(6028):427-8

Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/science.1205992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183821PMC
April 2011

The ribonucleotide reductase R1 subunits of herpes simplex virus types 1 and 2 protect cells against TNFα- and FasL-induced apoptosis by interacting with caspase-8.

Apoptosis 2011 Mar;16(3):256-71

Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM) and Institut du cancer de Montréal, Hôpital Notre-Dame, 1560 Sherbrooke Est, Montreal, QC, Canada.

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http://dx.doi.org/10.1007/s10495-010-0560-2DOI Listing
March 2011

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS).

J Exp Med 2011 Mar 31;208(3):519-33. Epub 2011 Jan 31.

Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutesof Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1084/jem.20102049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058571PMC
March 2011

Harnessing programmed cell death as a therapeutic strategy in rheumatic diseases.

Nat Rev Rheumatol 2011 Mar 1;7(3):152-60. Epub 2011 Feb 1.

Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases/NIH, 10 Center Drive, Bethesda, MD 20892-1930, USA.

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http://dx.doi.org/10.1038/nrrheum.2010.225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437254PMC
March 2011

CCR2 identifies a stable population of human effector memory CD4+ T cells equipped for rapid recall response.

J Immunol 2010 Dec 27;185(11):6646-63. Epub 2010 Oct 27.

Inflammation Biology Section, Laboratory of Molecular Immunology, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.0904156
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http://dx.doi.org/10.4049/jimmunol.0904156DOI Listing
December 2010

Concerted action of wild-type and mutant TNF receptors enhances inflammation in TNF receptor 1-associated periodic fever syndrome.

Proc Natl Acad Sci U S A 2010 May 10;107(21):9801-6. Epub 2010 May 10.

Inflammatory Biology Section, Laboratory of Clinical Investigation and Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.0914118107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906866PMC
May 2010

Many checkpoints on the road to cell death: regulation of Fas-FasL interactions and Fas signaling in peripheral immune responses.

Results Probl Cell Differ 2009 ;49:17-47

Immunoregulation Unit, Autoimmunity Branch, NIAMS, National Institutes of Health, Bethesda MD 20892, USA.

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http://dx.doi.org/10.1007/400_2008_24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825281PMC
March 2010

New insights into T cell biology and T cell-directed therapy for autoimmunity, inflammation, and immunosuppression.

Ann N Y Acad Sci 2010 Jan;1183:123-48

Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2009.05124.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950114PMC
January 2010

Wishing away inflammation? New links between serotonin and TNF signaling.

Mol Interv 2009 Dec;9(6):299-301

Immunoregulation Section, Autoimmunity Branch, NIAMS, NIH, Bethesda, MD 20814, USA.

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http://dx.doi.org/10.1124/mi.9.6.5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861806PMC
December 2009

Rheumatologic and autoimmune manifestations of primary immunodeficiency disorders.

Curr Opin Rheumatol 2009 Jan;21(1):78-84

Office of the Clinical Director, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1097/BOR.0b013e32831cb939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760066PMC
January 2009

Type III secretion decreases bacterial and host survival following phagocytosis of Yersinia pseudotuberculosis by macrophages.

Infect Immun 2008 Sep 30;76(9):4299-310. Epub 2008 Jun 30.

Department of Molecular Genetics and Microbiology, Center for Infectious Diseases, SUNY Stony Brook, Stony Brook, New York 11794-5222, USA.

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http://dx.doi.org/10.1128/IAI.00183-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519449PMC
September 2008

The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases.

Immunity 2008 Jul 19;29(1):79-89. Epub 2008 Jun 19.

Immunoregulation Unit, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892.

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http://dx.doi.org/10.1016/j.immuni.2008.04.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760084PMC
July 2008

Falling into TRAPS--receptor misfolding in the TNF receptor 1-associated periodic fever syndrome.

Arthritis Res Ther 2007 ;9(4):217

Laboratory for Experimental Oncology and Radiobiology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/ar2197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206363PMC
April 2008

Cutting edge: Rac GTPases sensitize activated T cells to die via Fas.

J Immunol 2007 Nov;179(10):6384-8

Immunoregulation Unit, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.4049/jimmunol.179.10.6384DOI Listing
November 2007

Impaired in vitro regulatory T cell function associated with Wiskott-Aldrich syndrome.

Clin Immunol 2007 Jul 18;124(1):41-8. Epub 2007 May 18.

Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, 49 Convent Dr., Blg. 49, Rm 3A20, Bethesda, MD 20892-4442, USA.

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http://dx.doi.org/10.1016/j.clim.2007.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1986664PMC
July 2007

Dominant-negative effect of the heterozygous C104R TACI mutation in common variable immunodeficiency (CVID).

J Clin Invest 2007 Jun 10;117(6):1550-7. Epub 2007 May 10.

Division of Immunology, Children's Hospital Boston, Boston, Massachusetts 02115, USA.

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http://www.jci.org/cgi/doi/10.1172/JCI31023
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http://dx.doi.org/10.1172/JCI31023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1865037PMC
June 2007

The Yersinia effector protein YpkA induces apoptosis independently of actin depolymerization.

J Immunol 2007 May;178(10):6426-34

Molecular Immunology and Inflammation Branch, Immunoregulation Unit, National Institute and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.4049/jimmunol.178.10.6426DOI Listing
May 2007

A FAScinating receptor in self-tolerance.

Immunity 2007 May;26(5):545-7

Immunoregulation Unit, Autoimmunity Branch, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.immuni.2007.05.004DOI Listing
May 2007

Autoimmunity versus tolerance: can dying cells tip the balance?

Clin Immunol 2007 Feb 5;122(2):125-34. Epub 2006 Oct 5.

Cell Signaling Section, Genetic Disease Research Branch NHGRI, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.clim.2006.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805813PMC
February 2007

T cell-directed therapies: lessons learned and future prospects.

Nat Immunol 2007 Jan;8(1):25-30

Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/ni1429DOI Listing
January 2007

A new web resource for NIH immunology.

Authors:
Richard M Siegel

Nat Immunol 2006 Oct;7(10):1007

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http://dx.doi.org/10.1038/ni1006-1007DOI Listing
October 2006

Abnormal disulfide-linked oligomerization results in ER retention and altered signaling by TNFR1 mutants in TNFR1-associated periodic fever syndrome (TRAPS).

Blood 2006 Aug 9;108(4):1320-7. Epub 2006 May 9.

Immunoregulation Unit, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda MD 20892, USA.

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http://dx.doi.org/10.1182/blood-2005-11-006783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895878PMC
August 2006

Caspases at the crossroads of immune-cell life and death.

Authors:
Richard M Siegel

Nat Rev Immunol 2006 Apr;6(4):308-17

Immunoregulation Unit, Autoimmunity Branch, NIAMS, National Institutes of Health, Building 10 Room 9N238, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nri1809DOI Listing
April 2006

Progressive glomerulonephritis and histiocytic sarcoma associated with macrophage functional defects in CYP1B1-deficient mice.

Toxicol Pathol 2004 Nov-Dec;32(6):710-8

The National Institute of Allergy and Infectious Diseases, NIH and SoBran, Inc., Twinbrook 3, Room 2W-01A, Bethesda, Maryland 20892-8135, USA.

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http://dx.doi.org/10.1080/01926230490885706DOI Listing
March 2005

Inhibition of MAPK signaling pathways by VopA from Vibrio parahaemolyticus.

J Biol Chem 2004 Dec 30;279(50):51953-7. Epub 2004 Sep 30.

Department of Molecular Biology, University of Texas Southwestern Medical School, Dallas, Texas 75390-9148, USA.

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http://dx.doi.org/10.1074/jbc.M407001200DOI Listing
December 2004

The NS3 protein of hepatitis C virus induces caspase-8-mediated apoptosis independent of its protease or helicase activities.

Virology 2004 Nov;329(1):53-67

Medical Virology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.virol.2004.08.012DOI Listing
November 2004

SPOTS: signaling protein oligomeric transduction structures are early mediators of death receptor-induced apoptosis at the plasma membrane.

J Cell Biol 2004 Nov;167(4):735-44

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1083/jcb.200406101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172594PMC
November 2004

Life and death decisions: secondary complexes and lipid rafts in TNF receptor family signal transduction.

Immunity 2004 Oct;21(4):461-5

Immunoregulation Unit, Autoimmunity Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.immuni.2004.10.001DOI Listing
October 2004

Viral FLIP impairs survival of activated T cells and generation of CD8+ T cell memory.

J Immunol 2004 May;172(10):6313-23

Immunoregulation Unit, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.4049/jimmunol.172.10.6313DOI Listing
May 2004

Measurement of apoptosis and other forms of cell death.

Curr Protoc Immunol 2004 May;Chapter 3:Unit 3.17

National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1002/0471142735.im0317s59DOI Listing
May 2004

Death receptor signaling and autoimmunity.

Immunol Res 2003 ;27(2-3):499-512

Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1385/IR:27:2-3:499DOI Listing
March 2004

Ligand-independent redistribution of Fas (CD95) into lipid rafts mediates clonotypic T cell death.

Nat Immunol 2004 Feb 25;5(2):182-9. Epub 2004 Jan 25.

Immunoregulation Unit, Autoimmunity Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1038/ni1024DOI Listing
February 2004

Selective recognition of acetylated histones by bromodomain proteins visualized in living cells.

Mol Cell 2004 Jan;13(1):33-43

Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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January 2004

Interaction of histone acetylases and deacetylases in vivo.

Mol Cell Biol 2003 Feb;23(3):1025-33

Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC140702PMC
http://dx.doi.org/10.1128/mcb.23.3.1025-1033.2003DOI Listing
February 2003

Apoptosis signaling pathways.

Curr Protoc Immunol 2002 Nov;Chapter 11:Unit 11.9C

National Institute of Allergy & Infectious Diseases, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1002/0471142735.im1109cs44DOI Listing
November 2002

Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency.

Nature 2002 Sep;419(6905):395-9

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nature01063DOI Listing
September 2002

Binding of FADD and caspase-8 to molluscum contagiosum virus MC159 v-FLIP is not sufficient for its antiapoptotic function.

J Virol 2002 Jan;76(2):697-706

Medical Virology Section, Laboratory of Clinical Investigation, Molecular Development of the Immune System Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC136828PMC
http://dx.doi.org/10.1128/jvi.76.2.697-706.2002DOI Listing
January 2002